Welcome to our dedicated page for Arrowhead Pharma news (Ticker: ARWR), a resource for investors and traders seeking the latest updates and insights on Arrowhead Pharma stock.
Arrowhead Pharmaceuticals (ARWR) is a clinical-stage biopharmaceutical company developing RNA interference therapies that silence disease-causing genes. The company's news flow centers on clinical trial developments, regulatory milestones, and partnership announcements that signal progress in its genetic medicine pipeline.
Clinical development updates represent the most significant category of Arrowhead news. Phase 1, 2, and 3 trial initiations reveal which therapeutic programs are advancing through human testing. Trial results demonstrate whether investigational RNAi therapeutics achieve target gene knockdown and clinical efficacy in patients. These updates often include pharmacodynamic data showing reductions in disease-related proteins, providing concrete evidence of biological activity.
Regulatory decisions from the FDA and international agencies mark critical validation points. Breakthrough therapy designations indicate regulators recognize substantial improvement potential over existing treatments. Investigational New Drug (IND) application clearances and Clinical Trial Authorization (CTA) approvals enable new studies to begin. Orphan drug designations for rare disease programs provide development incentives and potential market exclusivity.
Partnership announcements and collaborations with larger pharmaceutical companies signal external validation of Arrowhead's TRiM platform technology. These agreements typically involve upfront payments, development milestones, and royalty structures tied to commercial success. Partnership news often specifies which disease targets the collaboration will address and how responsibilities are divided between companies.
Corporate developments including financing activities, patent grants, and inducement grants provide context on the company's operational capacity. Public offerings and debt transactions affect the capital available for advancing clinical programs. Patent issuances strengthen intellectual property positions around specific RNAi molecules and delivery technologies.
Track Arrowhead Pharmaceuticals news to monitor genetic medicine development, understand RNAi therapeutic progress across multiple disease areas, and follow regulatory advancements in gene silencing technologies.
Arrowhead Pharmaceuticals presented new clinical data on RNAi-based therapies ARO-APOC3, ARO-ANG3, and olpasiran at the AHA Scientific Sessions 2022. ARO-APOC3 showed significant decreases in triglycerides by 86% and increases in HDL-C by 99%. ARO-ANG3 reduced triglycerides by 59% and LDL-C by 32%, while olpasiran decreased lipoprotein(a) levels by over 95% in ASCVD patients. The company plans to discuss these findings and its future plans in a virtual event on November 9, 2022.
Arrowhead Pharmaceuticals, Inc. (NASDAQ: ARWR) announced on October 4, 2022, the approval of inducement grants for 39 new employees, totaling up to 117,500 restricted stock units. This includes 30,000 restricted stock units awarded to Peter Carignan, the new vice president of clinical operations. The grants, which fall under NASDAQ Listing Rules, are outside existing shareholder-approved equity incentive plans and will vest over four years.
Arrowhead Pharmaceuticals (NASDAQ: ARWR) will present interim clinical data on ARO-APOC3 and ARO-ANG3 at the American Heart Association Scientific Sessions 2022 in Chicago, from
Arrowhead Pharmaceuticals, Inc. (NASDAQ: ARWR) will participate in several upcoming events in September 2022. Key presentations include:
- ERS International Congress: September 4-6, 2022, by Erik Bush on MMP7 gene silencing.
- Wells Fargo Healthcare Conference: September 7-9, 2022, investor meetings with Vincent Anzalone.
- H.C. Wainwright Global Investment Conference: September 12-14, 2022, fireside chat by Christopher Anzalone.
- Baird Global Healthcare Conference: September 13-14, 2022, also featuring Christopher Anzalone.
Arrowhead Pharmaceuticals (NASDAQ: ARWR) has submitted an application to commence a Phase 1/2a clinical trial for ARO-MMP7, an investigational RNA interference therapeutic targeting matrix metalloproteinase 7 (MMP7) for idiopathic pulmonary fibrosis (IPF). The trial aims to assess safety, tolerability, and pharmacokinetics in healthy volunteers and IPF patients. This initiative expands Arrowhead's clinical pipeline, which includes other lung disease candidates. The trial approval is pending from the local Ethics Committee and the New Zealand Medicines and Medical Devices Safety Authority.
Arrowhead Pharmaceuticals (NASDAQ: ARWR) announced its fiscal Q3 results for the period ending June 30, 2022, revealing a revenue of $32.4 million, down from $45.9 million in Q3 2021. The operating loss increased to $72.9 million, compared to $31.9 million the previous year. Notably, the company published promising Phase 2 clinical results for fazirsiran, with 58% of patients showing fibrosis regression. Arrowhead also initiated clinical studies for ARO-MUC5AC and ARO-RAGE and expanded its team. Cash resources stand at $582.4 million.
Arrowhead Pharmaceuticals (NASDAQ: ARWR) will host a webcast and conference call on August 4, 2022, at 4:30 p.m. ET to discuss its financial results for the fiscal 2022 third quarter ended June 30, 2022. Investors can access the live audio webcast on the Company's website. A replay will be available for 90 days.
Arrowhead develops innovative RNAi-based therapeutics targeting intractable diseases through gene silencing.
Arrowhead Pharmaceuticals (NASDAQ: ARWR) has approved inducement grants for 34 new employees on July 1, 2022. The grants comprise a total of 138,000 restricted stock units, with 70,000 units awarded to the new chief commercial officer, Tracie Oliver. These grants are outside the company's stockholder-approved equity incentive plans and will vest over four years. Arrowhead focuses on developing RNA interference-based therapies to treat severe diseases by silencing problematic genes.
Arrowhead Pharmaceuticals (NASDAQ: ARWR) has initiated dosing in two Phase 1/2a clinical trials for ARO-MUC5AC and ARO-RAGE, innovative RNA interference therapeutics targeting mucin production and inflammatory responses in lung diseases. ARO-MUC5AC-1001 and ARO-RAGE-1001 trials aim to evaluate safety, tolerability, pharmacokinetics, and pharmacodynamics in healthy volunteers and asthma patients. CEO Chris Anzalone highlighted this as a pivotal milestone in the company's mission to tackle difficult-to-drug targets in respiratory conditions.
Takeda (TAK) and Arrowhead Pharmaceuticals (NASDAQ: ARWR) announced promising results from the Phase 2 AROAAT-2002 study of fazirsiran for liver disease due to alpha-1 antitrypsin deficiency (AATD). Key findings include a 58% fibrosis regression in treated patients, an 83% median reduction in Z-AAT accumulation in the liver, and a 69% reduction in histologic globule burden. Fazirsiran aims to tackle AATD's liver manifestations, with plans for a Phase 3 study on the horizon. The collaboration has received Breakthrough Therapy and Orphan Drug designations from the FDA.
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