Bruker Introduces Novel NMR Scientific Capabilities for Structural Biology Discoveries in Membrane Proteins and Protein Aggregates

Rhea-AI Summary

Bruker introduces novel high-resolution solid-state NMR scientific capabilities at the 65th ENC, enabling structural biology discoveries in large proteins, membrane proteins, and protein aggregates. The new ultra-fast CP/MAS iProbe with 160 kHz MAS system provides enhanced 1H-NMR resolution and T2' times, advancing the study of biological samples. The introduction of standard-bore DNP Probes for 600 and 800 MHz expands solid-state DNP-NMR research accessibility, offering sensitivity enhancements of 50x to 200x.

Insights

Market Research Analyst

The introduction of Bruker Corporation's new ultra-fast CP/MAS iProbe and the associated high-resolution solid-state NMR scientific capabilities appears to be a significant advancement in the field of structural biology. The technological leap in NMR spectroscopy could potentially lead to breakthroughs in understanding large proteins and membrane proteins, which are important in disease research and drug development. The market for NMR spectroscopy is niche but vital and Bruker's innovation could solidify its position as a market leader, potentially impacting its financial performance positively.

With the installation of the 160 kHz MAS probe at CNRS Lyon, Bruker is not only showcasing its commitment to advancing scientific research but also strategically placing its technology in a prominent research institution, which could lead to increased visibility and adoption in the scientific community. The expansion into standard-bore DNP Probes for more economical SB NMR magnets could democratize access to high-sensitivity NMR, potentially expanding Bruker's market and driving sales growth.

Biotech Industry Analyst

From a biotech industry perspective, Bruker's advancements in NMR technology could be transformative. The enhanced resolution and sensitivity in NMR spectroscopy are critical for gaining insights into the structure and dynamics of biomolecules, which is fundamental for the development of new therapeutics. The ability to study protein aggregates in greater detail is particularly relevant for research into neurodegenerative diseases like Alzheimer's and Parkinson's, where such aggregates are implicated.

The introduction of technology that supports ultra-high DNP-NMR sensitivity in standard-bore magnets is especially noteworthy. It represents a significant reduction in the barrier to entry for research institutions that could not previously afford the cost of wide-bore NMR magnets. This could lead to a broader adoption of NMR technology, potentially resulting in an increase in demand for Bruker's products. In the long term, this could translate to a stronger pipeline of drug candidates and a more robust drug discovery process industry-wide.

Financial Analyst

Analyzing the financial implications of Bruker Corporation's announcement from an investment perspective, the introduction of novel NMR capabilities could be seen as a strategic move to capture a larger share of the NMR market. The investment in developing high-field gyrotrons for solid-state DNP-NMR at higher frequencies indicates a commitment to staying at the forefront of the NMR technology curve, which may be attractive to investors looking for companies with a strong focus on innovation.

However, the actual impact on Bruker's financials will depend on the adoption rate of the new technology by research institutions and the pharmaceutical industry. The potential revenue growth from these innovations could be substantial, but it's also important to consider the research and development costs associated with bringing such advanced technology to market. Investors will need to weigh these factors against the projected increase in sales and market share when evaluating Bruker's stock performance.

ASILOMAR, Calif.--(BUSINESS WIRE)-- Bruker Corporation (Nasdaq: BRKR), the leading provider of nuclear magnetic resonance (NMR) spectroscopy solutions, announces the introduction of novel high-resolution solid-state NMR scientific capabilities that can enable unprecedented structural biology discoveries in large proteins, membrane proteins and in protein aggregates.

The rotor for the new CPMAS iProbe is 0.4 mm in diameter, rotating mechanically at 160kHz (pencil for scale) (Photo: Business Wire)

At the 65^th ENC (www.enc-conference.org), Bruker introduces a new ultra-fast CP/MAS iProbe as the latest innovation in solid-state NMR technology. Featuring a 160 kHz Magic Angle Spinning (MAS) system, it takes high-resolution MAS and proton detection on solid biological samples to the next level, enabling new scientific discoveries. The dramatically enhanced 1H-NMR resolution and enhanced T2' times make 160 kHz MAS suitable for the study of large proteins, membrane proteins and protein aggregates. Multiple 160 kHz MAS probes are available for customer demonstrations and collaborations on 700 and 800 MHz NMR spectrometers in Bruker’s applications facility in Germany. In addition, a 160 kHz MAS probe is now installed on the 1.0 GHz NMR at CNRS Lyon, where it expands the scientific capabilities of biological solid-state research.

Professor Guido Pintacuda, CNRS researcher at the Institute of Analytical Sciences in Lyon, commented: “With the new 160 kHz MAS probe we witness a leap forward in resolution, now enabling us to reveal the subtlest nuances of molecular structures and interactions. This is a bold step into the atomic-level description of biomolecules and will contribute to lift the role of NMR in disease research to the next level.”

Bruker also introduces novel technology for standard-bore (SB) DNP Probes for 600 and 800 MHz, and eventually for GHz SB magnets to allow scientists to study small molecules, proteins or materials with ultrahigh DNP-NMR sensitivity. The new SB-DNP probe technology broadens the accessibility of solid-state DNP-NMR research. Previously, wide-bore (WB) NMR magnets were required for DNP, and now the same DNP-NMR sensitivity enhancements of 50x to 200x can be achieved with more economical and widely adopted SB NMR magnets.

The new HCN SB DNP probes are available for LT-MAS below 100 Kelvin, with 1.3 mm or 0.7 mm MAS rotor diameters for high-resolution MAS even at low temperatures. Bruker is in the process of developing high-field gyrotrons for microwave frequencies of 658 GHz to 790 GHz for solid-state DNP-NMR at 1.0 and 1.2 GHz.

About Bruker Corporation – Leader of the Post-Genomic Era (Nasdaq: BRKR)

Bruker is enabling scientists and engineers to make breakthrough post-genomic discoveries and develop new applications that improve the quality of human life. Bruker’s high performance scientific instruments and high value analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular, and microscopic levels. In close cooperation with our customers, Bruker is enabling innovation, improved productivity, and customer success in post-genomic life science molecular and cell biology research, in applied and biopharma applications, in microscopy and nanoanalysis, as well as in industrial and cleantech research, and next-gen semiconductor metrology in support of AI. Bruker offers differentiated, high-value life science and diagnostics systems and solutions in preclinical imaging, clinical phenomics research, proteomics and multiomics, spatial and single-cell biology, functional structural and condensate biology, as well as in clinical microbiology and molecular diagnostics. For more information, please visit www.bruker.com.

View source version on businesswire.com: https://www.businesswire.com/news/home/20240408860289/en/

Investor Contact:

Justin Ward

Sr. Director, Investor Relations & Corporate Development

Bruker Corporation

T: +1 (978) 313-5800

E: Investor.Relations@bruker.com

Media Contact:

Markus Ziegler

Sr. Director and Head of Group Marketing

Bruker BioSpin

T: +49 172 3733531

E: pr@bruker.com

Source: Bruker Corporation

FAQ

What is Bruker announcing at the 65th ENC?

Bruker is introducing novel high-resolution solid-state NMR scientific capabilities at the 65th ENC, enabling structural biology discoveries in large proteins, membrane proteins, and protein aggregates.

What is the new technology introduced by Bruker ?

Bruker introduces a new ultra-fast CP/MAS iProbe with a 160 kHz MAS system, providing enhanced 1H-NMR resolution and T2' times for the study of biological samples.

What are the benefits of the 160 kHz MAS probe?

The 160 kHz MAS probe enables new scientific discoveries by offering enhanced resolution suitable for the study of large proteins, membrane proteins, and protein aggregates.

What is the significance of the standard-bore DNP Probes introduced by Bruker ?

The standard-bore DNP Probes for 600 and 800 MHz expand solid-state DNP-NMR research accessibility, providing sensitivity enhancements of 50x to 200x for studying small molecules, proteins, or materials.

Where can customers access the 160 kHz MAS probes for demonstrations and collaborations?

Customers can access multiple 160 kHz MAS probes for demonstrations and collaborations on 700 and 800 MHz NMR spectrometers at Bruker's applications facility in Germany.