Awakn Announces Opening of Four Additional AWKN-001 Phase 3 Trial Sites
Awakn Life Sciences Corp. (CSE: AWKN) (OTCQB: AWKNF) has opened four additional clinical trial sites for its Phase 3 'MORE-KARE' trial of AWKN-001, a novel treatment for severe Alcohol Use Disorder (AUD). This brings the total active trial sites to 7 across the UK. AWKN-001 combines intravenous ketamine with psycho-social support.
The study, co-funded by the UK's Medical Research Council, National Institute for Health and Care Research, and Awakn, aims to evaluate the efficacy of a single treatment cycle of AWKN-001. Participants will receive varying doses of ketamine infusion and psycho-social support, with both participants and researchers blinded to the assignments.
This landmark trial is the largest of its kind investigating ketamine-assisted therapy for AUD, with an estimated total cost of £2.4 million / CAD 4.2 million. Awakn is contributing £0.8 million / CAD 1.4 million to the study, which is being conducted at eight NHS sites across the UK.
Awakn Life Sciences Corp. (CSE: AWKN) (OTCQB: AWKNF) ha aperto quattro nuovi centri di sperimentazione clinica per il suo trial di fase 3 'MORE-KARE' sull'AWKN-001, un trattamento innovativo per il grave Disturbo da Uso di Alcol (AUD). Questo porta il numero totale di centri attivi a 7 nel Regno Unito. L'AWKN-001 combina ketamina endovenosa con supporto psico-sociale.
Lo studio, co-finanziato dal Medical Research Council del Regno Unito, dal National Institute for Health and Care Research e da Awakn, ha l'obiettivo di valutare l'efficacia di un ciclo di trattamento singolo con l'AWKN-001. I partecipanti riceveranno dosi variabili di infusione di ketamina e supporto psico-sociale, con sia i partecipanti che i ricercatori in cieco riguardo agli incarichi.
Questo trial pionieristico è il più grande della sua categoria a indagare la terapia assistita da ketamina per l'AUD, con un costo totale stimato di £2.4 milioni / CAD 4.2 milioni. Awakn sta contribuendo con £0.8 milioni / CAD 1.4 milioni allo studio, che si svolge in otto centri NHS nel Regno Unito.
Awakn Life Sciences Corp. (CSE: AWKN) (OTCQB: AWKNF) ha abierto cuatro nuevos centros de ensayos clínicos para su estudio de fase 3 'MORE-KARE' sobre el AWKN-001, un tratamiento novedoso para el grave Trastorno por Consumo de Alcohol (AUD). Esto eleva el número total de centros activos a 7 en el Reino Unido. El AWKN-001 combina ketamina intravenosa con apoyo psicosocial.
El estudio, cofinanciado por el Medical Research Council del Reino Unido, el National Institute for Health and Care Research y Awakn, tiene como objetivo evaluar la eficacia de un ciclo de tratamiento único con AWKN-001. Los participantes recibirán dosis variables de infusión de ketamina y apoyo psicosocial, con tanto los participantes como los investigadores sin conocer las asignaciones.
Este estudio innovador es el más grande de su tipo que investiga la terapia asistida por ketamina para AUD, con un costo total estimado de £2.4 millones / CAD 4.2 millones. Awakn está contribuyendo con £0.8 millones / CAD 1.4 millones al estudio, que se lleva a cabo en ocho centros de NHS en el Reino Unido.
Awakn Life Sciences Corp. (CSE: AWKN) (OTCQB: AWKNF)는 4개의 추가 임상 시험 사이트를 개설했습니다 AWKN-001에 대한 3상 'MORE-KARE' 시험을 위해, 이는 중증 알코올 사용 장애(AUD)에 대한 혁신적인 치료법입니다. 이렇게 해서 영국 전역에서 총 7개의 활성 시험 사이트가 존재하게 되었습니다. AWKN-001은 정맥 주사 케타민과 심리 사회적 지원을 결합합니다.
이번 연구는 영국의 의학 연구 위원회, 보건 및 사회 연구국, Awakn이 공동 자금을 지원하고 있으며, AWKN-001의 단일 치료 주기의 효과를 평가하는 것을 목표로 합니다. 참가자들은 다양한 케타민 주입량과 심리 사회적 지원을 받고, 참가자와 연구자 모두에게 할당 내용이 공개되지 않습니다.
이 획기적인 시험은 AUD에 대한 케타민 보조 요법을 조사하는 가장 큰 규모의 연구로, 총 예산은 £2.4 백만 / CAD 4.2 백만으로 추정됩니다. Awakn은 이번 연구에 £0.8 백만 / CAD 1.4 백만을 기여하고 있으며, 이번 연구는 영국 내 8개의 NHS 사이트에서 진행됩니다.
Awakn Life Sciences Corp. (CSE: AWKN) (OTCQB: AWKNF) a ouvert quatre nouveaux sites d'essai clinique pour son essai de phase 3 'MORE-KARE' sur AWKN-001, un traitement novateur pour les troubles graves de l'usage de l'alcool (AUD). Cela porte le nombre total de sites d'essai actifs à 7 au Royaume-Uni. L'AWKN-001 combine la kétamine intraveineuse avec un soutien psychosocial.
Cette étude, cofinancée par le Medical Research Council du Royaume-Uni, le National Institute for Health and Care Research et Awakn, vise à évaluer l'efficacité d'un cycle de traitement unique avec l'AWKN-001. Les participants recevront des doses variées d'infusion de kétamine et un soutien psychosocial, avec des participants et des chercheurs aveugles à l'assignation.
Ce procès novateur est le plus grand de son genre à étudier la thérapie assistée par kétamine pour AUD, avec un coût total estimé à £2,4 millions / CAD 4,2 millions. Awakn contribue avec £0,8 millions / CAD 1,4 millions à l'étude, qui se déroule dans huit sites NHS au Royaume-Uni.
Awakn Life Sciences Corp. (CSE: AWKN) (OTCQB: AWKNF) hat vier zusätzliche klinische Prüfstellen eröffnet für seine Phase-3-Studie 'MORE-KARE' zu AWKN-001, einer neuartigen Therapie für schwere Alkoholgebrauchsstörungen (AUD). Damit steigt die Gesamtzahl der aktiven Prüfstellen auf 7 im Vereinigten Königreich. AWKN-001 kombiniert intravenöse Ketaminverabreichung mit psychosozialer Unterstützung.
Die Studie, die mitfinanziert wird vom Medical Research Council des Vereinigten Königreichs, dem National Institute for Health and Care Research und Awakn, zielt darauf ab, die Wirksamkeit eines einzelnen Behandlungszyklus mit AWKN-001 zu bewerten. Die Teilnehmer erhalten unterschiedliche Dosen von Ketamin-Infusionen und psychosozialer Unterstützung, wobei sowohl die Teilnehmer als auch die Forscher über die Zuweisungen im Unklaren sind.
Diese bahnbrechende Studie ist die größte ihrer Art, die die ketaminassistierte Therapie für AUD untersucht, mit geschätzten Gesamtkosten von £2,4 Millionen / CAD 4,2 Millionen. Awakn trägt £0,8 Millionen / CAD 1,4 Millionen zu der Studie bei, die an acht NHS-Standorten im Vereinigten Königreich durchgeführt wird.
- Expansion to 7 active trial sites for Phase 3 study of AWKN-001
- Co-funding from UK's Medical Research Council and National Institute for Health and Care Research
- Largest study of its kind for ketamine-assisted therapy in AUD
- Potential to change standard of care for severe AUD in the UK
- Significant financial investment required (£0.8 million / CAD 1.4 million from Awakn)
Toronto, Ontario--(Newsfile Corp. - October 22, 2024) - Awakn Life Sciences Corp. (CSE: AWKN) (OTCQB: AWKNF) (FSE: 954) ("Awakn" or the "Company"), a clinical-stage biotechnology company developing therapeutics for substance use and mental health disorders, announces the opening of four additional clinical trial sites: University Hospitals Sussex NHS Foundation Trust; South London and Maudsley NHS Foundation Trust; Greater Manchester Mental Health NHS Foundation Trust; and University Hospitals Plymouth NHS Trust. This brings the total active trial sites to 7 in the landmark 'MORE-KARE' Phase 3 trial of AWKN-001 for severe AUD.
AWKN-001 is an investigational, novel medication-assisted treatment for severe AUD, consisting of an N-methyl-D-aspartate receptor-modulating drug (ketamine) delivered intravenously (IV) in combination with manualized psycho-social support for severe AUD.
The MORE-KARE study, or the Multicentre Investigation of Ketamine for Reduction of Alcohol Relapse, is co-funded by a partnership between the UK's Medical Research Council (MRC) and the National Institute for Health and Care Research (NIHR), and Awakn Life Sciences Corp. It is managed by the Exeter Clinical Trials Unit at the University of Exeter.
The Phase 3 trial aims to evaluate the efficacy of a single treatment cycle of AWKN-001. Participants will be randomly allocated into a trial arm, receiving different doses of ketamine infusion along with psycho-social support sessions from a trial therapist. The specific dose and type of psychological support for each participant will be randomly assigned by a computer. Both participants and the research team will be blinded to the assigned dose/support.
Anthony Tennyson, CEO, Awakn, commented: "The expansion of trial sites marks a significant milestone in our mission to address the pressing need for innovative treatments for AUD. We are confident that AWKN-001, has the potential to change the standard of care for individuals suffering from severe alcohol use disorder in the UK, offering them a novel, more effective treatment pathway."
Prof. David Nutt, Chief Research Officer of Awakn, added: "The opening of these additional sites accelerates our ability to gather robust clinical data, essential for bringing this groundbreaking treatment to more patients. With the support of the UK's leading research institutions, we are well-positioned to demonstrate the effectiveness of AWKN-001."
This study is the largest of its kind investigating ketamine-assisted therapy for AUD. The total trial cost is estimated at £2.4 million / CAD 4.2 million, with Awakn contributing £0.8 million / CAD 1.4 million. The trial is being conducted at eight National Health Service (NHS) sites across the UK.
About AWKN-001
AWKN-001 is an investigational, novel medication-assisted treatment for severe AUD, consisting of an N-methyl-D-aspartate receptor-modulating drug (ketamine) delivered intravenously (IV) in combination with manualized psycho-social support in the UK market only.
A phase 2 trial was successfully completed with efficacy proven, achieving
A phase 3 clinical trial ("MORE KARE") is being run by the University of Exeter. This trial is co-funded by the Efficacy and Mechanism Evaluation (EME) Programme - a partnership between the UK's National Institute for Health Research (NIHR) and the Medical Research Council (MRC) - and Awakn Life Sciences Corp.
About Awakn Life Sciences Corp.
Awakn Life Sciences Corp. is a clinical-stage biotechnology company developing therapeutics targeting substance use and mental health disorders. Awakn has a near-term focus on AUD, a condition affecting approximately 29 million adults in the US and approximately 40 million in the US and key European markets for which the current standard of care is inadequate. Our goal is to provide breakthrough therapeutics to addiction sufferers in desperate need and our strategy is focused on commercialising our R&D pipeline across multiple channels.
www.awaknlifesciences.com | LinkedIn | X (formerly Twitter)
About the University of Exeter
The University of Exeter is the sponsor of this clinical trial with overall trial management, data management and statistical analysis provided in collaboration with the Exeter Clinical Trials Unit (University of Exeter). At the University of Exeter, we combine teaching excellence and high levels of student satisfaction with world class research at our campuses in Exeter and Cornwall. We are a member of the Russell Group of leading research-intensive universities.
About The National Institute for Health and Care Research (NIHR)
The mission of the National Institute for Health and Care Research (NIHR) is to improve the health and wealth of the nation through research. We do this by:
- Funding high quality, timely research that benefits the NHS, public health and social care;
- Investing in world-class expertise, facilities and a skilled delivery workforce to translate discoveries into improved treatments and services;
- Partnering with patients, service users, carers and communities, improving the relevance, quality and impact of our research;
- Attracting, training and supporting the best researchers to tackle complex health and social care challenges;
- Collaborating with other public funders, charities and industry to help shape a cohesive and globally competitive research system;
- Funding applied global health research and training to meet the needs of the poorest people in low and middle income countries.
NIHR is funded by the Department of Health and Social Care. Its work in low and middle income countries is principally funded through UK Aid from the UK government.
About the Medical Research Council
The UKRI Medical Research Council is at the forefront of scientific discovery to improve human health. Founded in 1913 to tackle tuberculosis, the MRC now invests taxpayers' money in some of the best medical research in the world across every area of health. Thirty-three MRC-funded researchers have won Nobel prizes in a wide range of disciplines, and MRC scientists have been behind such diverse discoveries as vitamins, the structure of DNA and the link between smoking and cancer, as well as achievements such as pioneering the use of randomised controlled trials, the invention of MRI scanning, and the development of a group of antibodies used in the making of some of the most successful drugs ever developed.
Today, MRC-funded scientists tackle some of the greatest health problems facing humanity in the 21st century, from the rising tide of chronic diseases associated with ageing to the threats posed by rapidly mutating micro-organisms. The Medical Research Council is part of UK Research and Innovation.
Notice Regarding Forward-Looking Information
This news release contains certain forward-looking information and forward-looking statements, as defined in applicable securities laws (collectively referred to herein as "forward-looking statements"). Forward-looking statements reflect current expectations or beliefs regarding future events or the Company's future performance. All statements other than statements of historical fact are forward-looking statements. Often, but not always, forward-looking statements can be identified by the use of words such as "plans", "expects", "is expected", "budget", "scheduled", "estimates", "continues", "forecasts", "projects", "predicts", "intends", "anticipates", "targets" or "believes", or variations of, or the negatives of, such words and phrases or state that certain actions, events or results "may", "could", "would", "should", "might" or "will" be taken, occur or be achieved, including statements relating the business of the Company. All forward-looking statements, including those herein are qualified by this cautionary statement.
Although the Company believes that the expectations expressed in such statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results or developments may differ materially from those in the statements. There are certain factors that could cause actual results to differ materially from those in the forward-looking information. These include, but are not limited to: fluctuations in general macroeconomic conditions; the business plans and strategies of the Company; the ability of the Company to comply with all applicable governmental regulations in a highly regulated business; the inherent risks in investing in target companies or projects which have limited or no operating history and are engaged in activities currently considered illegal in some jurisdictions; changes in laws; limited operating history; reliance on management; requirements for additional financing; competition; fluctuations in securities markets; inconsistent public opinion and perception regarding the medical-use of psychedelic drugs; expectations regarding the size of the addiction market; and regulatory or political change. Readers are cautioned that the foregoing list of factors is not exhaustive of the factors that may affect forward-looking statements. Accordingly, readers should not place undue reliance on forward-looking statements. The forward-looking statements in this news release speak only as of the date of this news release or as of the date or dates specified in such statements.
Investors are cautioned that any such statements are not guarantees of future performance and actual results or developments may differ materially from those projected in the forward-looking information. For more information on the Company, investors are encouraged to review the Company's public filings on SEDAR at www.sedar.com. The Company disclaims any intention or obligation to update or revise any forward- looking information, whether as a result of new information, future events or otherwise, other than as required by law.
Investor Enquiries:
Anthony Tennyson, CEO, Awakn Life Sciences
anthony.tennyson@awaknlifesciences.com
416-270-9566
To view the source version of this press release, please visit https://www.newsfilecorp.com/release/227370
FAQ
What is the purpose of Awakn's Phase 3 MORE-KARE trial for AWKNF stock?
How many clinical trial sites are now active for Awakn's AWKNF Phase 3 study?
What is the estimated cost of Awakn's Phase 3 trial for AWKNF investors?
Who is funding Awakn's Phase 3 trial for AWKN-001 (AWKNF stock)?
