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Autolus Therapeutics plc reports news on its commercial-stage biopharmaceutical business developing, manufacturing and delivering next-generation programmed T cell therapies. Updates center on AUCATZYL (obecabtagene autoleucel, or obe-cel), product revenue, manufacturing capacity, gross margin plans and the company’s acute lymphoblastic leukemia business.
Company announcements also cover clinical programs using obe-cel and related T cell therapy candidates in pediatric relapsed/refractory acute lymphoblastic leukemia, lupus nephritis and progressive multiple sclerosis. Other recurring items include financial results, operational efficiency actions, investor presentations, Nasdaq inducement equity grants and ADR-related public-company disclosures.
Autolus Therapeutics (Nasdaq: AUTL) will participate in two investor conferences in early June 2026. CEO Dr. Christian Itin will present at the William Blair 46th Annual Growth Stock Conference on June 2 and the Jefferies Global Healthcare Conference on June 3, with live webcasts and 90-day replays.
Autolus Therapeutics (Nasdaq: AUTL) announced an abstract for the ASCO 2026 meeting reporting a post-hoc analysis of the Phase Ib/II FELIX study of obe-cel in adult relapsed/refractory B-ALL, including patients with extramedullary disease (EMD).
Of 127 obe-cel–infused patients, 27 (21%) had EMD at lymphodepletion. In patients with EMD, the overall remission rate was 59% and median duration of response was 42.6 months, supporting a favorable benefit–risk profile.
Autolus Therapeutics (Nasdaq: AUTL) reported Q1 2026 net product revenue of $26.2 million from AUCATZYL, up from $9.0 million a year earlier, and a positive gross profit of $1.6 million for its ALL business.
The UK launch began in January 2026. Autolus announced a cost-reduction plan, including a 13% workforce reduction expected to cut annual operating expenses by about $15 million from 2027, with roughly $8 million of restructuring charges. Net loss was $71.6 million, and cash, cash equivalents and marketable securities totaled $229.4 million, with runway projected into Q4 2027. Multiple obe-cel and AUTO8 trials are enrolling, with key data readouts expected from 2026 through 2028.
Autolus Therapeutics (Nasdaq: AUTL) will release first quarter 2026 financial results and operational highlights before U.S. market open on May 14, 2026.
Management will host a conference call and webcast on May 14, 2026 at 8:30am EDT / 1:30pm BST to discuss results and provide a general business update; preregistration is required for dial‑in access and PINs.
Autolus (NASDAQ: AUTL) announced a strategic initiative to improve operational efficiency and reduce costs, including a workforce reduction of ~13% and doubled manufacturing for commercial and clinical patients in 2026. The company reiterated 2026 AUCATZYL net revenue guidance of $120–$135 million and expects a shift to positive gross margin in 2026. Actions are expected to reduce operating expenses by ~$15 million annually beginning 2027 and to incur ~ $8 million in restructuring charges, mostly recognized in H1 2026. Autolus expects cash runway into Q4 2027 based on current plans.
Autolus Therapeutics (Nasdaq: AUTL) granted inducement equity awards under its 2025 Inducement Plan on April 14, 2026. The Compensation Committee awarded options for 68,500 ADS and 57,765 RSUs to 15 employees, with options priced at $1.47 and ten-year terms.
Options vest over four years (25% after one year, then monthly over three years); RSUs vest in four equal annual installments. Awards are conditioned on continued service and were granted as inducements under Nasdaq Listing Rule 5635(c)(4).
Autolus Therapeutics (Nasdaq: AUTL) will participate in two investor conferences in April 2026. The CEO, Dr. Christian Itin, will present at the 25th Annual Needham Virtual Healthcare Conference on April 13, 2028 at 10:15am EDT / 3:15pm BST. A webcast and 90-day replay will be available on the company's Events page. Management will also host investor meetings at the Van Lanschot Kempen Life Sciences Conference in Amsterdam on April 16, 2026.
Autolus (NASDAQ: AUTL) reported Q4 2025 product revenue of $23.3M and full-year AUCATZYL net product revenue of $74.3M. The company forecasts $120M–$135M AUCATZYL revenue and a shift to positive gross margin in 2026, and expects cash to fund operations into Q4 2027.
Clinical programs advanced: pediatric B-ALL, lupus nephritis, progressive MS and AL amyloidosis; multiple initial data readouts expected by year-end 2026–2028.
Autolus Therapeutics (Nasdaq: AUTL) will release fourth quarter and full year 2025 financial results and operational highlights before U.S. market open on March 27, 2026. Management will host a conference call and webcast at 8:30am EDT / 12:30pm GMT to discuss results and provide a business update.
Participants must pre-register to receive dial-in numbers and a personal PIN. A simultaneous audio webcast and replay will be available on the company events website.
Autolus Therapeutics (Nasdaq: AUTL) will participate in two investor events in March 2026. The company will present at the TD Cowen 46th Annual Health Care Conference on March 3, 2028 at 11:10am EST / 4:10pm GMT, with CEO Dr. Christian Itin presenting and a webcast available. A replay will be archived for 90 days. Management will host investor meetings at Jefferies Biotech on the Beach Summit on March 10, 2026 in Miami, FL.