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Ascendis Pharma A/S reports developments as a global biopharmaceutical company applying its TransCon technology platform to new therapies in endocrinology, rare disease and oncology. News commonly centers on TransCon CNP, also known as navepegritide, including YUVIWEL for pediatric achondroplasia, as well as TransCon hGH combination data and growth-disorder clinical programs.
Recurring company updates also include financial results and business updates, U.S. regulatory and commercialization milestones, patient-access programs, and capital-structure actions such as convertible senior note activity. Corporate news also documents the completed transition from American Depositary Shares to ordinary shares trading on Nasdaq under ASND.
Ascendis Pharma (Nasdaq: ASND) reported Week 182 Phase 3 PaTHway data showing long-term TransCon PTH (palopegteriparatide) treatment sustained efficacy and safety in adults with hypoparathyroidism.
86% met a multi-component endpoint, 89% completed the 3.5-year trial, kidney function and quality-of-life measures improved and remained stable, and no anti-PTH antibodies emerged.
Ascendis Pharma (Nasdaq: ASND) reported 5-year Phase 2 PaTH Forward data showing TransCon PTH (palopegteriparatide) maintained normalized calcium, improved kidney function, and supported quality of life in adults with hypoparathyroidism.
At Week 266, 82% met the multi-component response, 95% completed treatment, and safety remained generally well-tolerated.
Ascendis (Nasdaq: ASND) will present new data from its rare endocrine disease programs at ENDO 2026 in Chicago, June 13–16, 2026.
Presentations cover hypoparathyroidism, achondroplasia, and pediatric growth hormone deficiency, including Phase 3 PaTHway and Phase 2 COACH trial results and registry data on lonapegsomatropin.
Ascendis Pharma (Nasdaq: ASND) reported Q1 2026 results: total revenue €247m, driven by YORVIPATH €197m and SKYTROFA €44m. The company received FDA accelerated approval and orphan exclusivity for YUVIWEL and agreed to sell a Rare Pediatric Disease PRV for $187.5m. Q1 net profit was €629m including recognition of €679m deferred tax assets; non-IFRS net profit was €18m. Cash and cash equivalents were €573m as of March 31, 2026.
Ascendis Pharma (Nasdaq: ASND) reported 2-year subgroup data from the pivotal ApproaCH trial showing children with achondroplasia aged ≥5 at enrollment treated with once-weekly TransCon CNP (navepegritide) had greater annualized growth velocity (AGV) versus placebo at Week 52 and sustained growth through Week 104.
Key metrics: Week 52 AGV treatment difference +1.78 cm/year (LS mean, 95% CI [1.22,2.33]); ACH-specific height Z-score change +0.31 vs placebo. Safety through two years showed low, mild injection-site reactions, no symptomatic hypotension, and no bone-age acceleration.
Ascendis Pharma (Nasdaq: ASND) will report first quarter 2026 financial results and provide a business update on May 7, 2026, before U.S. market open. The company will host a conference call and live webcast on May 7, 2026 at 8:00 a.m. ET.
Registration links and a live-webcast link will be available via the Investors & News section of the Ascendis Pharma website. A replay will be posted and available for 30 days after the event.
Ascendis Pharma (Nasdaq: ASND) called for redemption of all $575.0 million aggregate principal amount of its 2.25% Convertible Senior Notes due 2028, with a redemption date of May 6, 2026.
Holders may convert through 5:00 p.m. NY on May 4, 2026; conversion rate is 6.0118 shares per $1,000, increased to 6.3232 shares during the Make-Whole Conversion Period, making up to 3,635,840 ordinary shares issuable if converted.
Ascendis Pharma (Nasdaq: ASND) commenced trading of its ordinary shares on the Nasdaq Global Select Market on April 20, 2026, replacing its American Depositary Shares (ADSs).
The ordinary shares trade under the same ticker ASND, CUSIP K08588103 and ISIN DK0060606333. The company completed a mandatory exchange of all outstanding ADSs for ordinary shares, with the last ADS trading day on Nasdaq on April 17, 2026. A FAQ is available on the company investor website for details on the exchange and listing.
Ascendis Pharma (Nasdaq: ASND) will list its ordinary shares directly on The Nasdaq Global Select Market, effective at the open on April 20, 2026. All outstanding ADSs will be exchanged 1-for-1 for ordinary shares, which will trade under the existing ticker ASND.
The ordinary shares will use new identifiers: CUSIP K08588103 and ISIN DK0060606333. The company said the simplified listing aims to broaden investor access, potentially support index inclusion, and enhance institutional ownership and liquidity. A FAQ will be posted on the company's investor website.
Ascendis Pharma (Nasdaq: ASND) reported Week 52 COACH Phase 2 data showing that once-weekly TransCon hGH added to once-weekly TransCon CNP accelerated benefits beyond linear growth in children with achondroplasia. Key results: arm span Z-score +1.02 (treatment-naïve) and +0.66 (treated); arm gains +9.4 cm and +7.9 cm. Spinal L1-L5 IPD changes +1.7 mm (naïve) and +1.1 mm (treated) vs +0.6 mm with monotherapy. Tibial femoral angle improved -3.0° (combination) vs -1.3° (monotherapy); TFA Z-score -0.86 vs -0.47. TransCon CNP (YUVIWEL) received FDA approval Feb 2026; TransCon hGH (SKYTROFA) is approved for GH deficiency but investigational in achondroplasia.