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AC Immune SA (NASDAQ: ACIU) is a clinical-stage biopharmaceutical company headquartered in Lausanne, Switzerland, committed to pioneering precision medicine for neurodegenerative diseases. The company specializes in designing, discovering, and developing innovative therapeutic and diagnostic products aimed at preventing and modifying diseases caused by misfolded proteins. Utilizing its two proprietary technology platforms, SupraAntigen® and Morphomer®, AC Immune develops a broad spectrum of antibodies, small molecules, and vaccines targeting conditions such as Alzheimer’s disease (AD), Parkinson’s disease, and NeuroOrphan indications.
With a robust pipeline consisting of sixteen therapeutic and diagnostic programs, AC Immune currently has six product candidates in clinical trials, including five in Phase 2 and one in Phase 3. The most advanced candidate, Crenezumab, is a humanized anti-amyloid-β monoclonal antibody in Phase 3 trials aimed at treating Alzheimer’s disease. Other notable candidates include ACI-24.060, a promising anti-Abeta active immunotherapy for AD and Down syndrome, which has received FDA Fast Track Designation, and ACI-35.030, an anti-pTau active immunotherapy in Phase 2b trials for preclinical AD conducted by Janssen Pharmaceuticals.
Beyond its rich pipeline, AC Immune is known for its strategic partnerships with leading global pharmaceutical companies such as Genentech (a Roche Group member), Eli Lilly and Company, and Takeda. These collaborations have resulted in significant non-dilutive funding and milestone payments totaling over $4.5 billion.
AC Immune recently secured an exclusive option and license agreement with Takeda for its ACI-24.060 product, potentially worth $2.1 billion, and completed a $50 million equity financing to support its operations into 2026. The company's focused efforts on precision prevention are reinforced by its ongoing Phase 2 trials and collaborations aimed at leveraging advanced diagnostic techniques like PET imaging and novel therapeutic approaches for early and effective intervention in neurodegenerative diseases.
AC Immune SA (NASDAQ: ACIU) hosted an investor webinar on March 31, 2021, highlighting its innovative Morphomer™ technology platform aimed at developing therapeutics and diagnostics for neurodegenerative diseases. CEO Prof. Andrea Pfeifer emphasized the platform's ability to create first-in-class candidates targeting key proteins like Tau and TDP-43. Notable financial achievements include over CHF 174 million from strategic partnerships. The webinar also showcased advancements in clinical validation of Morphomer candidates, including the Phase 1 study success of candidate ACI-3024.
AC Immune, a clinical-stage biopharmaceutical company, will host a corporate update webinar on March 31, 2021, from 10:00 AM to 11:30 AM ET. The focus will be on the company’s innovative Morphomer™ technology for developing targeted therapies for neurodegenerative diseases. The current pipeline includes two clinical-stage diagnostic candidates and one therapeutic candidate that has completed Phase 1. Key speakers will include CEO Andrea Pfeifer and CSO Marie Kosco-Vilbois, among others. This event will include an interactive Q&A session with the audience.
AC Immune SA (NASDAQ: ACIU) announced positive interim results from its Phase 1b/2a study of the anti-pTau Alzheimer's vaccine, demonstrating strong safety and immune responses. The financial update revealed a cash position of CHF 225.9 million, sufficient to sustain operations into Q1 2024. However, contract revenues decreased significantly from CHF 110.5 million in 2019 to CHF 15.4 million in 2020, primarily due to reduced milestone payments. The company anticipates 2021 cash burn between CHF 65 million and CHF 75 million, while further clinical data is expected in Q2.
AC Immune (NASDAQ: ACIU) reported promising Phase 1b results for its novel anti-amyloid-beta vaccine at a global Down syndrome symposium. The vaccine, ACI-24, demonstrated significant immunogenicity and safety, with no serious adverse events recorded. The trial achieved a high retention rate and showed positive pharmacodynamic responses. The company plans to advance the vaccine into mid-stage clinical trials for treating Alzheimer's disease related to Down syndrome, while optimizing its formulation based on encouraging preclinical data.
AC Immune SA (NASDAQ: ACIU) has showcased innovative findings at the AD/PD 2021 conference, focusing on therapies targeting alpha-synuclein and TDP-43, associated with neurodegenerative diseases. Highlights include first-in-class PET tracers and antibody candidates demonstrating significant in vivo actions. The alpha-synuclein program is anticipated to yield first clinical results by Q3 2021, potentially enabling precise disease diagnostics and tailored therapies. With a robust pipeline and strategic collaborations, AC Immune aims to lead in precision medicine for neurodegenerative conditions.
AC Immune (NASDAQ: ACIU) has announced four new data presentations at the upcoming 15th International Conference on Alzheimer’s & Parkinson’s Diseases (AD/PDTM), taking place virtually from March 9–14, 2021. The presentations will focus on preclinical results from the company's therapeutic and diagnostic programs targeting alpha-synuclein and TDP-43. Highlights include two oral presentations on PET imaging agents and therapeutic antibodies, alongside e-posters on small molecule aggregation inhibitors. These advancements underscore AC Immune's commitment to precision medicine in neurodegenerative diseases.
AC Immune SA (NASDAQ: ACIU) announced its participation in the SVB Leerink 10th Annual Global Healthcare Conference from February 22-26, 2021. During the event, CEO Prof. Andrea Pfeifer will discuss the company’s precision medicine strategy and the promising interim Phase 1b/2a results of its anti-phospho-Tau vaccine candidate, ACI-35.030, developed in collaboration with Janssen Pharmaceuticals. The results indicated strong immunogenicity and safety in patients with early Alzheimer’s disease. A webcast of the presentation will be available on the company’s website.
AC Immune announced promising interim results from its Phase 1b/2a trial of the ACI-35.030 vaccine for early Alzheimer’s disease. The trial showed 100% of older patients generated high levels of anti-pTau antibodies post-vaccination, significantly exceeding pre-vaccination levels. The vaccine was safe and well-tolerated, with no adverse events reported. The findings support advancing ACI-35.030 into Phase 2/3 trials. This innovation highlights the potential for early intervention in Alzheimer’s, utilizing a cutting-edge vaccine formulation aimed at combating Tau pathology.
AC Immune SA (NASDAQ: ACIU) has initiated a first-in-human study of ACI-12589, a novel PET imaging tracer for Parkinson's disease (PD). This tracer aims to accurately detect pathological alpha-synuclein deposits in the brain, a hallmark of PD. Supported by the Michael J. Fox Foundation, results are expected in Q3 2021. In preclinical studies, ACI-12589 displayed improved sensitivity and specificity compared to previous candidates, potentially leading to earlier diagnosis and effective monitoring of disease progression.
AC Immune SA (NASDAQ: ACIU) announced advancements in its small molecule and antibody therapeutic programs targeting the NLRP3 inflammasome, crucial for neurodegenerative diseases like Alzheimer’s. The company has identified potent small molecule NLRP3 inhibitors, demonstrating significant biological activity in animal models. AC Immune plans to initiate in vivo proof-of-concept studies by year-end to evaluate CNS delivery and efficacy. Additionally, high-affinity antibodies that inhibit ASC-mediated inflammatory responses are under development. These pipeline advancements highlight AC Immune's commitment to addressing neurodegeneration.
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