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Arrowhead Pharmaceuticals Inc. (NASDAQ: ARWR) is a leading clinical-stage biotechnology company dedicated to developing innovative medicines that address intractable diseases through gene silencing. The company utilizes an extensive array of RNA chemistries and efficient delivery systems to harness the power of RNA interference (RNAi) mechanisms. This approach allows for the rapid, deep, and durable knockdown of target genes, thereby reducing the production of specific proteins that cause diseases.
Arrowhead's groundbreaking therapies are at the forefront of genetic-based treatments, presenting potential life-changing solutions for patients. Notable among their technologies is the Targeted RNAi Molecule (TRiMTM) platform. This platform employs ligand-mediated delivery for tissue-specific targeting while maintaining structural simplicity. The TRiMTM platform is built upon over a decade of research in actively targeted drug delivery, offering advantages such as simplified manufacturing processes and enhanced specificity.
The company's diverse portfolio includes promising treatments for conditions such as Hepatitis B, Alpha-1 Antitrypsin Deficiency, thrombosis and angioedema, clear-cell and renal cell carcinoma, and cardiovascular diseases. Arrowhead is continuously engaged in advancing its clinical programs and forging strategic partnerships to bring its novel therapies to market.
With headquarters in Pasadena, California, Arrowhead Pharmaceuticals remains committed to transforming the landscape of genetic medicine and improving patient outcomes worldwide. Their dedication to scientific innovation and patient care positions them as a pivotal player in the biotechnology sector.
Arrowhead Pharmaceuticals (NASDAQ: ARWR) will host a KOL webinar on October 26, 2021, at 3:00 p.m. ET to discuss ARO-C3, an investigational RNAi therapeutic for complement mediated diseases. Presenters include experts Richard J. Glassock and Peter Browett, who will cover treatment landscapes and unmet needs in renal and hematological complement mediated diseases. The management team will explain preclinical data and clinical plans, aiming to file a CTA in Q4 2021 for clinical studies. Access the webinar on Arrowhead's website under Events and Presentations.
Arrowhead Pharmaceuticals (NASDAQ: ARWR) has initiated dosing for the first patient in the AROAPOC3-2002 Phase 2b study of ARO-APOC3, targeting adults with mixed dyslipidemia. This investigational RNAi therapeutic aims to address severe hypertriglyceridemia, mixed dyslipidemia, and familial chylomicronemia syndrome. As part of its clinical program, Arrowhead plans to start a Phase 3 study for patients with familial chylomicronemia syndrome in Q4 2021. Approximately 320 participants will be enrolled in the ongoing study.
Arrowhead Pharmaceuticals (NASDAQ: ARWR) will participate in key upcoming events in October 2021. On October 4, Vince Anzalone will join a fireside chat at Chardan's 5th Annual Genetics Medicines Conference. Following that, on October 12, James Hamilton will present at the H.C. Wainwright 5th Annual NASH Investor Conference. For detailed presentation materials and live webcast links, visit the Events and Presentations section on Arrowhead's website.
Arrowhead Pharmaceuticals (NASDAQ: ARWR) announced a milestone payment of
Arrowhead Pharmaceuticals (NASDAQ: ARWR) has announced its participation in several upcoming virtual investing events. Key dates include the Citi’s 16th Annual BioPharma Virtual Conference from September 8-10, with Arrowhead hosting virtual investor meetings on September 9. CEO Chris Anzalone will present during the HC Wainwright 23rd Annual Global Investment Conference on September 13 and the Cantor Virtual Global Healthcare Conference on September 29. These events will showcase Arrowhead's innovative RNA interference therapeutics targeting intractable diseases.
Arrowhead Pharmaceuticals (NASDAQ: ARWR) reported financial results for Q3 2021, with revenue rising to $45.9 million compared to $27.4 million in Q3 2020. Operating loss widened to $31.9 million, and net loss increased to $29.9 million, or $(0.29) per diluted share. Notable achievements include receiving Breakthrough Therapy designation for ARO-AAT and positive interim study results for ARO-HSD and ARO-HIF2. The company maintains cash resources of $644.7 million, supporting ongoing clinical trials.
Arrowhead Pharmaceuticals (NASDAQ: ARWR) announced that the U.S. FDA granted Breakthrough Therapy designation for its investigational RNA interference therapeutic, ARO-AAT, co-developed with Takeda, aimed at treating alpha-1 antitrypsin deficiency (AATD)-associated liver disease. ARO-AAT also has Orphan Drug and Fast Track designations. The Phase 2 SEQUOIA study has reached full enrollment of 40 patients, with interim results suggesting a significant reduction in toxic Z-AAT protein production, potentially improving liver disease outcomes.
Arrowhead Pharmaceuticals (NASDAQ: ARWR) will host a webcast and conference call on August 5, 2021, at 4:30 p.m. ET to discuss its financial results for the fiscal third quarter ending June 30, 2021. Investors can access the live audio on the Company's website. A replay will be available shortly after the call concludes. Arrowhead focuses on developing therapies that utilize RNA interference to address intractable diseases by silencing specific genes.
Arrowhead Pharmaceuticals (NASDAQ: ARWR) announced on July 1, 2021, the approval of "inducement" grants to 42 new employees by its Board of Directors’ Compensation Committee. These grants, totaling up to 157,000 restricted stock units, are outside of the company's stockholder-approved equity incentive plans and vest annually over four years. Arrowhead develops RNAi-based therapeutics targeting intractable diseases by silencing specific genes, aiming for effective gene expression inhibition.
Arrowhead Pharmaceuticals (NASDAQ: ARWR) announced positive interim results from its Phase 1b AROHIF21001 study, evaluating ARO-HIF2 for treating clear cell renal cell carcinoma (ccRCC). The study has enrolled 17 patients, with 9 having evaluable tumor samples. Results showed that 7 of 9 patients had reductions in HIF2α protein levels, averaging 48%. Notably, one patient experienced a partial response with a 65% tumor shrinkage. Arrowhead is currently enrolling the third cohort and plans to present further data at an upcoming medical congress.