ANGLE Presentation Via Investor Meet Company

Rhea-AI Summary

ANGLE plc (OTCQX:ANPCY) announced it will present on the Investor Meet Company platform at 11:00 am (BST) on April 28, 2023. The session will feature insights from CEO Andrew Newland and CFO Ian Griffiths, focusing on the company's strategic activities. Investors have the opportunity to submit questions until April 26, 2023, that will be addressed during the presentation. ANGLE is known for its Parsortix system, the first FDA-cleared device for harvesting intact circulating tumor cells (CTCs) from blood, primarily for metastatic breast cancer. The technology shows promising clinical results in ongoing studies, demonstrating high accuracy in cancer detection and analysis. For details and registration, investors can visit the provided link.

Positive

• ANGLE's Parsortix technology is the first FDA-cleared system for harvesting intact circulating tumor cells from blood.
• Recent clinical studies for ovarian cancer show best-in-class accuracy with an AUC-ROC of 95.4%, sensitivity of 90%, and specificity of 93%.
• Establishment of clinical services laboratories in the UK and US to accelerate the commercialization of Parsortix.

Negative

• None.

GUILDFORD, SURREY / ACCESSWIRE / April 21, 2023 / ANGLE plc (AIM:AGL OTCQX:ANPCY), a world-leading liquid biopsy company, is pleased to announce it will be presenting via the Investor Meet Company platform at 11:00 am (BST) on Friday 28 April 2023.

The presentation by Andrew Newland and Ian Griffiths will give existing and prospective investors an opportunity to hear an overview presentation of the Company's current activities and strategy. There will also be time allocated to answering questions submitted by shareholders and interested investors.

Questions can be submitted in advance of the presentation via the Investor Meet Company dashboard up until 5:00 pm (BST) Wednesday 26 April 2023. Questions will be grouped and addressed under key themes. Please note that there will be no facility to ask questions during the presentation.

Investors can register for the ANGLE plc presentation via Investor Meet Company using the link https://www.investormeetcompany.com/angle-plc/register-investor

For further information:

ANGLE plc	+44 (0) 1483 343434
Andrew Newland, Chief Executive Ian Griffiths, Chief Financial Officer Andrew Holder, Head of Investor Relations
Berenberg (NOMAD and Joint Broker) Toby Flaux, Ciaran Walsh, Milo Bonser	+44 (0) 20 3207 7800
Jefferies (Joint Broker) Thomas Bective, Shaam Vora	+44 (0) 20 7029 8000
FTI Consulting Simon Conway, Ciara Martin Matthew Ventimiglia (US)	+44 (0) 203 727 1000 +1 (212) 850 5624

For Frequently Used Terms, please see the Company's website on https://angleplc.com/investor-relations/glossary/

Notes for editors

About ANGLE plc www.angleplc.com

ANGLE is a world leading liquid biopsy company with sample-to-answer solutions. ANGLE's proven patent protected circulating tumor cell (CTC) harvesting technology is known as the Parsortix^® system.

ANGLE's Parsortix^® system is FDA cleared for its intended use in metastatic breast cancer and is currently the first and only FDA cleared medical device to harvest intact circulating cancer cells from blood.

Intended use

The Parsortix^® PC1 system is an in vitro diagnostic device intended to enrich circulating tumor cells (CTCs) from peripheral blood collected in K₂EDTA tubes from patients diagnosed with metastatic breast cancer. The system employs a microfluidic chamber (a Parsortix cell separation cassette) to capture cells of a certain size and deformability from the population of cells present in blood. The cells retained in the cassette are harvested by the Parsortix PC1 system for use in subsequent downstream assays. The end user is responsible for the validation of any downstream assay. The standalone device, as indicated, does not identify, enumerate or characterize CTCs and cannot be used to make any diagnostic/prognostic claims for CTCs, including monitoring indications or as an aid in any disease management and/or treatment decisions.

The Parsortix system enables a liquid biopsy (a simple blood test) to be used to provide the circulating metastatic breast cancer cells to the user in a format suitable for multiple types of downstream analyses. The system is based on a microfluidic device that captures cells based on a combination of their size and compressibility. The system is epitope independent and can capture all phenotypes of CTCs (epithelial, mesenchymal and EMTing CTCs) as well as CTC clusters in a viable form (alive). CTCs harvested from the system enable a complete picture of a cancer to be seen; as being an intact cell they allow DNA, RNA and protein analysis as well as cytological and morphological examination and may provide comparable analysis to a tissue biopsy in metastatic breast cancer. Because CTC analysis is a non-invasive process, unlike tissue biopsy, it can be repeated as often as needed. This is important because cancer develops and changes over time and there is a clear medical need for up-to-date information on the status of a patient's tumor. In addition, the live CTCs harvested by the Parsortix system can be cultured, which offers the potential for testing tumor response to drugs outside the patient.

The Parsortix technology is the subject of 26 granted patents in Europe, the United States, China, Australia, Canada, India, Japan and Mexico with three extensive families of patents are being progressed worldwide

In the United States, the Parsortix^® PC1 system has received a Class II Classification from FDA for use with metastatic breast cancer patients. FDA clearance is seen as the global gold standard. ANGLE's Parsortix system is the first ever FDA cleared system for harvesting CTCs for subsequent analysis. ANGLE has applied the IVD CE Mark to the same system for the same intended use in Europe.

ANGLE has also completed three separate 200 subject clinical studies under a programme designed to develop an ovarian cancer pelvic mass triage test, with the results showing best in class accuracy (AUC-ROC) of 95.4% with sensitivity of 90% and specificity of 93%. This excellent clinical result demonstrates the utility of cells harvested by the Parsortix system, which the Company believes is the "best sample" for liquid biopsy analysis as it recovers intact, living cancer cells that are involved in the progression of the disease providing prospective information.

ANGLE has established formal collaborations with world-class cancer centres and major corporates such as Abbott, Philips and QIAGEN, and works closely with leading CTC translational research customers. These Key Opinion Leaders (KOLs) are working to identify applications with medical utility (clear benefit to patients), and to secure clinical data that demonstrates that utility in patient studies. The body of evidence as to the benefits of the Parsortix system is growing rapidly from our own clinical studies in metastatic breast cancer and ovarian cancer and also from KOLs with 77 peer-reviewed publications and numerous publicly available posters from 33 independent cancer centres, available on our website.

ANGLE has established clinical services laboratories in the UK and the United States to accelerate commercialisation of the Parsortix system and act as demonstrators to support product development. The laboratories offer services globally to pharmaceutical and biotech customers for use of Parsortix in cancer drug trials and, once the laboratories are accredited and tests validated, will provide Laboratory Developed Tests (LDTs) for patient management.

This information is provided by Reach, the non-regulatory press release distribution service of RNS, part of the London Stock Exchange. Terms and conditions relating to the use and distribution of this information may apply. For further information, please contact rns@lseg.com or visit www.rns.com.

SOURCE: ANGLE plc

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FAQ

What is ANGLE plc's upcoming presentation date?

ANGLE plc will present on April 28, 2023.

Where can I register for ANGLE plc's presentation?

Investors can register via the Investor Meet Company platform using the provided link.

What is the significance of ANGLE plc's Parsortix system?

Parsortix is the first FDA-cleared system for harvesting intact circulating tumor cells, primarily used in metastatic breast cancer.

What clinical results has ANGLE plc achieved with its Parsortix system?

ANGLE's clinical studies show a best-in-class accuracy of 95.4%, with 90% sensitivity and 93% specificity for ovarian cancer detection.

How can I submit questions for ANGLE plc's presentation?

Questions can be submitted via the Investor Meet Company dashboard until April 26, 2023.