Alpha Cognition Announce Data from Pre-Clinical Study of ALPHA-1062 for Traumatic Brain Injury

Rhea-AI Summary

Alpha Cognition Inc. (TSX-V: ACOG, OTCQB: ACOGF) announced promising data from its ALPHA-1062 program for treating Traumatic Brain Injury (TBI). In preclinical studies, ALPHA-1062 significantly reduced functional deficits in TBI subjects, showing recovery comparable to uninjured animals. The treatment, started two hours post-injury and administered for 35 days, improved both motor and cognitive functions. Current estimates suggest nearly 3 million TBI cases annually in the U.S., highlighting the potential market for effective treatments.

Positive

• ALPHA-1062 showed significant improvement in motor and cognitive recovery in TBI models.
• The treatment's efficacy was statistically similar to that of healthy controls in four out of five recovery measures.
• Ongoing neuropathological assessments promise further insights into treatment impact.

Negative

• None.

VANCOUVER, British Columbia--(BUSINESS WIRE)-- Alpha Cognition Inc. (TSX-V: ACOG) (OTCQB: ACOGF) (“Alpha Cognition”, or the “Company”), a biopharmaceutical company committed to developing novel therapies with the potential to transform the lives of people with debilitating neurodegenerative disorders, is pleased to announce functional data from their ALPHA-1062 intranasal Traumatic Brain Injury (TBI) program. ALPHA-1062 administration significantly, acutely reduced the extent of the functional deficit, and improved functional recovery of TBI animals compared to untreated animals suffering a TBI. Notably, in four of five functional measures of recovery, the performance of ALPHA-1062 treated group was statistically indistinguishable from that of the uninjured cohort.

Denis Kay, the Company’s Chief Scientific Officer commented: “These preclinical results, combined with our clinical data demonstrating the safety and tolerability of ALPHA-1062, support its continued development for the treatment of TBI, which we believe has the potential to help millions of Americans who suffer from a TBI each year. We are encouraged by the data thus far and confident in our progress towards developing a safe and effective treatment for this underserved population.”

In a rodent model of TBI, ALPHA-1062 or vehicle (purified water as treatment control) was administered intranasally, with treatment initiated 2 hours after injury and continued twice daily for 35 days. ALPHA-1062 demonstrated acute (functional) protection from injury, and significantly improved:

1. motor and sensory functional recovery measured by motor skill assessment, sensory/motor skill assessment, and Modified Neurological Severity Score which comprises motor, sensory, balance and reflex assessment.
2. cognitive functional recovery measured by tests which assess recognition memory, and spatial learning and memory.

The neuropathological assessment of the brains from each experimental group is ongoing and top line results will be released in Q1, 2022.

TBI is a highly prevalent and increasingly common condition, with nearly 3 million diagnosed events occurring in the United States alone in 2019 [DRG Executive Insights - Traumatic Brain Injury, June 2020]. TBI is a major cause of death and disability in the US and there is currently no proven effective pharmacological intervention for patients who sustain an acute closed head injury.

About Alpha Cognition Inc.

Alpha Cognition Inc. is a clinical stage, biopharmaceutical company dedicated to developing treatments for under-served neurodegenerative diseases, such as Alzheimer's Dementia and Amyotrophic Lateral Sclerosis (ALS).

ALPHA-1062, is a patented new chemical entity that has demonstrated safety and improved tolerability in human clinical trials. It is being developed as a new generation acetylcholinesterase inhibitor for the treatment of Alzheimer's disease, with minimal gastrointestinal side effects and novel routes of administration. ALPHA-1062's active metabolites are differentiated from donepezil and rivastigmine in that they may sensitize neuronal nicotinic receptors, most notably the alpha-7 subtype, which is known to have a positive effect on cognition. ALPHA-1062 is also being developed in combination with memantine to treat moderate to severe Alzheimer's dementia and in a nasal spray formulation to treat traumatic brain injury.

ALPHA-0602 (Progranulin) is expressed in several cell types in the central nervous system and in peripheral tissues, regulates cell survival and certain inflammatory processes, and plays a major role in regulating lysosomal function and microglial responses to disease. Its use for the treatment of neurodegenerative diseases has been patented by the Company and granted an Orphan Drug Designation.

Neither TSX Venture Exchange (the “TSX-V”), OTC Markets Group, nor the TSX-V’s Regulation Services Provider (as that term is defined in policies of the TSX-V) accepts responsibility for the adequacy or accuracy of this release.

Forward-looking Statements

This news release is not, and under no circumstances is to be construed as, an advertisement or a public offering of securities. No securities commission or similar authority in Canada or in any other jurisdiction has reviewed or in any way passed upon this news release or the merits of the securities described herein and any representation to the contrary is an offence.

This news release includes forward-looking statements within the meaning of applicable securities laws. Except for statements of historical fact, any information contained in this news release may be a forward-looking statement that reflects the Company’s current views about future events and are subject to known and unknown risks, uncertainties, assumptions and other factors that may cause the actual results, levels of activity, performance or achievements to be materially different from the information expressed or implied by these forward-looking statements. Forward-looking statements can be identified by the words “may,” “might,” “will,” “could,” “would,” “should,” “expect,” “intend,” “plan,” “objective,” “anticipate,” “believe,” “estimate,” “predict,” “project,” “potential,” “target,” “seek,” “contemplate,” “continue” and “ongoing,” or the negative of these terms, or other comparable terminology intended to identify statements about the future. Forward‐looking statements in this news release include statements regarding the Company’s business strategy, market size, potential growth opportunities, capital requirements, clinical development activities, the timing and results of clinical trials, regulatory submissions, potential regulatory approval and commercialization of the technology. Although the Company believes that we have a reasonable basis for each forward-looking statement, we caution you that these statements are based on a combination of facts and factors currently known by us and our expectations of the future, about which we cannot be certain. The Company cannot assure that the actual results will be consistent with these forward-looking statements as a result of known and unknown risks, uncertainties, assumptions and other factors. These risks, uncertainties, assumptions and other factors include those associated with clinical studies and manufacturing, as well as development and commercialization of the Company’s products; the need for additional financing to maintain operations; risks posed by the economic and political environments in which the Company operates and intends to operate; market instability due to the COVID-19 pandemic; the potential for losses arising from the expansion of operations into new markets; increased competition; assumptions regarding market trends and the expected demand and desires for the Company’s products and proposed products; reliance on industry manufacturers, suppliers and key personnel; the failure to adequately protect intellectual property; a failure to adequately manage future growth; adverse market conditions; and failure to satisfy ongoing regulatory requirements or obtain regulatory approvals. These forward‐looking statements speak only as of the date of this news release and, other than as required by applicable securities laws, the Company undertakes no obligation to revise or update any forward‐looking statements, even if new information becomes available in the future.

This news release may also contain estimates and other statistical, market and industry data from independent parties or made by the Company relating to our industry. This data involves a number of assumptions and limitations, and you are cautioned not to give undue weight to such estimates. We cannot guarantee the accuracy and completeness of information from third party sources.

View source version on businesswire.com: https://www.businesswire.com/news/home/20211206005092/en/

Bristol Investor Relations

Stefan Eftychiou

905 326 1888 ext 6

stefan@bristolir.com

https://www.alphacognition.com/

Source: Alpha Cognition Inc.

FAQ

What are the recent developments for Alpha Cognition Inc. (ACOGF)?

Alpha Cognition has released functional data from its ALPHA-1062 program, demonstrating significant recovery in preclinical TBI studies.

What is the purpose of ALPHA-1062 in treating TBI?

ALPHA-1062 aims to improve functional recovery for patients suffering from Traumatic Brain Injury.

What were the results of the ALPHA-1062 TBI studies?

The studies indicated ALPHA-1062 significantly reduced functional deficits, with recovery similar to uninjured subjects.

How could ALPHA-1062 impact the market for TBI treatments?

With nearly 3 million TBI cases in the U.S. annually, effective treatments like ALPHA-1062 could address a significant unmet medical need.