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Assembly Biosciences, Inc. (NASDAQ: ASMB) is a public clinical-stage biotechnology company dedicated to advancing innovative therapies for serious viral diseases. The company focuses on two key platform programs: the treatment of Hepatitis B virus (HBV) infection and the development of novel oral live biotherapeutics for disorders associated with the microbiome.
In the HBV program, Assembly Biosciences is pioneering a new class of oral therapeutics aimed at increasing cure rates for patients with chronic HBV. The company has developed several drug candidates that inhibit various steps in the HBV lifecycle, including novel core protein allosteric modulators (CpAMs). These small molecules target and modulate the HBV core protein, a crucial component in the virus's replication process.
The microbiome program is designed to address diseases linked to dysbiosis, an imbalance in the microbial community of the gut. Assembly Biosciences employs a robust strain identification and selection process, methods for strain isolation and growth under Good Manufacturing Practices (GMP), and a patent-pending delivery system known as GEMICEL®. This system ensures targeted delivery of live biotherapeutics to specific areas in the gastrointestinal tract.
Recent achievements for Assembly Biosciences include a long-term partnership with Gilead Sciences to accelerate the development of their antiviral pipeline. This collaboration is expected to enhance the company's financial and scientific resources, positioning them to achieve critical milestones and deliver innovative treatments to patients.
Financial results for the third quarter of 2023 highlighted the company's ongoing progress, including the advancement of multiple antiviral candidates targeting herpesviruses, HBV, and hepatitis delta virus (HDV). Assembly Biosciences also announced leadership enhancements, including the appointment of Dr. Anuj Gaggar as Chief Medical Officer.
Looking ahead, Assembly Biosciences plans to have four candidates in clinical studies by the end of 2024. These include the initiation of trials for ABI-5366, a long-acting herpes simplex virus helicase-primase inhibitor, and the development of ABI-6250, an orally bioavailable small molecule for treating chronic HDV.
For more information, visit assemblybio.com.
Assembly Biosciences (ASMB) has announced a new research program focusing on a novel oral interferon-α receptor agonist, aimed at enhancing treatment for hepatitis B. This program will leverage the antiviral mechanisms of interferon-α while minimizing systemic exposure, potentially improving patient tolerability. A live webcast is scheduled for July 26, 2022, featuring key speakers including Professor Edward J. Gane and CEO John McHutchison. The company remains committed to developing curative therapies for the 296 million individuals affected by HBV globally.
Assembly Biosciences, Inc. (Nasdaq: ASMB), a clinical-stage biotechnology firm, announced the acceptance of six abstracts for presentation at the International Liver Congress™ 2022 held from June 22-26. The data covers investigational core inhibitors including vebicorvir and two new candidates, ABI-H3733 and ABI-4334. CEO John McHutchison emphasized the significance of the presentations, which support the company's goal of developing finite therapies for hepatitis B virus (HBV). The posters will be accessible online for conference registrants, showcasing new insights into their drug candidates.
Assembly Biosciences, Inc. (Nasdaq: ASMB) has initiated a Phase 1b trial for its next-generation core inhibitor, ABI-H3733, targeting chronic hepatitis B virus (cHBV) infection. This trial follows a successful Phase 1a study that showed a favorable safety profile and assesses a new tablet formulation designed for once-daily dosing. Approximately 50 treatment-naïve patients will participate in a 28-day, randomized, double-blind study to evaluate the drug's safety and antiviral activity, with results supporting future Phase 2 trial dose selection.
Assembly Biosciences, Inc. (Nasdaq: ASMB) announced a grant of stock options for 16,000 shares to a new employee at an exercise price of $1.87 per share. The options will vest over four years and were given as a material inducement for employment. This grant aligns with the company’s 2017 Inducement Award Plan and adheres to Nasdaq Listing Rule 5635(c)(4). Assembly Bio specializes in innovative therapeutics for hepatitis B virus (HBV), aiming to provide curative treatments for the 296 million people affected globally.
Assembly Biosciences (ASMB) reported its financial results for Q1 2022, highlighting a cash position of $146.5 million, down from $174.6 million at year-end 2021, expected to fund operations into Q4 2023. The company introduced a new small molecule entry inhibitor targeting HBV and HDV, expanding its pipeline. Research and development expenses decreased to $17.2 million from $18.6 million year-over-year, while general and administrative costs also fell to $6.0 million. Net loss narrowed to $23.1 million ($0.48 per share) from $27.2 million ($0.69 per share) in Q1 2021.
Assembly Biosciences (ASMB), a clinical-stage biotech company, announced the granting of stock options to a new employee for 19,000 shares at an exercise price of $2.06, the closing price on April 1, 2022. The stock options will vest over four years, with the first quarter vesting after one year. This grant is part of Assembly Bio's 2017 Inducement Award Plan and was approved by the independent Compensation Committee. Assembly Bio focuses on developing therapies for hepatitis B virus and aims to provide curative treatments for the 296 million affected individuals worldwide.
Assembly Biosciences announces the addition of Professor Michael P. Manns, MD, to its leadership team, focusing on hepatitis B and delta viruses. A webcast is scheduled for March 31, 2022, to unveil a new research program targeting HBV and HDV via an innovative orally bioavailable small-molecule approach. Key speakers include Manns, Assembly Bio CEO John McHutchison, and Chief Scientific Officer William Delaney. The company aims to advance therapies for the 296 million individuals with HBV globally, emphasizing the urgent need for treatment options.
Assembly Biosciences (ASMB) reported its Q4 and full-year 2021 financial results, highlighting a net loss of $129.9 million, up from $62.2 million in 2020. The cash position decreased to $174.6 million as of December 31, 2021. Revenues dropped significantly to $6.3 million, compared to $79.1 million in 2020, primarily due to prior collaborations. R&D expenses decreased to $68.5 million, while general and administrative expenses fell to $28.8 million. The company aims to advance its pipeline with key studies expected in 2022, including the initiation of trials for new core inhibitor candidates.
Assembly Biosciences, Inc. (Nasdaq: ASMB) announced that CEO John McHutchison will speak at the SVB Leerink 11th Annual Global Healthcare Conference on February 17, 2022, at 3:40 p.m. ET. The virtual fireside chat will be accessible via webcast on Assembly Bio's website, with a replay available for 30 days. Assembly Bio focuses on innovative therapies for hepatitis B virus (HBV) and aims to develop curative treatments for the 270 million people affected worldwide. Its portfolio includes next-generation core inhibitors targeting HBV replication.
Assembly Biosciences, Inc. (Nasdaq: ASMB), a clinical-stage biotechnology company, announced the grant of stock options to two new employees, allowing the purchase of 7,000 shares at an exercise price of $2.45 each. The options have a ten-year term and vest over four years. This action aims to attract talent through financial incentives and follows Nasdaq Listing Rule requirements. Assembly Bio focuses on developing therapies targeting hepatitis B virus, aiming to provide innovative treatments for the 270 million infected globally.
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