Autonomix Medical, Inc. Announces U.S. Patent Granted Covering the Treatment of Cancerous Tumors and Cancer Related Pain with Company’s Proprietary Catheter-Based Technology

Rhea-AI Summary

Autonomix Medical (NASDAQ: AMIX) has been granted U.S. patent 12,064,256 covering technology for treating cancerous tumors and cancer-related pain. The company's growing patent portfolio includes over 80 issued patents and 40+ pending applications. A preclinical mouse study showed statistically significant reductions in both metastases and tumor mass through targeted nerve ablation.

The company's proprietary catheter-based technology features a microchip sensing array antenna with up to 3,000 times greater sensitivity than current technologies. Initially focusing on pancreatic cancer-related pain, Autonomix's platform combines nerve detection and RF ablation capabilities for precise treatment. The company is currently conducting a proof-of-concept human clinical trial focused on pain reduction.

Positive

• Granted new U.S. patent for cancer treatment and pain management technology
• Preclinical study showed significant reduction in metastases and tumor mass
• Technology demonstrates 3,000x greater sensitivity than current solutions
• Strong IP portfolio with 80+ issued patents and 40+ pending applications

Negative

• Human clinical trials still in early proof-of-concept stage
• Currently to pain reduction studies, with cancer treatment applications still theoretical

Insights

Patent Law Expert

<p>The USPTO grant of patent '256 represents a <b>significant intellectual property milestone</b> for Autonomix Medical. The patent's scope, covering both cancer treatment and pain management applications, creates a robust defensive moat around their core technology. With <b>80 issued patents and 40 pending applications</b>, the company has built a formidable IP portfolio that could deter potential competitors and increase licensing opportunities.</p><p>The strategic timing of this patent issuance, combined with their preclinical study results, strengthens their market position in the medical device sector. The broad claims covering both therapeutic and diagnostic applications provide multiple commercialization pathways and potential revenue streams.</p>

Medical Device Analyst

<p>The dual functionality of Autonomix's catheter-based technology - combining neural sensing with precision ablation - represents a <b>significant technological advancement</b>. Their microchip sensing array's <b>3,000x greater sensitivity</b> compared to existing solutions could revolutionize targeted nerve treatment. The preclinical results showing statistically significant reductions in both metastases and tumor mass suggest broader applications beyond pain management.</p><p>Think of this technology as a GPS system for nerves - it can both map and precisely target specific neural pathways with unprecedented accuracy. This precision could dramatically reduce collateral tissue damage and improve treatment outcomes, particularly in delicate areas like the pancreas.</p>

Market Research Analyst

<p>For a company with a <money>$6.17 million</money> market cap, this patent grant and the promising preclinical results could be transformative. The pancreatic cancer pain management market represents a <b>significant unmet need</b>, with current solutions like opioids and ethanol injections being suboptimal. The potential expansion into cancer progression treatment could open up an even larger market opportunity.</p><p>The technology's versatility, with applications in chronic pain management, hypertension and cardiology, provides multiple paths to market growth. This diversification reduces risk and increases the probability of successful commercialization in at least one major indication.</p>

Growing global patent portfolio to over 120 patents with 80 issued patents and over 40 pending patent applications

Previously completed preclinical study evaluating targeted nerve ablation demonstrated statistically significant reduction of metastases and statistically significant reduction in tumor mass

THE WOODLANDS, TX, Dec. 30, 2024 (GLOBE NEWSWIRE) -- Autonomix Medical, Inc. (NASDAQ: AMIX) (“Autonomix” or the “Company”), a medical device company focused on advancing innovative technologies to revolutionize how diseases involving the nervous system are diagnosed and treated, today announced the United States Patent and Trademark Office (USPTO) has issued U.S. patent 12,064,256 (‘256 patent) titled, Systems and Methods for Treating Cancer and/or Augmenting Organ Function.

The issued ‘256 patent covers technology including, but not limited to, systems, methods and devices for interventionally treating cancerous tumors and cancer related pain. The Company is initially advancing the development of its technology to address pancreatic cancer-related pain.

“As we continue to advance the development of this potentially groundbreaking technology, bolstering our patent protection remains a key priority,” commented Brad Hauser, CEO of Autonomix. “Supported by recent positive preclinical results demonstrated to date, we believe the depth and breadth of our proprietary technology provides the opportunity for further evaluation and we intend to explore its potential to reduce cancer progression and metastases.”

Results from a previously completed preclinical mouse study evaluating the ability of targeted nerve ablation demonstrated statistically significant reduction of metastases and statistically significant reduction in tumor mass, further supporting that neural pathways are especially impactful in the pathogenesis of pancreatic cancer. While the Company’s ongoing proof-of-concept human clinical trial is strictly focused on pain reduction from the ablation of target nerves near the pancreas, additional studies will explore whether these preclinical findings translate to the clinical application of Autonomix’s technology. Based on the preclinical results demonstrated to date, the Company intends to further explore the potential of its ablation technology to slow human pancreatic cancer growth and metastasis.

Autonomix’s first-in-class catheter-based sensing technology is covered by its global patent portfolio with over 80 issued patents and over 40 pending patent applications. In addition to the ‘256 patent, the USPTO has recently issued 12,053,634 (‘634 patent) titled, Endoscopic Sympathectomy Systems and Methods, and 12,070,334 (‘334 patent) titled, Elongated Conductors and Methods of Making and Using the Same.

The Company’s first-in-class technology platform utilizes a catheter-based microchip sensing array antenna that has the ability to detect and differentiate neural signals with up to 3,000 times greater sensitivity than currently available technologies. Once target nerves are identified, Autonomix uses its proprietary radio frequency (RF) ablation technology to kill targeted nerves, enabling a precision guided sense, treat and verify approach to addressing a number of disease categories from chronic pain management to hypertension and cardiology. Current approaches, primarily relying on opioids or invasive ethanol injections, can provide only limited relief and may lead to risky side effects.

For more information about the Company’s technology, please visit autonomix.com.

About Autonomix Medical, Inc.

Autonomix is a medical device company focused on advancing innovative technologies to revolutionize how diseases involving the nervous system are diagnosed and treated. The Company’s first-in-class platform system technology includes a catheter-based microchip sensing array that may have the ability to detect and differentiate neural signals with approximately 3,000 times greater sensitivity than currently available technologies. We believe this will enable, for the first time ever, transvascular diagnosis and treatment of diseases involving the peripheral nervous system virtually anywhere in the body.

We are initially developing this technology for the treatment of pain, with initial trials focused on pancreatic cancer, a condition that causes debilitating pain and is without a reliable solution. Our technology constitutes a platform to address dozens of potential indications, including cardiology, hypertension and chronic pain management, across a wide disease spectrum. Our technology is investigational and has not yet been cleared for marketing in the United States.

For more information, visit autonomix.com and connect with the Company on X, LinkedIn, Instagram and Facebook.

Forward Looking Statements

Some of the statements in this release are “forward-looking statements,” which involve risks and uncertainties. Forward-looking statements in this press release include, without limitation, the potential of the technology to treat cancerous tumors and the pain associated with pancreatic cancer. Such forward-looking statements can be identified by the use of words such as “should,” “might,” “may,” “intends,” “anticipates,” “believes,” “estimates,” “projects,” “forecasts,” “expects,” “plans,” and “proposes.”

Although Autonomix believes that the expectations reflected in these forward-looking statements are based on reasonable assumptions, there are a number of risks and uncertainties that could cause actual results to differ materially from such forward-looking statements. You are urged to carefully review and consider any cautionary statements and other disclosures, including the statements made under the heading “Risk Factors” and elsewhere in the Annual Report on Form 10-K filed with the U.S. Securities and Exchange Commission (SEC) on May 31, 2024. Forward-looking statements speak only as of the date of the document in which they are contained and Autonomix does not undertake any duty to update any forward-looking statements except as may be required by law.

Investor and Media Contact
JTC Team, LLC
Jenene Thomas
908.824.0775
autonomix@jtcir.com

FAQ

What are the key findings of AMIX's preclinical mouse study for cancer treatment?

The preclinical mouse study demonstrated statistically significant reductions in both metastases and tumor mass through targeted nerve ablation, particularly in pancreatic cancer cases.

How does AMIX's catheter-based sensing technology compare to existing solutions?

Autonomix's technology offers up to 3,000 times greater sensitivity in detecting and differentiating neural signals compared to currently available technologies.

What is the current status of AMIX's clinical trials for pancreatic cancer pain treatment?

The company is currently conducting a proof-of-concept human clinical trial focused specifically on pain reduction from the ablation of target nerves near the pancreas.

How many patents does AMIX currently hold?

Autonomix Medical has over 120 patents in total, with 80 issued patents and more than 40 pending patent applications.

What is the primary focus of AMIX's new U.S. patent 12,064,256?

The patent covers systems, methods, and devices for interventionally treating cancerous tumors and cancer-related pain, particularly focusing on pancreatic cancer-related pain.