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Agenus Inc. (NASDAQ: AGEN) is a pioneering clinical-stage immuno-oncology company headquartered in Lexington, Massachusetts. Agenus is steadfast in its mission to develop innovative immunological therapies aimed at leveraging the body's immune system to combat cancer and other diseases. The company’s diverse product pipeline includes immune-modulatory antibodies, adoptive cell therapies through its subsidiary MiNK Therapeutics Inc., and vaccine adjuvants through its subsidiary SaponiQx Inc. These products are bolstered by in-house capabilities such as current good manufacturing practice (cGMP) manufacturing and a clinical operations platform.
Agenus has developed several key product candidates, including botensilimab (AGEN1811), a next-generation Fc-engineered CTLA-4 antibody, and balstilimab, a PD-1 antibody. They are currently under investigation for their potential to treat various cancers, particularly difficult-to-treat solid tumors.
The company has achieved significant milestones, including the initiation of various clinical trials for botensilimab and balstilimab. Notably, in April 2024, Agenus announced a one-for-twenty reverse stock split of its issued and outstanding common stock to increase its stock price and meet Nasdaq Capital Market listing requirements. This move is part of a strategic plan to enhance future financing and qualify for inclusion in the Russell Indices.
In its ongoing pursuit of innovative cancer treatments, Agenus recently announced Phase 1 trial results demonstrating encouraging survival rates in patients with metastatic colorectal cancer. The Phase 2 data is expected to be submitted to a major medical conference in the latter half of 2024.
Agenus also engages in strategic partnerships to accelerate its development programs. For instance, a recent agreement with Ligand Pharmaceuticals secures a $100 million capital infusion, specifically aimed at supporting the clinical development and launch readiness of the BOT/BAL combination therapy.
The team at Agenus comprises scientists, researchers, biotechnologists, physicians, and business professionals united by the shared goal of achieving breakthroughs in cancer treatment. This collaborative spirit ensures that Agenus remains at the forefront of transformative cancer therapies, aiming to enhance patient outcomes and extend lives.
For more information, visit www.agenusbio.com or follow @agenus_bio on social media.
Agenus (Nasdaq: AGEN), a clinical-stage immuno-oncology company, will present updated data on its lead program botensilimab at the Society of Gynecologic Oncology (SGO) 37th Annual Meeting on Women’s Cancer from March 25-28, 2023, in Tampa, FL.
The presentation will focus on the combination of botensilimab with balstilimab in patients with recurrent platinum refractory/resistant ovarian cancer, scheduled for March 27 at 9:18am ET. Botensilimab aims to treat 'cold' tumors, showing promising results in over 300 patients across various cancers. A global Phase 3 trial in microsatellite-stable colorectal cancer is planned for 2023.
Agenus (NASDAQ: AGEN), a clinical-stage immuno-oncology company, announced that Dr. Garo Armen, Chairman and CEO, along with Dr. Steven O’Day, Chief Medical Officer, will present at two upcoming investor conferences. The Guggenheim 5th Annual Oncology Day will feature a fireside chat on February 9, 2023, at 9:35 AM ET, while the SVB Securities Global Biopharma Conference will host a virtual fireside chat on February 16, 2023, at 10:00 AM ET. Interested parties can access live webcasts through the company’s website. Agenus focuses on cancer immunotherapy, leveraging various therapeutic approaches and resources.
Agenus reported promising clinical data from a Phase 1b study of botensilimab combined with balstilimab in treating microsatellite stable colorectal cancer (MSS CRC). In an expanded cohort of 70 heavily pre-treated patients, the overall response rate (ORR) was 23%, while the disease control rate (DCR) was 76%. Remarkably, 69% of responses were ongoing at the data cut-off, and median overall survival has not yet been reached. The company plans to initiate a Phase 3 trial for MSS CRC in 2023, underscoring a commitment to address the significant unmet needs in this patient population.
Agenus (NASDAQ: AGEN), an immuno-oncology firm, announced participation by Chairman and CEO Dr. Garo Armen and Chief Medical Officer Dr. Steven O’Day in a virtual fireside chat at the B Riley Securities’ 2023 Virtual Oncology Conference on January 18th at 11:30 am ET. This event offers insights into Agenus's innovative therapies targeting cancer and infections. Interested participants can register for the webcast at B Riley's website. An archived version will be available later on Agenus's Investor page, providing ongoing updates about the company's developments.
Agenus Inc. (NASDAQ: AGEN) announced it will present expanded data on botensilimab, an anti-CTLA-4, in combination with balstilimab, an anti-PD-1, at the American Society of Clinical Oncology – Gastrointestinal Cancers Symposium (ASCO-GI) from January 19-21, 2023, in San Francisco, CA. The presentation will focus on data from the microsatellite stable colorectal cancer cohort of its Phase 1 study and occurs on January 21, 2023, at 10:00am ET. Abstract details, including the presenting author, will be released on January 17, 2023.
Agenus (Nasdaq: AGEN) reported promising results from its Phase 1 study of botensilimab and balstilimab for advanced sarcoma treatment. The study revealed a 46% overall response rate and a 69% disease control rate in heavily pre-treated patients. Notably, responses were observed in historically resistant sarcoma subtypes, including visceral angiosarcoma. Furthermore, 67% of responses lasted over a year. With a 12-month overall survival rate of 77%, Agenus plans further Phase 2 trials in 2023.
Agenus (NASDAQ: AGEN), a leader in immuno-oncology, will participate in the 5th Annual Evercore ISI HealthCONx Conference. Dr. Garo Armen and Dr. Steven O'Day will join a virtual fireside chat on November 30th at 12:35 PM ET. The conference runs from November 29th to December 1st, including one-on-one investor meetings. Interested attendees can register for the webcast, which will also be archived on Agenus' investor website following the event. Agenus focuses on therapies that harness the immune system to combat cancer and infections.
Agenus (Nasdaq: AGEN) reported promising results from its Phase 1 study of botensilimab and balstilimab for treating treatment-resistant tumors, including MSS-CRC, ovarian, and NSCLC. The response rates ranged from 22% in MSS-CRC to 60% in anti-PD-(L)1 resistant NSCLC. The company has initiated Phase 2 ACTIVATE trials for botensilimab in advanced MSS-CRC and melanoma, with pancreatic cancer trials expected by year-end. The therapy has shown higher efficacy and tolerability compared to existing treatments, marking a significant step forward in immuno-oncology.
Agenus Inc. (NASDAQ: AGEN) provided a corporate update and third-quarter 2022 financial results, highlighting the promising Phase 1 study of botensilimab, an anti-CTLA-4 therapy. The company initiated Phase 2 ACTIVATE trials for botensilimab in advanced colorectal cancer and melanoma. The firm ended Q3 with $218 million in cash and reported a net loss of $56.7 million, or $0.19 per share. Revenue for the quarter was $22.8 million, down significantly from the previous year. Agenus plans to present expanded data at the SITC Annual Meeting on November 12.
Agenus (NASDAQ: AGEN) announced it will release its Q2 2022 financial results before the market opens on November 8, 2022. The company will host a conference call at 8:30 a.m. ET to discuss the results and provide updates. On November 12, 2022, Agenus will hold an R&D event titled “The Road Taken” in Boston, featuring insights from oncology experts regarding botensilimab and its development in cold tumors. Investors may access the conference call and R&D event via dial-in and webcast, respectively.
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