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Breakthrough CRISPR Technology Study Published in Nature
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Benson Hill, Inc. (NYSE: BHIL) has announced a significant breakthrough in CRISPR technology through a study published in Nature. The research reveals a new mechanism for CRISPR systems, focusing on Cas12a2, which has demonstrated potential for applications beyond gene editing, including cancer therapeutics and programmable microbial community shaping. This collaboration with international scientists aims to harness genetic diversity to advance food innovation. The study also demonstrates that specific sequences can enable RNA detection, enhancing CRISPR-based tools for targeted cellular activity.
Positive
Published groundbreaking research on CRISPR technology in the journal Nature.
Discovery of new enzymatic capabilities in CRISPR systems, potentially expanding applications.
Collaboration with international scientists enhances company reputation and innovation potential.
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None.
Benson Hill’s world-class scientists discover new mechanism for CRISPR technology that detects RNA
ST. LOUIS--(BUSINESS WIRE)--
A groundbreaking research study by a team that included scientists from Benson Hill, Inc. (NYSE: BHIL, the “Company” or “Benson Hill”), has been published this month in Nature, the world’s leading multidisciplinary journal, highlighting a new mechanism for Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology. The research paper, titled “Cas12a2 elicits abortive infection via RNA-triggered destruction of dsDNA,” discusses the discovery of a new enzymatic capability for CRISPR systems, opening the possibility of using CRISPR in new applications beyond gene editing – including cancer therapeutics, programmable shaping of microbial communities, and counterselection to enhance gene editing.
A groundbreaking research study by a team that included scientists from Benson Hill, Inc., has been published this month in Nature, the world’s leading multidisciplinary journal, highlighting a new mechanism for Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology. (Photo: Business Wire)
As part of its work to unlock the genetic diversity of plants, Benson Hill’s team collaborated with members of its Scientific Advisory Board, including university scientists from the U.S. and Germany, to uncover insights and solve a complex biological problem for how CRISPR enzymes work. In doing so, they discovered the underlying biology and a new mechanism for how CRISPR nucleases, specifically Cas12a2, can function. The study concludes that Cas12a2 holds substantial potential for CRISPR technologies as a biotechnological tool.
In a proof-of-principle demonstration, the research team showed that a specific amino acid sequence (SuCas12a2) can be repurposed for RNA detection and potentially expand and enhance the CRISPR-based toolkit. More specifically, the study notes that RNA targeted CRISPR activity could enable programmable killing of multiple cell types.
“At Benson Hill we recognize that it will take an entire community of innovators to solve the challenges of today. This is a great example of us partnering with the broader scientific community to better understand CRISPR technologies,” said Gina Neumann, Senior Scientific Manager, Research and Development at Benson Hill. “It truly takes a diversity of thought and approaches to unlock biology. I’m glad we could partner with fantastic academic collaborators to characterize this new enzymatic capability and lay a foundation for future innovative applications.”
From the early days of Benson Hill, the company has taken a bold approach to learning how genetic diversity can solve problems and create new technologies.
In November 2022Benson Hill formally endorsed the Framework for Responsible Use of Gene Editing in Agriculture. For Benson Hill, the precision of advanced breeding techniques like gene editing unlocks the opportunity to improve diverse crops and focus on benefits like taste, nutrition, and sustainability to leverage the full power of plants and deliver better food choices to consumers.
Benson Hill moves food forward with the CropOS® platform, a cutting-edge food innovation engine that combines data science and machine learning with biology and genetics. Benson Hill empowers innovators to unlock nature’s genetic diversity from plant to plate, with the purpose of creating nutritious, great-tasting food and ingredient options that are both widely accessible and sustainable. More information can be found at bensonhill.com or on Twitter at @bensonhillinc.
What is the significance of Benson Hill's new CRISPR research?
Benson Hill's research identifies a new mechanism of CRISPR technology that could expand its applications beyond gene editing, potentially aiding in cancer treatments.
When was the new CRISPR research published?
The research was published in the January 2023 issue of Nature.
What potential applications does the new CRISPR technology have?
The new CRISPR technology may be used in cancer therapeutics, programmable microbial community shaping, and enhanced gene editing.
What is Benson Hill's stock symbol?
Benson Hill's stock symbol is BHIL.
How could this research impact Benson Hill's stock performance?
The breakthrough in CRISPR technology could position Benson Hill favorably in biotech markets, potentially impacting stock performance positively.
