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Altimmune - ALT STOCK NEWS

Welcome to our dedicated page for Altimmune news (Ticker: ALT), a resource for investors and traders seeking the latest updates and insights on Altimmune stock.

Overview of Altimmune Inc

Altimmune Inc is a clinical-stage biopharmaceutical company that advances peptide-based therapeutics through innovative research and development. The company is focused on addressing major public health challenges by developing novel treatments for obesity, metabolic diseases, and liver conditions such as metabolic-associated steatohepatitis (MASH). Its product candidate, pemvidutide, harnesses the mechanism of a GLP-1/glucagon dual receptor agonist to mimic complementary physiological effects similar to diet and exercise. This approach aims to modulate appetite, increase energy expenditure, and affect lipid metabolism, which collectively contribute to substantial weight loss and improved metabolic profiles.

Innovative Therapeutic Approach

At the heart of Altimmune's strategy is the development of next-generation peptide-based therapeutics. The company’s investigational product, pemvidutide, leverages a dual agonist mechanism to bind and activate both the GLP-1 and glucagon receptors. This unique mechanism is designed to produce a synergistic effect, where the activation of GLP-1 suppresses appetite while glucagon stimulates energy expenditure and promotes favorable lipid metabolism. This dual receptor engagement differentiates Altimmune’s approach from traditional single-target treatments and positions the company as a contender in the evolving landscape of metabolic disease therapies.

Clinical Development and Research Focus

Altimmune stands out as an expert in the clinical-stage development of biotherapeutics. The company is currently engaged in intensive clinical research evaluating the safety, tolerability, and efficacy of pemvidutide in patients dealing with obesity and MASH. By conducting robust clinical trials that measure key health indicators such as weight loss, liver fat reduction, and improvements in serum lipid profiles, Altimmune is committed to establishing a comprehensive understanding of its product's benefits. This rigorous clinical approach helps to solidify the company’s reputation for precision and reliability within the biopharmaceutical research community.

Market Position and Competitive Landscape

Operating within an industry defined by rapid advancements in biotechnology and therapeutic innovation, Altimmune Inc has carved a niche by targeting complex metabolic conditions that are traditionally difficult to treat. Its emphasis on peptide therapeutics places it in direct competition with other clinical-stage companies pursuing similar targets in obesity and liver diseases. However, the strategic design of a dual receptor agonist not only distinguishes its product profile but also showcases the company’s deep technical expertise and understanding of disease pathways. This innovation is critical for positioning Altimmune as a significant contributor to next-generation treatment solutions in a competitive market landscape.

Scientific Rationale and Developmental Insights

The scientific premise behind Altimmune's research is rooted in the idea that the coordinated activation of multiple hormonal pathways can more effectively counteract complex metabolic disorders. By fostering a better balance between appetite suppression and energy metabolism, pemvidutide is engineered to ensure effective weight loss while preserving lean muscle mass, a critical factor when addressing obesity. These innovative insights into the interplay of metabolic processes underscore the company’s commitment to designing therapies that are both safe and effective.

Operational Strategy and Future Research Directions

While Altimmune Inc is primarily a research-driven entity without established revenue streams from commercial products, its ongoing clinical trials and technology platform underscore its commitment to transforming the treatment landscape in metabolic health. The company continues to build its clinical portfolio by exploring additional therapeutic indications that leverage the unique properties of its peptide-based platform technology. Its operational focus includes establishing partnerships, advancing clinical trials efficiently, and ensuring that manufacturing processes for its candidates meet rigorous quality standards.

Conclusion

Altimmune Inc exemplifies a forward-thinking, research-oriented approach in the realm of clinical-stage biopharmaceutical development. Through its innovative dual receptor agonist technology and deep understanding of metabolic biology, the company aims to deliver transformative therapies for obesity, metabolic diseases, and MASH. The detailed clinical research and robust development pipeline not only underscore its scientific acumen but also provide valuable insights for investors and stakeholders seeking to understand the critical dynamics of next-generation therapeutic solutions.

Rhea-AI Summary

Altimmune presented new data at the EASL International Liver Congress 2024 highlighting the potential of pemvidutide in treating Metabolic Dysfunction-Associated Steatohepatitis (MASH). The data from Phase 1 trials indicate significant improvements in non-invasive tests, suggesting potential histologic benefits by Q1 2025. The trials show that pemvidutide's dual GLP-1/glucagon agonism could outperform GLP-1 alone in resolving MASH and reducing fibrosis. Additionally, lipidomic profiling supports its potential in addressing MASH-related co-morbidities like cardiovascular disease. Pemvidutide is currently being evaluated in a Phase 2b trial.

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On May 29, 2024, Altimmune (Nasdaq: ALT), a clinical-stage biopharmaceutical company, announced its participation in two upcoming investor conferences. The company management will attend the Jefferies Global Healthcare Conference in New York on June 5, 2024, with a fireside chat at 2:00 p.m. ET. They will also attend the Goldman Sachs Global Healthcare Conference in Miami Beach on June 12, 2024, with a fireside chat at 9:20 a.m. ET. Both sessions will be webcast and accessible via the Events section of Altimmune's website.

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Altimmune, a clinical-stage biopharmaceutical company, announced new data on pemvidutide, a novel peptide-based GLP-1/glucagon dual receptor agonist, at the EASL International Liver Congress™ 2024 in Milan. Pemvidutide is under development for treating obesity and metabolic dysfunction-associated steatohepatitis (MASH). The data highlights its anti-inflammatory and anti-fibrotic properties in subjects with metabolic dysfunction-associated steatotic liver disease (MASLD). Presentations include:

- Dr. Sarah Browne on metabolic dysfunction-associated steatohepatitis activity and fibrosis.

- Dr. Scot Roberts on plasma lipidomic profiling in subjects with obesity.

- Dr. Shaheen Tomah on noninvasive tests indicating histologic response in MASLD subjects.

These presentations will occur on June 5, 2024, at 8:30 am CEST, with posters displayed throughout the congress.

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Roundhill Investments has launched the Roundhill GLP-1 & Weight Loss ETF (OZEM), now trading on Nasdaq. OZEM targets the growing market of GLP-1 receptor agonists and weight management drugs, which is projected to hit $100 billion by 2030. The ETF offers exposure to companies leading in obesity treatment innovation, including Eli Lilly, Novo Nordisk, and Innovent Biologics. CEO Dave Mazza emphasizes the substantial growth potential due to the rising global obesity rates. Key holdings in the ETF feature major pharmaceutical companies with a focus on weight loss therapeutics.

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Altimmune announced its financial results for the first quarter of 2024, revealing cash, cash equivalents, and short-term investments of $182.1 million as of March 31, 2024. The company highlighted the ongoing IMPACT Phase 2b trial of pemvidutide in MASH, with top-line results expected in Q1 2025. Altimmune also emphasized the upcoming End-of-Phase 2 meeting with the FDA and the positive data from the Phase 2 MOMENTUM trial of pemvidutide in obesity. The company continues to advance enrollment in the IMPACT trial, with topline data anticipated in Q1 2025.

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Altimmune, Inc. (Nasdaq: ALT) will participate in two upcoming investor conferences, the JMP Life Sciences Conference in New York on May 14, 2024, and the UBS Obesity Therapeutics Day virtual conference on May 23, 2024. The company's management team will be available for 1x1 meetings and will hold Fireside Chats at specific times. The sessions will be webcast on the Altimmune website.

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Altimmune, Inc. (Nasdaq: ALT) will report its first quarter 2024 financial results and provide a business update on May 9, 2024. Altimmune management will host a conference call to discuss the financial results and business update.

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Altimmune, Inc. (Nasdaq: ALT) will be represented by Dr. Scott Harris, Chief Medical Officer, at two upcoming conferences: BTIG Obesity Health Forum and GLP-1-Based Therapeutics Summit. The presentations will focus on emerging therapeutics and the use of GLP-1s in treating MASH & Fatty Liver Disease.

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Altimmune expresses condolences on the passing of Dr. Stephen Harrison, a key figure in the field of metabolic liver disease. Dr. Harrison's contributions and advocacy for patients will leave a lasting impact on the community.
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Altimmune, Inc. (ALT) announces positive results from body composition study showing lean mass preservation in obesity trial. Enrollment ongoing in Phase 2b trial for pemvidutide in Metabolic Dysfunction-Associated Steatohepatitis. Preclinical study demonstrates anti-fibrotic effect in liver fibrosis model. Company reports $198.0 million in cash, cash equivalents, and short-term investments. Webcast scheduled for March 27, 2024.
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FAQ

What is the current stock price of Altimmune (ALT)?

The current stock price of Altimmune (ALT) is $4.24 as of April 4, 2025.

What is the market cap of Altimmune (ALT)?

The market cap of Altimmune (ALT) is approximately 331.9M.

What is the primary focus of Altimmune Inc?

Altimmune Inc is dedicated to developing innovative peptide-based therapeutics for the treatment of obesity, metabolic diseases, and liver conditions such as MASH. Its research is centered around a dual receptor agonist mechanism.

What is pemvidutide and how does it work?

Pemvidutide is an investigational peptide-based GLP-1/glucagon dual receptor agonist. It works by simultaneously activating the GLP-1 receptor to suppress appetite and the glucagon receptor to boost energy expenditure and optimize lipid metabolism.

How is Altimmune positioned within the clinical-stage biopharmaceutical sector?

Altimmune operates in the highly competitive clinical-stage biopharmaceutical space, focusing on unmet medical needs in metabolic and liver diseases. Its novel dual agonist approach distinguishes it from companies with single-target therapies.

What clinical development activities is Altimmune currently undertaking?

The company is actively engaged in clinical trials evaluating the safety, tolerability, and efficacy of pemvidutide in patients with obesity and MASH. Their approach is marked by robust clinical assessments and detailed metabolic profiling.

How does Altimmune’s dual receptor agonist differ from traditional treatments?

Unlike traditional single-target treatments, Altimmune’s dual receptor agonist activates both the GLP-1 and glucagon receptors. This coordinated mechanism helps in achieving effective weight loss while promoting improvements in metabolic markers.

What are some challenges that Altimmune might face in its development process?

As a clinical-stage biopharma, Altimmune faces challenges including regulatory review complexities, clinical trial enrollment, manufacturing scale-up, and overall market competition. These factors are intrinsic to innovative drug development.

Who are the typical competitors in the field of metabolic disease therapeutics?

Competitors typically include other clinical-stage companies and established firms developing treatments for obesity and metabolic disorders. Altimmune differentiates itself with a unique dual receptor approach, targeting multiple pathways concurrently.
Altimmune

Nasdaq:ALT

ALT Rankings

ALT Stock Data

331.93M
76.40M
0.84%
53.69%
28.13%
Biotechnology
Pharmaceutical Preparations
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United States
GAITHERSBURG