BioMarin Holds Investor Day; Provides New Corporate Strategy and Introduces 2027 Financial Guidance
BioMarin Pharmaceutical Inc. (NASDAQ: BMRN) hosted an Investor Day, unveiling a new corporate strategy and financial guidance for 2027. The company aims to deliver sustained value creation through a restructured organization built around three business units: Enzyme Therapies, Skeletal Conditions, and ROCTAVIAN®. BioMarin plans to implement a $500 million cost transformation program to support Non-GAAP Operating margin targets.
Key financial projections include:
- Total Revenues of $4 billion by 2027
- Non-GAAP Operating Margin in the low-to-mid 40%s starting with 40% in 2026
- Operating Cash flow of $1.25 billion+ by 2027
The company reaffirmed its 2024 guidance, projecting Total Revenues of $2.750B to $2.825B and Non-GAAP Operating Margin of 26% to 27%.
BioMarin Pharmaceutical Inc. (NASDAQ: BMRN) ha organizzato un Investor Day, svelando una nuova strategia aziendale e indicazioni finanziarie per il 2027. L'azienda punta a creare valore sostenuto attraverso un'organizzazione ristrutturata attorno a tre unità aziendali: Terapie Enzimatiche, Condizioni Scheletriche e ROCTAVIAN®. BioMarin prevede di attuare un programma di trasformazione dei costi di $500 milioni per supportare gli obiettivi di margine operativo Non-GAAP.
Le principali proiezioni finanziarie includono:
- Fatturato totale di $4 miliardi entro il 2027
- Margine operativo Non-GAAP nel basso-medio 40%, partendo dal 40% nel 2026
- Flusso di cassa operativo di $1.25 miliardi+ entro il 2027
L'azienda ha confermato le sue previsioni per il 2024, proiettando un fatturato totale compreso tra $2.750B e $2.825B e un margine operativo Non-GAAP del 26% al 27%.
BioMarin Pharmaceutical Inc. (NASDAQ: BMRN) celebró un Investor Day, revelando una nueva estrategia corporativa y orientación financiera para 2027. La compañía tiene como objetivo crear valor sostenido a través de una organización reestructurada centrada en tres unidades de negocio: Terapias Enzimáticas, Condiciones Esqueléticas y ROCTAVIAN®. BioMarin planea implementar un programa de transformación de costos de $500 millones para apoyar los objetivos de margen operativo Non-GAAP.
Las proyecciones financieras clave incluyen:
- Ingresos totales de $4 mil millones para 2027
- Margen operativo Non-GAAP en el bajo-medio 40%, comenzando con 40% en 2026
- Flujo de caja operativo de $1.25 mil millones+ para 2027
La empresa reaffirmó su orientación para 2024, proyectando ingresos totales de $2.750B a $2.825B y un margen operativo Non-GAAP del 26% al 27%.
BioMarin Pharmaceutical Inc. (NASDAQ: BMRN)는 투자자 날 행사에서 2027년을 위한 새로운 기업 전략과 재무 지침을 발표했습니다. 회사는 효소 요법, 골격 질환 및 ROCTAVIAN® 등 세 개의 사업 부문을 중심으로 재편성된 조직을 통해 지속 가능한 가치 창출을 목표로 하고 있습니다. BioMarin은 Non-GAAP 운영 마진 목표를 지원하기 위해 5억 달러 규모의 비용 변혁 프로그램을 시행할 계획입니다.
주요 재무 전망은 다음과 같습니다:
- 2027년까지 총 수익 $4억 달러
- 2026년 40%에서 시작하여 40%대 중반의 Non-GAAP 운영 마진
- 2027년까지 운영 현금 흐름 $12.5억 달러 이상
회사는 2024년에 대한 가이드를 재확인하며, 총 수익은 $2.750B에서 $2.825B 사이, Non-GAAP 운영 마진은 26%에서 27%로 예상하고 있습니다.
BioMarin Pharmaceutical Inc. (NASDAQ: BMRN) a organisé une Journée Investisseurs, dévoilant une nouvelle stratégie d'entreprise et des prévisions financières pour 2027. L'entreprise vise à créer de la valeur durable grâce à une organisation restructurée autour de trois unités commerciales : Thérapies enzymatiques, Conditions squelettiques et ROCTAVIAN®. BioMarin prévoit de mettre en œuvre un programme de transformation des coûts de 500 millions de dollars pour soutenir les objectifs de marge opérationnelle Non-GAAP.
Les principales projections financières comprennent :
- Revenus totaux de 4 milliards de dollars d'ici 2027
- Marge opérationnelle Non-GAAP dans la fourchette basse à moyenne des 40%, commençant à 40% en 2026
- Flux de trésorerie d'exploitation de 1,25 milliard de dollars+ d'ici 2027
L'entreprise a réaffirmé ses prévisions pour 2024, projetant des revenus totaux de 2,750 à 2,825 milliards de dollars et une marge opérationnelle Non-GAAP de 26% à 27%.
Die BioMarin Pharmaceutical Inc. (NASDAQ: BMRN) hat einen Investor Day veranstaltet, bei dem eine neue Unternehmensstrategie und finanzielle Ziele für 2027 vorgestellt wurden. Das Unternehmen zielt darauf ab, durch eine umstrukturierte Organisation, die auf drei Geschäftsbereiche ausgerichtet ist: Enzymtherapien, Skeletterkrankungen und ROCTAVIAN®, einen nachhaltigen Wert zu schaffen. BioMarin plant die Umsetzung eines Kostentransformationsprogramms in Höhe von 500 Millionen US-Dollar, um die Non-GAAP-Betriebszinzziele zu unterstützen.
Wichtige Finanzprognosen sind:
- Gesamtumsätze von 4 Milliarden US-Dollar bis 2027
- Non-GAAP-Betriebszinssätze im unteren bis mittleren 40%-Bereich, beginnend mit 40% im Jahr 2026
- Betriebliches Cashflow von 1,25 Milliarden US-Dollar+ bis 2027
Das Unternehmen bekräftigte die Prognosen für 2024 und rechnet mit Gesamtumsätzen von 2,750 bis 2,825 Milliarden US-Dollar und einem Non-GAAP-Betriebszins von 26% bis 27%.
- New corporate strategy focused on three key business units to drive sustainable growth
- Implementation of a $500 million cost transformation program
- Projected Total Revenues of $4 billion by 2027, up from 2024 guidance of $2.750B to $2.825B
- Expected improvement in Non-GAAP Operating Margin from 26-27% in 2024 to low-to-mid 40%s by 2026
- Anticipated Operating Cash flow of $1.25 billion+ by 2027
- None.
Insights
BioMarin's Investor Day presentation unveils an ambitious growth strategy with significant financial implications. The company's projection of
The planned
The
BioMarin's restructuring into three business units - Enzyme Therapies, Skeletal Conditions and ROCTAVIAN® - signals a strategic shift towards market specialization. This approach could enhance the company's ability to capture market share and respond more effectively to specific therapeutic needs.
The emphasis on "creating and leading new therapeutic markets" suggests a focus on innovative, first-to-market treatments. This strategy, if successful, could position BioMarin as a pioneer in underserved medical areas, potentially leading to higher profit margins and market exclusivity.
However, investors should be aware that pioneering new markets also carries higher risks. The success of this strategy will heavily depend on BioMarin's R&D pipeline, regulatory approvals and ability to educate healthcare providers and patients about new treatment options.
"Over the last 9 months, we have undertaken the transformation of BioMarin's operations and ways of working with the goal of accelerating and delivering substantial value to all our stakeholders – patients, employees and shareholders," said Mr. Hardy. "Our new corporate strategy harnesses BioMarin's unique capabilities creating and leading new therapeutic markets around the world to deliver innovative medicines to the patients we serve. We are confident in our ability to realize the ambitious plans outlined today and excited to deliver on our new vision for BioMarin's future."
Corporate Strategy
The company reviewed BioMarin's differentiated strategy including its new company structure and updated organizational model, now built around three business units, Enzyme Therapies, Skeletal Conditions and ROCTAVIAN®, designed to support the focus on sustainable growth. The updated corporate strategy also includes the implementation of a
Value Commitment
BioMarin provided an overview of its long-term financial outlook, based on its strategic plan to drive revenue growth and expand Non-GAAP Operating Margin. The summary table below includes the company's full year 2024 guidance, reaffirmed today, and the newly introduced outlook for 2026 with respect to Non-GAAP Operating Margin and other metrics for 2027, shared at BioMarin's Investor Day.
Item | FY 2024 (reaffirmed) | FY 2027 |
Total Revenues | ||
Non-GAAP Operating Margin (1) | Low-to-mid | |
Non-GAAP Diluted EPS (1)(2) | N/A | |
Operating Cash flow | N/A |
(1) | Refer to Non-GAAP Information beginning on page 4 of this press release for the definitions of Non-GAAP Operating Margin and Non-GAAP Diluted EPS. Reconciliation of forward-looking Non-GAAP Operating Margin and Non-GAAP Diluted EPS to the most directly comparable U.S. GAAP reported financial measures is not available. Refer to Forward-Looking Non-GAAP Financial Measures beginning on page 5 of this press release for further information regarding forward-looking Non-GAAP financial measures. |
(2) | Non-GAAP Diluted EPS guidance assumes approximately 200 million Non-GAAP weighted-average diluted shares outstanding. |
Innovation
The company highlighted its innovation strategy that supports BioMarin's pipeline of high impact medicines, including 11 anticipated product launches by 2034 and two by 2027. Building on its 25-year history developing medicines that target serious genetic conditions, several programs that are currently advancing through the pipeline, include:
- Phase 3 enrollment of VOXZOGO® for the treatment of hypochondroplasia, with expected data readout targeted in 2026, and potential approval in 2027
- Clinical updates on four additional skeletal conditions, including idiopathic short stature, Noonan Syndrome, Turner Syndrome and SHOX Deficiency, all progressing through or beginning Phase 2 studies
- PALYNZIQ® age label expansion to include 12-17-year-olds in
the United States and 12-15-year-olds outside ofthe United States , with targeted filings in late 2025 and early 2026, respectively - BMN 390 for the treatment of phenylketonuria (PKU) with a targeted profile that reduces immunogenicity from novel pegylation, and targeted Investigational New Drug (IND) application planned for late 2025
- BMN 351 for the treatment of Duchenne Muscular Dystrophy that targets a unique novel site for exon skipping that may enable dystrophin expression up to
40% , based on observations preclinically. Target Proof of Concept (POC) is expected in 2025 - BMN 349 for the treatment of Alpha-1 Antitrypsin Deficiency with a unique mechanism of action that has the potential to transform liver health and with target POC in 2026
- BMN 370 for the treatment of von Willebrand Disease (vWD) has the potential to normalize bleeding events, based on results from a vWD preclinical model, and is designed to be delivered with a single subcutaneous injection. The targeted IND is planned for late 2025.
Growth:
The company highlighted its strategy for optimizing its growing and durable Enzyme Therapies business unit, as well as its plan for sustainable leadership across multiple Skeletal Conditions, building on the strength of VOXZOGO for the treatment of achondroplasia. The combined business units are expected to drive a targeted mid-teen Compounded Annual Growth Rate through 2034.
A replay of today's event and accompanying presentation slides can be found at investors.biomarin.com.
About BioMarin
Founded in 1997, BioMarin is a global biotechnology Company dedicated to transforming lives through genetic discovery. The Company develops and commercializes targeted therapies that address the root cause of genetic conditions. BioMarin's unparalleled research and development capabilities have resulted in eight transformational commercial therapies for patients with rare genetic disorders. The Company's distinctive approach to drug discovery has produced a diverse pipeline of commercial, clinical, and pre-clinical candidates that address a significant unmet medical need, have well-understood biology, and provide an opportunity to be first-to-market or offer a substantial benefit over existing treatment options. For additional information, please visit www.biomarin.com.
Forward-Looking Statements
This press release and the associated conference call and webcast contain forward-looking statements about the business prospects of BioMarin Pharmaceutical Inc. (BioMarin), including, without limitation, statements about: future financial performance, including the expectations of Total Revenues, Non-GAAP Operating Margin percentage, Non-GAAP Diluted EPS, Operating Cash Flow and Revenue Compound Annual Growth Rate (CAGR) for, in certain instances, the full-year 2024 and future periods and the underlying assumptions; BioMarin's new corporate strategy, including plans and expectations regarding innovation and growth, the
These forward-looking statements are predictions and involve risks and uncertainties such that actual results may differ materially from these statements. These risks and uncertainties include, among others, those factors detailed in BioMarin's filings with the Securities and Exchange Commission, including, without limitation, the factors contained under the caption "Risk Factors" in BioMarin's Quarterly Report on Form 10-Q for the quarter ended June 30, 2024, as such factors may be updated by any subsequent reports. You should carefully consider that information before you make an investment decision. You should not place undue reliance on forward-looking statements, which speak only as of the date hereof. These forward-looking statements are based on the beliefs and assumptions of the Company's management based on information currently available to management and should be considered in connection with any written or oral forward-looking statements that the Company may issue in the future as well as other cautionary statements the Company has made and may make. Except as required by law, BioMarin does not undertake any obligation to update or alter any forward-looking statement, whether as a result of new information, future events or otherwise.
BioMarin®, BRINEURA®, KUVAN®, NAGLAZYME®, PALYNZIQ®, ROCTAVIAN®, VIMIZIM® and VOXZOGO® are registered trademarks of BioMarin Pharmaceutical Inc., or its affiliates. ALDURAZYME® is a registered trademark of BioMarin/Genzyme LLC. All other brand names and service marks, trademarks and other trade names appearing in this release are the property of their respective owners.
Non-GAAP Information
This press release includes both GAAP information and Non-GAAP information. Non-GAAP Income is defined by the company as GAAP Net Income excluding amortization of intangible assets, stock-based compensation expense and, in certain periods, certain other specified items, as detailed below when applicable. The company also includes a Non-GAAP adjustment for the estimated tax impact of the reconciling items. Non-GAAP Operating Margin percentage is defined by the company as GAAP Income from Operations, excluding amortization of intangible assets, stock-based compensation expense, and, in certain periods, certain other specified items, divided by GAAP Total Revenues. Non-GAAP Diluted EPS is defined by the company as Non-GAAP Income divided by Non-GAAP weighted-average diluted shares outstanding. Non-GAAP weighted-average diluted shares outstanding is defined by the company as GAAP weighted-average diluted shares outstanding, adjusted to include any common shares issuable under the company's equity plans and convertible debt in periods when they are dilutive under Non-GAAP.
BioMarin regularly uses both GAAP and Non-GAAP results and expectations internally to assess its financial operating performance and evaluate key business decisions related to its principal business activities: the discovery, development, manufacture, marketing and sale of innovative biologic therapies. Because Non-GAAP Income, Non-GAAP Operating Margin percentage, Non-GAAP Diluted EPS and Non-GAAP weighted-average diluted shares outstanding are important internal measurements for BioMarin, the company believes that providing this information in conjunction with BioMarin's GAAP information for historical results enhances investors' and analysts' ability to meaningfully compare the company's results from period to period and to its forward-looking guidance, and to identify operating trends in the company's principal business. BioMarin also uses Non-GAAP Income internally to understand, manage and evaluate its business and to make operating decisions, and compensation of executives is based in part on this measure.
Non-GAAP measures are not meant to be considered in isolation or as a substitute for, or superior to, comparable GAAP measures and should be read in conjunction with the consolidated financial information prepared in accordance with GAAP. Investors should note that the Non-GAAP information is not prepared under any comprehensive set of accounting rules or principles and does not reflect all of the amounts associated with the company's results of operations as determined in accordance with GAAP. Investors should also note that these Non-GAAP financial measures have no standardized meaning prescribed by GAAP and, therefore, have limits in their usefulness to investors. In addition, from time to time in the future there may be other items that the company may exclude for purposes of its Non-GAAP financial measures; likewise, the company may in the future cease to exclude items that it has historically excluded for purposes of its Non-GAAP financial measures. Because of the non-standardized definitions, the Non-GAAP financial measure as used by BioMarin in this press release may be calculated differently from, and therefore may not be directly comparable to, similarly titled measures used by other companies.
Forward-Looking Non-GAAP Financial Measures
BioMarin does not provide guidance for GAAP reported financial measures (other than revenue) or a reconciliation of forward-looking Non-GAAP financial measures to the most directly comparable GAAP reported financial measures because the company is unable to predict with reasonable certainty the financial impact of changes resulting from its strategic portfolio and business operating model reviews; potential future asset impairments; gains and losses on investments; and other unusual gains and losses without unreasonable effort. These items are uncertain, depend on various factors, and could have a material impact on GAAP reported results for the guidance period. As such, any reconciliations provided would imply a degree of precision that could be confusing or misleading to investors.
Contacts: | |
Investors | Media |
Traci McCarty | Marni Kottle |
BioMarin Pharmaceutical Inc. | BioMarin Pharmaceutical Inc. |
(415) 455-7558 | (415) 218-7111 |
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