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Astellas Pharma Inc. is a global pharmaceutical company with operations in over 70 countries. The company focuses on creating innovative drugs to treat diseases with high unmet medical needs by emphasizing Biology and Modality. Beyond traditional pharmaceuticals, Astellas is exploring Rx+® healthcare solutions in collaboration with cutting-edge technology partners. Astellas recently opened a state-of-the-art West Coast Innovation Center in South San Francisco, enhancing its commitment to biotech innovation.
The company is actively involved in research and development, with recent advancements in cancer therapies like zolbetuximab, a monoclonal antibody targeting gastric and gastroesophageal cancers. Astellas' collaborations with Pfizer and Merck, as well as YASKAWA Electric Corporation, demonstrate its commitment to pioneering research and creating new treatment paradigms by integrating pharmaceutical and robotics technologies.
Astellas Pharma announced the publication of results from the Phase 3 SPOTLIGHT trial evaluating zolbetuximab in combination with mFOLFOX6 for patients with CLDN18.2-positive, HER2-negative gastric or gastroesophageal junction adenocarcinoma. Published in The Lancet, the trial met its primary endpoint of progression-free survival (PFS) and secondary endpoint of overall survival (OS). Key findings include a 24.9% reduced risk of progression or death and a median PFS of 10.61 months for zolbetuximab versus 8.67 months for placebo. OS data revealed a 25% reduced risk of death, with median OS of 18.23 months for the treatment group. The SPOTLIGHT study establishes the clinical benefit of zolbetuximab, supporting Astellas' development efforts in gastric cancer.
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