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APOLLOMICS INC - APLMW STOCK NEWS

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About Apollomics Inc.

Apollomics Inc. (Nasdaq: APLMW) is a clinical-stage biopharmaceutical company dedicated to transforming the treatment landscape for oncology through innovative and targeted therapies. The company focuses on the discovery and development of drug candidates that harness the immune system and target specific molecular pathways to inhibit cancer progression. By addressing unmet medical needs in hard-to-treat and treatment-resistant cancers, Apollomics aims to deliver groundbreaking solutions to improve patient outcomes.

Core Business and Lead Programs

Apollomics operates at the forefront of precision oncology, with a robust pipeline of nine drug candidates across multiple clinical and preclinical programs. Six of these candidates are in the clinical stage, underscoring the company’s commitment to advancing therapies through rigorous research and development. Its lead programs include:

  • Vebreltinib (APL-101): A potent and selective c-Met inhibitor designed to treat non-small cell lung cancer (NSCLC) and other advanced tumors with c-Met alterations. This therapy targets a critical molecular pathway known to drive cancer progression, offering a potential solution for patients with limited treatment options.
  • Uproleselan (APL-106): A specific E-Selectin antagonist with the potential to enhance the efficacy of standard chemotherapy in treating acute myeloid leukemia (AML). By targeting the E-Selectin pathway, uproleselan disrupts the protective environment that cancer cells exploit, improving the effectiveness of existing treatments.

Innovative Approach to Oncology

Apollomics leverages a dual approach of immune system engagement and molecular targeting to develop therapies that can be combined with existing treatments. This strategy enhances the therapeutic potential of its drug candidates, particularly in cancers with complex resistance mechanisms. The company’s focus on c-Met and E-Selectin pathways demonstrates its expertise in addressing specific molecular drivers of cancer, positioning it as a key player in the precision oncology space.

Market Position and Industry Context

Operating within the highly competitive biopharmaceutical industry, Apollomics targets a growing market for oncology therapies, driven by rising cancer incidence and demand for personalized medicine. The company’s emphasis on treatment-resistant cancers and combination therapies differentiates it from competitors. While still in the clinical stage, its diversified pipeline reduces dependency on a single product, enhancing its potential resilience in a challenging regulatory and commercial landscape.

Challenges and Opportunities

As a clinical-stage company, Apollomics faces challenges typical of the biopharma sector, including high R&D costs, stringent regulatory requirements, and the need for successful clinical trial outcomes. However, its innovative pipeline and focus on precision oncology present significant growth opportunities. By addressing unmet needs in oncology and leveraging strategic collaborations, Apollomics aims to establish itself as a leader in the field.

Conclusion

Apollomics Inc. exemplifies innovation in oncology, with a strong focus on developing therapies that address critical gaps in cancer treatment. Its lead programs, vebreltinib and uproleselan, highlight its expertise in targeting molecular pathways and enhancing existing treatment modalities. While navigating the inherent challenges of a clinical-stage company, Apollomics’ commitment to precision medicine positions it as a promising player in the fight against cancer.

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Apollomics Inc. received a notification from Nasdaq stating that the company is not in compliance with the requirement to maintain a minimum closing bid price of $1.00 per share. The company has 180 days to regain compliance, with the possibility of an additional 180-day period if needed. Failure to regain compliance may lead to delisting from the Nasdaq Capital Market.
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Apollomics Inc. announced that its Chairman and CEO, Guo-Liang Yu, and President, Sanjeev Redkar, will participate in a Fireside Chat at the B. Riley Securities 2024 Virtual Oncology Conference. The event will take place on January 18, 2024, at 11:00 a.m. ET. The live webcast will be accessible through B. Riley Securities, and an archived replay will be available on the Apollomics website.
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Apollomics Inc. (Nasdaq: APLM) completes enrollment in Phase 3 bridging study for uproleselan in relapsed or refractory acute myeloid leukemia patients in China
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Apollomics Inc. (APL) announced that Sanjeev Redkar, Ph.D., Co-Founder and President, will present at the 2024 Biotech Showcase on January 8, 2024, to discuss the development of medicines for difficult-to-treat cancers. The presentation will be available via webcast and archived replay on the company's website.
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Apollomics Inc. (Nasdaq: APLM) announced the presentation of vebreltinib efficacy and safety data from the ongoing multi-cohort Phase 2 KUNPENG trial (NCT04258033) and the ongoing global multi-cohort Phase 2 SPARTA trial (NCT03175224) at the 2023 IASLC North America Conference on Lung Cancer (NACLC). Vebreltinib appears efficacious in non-small cell lung cancer (NSCLC) patients with MetExon14 skipping mutation with or without co-occurring MET amplification. The preliminary data from NSCLC patients with MetExon14 skipping mutation from the KUNPENG and SPARTA trials showed the following efficacy and safety results: ORR in patients without co-occurring MET amplification (gene copy number<4, n=76) was 64.5%, with median DOR of 15.9 months and Disease Control Rate (DCR) of 88%. ORR in patients with MET amplification (GCN≥4, n=7) was 85.7%, with DCR of 100%. mDOR was not reached. Treatment-related adverse events of grade 3 or higher were reported in 42.2% of patients, with the most common being edema (13.3%) and ALT increase (7.2%).
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Apollomics Inc. (APL) to participate in Fireside Chat at H.C. Wainwright 4th Annual Precision Oncology Virtual Conference. Co-Founders Dr. Guo-Liang Yu and Dr. Sanjeev Redkar will discuss the company's oncology drug candidates for difficult-to-treat cancers.
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Apollomics Inc. (APLM) presents clinical results for vebreltinib in the treatment of NSCLC with MET exon 14 skipping mutation at 2023 NACLC
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Apollomics Inc. (Nasdaq: APLM) announces that its partner in China, Avistone Biotechnology Co. Ltd., has received conditional approval from the National Medical Products Administration (NMPA) of China for the commercialization of vebreltinib to treat patients with MET exon 14 skipping non-small cell lung cancer (NSCLC). Vebreltinib, a potent c-Met inhibitor, offers a potential breakthrough for patients with MET exon 14 skipping NSCLC and other cancers driven by c-Met alterations. The approval is based on compelling clinical data and supports continued development of vebreltinib for the rest of the world. NSCLC accounts for approximately 85% of all lung cancer cases and remains a leading cause of cancer-related deaths worldwide, making this approval a significant achievement.
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Apollomics Inc. announced the addition of two new cohorts in its Phase 2 SPARTA study, evaluating vebreltinib in patients with non-small cell lung cancer and other solid tumors. The first cohort will evaluate vebreltinib in combination with osimertinib for patients with EGFR-mutated NSCLC, while the second cohort will evaluate vebreltinib monotherapy in solid tumors with high expression of c-MET and HGF. The company aims to address treatment resistance resulting from dysregulations in the HGF/c-MET axis.
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Apollomics Inc. announces positive clinical results for vebreltinib in treating GBM with PTPRZ-MET fusion at ESMO 2023
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FAQ

What is the current stock price of APOLLOMICS (APLMW)?

The current stock price of APOLLOMICS (APLMW) is $0.0147 as of February 27, 2025.

What is the market cap of APOLLOMICS (APLMW)?

The market cap of APOLLOMICS (APLMW) is approximately 25.1M.

What does Apollomics Inc. specialize in?

Apollomics focuses on developing innovative oncology therapies that harness the immune system and target molecular pathways to treat advanced and treatment-resistant cancers.

What are Apollomics’ lead drug candidates?

The company’s lead programs include vebreltinib, a c-Met inhibitor for non-small cell lung cancer, and uproleselan, an E-Selectin antagonist for acute myeloid leukemia.

How does Apollomics differentiate itself in the oncology market?

Apollomics emphasizes precision medicine, targeting specific molecular pathways and combining therapies to address treatment-resistant cancers, setting it apart in the competitive oncology market.

What challenges does Apollomics face as a clinical-stage company?

Apollomics faces challenges such as high R&D costs, regulatory hurdles, and the need for successful clinical trial outcomes before commercialization.

What is the significance of vebreltinib and uproleselan in cancer treatment?

Vebreltinib targets c-Met alterations in advanced tumors, while uproleselan enhances chemotherapy efficacy by targeting the E-Selectin pathway, addressing unmet needs in oncology.

What is Apollomics’ approach to drug development?

Apollomics employs a dual approach of immune system engagement and molecular targeting, focusing on therapies that can be combined with existing treatments for enhanced efficacy.

What market segment does Apollomics target?

Apollomics targets the oncology market, specifically addressing treatment-resistant cancers and leveraging precision medicine to meet unmet medical needs.

How does Apollomics mitigate risks associated with clinical-stage development?

Apollomics mitigates risks by maintaining a diversified pipeline of nine drug candidates across multiple programs, reducing reliance on a single product.
APOLLOMICS INC

Nasdaq:APLMW

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25.09M
109.97M