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Anavex Life Sciences Corp. (Nasdaq: AVXL) is a clinical-stage biopharmaceutical company dedicated to the development of novel therapeutics for neurodegenerative and neurodevelopmental disorders. Headquartered in New York, Anavex focuses on precision medicine to treat diseases with high unmet medical needs, such as Alzheimer's disease, Parkinson's disease, Rett syndrome, and schizophrenia.
Anavex's lead compound, ANAVEX 2-73 (blarcamesine), is an orally available small molecule targeting sigma-1 and muscarinic receptors. It aims to restore cellular homeostasis, showing promise in multiple CNS disorders. Blarcamesine has successfully completed Phase 2a and Phase 2b/3 trials for Alzheimer's disease and various studies in Rett syndrome, including a recent Phase 2/3 EXCELLENCE pediatric trial demonstrating significant improvements in Rett Syndrome Behaviour Questionnaire (RSBQ) scores.
The company also has other promising drug candidates, such as ANAVEX 3-71, targeting sigma-1 and M1 muscarinic receptors. This candidate has exhibited disease-modifying activity in Alzheimer's disease models and is currently in a Phase 2 trial for schizophrenia.
Anavex actively engages in partnerships and collaborations, including support from the Michael J. Fox Foundation for Parkinson's Research. With a robust intellectual property portfolio, Anavex is committed to advancing its pipeline through rigorous clinical trials to bring effective treatments to market.
Recent highlights include presenting at key industry conferences and filing a Marketing Authorisation application with the European Medicines Agency (EMA) for blarcamesine in Alzheimer's disease. Anavex also recently bolstered its executive team with seasoned professionals to drive its R&D and clinical strategies forward.
For more information, visit www.anavex.com or follow the company on Twitter, Facebook, Instagram, and LinkedIn.
Anavex Life Sciences Corp. (Nasdaq: AVXL) announced promising results for its drug candidate ANAVEX®3-71 at the Alzheimer’s Association International Conference. The study showed a significant decrease in amyloid beta deposition and reduced inflammatory responses in transgenic rat models of Alzheimer’s disease. Key behavioral tests demonstrated that ANAVEX®3-71 reversed cognitive deficits, with statistical significance (p ≤ 0.01). This data supports Anavex’s Precision Medicine platform and raises confidence in addressing neurodegenerative diseases.
Anavex Life Sciences Corp. (Nasdaq: AVXL) announced significant results from their Phase 2 PDD study of ANAVEX®2-73 at the AAIC conference. The study demonstrated the restoration of expression levels of neurodegenerative genes associated with Alzheimer's and Parkinson's diseases (p<0.005). Conducted on 132 patients, the trial exhibited dose-dependent improvements in cognitive and motor assessments. Dr. Jaime Kulisevsky highlighted the study as a novel exploration of therapeutic effects in Parkinson’s disease dementia, marking ANAVEX®2-73 as a potential breakthrough treatment.
Anavex Life Sciences Corp. (Nasdaq: AVXL) has announced the launch of its first Educational Video News Release, aimed at enhancing public understanding of its work in developing treatments for neurodegenerative and neurodevelopmental disorders like Alzheimer’s and Parkinson’s diseases. The company's lead candidate, ANAVEX®2-73, has shown promising results in clinical trials for various CNS disorders. The complete video release is available on Anavex's newsroom, further emphasizing its commitment to transparency and education.
On June 8, 2022, Anavex Life Sciences Corp. (Nasdaq: AVXL) announced a publication in the American Journal of Medical Genetics regarding the use of blood biomarkers to monitor the treatment effects of ANAVEX®2-73 in Fragile X Syndrome (FXS). FXS is a leading cause of autism, affecting an estimated 62,500 individuals in the U.S. The findings indicated that treatment with ANAVEX®2-73 improved behavioral issues in a mouse model, correlating with positive changes in blood biomarkers. The publication supports further clinical trials, aiming to expand therapeutic applications within the autism spectrum disorder market.
Anavex Life Sciences Corp. (Nasdaq: AVXL) announced CEO Christopher U Missling, PhD, will present at the H. C. Wainwright Global Investment Conference 2022 on May 25, 2022, at 12:00 PM ET. A live audio webcast will be available on the company’s website, with an archived version accessible later that day. Anavex focuses on developing therapeutics for neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases. Its lead drug candidate, ANAVEX®2-73, has completed Phase 2 trials and shows potential in treating various CNS diseases.
Anavex Life Sciences Corp. (Nasdaq: AVXL) reported its financial results for Q2 2022, highlighting a net loss of $10.4 million, or $0.14 per share, up from a loss of $8.1 million in Q2 2021. Cash and cash equivalents stood at $153.3 million as of March 31, 2022. The company is advancing its lead product candidate ANAVEX®2-73 in Alzheimer’s disease and Rett syndrome, with key data readouts expected in 2H 2022. An R&D Day is planned for June 21, 2022, to present pipeline developments and the SIGMAR1 platform portfolio.
Anavex Life Sciences Corp. (Nasdaq: AVXL) announced a conference call scheduled for May 10, 2022, at 4:30 PM ET to discuss financial results for the quarter ending March 31, 2022. The call will also provide updates on its growth strategy. Anavex focuses on developing therapeutics for neurodegenerative diseases, including Alzheimer’s and Parkinson’s. Its lead candidate, ANAVEX®2-73, has shown promise in clinical trials, targeting critical pathways to address these conditions. The call will be accessible via a live webcast and a dial-in option for U.S. participants.
Anavex Life Sciences Corp. (Nasdaq: AVXL) announced presentations at the IRSF Rett Syndrome Scientific Meeting on April 26-27, 2022, covering the Psychometric Evaluation of the Rett Syndrome Behaviour Questionnaire (RSBQ) and a Burden of Illness (BOI) study. Dr. Walter E Kaufmann discussed improvements in RSBQ's psychometric properties, while a global collaboration evaluated disease burden through a caregiver survey involving 756 participants. The ongoing ANAVEX®2-73 pediatric study targets patients ages 5-17. The company emphasized the importance of understanding Rett syndrome's impact on patients and caregivers.
On April 26, 2022, Anavex Life Sciences Corp. (Nasdaq: AVXL) announced that its CEO, Christopher U Missling, PhD, will present at the B. Riley Securities' 2022 Virtual Neuro & Ophthalmology Conference on April 27, 2022, at 11:00 AM ET. Anavex focuses on developing therapies for neurodegenerative and neurodevelopmental conditions, including Alzheimer's and Parkinson's diseases. Its lead drug candidate, ANAVEX®2-73, has completed several clinical trials, showing promise in treating Alzheimer’s disease and other CNS disorders. A live audio webcast will be available on their website.
Anavex Life Sciences Corp. (Nasdaq: AVXL), a clinical-stage biopharmaceutical company, announced its participation in the 21st Annual Needham Virtual Healthcare Conference on April 14, 2022, at 3:45 PM ET. The presentation will be accessible via a live audio webcast through their website. Anavex specializes in developing therapeutics for neurodegenerative disorders, with its lead drug candidate, ANAVEX®2-73, demonstrating potential in clinical trials for Alzheimer's and Parkinson's diseases. The company continues to innovate in the field of central nervous system diseases.
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