Welcome to our dedicated page for Bioxytran news (Ticker: BIXT), a resource for investors and traders seeking the latest updates and insights on Bioxytran stock.
Bioxytran Inc is a clinical-stage biopharmaceutical company developing oxygen transport and antiviral therapeutics using proprietary carbohydrate-based technologies. The company's research focuses on two primary platforms: hemoglobin-based oxygen carriers for treating tissue hypoxia, and broad-spectrum antiviral drugs that target galectin proteins involved in viral infection and inflammation.
The oxygen transport platform utilizes hemoglobin stabilized with glyco-polymer technology to create molecules significantly smaller than red blood cells, enabling penetration into ischemic tissues beyond blood clots. Target applications include ischemic stroke, traumatic brain injury, chronic kidney disease, and other conditions where oxygen delivery is compromised. The company has established partnerships to develop Universal Oxygen Carriers as potential alternatives to traditional blood transfusions, addressing global blood supply challenges.
The antiviral program employs glycovirology principles to develop therapeutics that antagonize galectins, preventing viral adhesion to host cells. The lead antiviral candidate uses complex carbohydrate structures to target conserved regions on viral spike proteins, providing potential activity against multiple respiratory viruses. Clinical development has progressed under FDA Investigational New Drug applications, with trials evaluating viral clearance rates and safety profiles.
Bioxytran's research approach combines artificial intelligence analysis of biological targets with rational drug design to create optimized carbohydrate-based molecules. The company maintains patent protection for its co-polymer technologies and continues to advance multiple drug candidates through preclinical and clinical development stages. Strategic collaborations with government agencies and industry partners support the company's development programs and manufacturing capabilities.
News and developments related to Bioxytran typically involve clinical trial progress, regulatory clearances, partnership announcements, financing activities, and research findings related to the company's oxygen transport and antiviral platforms. Investors and stakeholders monitor updates on drug candidate advancement, intellectual property developments, and strategic initiatives that may impact the company's path toward potential product commercialization.
Bioxytran (OTCQB: BIXT) has announced a potential breakthrough in treating Bird Flu (H5N1) in egg-laying chickens through a new water-soluble galectin antagonist currently in preclinical trials. The treatment aims to prevent the need for mass culling during outbreaks by blocking viral entry into cells.
The company's approach leverages galectin antagonists that neutralize the virus by blocking viral adhesion, a mechanism previously demonstrated in Phase 2 human clinical trials and in vitro tests. The carbohydrate-based treatment targets viral spike proteins, preventing them from connecting to cells, potentially offering immediate containment of outbreaks.
This development could significantly impact the poultry industry, which currently faces billions in annual losses due to Bird Flu outbreaks and mandatory culling protocols. Bioxytran is actively seeking partnerships with organizations and government agencies to accelerate the treatment's development and deployment.
Bioxytran (OTCQB: BIXT) has secured a $1.6 million common stock purchase agreement with TRITON FUNDS LP, marking their second and larger investment in the company. The funding will serve two main purposes: $805,000 will be used to settle an existing convertible note, while the remaining amount will support regulatory pre-clinical and clinical trials and working capital needs.
Additionally, the company's management is forfeiting accrued salaries and expenses worth over $460,000. The investment aims to advance Bioxytran's development of Galectin Antagonists and support their FDA trial of PLM, while also enabling testing of various pandemic-potential viruses to demonstrate their broad-spectrum antiviral capability.
Bioxytran (OTCQB: BIXT) has released a preprint article exploring the potential enhancement of cancer immunotherapy through galectin-3 modulation. The research focuses on improving Immune Checkpoint Inhibitors (ICIs) effectiveness in cancer treatment. Key findings show that high galectin-3 levels correlate with treatment failure, with 90% of Non-Small Cell Lung Cancer patients with elevated levels failing to respond after three treatments.
The study reveals that galectin-3 protein interferes with ICI therapy by occupying the antibody's PD-1 receptor binding site, preventing effective treatment. However, in vitro tests indicate that galectin-3 antagonists could potentially reverse this effect. The company also published a presentation on cancer metastasis, highlighting the 'Galectin Effect' as cancer's primary defense mechanism against immune response.
Bioxytran (OTCQB: BIXT) held a significant Techwatch Light meeting with BARDA, attracting over 65 government personnel from various agencies including CDMRP, NIAID, NIH, DTRA, and DoD. The company presented four key Areas of Interest: influenza antiviral, immune modulators for lung repair, solutions for uncontrolled hemorrhaging, and a versatile strategic therapeutic.
The meeting focused primarily on discussions about the influenza antiviral and Universal Oxygen Carrier. BARDA provided guidance on program qualification requirements and potential funding opportunities. The company received feedback on development stages and supporting data needed for specific programs, marking a strategic step toward securing government funding for clinical trial development.
Bioxytran (OTCQB:BIXT) has announced a significant breakthrough in virology, validated in a peer-reviewed journal article. The company's drug candidate, Prolectin-M, has shown effectiveness in stopping COVID-19 and other viruses by blocking galectin, a protein important for viral attachment to cells. This discovery, made using advanced Nuclear Magnetic Resonance (NMR) spectroscopy, could impact both the antiviral and vaccination markets, collectively valued at approximately $147 billion.
The study revealed that galectins, located on the virus's spike protein, are an excellent drug target due to their stability. This could lead to the development of broad-spectrum antivirals effective against various viruses. Bioxytran's CEO, Dr. David Platt, believes this discovery represents a new era in antiviral drug development, potentially revolutionizing the treatment of viral diseases and even chronic illnesses like cancer.
Bioxytran (OTCQB: BIXT) has formed a Joint Venture with the Heme Foundation to develop a Universal Oxygen Carrier (UOC) as an alternative to blood transfusions. The Foundation pledged up to $10 million for the project, with $2 million already invested in prototypes and compound development. Bioxytran retains all intellectual property rights, while the Foundation gains usage rights for blood transfusion applications.
The UOC, a hemoglobin-based oxygen carrier, is designed to be compatible with all blood types, pathogen-free, and shelf-stable at room temperature for 5+ years. It has shown promise in small-scale animal trials and is preparing for a large-scale toxicology study. This technology could revolutionize transfusion medicine, particularly in remote areas with blood supply infrastructure.
Bioxytran's Science Advisor, Prof. Avraham Mayevsky, has published a book titled Hyperbaric Oxygenation Mitochondrial Activity and Brain Physiological Functions. The book, available as an eBook or hardcover from Springer, delves into the impact of hyperbaric oxygen on brain functions, particularly mitochondrial activity.
Central to the book is the MDX Viewer, an FDA-approved device that measures tissue oxygenation at the cellular level. The device's output, the Brain Metabolic Score (BMS), is essential for Bioxytran's acellular oxygen carrier (AOC) molecule, BXT-25, which is being developed for ischemic stroke and Alzheimer's disease treatments. Bioxytran aims to use BXT-25 to replace hyperbaric oxygen treatment (HBOT) in clinical trials.
The book offers a comprehensive overview of how hyperbaric oxygen impacts brain biochemical and physiological responses, influencing mitochondrial activity and enhancing brain functions.
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