Phase 3 Data Show TransCon® PTH Replicated Systemic Actions of Endogenous PTH Through Week 182 in Adults with Hypoparathyroidism
Rhea-AI Summary
Ascendis Pharma (Nasdaq: ASND) reported Week 182 Phase 3 PaTHway data showing long-term TransCon PTH (palopegteriparatide) treatment sustained efficacy and safety in adults with hypoparathyroidism.
86% met a multi-component endpoint, 89% completed the 3.5-year trial, kidney function and quality-of-life measures improved and remained stable, and no anti-PTH antibodies emerged.
AI-generated analysis. Not financial advice.
Positive
- 86% of patients met the multi-component responder endpoint at Week 182
- 89% of the 82 enrolled patients completed the three-and-a-half-year PaTHway Trial
- 100% of patients achieved independence from active vitamin D by Week 182
- 96% of patients achieved independence from therapeutic calcium doses (<600 mg/day)
- Mean eGFR increased 11.0 mL/min/1.73 m2 from baseline and was maintained
- Mean 24-hour urine calcium normalized within 26 weeks and stayed normal through Week 182
- Sustained improvements in symptoms and health-related quality of life on HPES and SF-36
- Mean BMD Z-scores corrected from high baseline levels and remained above 0 through Week 182
- TransCon PTH was generally well-tolerated, with mostly mild or moderate treatment-emergent adverse events
- No patients developed anti-PTH antibodies over three and a half years of treatment
Negative
- None.
News Market Reaction – ASND
On the day this news was published, ASND gained 2.40%, reflecting a moderate positive market reaction.
Data tracked by StockTitan Argus on the day of publication.
Key Figures
Peers on Argus
ASND gained 1.14% while close peers were mixed: SMMT up 7.77%, BMRN up 0.77%, EXEL, IONS, and BBIO down between 0.69% and 1.29%, suggesting a stock-specific reaction.
Previous Clinical trial Reports
| Date | Event | Sentiment | Move | Catalyst |
|---|---|---|---|---|
| Jun 11 | PTH Phase 2 data | Positive | +2.5% | 5-year Phase 2 PaTH Forward data showing sustained efficacy and safety. |
| Jan 08 | COACH Week 52 data | Positive | -2.8% | Phase 2 COACH topline showing durable growth benefits in achondroplasia. |
| Jul 14 | PTH 3-year Phase 3 | Positive | -0.1% | 3-year PaTHway data with high response and independence from therapy. |
| Jun 09 | COACH Week 26 data | Positive | +0.1% | Positive interim Phase 2 COACH results for combination CNP and hGH. |
| Jun 24 | ACcomplisH Phase 2 | Positive | +5.0% | Phase 2 ACcomplisH data showing functional and QoL gains in achondroplasia. |
Clinical trial updates have historically produced modest moves (average 0.93%) with a mix of aligned and divergent reactions to generally positive data.
Over the past year, Ascendis has repeatedly reported positive clinical data across TransCon PTH and TransCon CNP programs, including 3‑year Phase 3 PaTHway results and multiple achondroplasia studies, alongside solid financial progress and new product revenues. Clinical trial headlines on Jun 11, 2026 and earlier hypoparathyroidism updates emphasized sustained efficacy, kidney function benefits, and quality-of-life gains. Today’s Week 182 PaTHway data extend this narrative of durable, multi‑system benefit in hypoparathyroidism within a similar positive clinical framework.
Historical Comparison
Across five prior clinical-trial updates, ASND moved an average of 0.93%. Today’s 1.14% move on new PaTHway Phase 3 data falls within this typical reaction range.
Clinical releases show steady progression: multiple TransCon PTH hypoparathyroidism readouts and expanding TransCon CNP achondroplasia data from Phase 2 toward later-stage programs.
Regulatory & Risk Context
Market Pulse Summary
This announcement details three-and-a-half-year Phase 3 PaTHway data showing sustained multi-organ benefits of TransCon PTH in 82 adults with hypoparathyroidism, including high response rates, improved kidney function, and durable quality-of-life gains through Week 182. These results extend a pattern of positive TransCon PTH updates seen in prior years. Investors may track future readouts across the broader TransCon portfolio and ongoing commercial performance of YORVIPATH and related products as key next indicators.
Key Terms
hypoparathyroidism medical
parathyroid hormone medical
bone mineral density medical
DXA medical
Hypoparathyroidism Patient Experience Scales (HPES) medical
SF-36 medical
placebo-controlled medical
AI-generated analysis. Not financial advice.
- Multi-organ system and quality-of-life benefits sustained through three and a half years
86% response rate for the multi-component endpoint89% of patients completed the three-and-a-half-year trial
COPENHAGEN, Denmark, June 13, 2026 (GLOBE NEWSWIRE) -- Ascendis Pharma A/S (Nasdaq: ASND) today announced Week 182 data from its completed Phase 3 PaTHway Trial showing that long-term treatment with TransCon PTH (palopegteriparatide) demonstrated sustained efficacy and safety in adults with hypoparathyroidism. Over the three-and-a-half-year duration of the trial, TransCon PTH replicated the systemic actions of endogenous PTH, with a balanced, beneficial impact on the main target organ systems – CNS, kidney, small intestine, and bone – as demonstrated by improved quality of life and normalized and stable urine calcium, serum calcium, serum phosphate, and bone mineral density. These benefits were sustained while enabling independence from conventional therapy with active vitamin D and calcium.
“With its unique ability to replicate the systemic actions of endogenous parathyroid hormone, TransCon PTH has successfully addressed the physical and psychological burdens of hypoparathyroidism for the majority of treated patients,” said Aliya Khan, M.D., Clinical Professor of Medicine, Division of Endocrinology & Geriatrics, and Director of the Calcium Disorders Clinic at McMaster University in Canada. “These Phase 3 data reinforce the rapid and sustained benefits seen throughout clinical trials of TransCon PTH, including compelling improvements in quality of life reported by patients previously limited by the fatigue, cognitive challenges, and reduced physical functioning and well-being that are the hallmarks of this disease.”
Highlights of Week 182 Results from the Phase 3 PaTHway Trial
86% of patients were responders for the multi-component endpoint of (1) serum calcium in the normal range, (2) taking no active vitamin D, and (3) taking ≤600 mg/day of calcium.89% of patients had normal albumin-adjusted serum calcium levels and a mean value of 8.8 mg/dL.100% of patients achieved independence from active vitamin D, defined as not taking calcitriol or alfacalcidol.96% of patients achieved independence from therapeutic doses of calcium, defined as taking <600 mg/day of calcium.
- Significant improvements in kidney function were maintained, with mean (SE) eGFR of 80.2 (1.8) mL/min/1.73 m2 at Week 182, reflecting a mean (SE) increase of 11.0 (1.4) mL/min/1.73 m2 from baseline. Among patients randomized to TransCon PTH, eGFR increased from baseline through Week 38 and stabilized thereafter. After initiation of open-label treatment at Week 26, patients who had been receiving placebo in the double-blind period experienced a similar increase in eGFR. Following these eGFR increases, mean eGFR values were maintained through Week 182, in contrast to the expected typical age-related decline in eGFR in adults.i
- Mean 24-hour urine calcium decreased substantially, normalized within 26 weeks, and remained normal through Week 182.
- As measured by Hypoparathyroidism Patient Experience Scales (HPES), patients reported improvements in symptoms and health-related quality of life across all domains. Hypoparathyroidism-related physical and cognitive symptoms and impacts on physical functioning and daily life improved rapidly with TransCon PTH treatment and were maintained through Week 182.
- As measured by SF-36, all subscale scores and component summary scores demonstrated rapid and clinically meaningful improvements with TransCon PTH treatment which were sustained through Week 182.
- Mean BMD Z-scores (matched for age and sex) corrected from high baseline levels through Week 26 and remained above 0 through Week 182.
- In the trial, TransCon PTH treatment was generally well-tolerated, with no new safety signals identified. Treatment-emergent adverse events (AEs) were mostly mild or moderate, and no discontinuations were related to study drug.
- Over three and a half years of treatment, no patients developed anti-PTH antibodies.
“Regardless of disease origin, TransCon PTH has normalized key biochemistries and skeletal health while significantly improving kidney function and quality of life beginning at the earliest timepoints and continuing through multiple years of treatment,” said Aimee Shu, M.D., Executive Vice President, Chief Medical Officer at Ascendis Pharma. “We remain committed to continuing our work to advance treatment options for patients around the world living with this often-debilitating chronic disease.”
The PaTHway Trial of 82 adults with hypoparathyroidism (
TransCon PTH is a prodrug of PTH (1-34), administered once daily, designed to provide stable levels of active PTH within the physiological range for 24 hours/day, approved as YORVIPATH® in the United States, European Union, European Economic Area, and certain other jurisdictions as a treatment for adults with hypoparathyroidism.
A slide presentation with these data will be made available on the Investor Relations & News section of the Ascendis Pharma website: https://investors.ascendispharma.com.
About Hypoparathyroidism
Hypoparathyroidism is an endocrine disease caused by insufficient levels of parathyroid hormone (PTH), the primary regulator of calcium and phosphate balance in the body, acting directly on bone and kidney and indirectly on the intestine. Individuals with hypoparathyroidism may experience a range of severe and potentially life-threatening short-term and long-term complications, including neuromuscular irritability, renal complications, extra-skeletal calcifications, and cognitive impairment. Post-surgical hypoparathyroidism accounts for the majority of cases (70
About Ascendis Pharma A/S
Ascendis Pharma is a global biopharmaceutical company focused on applying our innovative TransCon technology platform to make a meaningful difference for patients. Guided by our core values of Patients, Science, and Passion, and following our algorithm for product innovation, we apply TransCon to develop new therapies that demonstrate best-in-class potential to address unmet medical needs. Ascendis is headquartered in Copenhagen, Denmark, and has additional facilities in Europe and the United States. Please visit ascendispharma.com to learn more.
Forward-Looking Statements
This press release contains forward-looking statements that involve substantial risks and uncertainties. All statements, other than statements of historical facts, included in this press release regarding Ascendis’ future operations, plans and objectives of management are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Examples of such statements include, but are not limited to, statements relating to (i) TransCon PTH’s ability to replicate endogenous parathyroid hormone and address the physical and psychological burdens of hypoparathyroidism, (ii) Ascendis’ commitment to continuing its work to advance treatment options for patients around the world with hypoparathyroidism, (iii) Ascendis’ ability to apply its TransCon technology platform to make a meaningful difference for patients and (iv) Ascendis’ use of TransCon to create new and potentially best-in-class therapies to address unmet medical needs. Ascendis may not actually achieve the plans, carry out the intentions or meet the expectations or projections disclosed in the forward-looking statements and you should not place undue reliance on these forward-looking statements. Actual results or events could differ materially from the plans, intentions, expectations and projections disclosed in the forward-looking statements. Various important factors could cause actual results or events to differ materially from the forward-looking statements that Ascendis makes, including, without limitation: dependence on third‑party manufacturers, distributors, and service providers for Ascendis’ products and product candidates; risks related to regulatory review and approval, including the possibility of delays, requests for additional data or analyses, restrictions or limitations on use, approval with labeling that is more limited than expected, or failure to obtain approval in the United States, European Union, or other jurisdictions; clinical development risks, including that results from ongoing or future trials may not confirm earlier data; unforeseen safety or efficacy findings in development programs or on‑market products; manufacturing, supply chain, quality, or logistics issues that could delay development or commercialization; unforeseen expenses related to commercialization of any approved Ascendis products; unforeseen research and development or selling, general and administrative expenses and other costs impacting Ascendis’ business generally; market acceptance, pricing, and reimbursement challenges, including payer coverage decisions and health technology assessments; competitive developments, including new or improved therapies; intellectual property protection, freedom‑to‑operate, and litigation risks; Ascendis’ ability to obtain additional funding, if needed, to support its business activities; cybersecurity, data privacy, and information technology disruptions; and the impact of international economic, political, legal, compliance, public health, and business factors, including tariffs, trade policies, currency fluctuations, and geopolitical events. For a further description of the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to Ascendis’ business in general, see Ascendis’ Annual Report on Form 20-F filed with the U.S. Securities and Exchange Commission (SEC) on February 11, 2026, and Ascendis’ other future reports filed with, or submitted to, the SEC. Forward-looking statements do not reflect the potential impact of any future licensing, collaborations, acquisitions, mergers, dispositions, joint ventures, or investments that Ascendis may enter into or make. Ascendis does not assume any obligation to update any forward-looking statements, except as required by law.
Ascendis, Ascendis Pharma, the Ascendis Pharma logo, TransCon, and YORVIPATH® are trademarks owned by the Ascendis Pharma group. © June 2026 Ascendis Pharma A/S.
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iGuppy M et al. BMJ Open. 2024;14(11):e089783. doi:10.1136/bmjopen-2024-089783
