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Altimmune, Inc. (Nasdaq: ALT) is a clinical-stage biopharmaceutical company dedicated to developing next-generation immunotherapeutics and vaccines addressing critical public health and biodefense needs. Leveraging the unique properties of its proprietary platform technologies, Altimmune is adept at swiftly designing product candidates targeting a range of diseases, including respiratory conditions, chronic infections, and cancer.
Altimmune's advanced Densigen™ T-cell platform technology is specifically designed to guide the immune system's response against complex disease targets by focusing on multiple antigens simultaneously. Another key platform, RespirVec™, uses needle-free intranasal delivery for faster and broader immunity against pathogens compared to traditional vaccines.
The company is also heavily involved in addressing obesity and liver diseases through its innovative peptide therapeutics. The lead product candidate, pemvidutide, is a GLP-1/glucagon dual receptor agonist under development for obesity and non-alcoholic steatohepatitis (NASH). Pemvidutide has shown promising results in clinical trials, achieving significant weight loss and liver fat reduction. It has received Fast Track designation from the U.S. FDA for treating NASH, highlighting its potential to meet significant unmet medical needs.
Altimmune's pipeline also includes HepTcell™, an immunotherapeutic designed to achieve a functional cure for chronic hepatitis B. However, the company has recently decided to cease further development on HepTcell based on Phase 2 trial findings.
Financially, Altimmune maintains a robust cash position, enabling it to advance its clinical programs. Recent financial results indicate a focused investment in research and development, ensuring continued progress in its pipeline.
Significant recent achievements include:
- Positive top-line results from the 48-week MOMENTUM Phase 2 obesity trial of pemvidutide.
- Ongoing Phase 2b IMPACT trial of pemvidutide in MASH with top-line results expected in Q1 2025.
- Strong financial position with substantial cash reserves to support ongoing and future research activities.
Altimmune is poised at the forefront of developing transformative therapies for serious health conditions, potentially delivering significant advancements in patient care.
Altimmune (Nasdaq: ALT), a clinical-stage biopharmaceutical company, will present data on their investigational drug, pemvidutide, at the American Diabetes Association’s (ADA) 84th Scientific Sessions from June 21-24, 2024, in Orlando, FL.
Pemvidutide, a GLP-1/glucagon dual receptor agonist, is being developed for obesity and NASH treatment. Two key presentations include:
- Dr. John J. Suschak discussing the effects of pemvidutide on cardioinflammatory lipids on June 22 at 4:45 PM EDT.
- Dr. Louis Aronne presenting 48-week Phase 2 trial data on June 23 at 1:45 PM EDT, also featured in ADA's Press Program.
Details will be available on Altimmune's website.
Altimmune presented new data at the EASL International Liver Congress 2024 highlighting the potential of pemvidutide in treating Metabolic Dysfunction-Associated Steatohepatitis (MASH). The data from Phase 1 trials indicate significant improvements in non-invasive tests, suggesting potential histologic benefits by Q1 2025. The trials show that pemvidutide's dual GLP-1/glucagon agonism could outperform GLP-1 alone in resolving MASH and reducing fibrosis. Additionally, lipidomic profiling supports its potential in addressing MASH-related co-morbidities like cardiovascular disease. Pemvidutide is currently being evaluated in a Phase 2b trial.
On May 29, 2024, Altimmune (Nasdaq: ALT), a clinical-stage biopharmaceutical company, announced its participation in two upcoming investor conferences. The company management will attend the Jefferies Global Healthcare Conference in New York on June 5, 2024, with a fireside chat at 2:00 p.m. ET. They will also attend the Goldman Sachs Global Healthcare Conference in Miami Beach on June 12, 2024, with a fireside chat at 9:20 a.m. ET. Both sessions will be webcast and accessible via the Events section of Altimmune's website.
Altimmune, a clinical-stage biopharmaceutical company, announced new data on pemvidutide, a novel peptide-based GLP-1/glucagon dual receptor agonist, at the EASL International Liver Congress™ 2024 in Milan. Pemvidutide is under development for treating obesity and metabolic dysfunction-associated steatohepatitis (MASH). The data highlights its anti-inflammatory and anti-fibrotic properties in subjects with metabolic dysfunction-associated steatotic liver disease (MASLD). Presentations include:
- Dr. Sarah Browne on metabolic dysfunction-associated steatohepatitis activity and fibrosis.
- Dr. Scot Roberts on plasma lipidomic profiling in subjects with obesity.
- Dr. Shaheen Tomah on noninvasive tests indicating histologic response in MASLD subjects.
These presentations will occur on June 5, 2024, at 8:30 am CEST, with posters displayed throughout the congress.
Roundhill Investments has launched the Roundhill GLP-1 & Weight Loss ETF (OZEM), now trading on Nasdaq. OZEM targets the growing market of GLP-1 receptor agonists and weight management drugs, which is projected to hit $100 billion by 2030. The ETF offers exposure to companies leading in obesity treatment innovation, including Eli Lilly, Novo Nordisk, and Innovent Biologics. CEO Dave Mazza emphasizes the substantial growth potential due to the rising global obesity rates. Key holdings in the ETF feature major pharmaceutical companies with a focus on weight loss therapeutics.
Altimmune announced its financial results for the first quarter of 2024, revealing cash, cash equivalents, and short-term investments of $182.1 million as of March 31, 2024. The company highlighted the ongoing IMPACT Phase 2b trial of pemvidutide in MASH, with top-line results expected in Q1 2025. Altimmune also emphasized the upcoming End-of-Phase 2 meeting with the FDA and the positive data from the Phase 2 MOMENTUM trial of pemvidutide in obesity. The company continues to advance enrollment in the IMPACT trial, with topline data anticipated in Q1 2025.
Altimmune, Inc. (Nasdaq: ALT) will participate in two upcoming investor conferences, the JMP Life Sciences Conference in New York on May 14, 2024, and the UBS Obesity Therapeutics Day virtual conference on May 23, 2024. The company's management team will be available for 1x1 meetings and will hold Fireside Chats at specific times. The sessions will be webcast on the Altimmune website.
Altimmune, Inc. (Nasdaq: ALT) will report its first quarter 2024 financial results and provide a business update on May 9, 2024. Altimmune management will host a conference call to discuss the financial results and business update.
Altimmune, Inc. (Nasdaq: ALT) will be represented by Dr. Scott Harris, Chief Medical Officer, at two upcoming conferences: BTIG Obesity Health Forum and GLP-1-Based Therapeutics Summit. The presentations will focus on emerging therapeutics and the use of GLP-1s in treating MASH & Fatty Liver Disease.
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