BioMark Diagnostics and Principal Investigators Publish an Important Approach Using Metabolomics and ML to Identify Biomarkers for NEN
BioMark Diagnostics Inc. (CSE: BUX) (FSE: 20B) (OTC Pink: BMKDF) has published a study in Cancers titled "Metabolic Profiling of Pulmonary Neuroendocrine Neoplasms." The research, which examined 153 metabolites in 657 samples, identifies specific metabolomic biomarkers for early diagnosis and monitoring of pulmonary neuroendocrine neoplasms (NENs).
Key findings reveal altered plasma concentrations of multiple metabolites in NENs, highlighting changes in key metabolic pathways. This research contributes to understanding cancer metabolism and its potential clinical applications for NENs, offering benefits for detection, diagnosis, and predictive biomarker development.
BioMark's liquid biopsy-based technology platform provides a non-invasive method for detecting NENs and has shown clinical utility in early detection of other hard-to-detect cancers. The study was funded by a MEDTEQ+ research grant and conducted in collaboration with IUCPQ and The Metabolomics Innovation Centre (TMIC).
BioMark Diagnostics Inc. (CSE: BUX) (FSE: 20B) (OTC Pink: BMKDF) ha pubblicato uno studio nella rivista Cancers intitolato "Profilazione Metabolica dei Neoplasmi Neuroendocrini Polmonari." La ricerca, che ha esaminato 153 metaboliti in 657 campioni, identifica specifici biomarcatori metabolomici per la diagnosi precoce e il monitoraggio dei neoplasmi neuroendocrini polmonari (NEN).
I risultati chiave rivelano concentrazioni plasmatiche alterate di numerosi metaboliti nei NEN, evidenziando cambiamenti in percorsi metabolici fondamentali. Questa ricerca contribuisce alla comprensione del metabolismo del cancro e delle sue potenziali applicazioni cliniche per i NEN, offrendo vantaggi per la rilevazione, la diagnosi e lo sviluppo di biomarcatori predittivi.
La piattaforma tecnologica di biopsia liquida di BioMark fornisce un metodo non invasivo per rilevare i NEN e ha dimostrato utilità clinica nella diagnosi precoce di altri tumori difficili da rilevare. Lo studio è stato finanziato da un grant di ricerca MEDTEQ+ ed è stato condotto in collaborazione con IUCPQ e The Metabolomics Innovation Centre (TMIC).
BioMark Diagnostics Inc. (CSE: BUX) (FSE: 20B) (OTC Pink: BMKDF) ha publicado un estudio en la revista Cancers titulado "Perfil Metabólico de Neoplasias Neuroendocrinas Pulmonares." La investigación, que examinó 153 metabolitos en 657 muestras, identifica biomarcadores metabolómicos específicos para el diagnóstico temprano y el monitoreo de neoplasias neuroendocrinas pulmonares (NEN).
Las principales conclusiones revelan concentraciones plasmáticas alteradas de múltiples metabolitos en los NEN, destacando cambios en vías metabólicas clave. Esta investigación contribuye a la comprensión del metabolismo del cáncer y sus aplicaciones clínicas potenciales para los NEN, ofreciendo beneficios para la detección, el diagnóstico y el desarrollo de biomarcadores predictivos.
La plataforma tecnológica de biopsia líquida de BioMark proporciona un método no invasivo para detectar los NEN y ha mostrado utilidad clínica en la detección precoz de otros cánceres de difícil diagnóstico. El estudio fue financiado por una subvención de investigación MEDTEQ+ y se llevó a cabo en colaboración con IUCPQ y The Metabolomics Innovation Centre (TMIC).
BioMark Diagnostics Inc. (CSE: BUX) (FSE: 20B) (OTC Pink: BMKDF)는 Cancers 저널에 "폐 신경내분비 신생물의 대사 프로파일링"이라는 연구를 발표했습니다. 657개의 샘플에서 153개의 대사물을 조사한 이 연구는 폐 신경내분비 신생물(NEN)의 조기 진단 및 모니터링을 위한 특정 대사체 바이오마커를 식별합니다.
주요 발견은 NEN의 여러 대사물의 혈장 농도가 변화하고 있음을 드러내며, 주요 대사 경로의 변화를 강조합니다. 이 연구는 암의 대사 이해와 NEN에 대한 잠재적인 임상 응용에 기여하며, 검출, 진단 및 예측 바이오마커 개발에 이점이 됩니다.
BioMark의 액체 생검 기반 기술 플랫폼은 NEN을 감지하기 위한 비침습적인 방법을 제공하며, 다른 검출하기 어려운 암의 조기 진단에서 임상적 유용성을 입증했습니다. 이 연구는 MEDTEQ+ 연구 보조금으로 자금 지원을 받았으며, IUCPQ 및 The Metabolomics Innovation Centre (TMIC)와 협력하여 수행되었습니다.
BioMark Diagnostics Inc. (CSE: BUX) (FSE: 20B) (OTC Pink: BMKDF) a publié une étude dans la revue Cancers intitulée "Profilage Métabolique des Néoplasmes Neuroendocriniens Pulmonaires." La recherche, qui a examiné 153 métabolites dans 657 échantillons, identifie des biomarqueurs métabolomiques spécifiques pour le diagnostic précoce et le suivi des néoplasmes neuroendocriniens pulmonaires (NEN).
Les principales conclusions révèlent des concentrations plasmatiques altérées de plusieurs métabolites dans les NEN, mettant en évidence des changements dans des voies métaboliques clés. Cette recherche contribue à la compréhension du métabolisme du cancer et à ses applications cliniques potentielles pour les NEN, offrant des avantages pour la détection, le diagnostic et le développement de biomarqueurs prédictifs.
La plateforme technologique de biopsie liquide de BioMark fournit une méthode non invasive pour détecter les NEN et a montré son utilité clinique dans la détection précoce d'autres cancers difficiles à détecter. L'étude a été financée par une bourse de recherche MEDTEQ+ et réalisée en collaboration avec IUCPQ et le Metabolomics Innovation Centre (TMIC).
BioMark Diagnostics Inc. (CSE: BUX) (FSE: 20B) (OTC Pink: BMKDF) hat eine Studie in der Zeitschrift Cancers mit dem Titel "Metabolische Profilierung von pulmonalen neuroendokrinen Neoplasmen" veröffentlicht. Die Forschung, die 153 Metaboliten in 657 Proben untersuchte, identifiziert spezifische metabolomische Biomarker für die Frühdiagnose und Überwachung von pulmonalen neuroendokrinen Neoplasmen (NEN).
Wichtige Ergebnisse zeigen veränderte Plasmakonzentrationen mehrerer Metaboliten in NEN, was auf Veränderungen in wichtigen Stoffwechselwegen hinweist. Diese Forschung trägt zum Verständnis des Krebsstoffwechsels und dessen potenziellen klinischen Anwendungen für NEN bei, indem sie Vorteile für die Erkennung, Diagnose und Entwicklung prädiktiver Biomarker bietet.
Die flüssigkeitsbasierte Biopsietechnologie von BioMark bietet eine nicht-invasive Methode zur Detektion von NEN und hat sich bei der frühen Detektion anderer schwer zu erkennender Krebserkrankungen als klinisch nützlich erwiesen. Die Studie wurde durch einen MEDTEQ+ Forschungsstipendium finanziert und in Zusammenarbeit mit IUCPQ und dem Metabolomics Innovation Centre (TMIC) durchgeführt.
- Publication of research in Cancers journal, enhancing scientific credibility
- Identification of specific metabolomic biomarkers for early NEN diagnosis
- Large study cohort of 657 samples, increasing statistical significance
- Demonstration of liquid biopsy technology's potential for non-invasive cancer detection
- Potential for clinical application in detection, diagnosis, and biomarker development
- None.
BioMark's Liquid Biopsy Technology Offers Promise for NEN Diagnosis
Vancouver, British Columbia--(Newsfile Corp. - September 24, 2024) - BioMark Diagnostics Inc. (CSE: BUX) (FSE: 20B) (OTC Pink: BMKDF), a leading developer of liquid biopsy tests for early cancer detection, is excited to announce that its latest work, has been published in Cancers, titled "Metabolic Profiling of Pulmonary Neuroendocrine Neoplasms." This paper sheds light on the metabolic alterations that define pulmonary neuroendocrine neoplasms (NENs), focusing on identifying specific metabolomic biomarkers for early diagnosis and monitoring. Earlier in March 2023, a poster related to this study was presented at the United States and Canadian Academy of Pathology (USCAP) held in New Orleans.
"The study examined 153 metabolites in a large cohort of 657 samples, encompassing NEN patients, healthy controls, and individuals with non-small cell lung cancers (NSCLCs). Multiple metabolites with consistently altered plasma concentrations in NENs, reveal key changes in key metabolic pathways. These findings contribute to a growing body of research that emphasizes the significance of cancer metabolism and its potential for clinical application specifically for NENs, and offers potential benefits for detection, diagnosis, and predictive biomarker development, says Dr. Philippe Jourbert. These findings could lead to new biomarkers for early detection and better management of lung NENs, ultimately improving patient outcomes.
"BioMark's versatile liquid biopsy-based technology platform not only offers a non-invasive method for accurately detecting NENs but has demonstrated its clinical utility in early detection of other hard-to-detect and treat cancers such as lung cancer", says CEO and President of BioMark Rashid Bux. He further adds, "Our platform allows for adjacency in the other cancers and more importantly it provides a more accessible, accurate, cost-effective, and timely option for patients and healthcare providers.
BioMark would like to thank all who collaborated on this project. This work was made possible through the efforts of the outstanding team at the IUCPQ. The Metabolomics Innovation Centre (TMIC), as well as through active collaboration with BioMark. The MEDTEQ+ research grant provided the funding for this project. This research was funded by MEDTEQ+, grant 15-G lung cancer biomarker, and BioMark Diagnostics Inc.
The published paper can be accessed at https://doi.org/10.3390/cancers16183179
About NENs and Lung Cancer
Lung cancer is the leading cause of cancer deaths, representing a major public health issue worldwide. Among the newly diagnosed lung cancers,
Use of Liquid Biopsy
Over the last decade, liquid biopsy (blood or other body fluids) has gained interest as a surrogate approach to diagnose pulmonary tumors. The advantages of a liquid biopsy are numerous: easy access to blood, quick turnaround time, and the possibility of making a diagnosis when a tissue biopsy is not feasible.
About BioMark Diagnostics Inc.
BioMark Diagnostics Inc. is a leading developer of liquid biopsy tests for the early detection of cancer that leverages the power of metabolomics and machine learning algorithms. The company's proprietary technology utilizes a simple blood draw to detect the presence of cancer-associated biomarkers, enabling earlier diagnosis and improved patient outcomes. The technology can also be used for measuring response to treatment and potentially for serial monitoring of cancer survivors. BioMark is committed to developing innovative and accessible diagnostic solutions to address unmet medical needs in oncology.
Further information about BioMark is available under its profile on the SEDAR+ website www.sedarplus.ca and the CSE website https://thecse.com/.
For further information on BioMark, please Contact:
Rashid Ahmed Bux
President & CEO
BioMark Diagnostics Inc.
Tel. 604-370-0779
Email: info@biomarkdiagnostics.com
Forward-Looking Information:
This press release may include forward-looking information within the meaning of Canadian securities legislation, concerning the business of BioMark. Forward-looking information is based on certain key expectations and assumptions made by the management of BioMark. Although BioMark believes that the expectations and assumptions on which such forward-looking information is based are reasonable, undue reliance should not be placed on the forward-looking information because BioMark can give no assurance that they will prove to be correct. Forward-looking statements contained in this press release are made as of the date of this press release. BioMark disclaims any intent or obligation to update publicly any forward-looking information, whether as a result of new information, future events, or results or otherwise, other than as required by applicable securities laws.
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FAQ
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