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Alterity Therapeutics Limited (symbol: ATHE) is a pioneering biopharmaceutical company based in Melbourne, Australia, focused on developing therapeutic drugs for neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Huntington's disease, and multiple system atrophy. Founded in 1997 and originally known as Prana Biotechnology Limited, the company rebranded to Alterity Therapeutics Limited in April 2019.
The company’s flagship drug candidate, ATH434, has successfully completed Phase I clinical trials and is geared towards treating Parkinson's disease and other associated movement disorders. The drug has shown promise in clinical evaluations to slow disease progression, thus improving the quality of life for patients.
Alterity is also advancing PBT2, another leading drug candidate, originally designed as an antimicrobial agent but repurposed for treating Alzheimer's and Huntington's diseases. PBT2 has garnered attention owing to its potential to tackle the cognitive decline associated with these debilitating conditions.
Alterity Therapeutics is actively engaged in multiple research collaborations and partnerships with academic institutions and pharmaceutical companies to enhance its drug development pipeline. Their multi-faceted approach to addressing neurodegenerative disorders underscores the company's commitment to innovation and patient care.
Recent achievements include a collaborative study titled “A multimodal approach for diagnosis of early Multiple System Atrophy,” presented at the MDS 2023 conference, demonstrating the company's dedication to advancing scientific understanding and treatment methodologies.
Financially, Alterity Therapeutics maintains a stable condition, actively investing in research and development to push forward its clinical programs. The company's strategic initiatives and ongoing projects highlight its pivotal role in the healthcare domain, with a focus on creating significant therapeutic advancements.
For investors and stakeholders, Alterity Therapeutics represents a compelling opportunity in the biopharmaceutical sector, with a clear focus on addressing unmet medical needs through innovative drug discovery and development.
Alterity Therapeutics (NASDAQ: ATHE) announced the granting of a new patent (No. 11,155,547) by the USPTO for compounds designed to treat neurodegenerative diseases, including Parkinson's and Alzheimer's. This composition of matter patent covers over 80 novel iron chaperone compounds, ensuring exclusivity until 2041. CEO David Stamler emphasized the significance of this patent in establishing the company as a leader in targeting iron for disease modification. The company is also seeking patent protection in other regions to strengthen its drug development and commercialization efforts.
Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE), a biotechnology company focused on neurodegenerative disease treatments, announced that CEO David Stamler will present at the H.C. Wainwright BIOCONNECT Virtual Conference from January 10-13, 2022. The presentation will be available on the company's website starting January 10, 2022 at 7:00 a.m. ET.
Alterity's lead asset, ATH434, targets various Parkinsonian disorders, underpinned by a broad drug discovery platform.
Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE) has received authorization from New Zealand's Medsafe for its Phase 2 clinical trial of ATH434 in treating Multiple System Atrophy (MSA), a rare neurodegenerative disorder. The trial, set to begin in Q1 2022, will evaluate the drug's impact on α-synuclein aggregation and iron balance in the brain. ATH434 has shown promise in Phase 1 trials for safety and bioavailability. This milestone positions Alterity to potentially address the unmet needs of MSA patients, for whom there are currently no disease-modifying treatments.
Alterity Therapeutics (NASDAQ: ATHE) announced participation in two upcoming virtual investor events. CEO David Stamler will speak at the MST Financial Lifesciences & Biotech Forum on November 24, 2021, at 5:20 p.m. PST, and the Benchmark Company Discovery Conference on December 2, 2021. These events aim to highlight Alterity's innovative treatments for neurodegenerative diseases, particularly their lead asset, ATH434, targeting Parkinsonian disorders. For further details, visit www.alteritytherapeutics.com.
Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE) announced its presentation at the American Autonomic Society's 32nd Annual International Symposium. The poster detailed findings from a Phase 1 trial of ATH434, a novel treatment for neurodegenerative conditions. The trial showed ATH434 was well tolerated with no cardiac adverse events and demonstrated favorable pharmacokinetics. The company plans to initiate a Phase 2 trial for Multiple System Atrophy in Q1 2022. ATH434 has received Orphan designation from the FDA and European Commission, supporting its potential in treating MSA.
Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE) announced the publication of two preclinical studies supporting the use of ATH434 in treating Parkinsonian disorders. The studies, published in Journal of Parkinson's Disease and Plos One, highlight ATH434's potential in alleviating gastrointestinal complications and reducing alpha-synuclein aggregation—key factors in Parkinson's disease. ATH434, well-tolerated in Phase 1 trials, has received Orphan designation for treating Multiple System Atrophy. Further research is ongoing to advance this candidate into proof-of-concept studies.
Alterity Therapeutics (NASDAQ: ATHE) announced two new preclinical studies showcasing the efficacy of ATH434 in treating Parkinsonian disorders. These studies published in the Journal of Parkinson's Disease and Plos One highlight the potential of ATH434 to alleviate gastrointestinal complications associated with Parkinson's disease by reversing colonic dysfunction and modulating iron trafficking. CEO David Stamler emphasized ATH434's promise in enhancing patient quality of life and mentioned ongoing preclinical studies aimed at advancing its clinical development.
Alterity Therapeutics Limited (ASX: ATH, NASDAQ: ATHE) provided an update on its clinical programs and financials for Q1 FY22, ending September 30, 2021. The company reported a cash balance of A$41.3M and a quarterly cash outflow of A$4.9M, consistent with ongoing clinical activities. Key highlights include advancements in the ATH434 Phase 2 trial for Multiple System Atrophy (MSA) and the expansion of its bioMUSE study, which aims to refine patient selection for therapies. Intellectual property have seen significant growth, enhancing future opportunities.
Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE) has announced an expansion of the Phase 2 clinical trial for ATH434 targeting Multiple System Atrophy (MSA), a rare neurodegenerative disorder. The double-blind, placebo-controlled study will assess ATH434's effects on biomarkers related to α-synuclein aggregation and iron levels over 12 months across 30 sites in Australia, New Zealand, Europe, and the U.S. Additionally, the bioMUSE study will expand to 20 patients, enhancing data for the trial. ATH434 has Orphan designation and aims to improve the quality of life for MSA patients.
Alterity Therapeutics (NASDAQ: ATHE) reported progress in its biomarker study, bioMUSE, for early Multiple System Atrophy (MSA) patients. Data presented at the International Parkinson and Movement Disorder Society Congress 2021 highlighted the identification of iron accumulation in the brain as a potential biomarker for MSA. This could enhance patient selection for the upcoming Phase 2 trial of ATH434, aimed at treating MSA. The ongoing study is vital for understanding disease progression in MSA, which currently has no approved therapies.
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