Welcome to our dedicated page for Arbutus Biopharm news (Ticker: ABUS), a resource for investors and traders seeking the latest updates and insights on Arbutus Biopharm stock.
Arbutus Biopharma Corporation (Nasdaq: ABUS) is a clinical-stage biopharmaceutical company focused on infectious disease, with a particular emphasis on chronic hepatitis B virus (cHBV) infection. The ABUS news feed highlights company announcements on clinical data, corporate strategy and intellectual property developments that shape the outlook for its pipeline and technology.
Investors and observers following ABUS news can find regular updates on imdusiran (AB-729), Arbutus’ RNAi therapeutic designed to reduce hepatitis B viral proteins and antigens including HBsAg. News items include results from Phase 1 and Phase 2a trials, such as reports of patients achieving what the company describes as functional cure, analyses of HBsAg and HBV DNA reductions, and presentations at major liver disease conferences including the European Association for the Study of the Liver (EASL) Congress and the American Association for the Study of Liver Diseases (AASLD) – The Liver Meeting.
The ABUS news stream also covers developments related to AB-101, the company’s oral PD-L1 inhibitor candidate. Releases describe safety, tolerability and pharmacodynamic findings from the ongoing Phase 1a/1b trial in healthy volunteers and cHBV patients, including data on PD-L1 receptor occupancy and the absence of AB-101-related serious adverse events reported to date.
Another recurring theme in Arbutus news is its LNP intellectual property. Joint announcements with Genevant Sciences and company updates detail U.S. and international patent infringement actions against Moderna and Pfizer/BioNTech concerning the use of LNP technology in COVID-19 vaccines. Corporate news also includes board and executive changes, restructuring actions, and strategic decisions such as reacquiring Greater China rights to imdusiran and forming a Scientific Advisory Board of cHBV experts.
For those tracking ABUS stock and the company’s progress in hepatitis B and LNP technology, this news page provides a centralized view of clinical milestones, litigation updates and corporate developments as disclosed by Arbutus in its press releases.
Arbutus Biopharma Corporation (Nasdaq: ABUS) has received FDA authorization for its Investigational New Drug application to initiate a Phase 2a clinical trial for AB-729, targeting chronic hepatitis B virus (CHB) infection. The trial will evaluate the safety and efficacy of AB-729 in combination with nucleos(t)ide analog therapy and short courses of Peg-IFNα-2a. The randomized trial aims to enroll 40 subjects and is expected to start this quarter, with the potential to establish AB-729 as a cornerstone therapy for CHB.
Arbutus Biopharma Corporation (Nasdaq: ABUS) and Vaccitech plc (Nasdaq: VACC) announced a clinical trial collaboration to assess a combination therapy for chronic hepatitis B (CHB) patients receiving nucleos(t)ide reverse transcriptase inhibitors (NrtIs). The Phase 2a trial will evaluate the safety and efficacy of Arbutus’s AB-729 and Vaccitech’s VTP-300 in a double-blind study. Enrollment is projected for 40 subjects, with initiation expected in the second half of 2021. Positive results may lead to a larger Phase 2b trial.
Arbutus Biopharma (Nasdaq: ABUS) and Antios Therapeutics have signed a clinical collaboration to evaluate a triple therapy for chronic hepatitis B involving Arbutus' AB-729 and Antios' ATI-2173, along with Viread. This Phase 2a trial will assess safety, pharmacokinetics, immunogenicity, and antiviral activity in patients. The trial is slated to start in H2 2021, with Antios covering the costs and Arbutus supplying AB-729. Early results for ATI-2173 show promise as a potential backbone in curative regimens, while AB-729 has demonstrated positive safety and efficacy in prior studies.
Arbutus Biopharma has announced promising results for its HBV treatment candidate, AB-729, which achieved a mean HBsAg decline of -1.87 log10 IU/mL after 44 weeks. In a clinical trial, 75% of subjects receiving AB-729 at 60 mg every 4 weeks had HBsAg levels below 100 IU/mL. Additionally, AB-729 demonstrated a favorable safety profile and showed potential for increased immune responses. The company is set to initiate Phase 2a trials later this year. The efficacy and safety data support AB-729 as a leading candidate in chronic hepatitis B treatment.
Arbutus Biopharma Corporation (Nasdaq: ABUS) announced acceptance of five abstracts for the International Liver Congress 2021, focusing on chronic hepatitis B virus (HBV) treatments. Key presentations include a late-breaker on the GalNAc-siRNA AB-729, demonstrating HBsAg suppression, and the preclinical profile of the HBV capsid inhibitor AB-836. A conference call is scheduled for June 28, 2021, to discuss these findings. Hepatitis B continues to pose significant health challenges globally, affecting over 250 million people.
Arbutus Biopharma Corporation (Nasdaq: ABUS), focused on chronic hepatitis B virus (HBV) and coronavirus therapies, announced participation in two virtual investor conferences. The first is the Jefferies Virtual Healthcare Conference on June 2, 2021, featuring a fireside chat at 9:00 am ET. Presenters include CEO William Collier and other executives. The second is the JMP Securities Life Sciences Conference on June 17, 2021, at 11:00 am ET, also featuring a fireside chat. Links to webcasts are available on their website.
Arbutus Biopharma Corporation (Nasdaq: ABUS) reported its Q1 2021 results, showcasing advancements in its HBV pipeline, particularly with AB-729 and AB-836. AB-729 has shown significant declines in hepatitis B surface antigen levels with promising safety profiles. The company commenced a Phase 2 clinical trial for a combination regimen involving AB-729 and other treatments for chronic HBV. Financially, Arbutus ended Q1 with $132 million in cash but recorded a net loss of $19.6 million. The firm anticipates significant data releases and trial advancements in the coming quarters.
Arbutus Biopharma Corporation (Nasdaq: ABUS) has announced its first quarter 2021 financial results and corporate update scheduled for May 5, 2021. Key details include the release of the financial results at 7:30 a.m. ET followed by a conference call/webcast at 8:45 a.m. ET. The domestic dial-in number for the call is (866) 393-1607, and international callers can reach (914) 495-8556 with conference ID 4445858. Arbutus focuses on developing treatments for chronic hepatitis B and coronaviruses.
Arbutus Biopharma (NASDAQ: ABUS), in collaboration with X-Chem and Proteros, has announced a new agreement to discover oral inhibitors targeting the SARS-CoV-2 nsp5 main protease. This partnership aims to speed up the development of treatments for COVID-19 and future coronaviruses. The collaboration leverages Arbutus's antiviral expertise, X-Chem's DNA-encoded library technology, and Proteros' structural biology capabilities. The financial terms of the agreement remain undisclosed, and the goal is to identify unique antiviral therapies that can lead to oral treatments for coronavirus-related diseases.
Arbutus Biopharma Corporation (Nasdaq: ABUS) has received regulatory approval to start a Phase 1a/1b clinical trial for AB-836, its oral capsid inhibitor targeting chronic hepatitis B virus (HBV) infection. The trial initiation is a significant milestone toward potential combinations with AB-729. Pre-clinical studies suggest that AB-836 may offer improved efficacy and safety compared to earlier capsid inhibitors. This candidate has demonstrated activity against resistant HBV variants, highlighting its potential in a large patient population suffering from chronic HBV, estimated at over 250 million globally.
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