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About AbCellera Biologics Inc.
AbCellera Biologics Inc. (NASDAQ: ABCL) is a pioneering biotechnology company based in Canada, specializing in the discovery and development of monoclonal antibody (mAb) therapeutics. Operating at the intersection of biology and technology, AbCellera leverages cutting-edge science and proprietary tools to accelerate the process of identifying optimal antibody candidates for therapeutic use. The company’s mission is to overcome traditional barriers in antibody discovery, enabling faster and more precise development of treatments for diseases such as cancer, autoimmune disorders, and infectious diseases.
Core Business and Market Position
At its core, AbCellera functions as an antibody discovery engine, partnering with pharmaceutical and biotechnology companies to streamline the identification of high-potential therapeutic antibodies. The company’s integrated platform combines advanced microfluidics, data science, and proprietary hardware and software to rapidly analyze antibodies directly from single immune cells. This unique approach allows AbCellera to identify rare and effective antibodies with greater speed and accuracy than conventional methods, addressing a critical bottleneck in drug development.
Technological Edge and Differentiation
One of AbCellera’s key differentiators is its ability to integrate diverse technologies into a cohesive discovery platform. By utilizing microfluidics, the company can analyze millions of immune cells at unprecedented speeds, while its proprietary data science tools enable the selection of antibodies with optimal therapeutic potential. This combination of hardware, software, and biology not only accelerates discovery timelines but also improves the likelihood of clinical success, providing significant value to its partners.
Partnership-Driven Business Model
AbCellera’s business model is built around strategic partnerships with pharmaceutical and biotech companies. By offering its platform as a service, the company collaborates with partners to identify and develop therapeutic antibodies tailored to specific medical challenges. This partnership model allows AbCellera to generate revenue through licensing agreements, milestone payments, and royalties, aligning its success with the success of its collaborators.
Industry and Market Context
AbCellera operates within the rapidly evolving biotechnology sector, a field marked by high innovation and intense competition. The growing demand for monoclonal antibody therapies, driven by their precision and effectiveness, positions AbCellera at the forefront of a critical market segment. The company’s ability to combine technological innovation with biological expertise ensures its relevance in an industry where speed, accuracy, and scalability are paramount.
Commitment to Innovation
As a spinoff from Dr. Carl Hansen’s research, AbCellera has its roots in academic innovation, which continues to inform its approach to discovery. The company’s commitment to pushing the boundaries of antibody development is evident in its ongoing investment in proprietary technologies and its focus on delivering transformative solutions to its partners and, ultimately, to patients.
AbCellera (Nasdaq: ABCL) has announced that its executives will present virtually at the Berenberg Conference USA 2021 on May 18, 2021, at 11:00 a.m. Pacific Time. A live audio webcast will be available through AbCellera’s Investor Relations website, with a replay accessible afterward.
AbCellera is a technology company focused on analyzing natural immune systems to discover antibodies for drug development. The company supports both large pharmaceutical and small biotechnology partners, enabling efficient and cost-effective drug development.
AbCellera (Nasdaq: ABCL) and Angios GmbH have announced a multi-year collaboration focused on discovering monoclonal and bispecific antibodies for eye vascular diseases, particularly diabetic retinopathy. AbCellera will leverage its AI-powered platform to create antibody panels for up to three targets selected by Angios. This partnership allows Angios to expedite their therapeutic development efforts without the need for extensive internal resources. Under the agreement, Angios will retain rights to develop and commercialize resulting therapies, while AbCellera will receive equity, research fees, milestone payments, and royalties.
AbCellera (Nasdaq: ABCL) announced that its second antibody, LY-CoV1404, has commenced clinical trials for treating patients with mild-to-moderate COVID-19. The ongoing BLAZE-4 trials, conducted with Eli Lilly, will assess LY-CoV1404 both solo and in combination with other antibodies. Preclinical results demonstrate that LY-CoV1404 effectively binds to a stable region of the SARS-CoV-2 spike protein, neutralizing all known variants of concern. This potent antibody may enable lower clinical dosing and potentially subcutaneous administration, supporting its role in combating COVID-19 long-term.
AbCellera (Nasdaq: ABCL) has commenced construction on an expanded global headquarters in Vancouver, aiming to grow its workforce from 250 to hundreds over the next few years. The new tech campus will span 380,000 square feet and is projected for completion in 2023 and 2024. CEO Carl Hansen emphasized that the facilities will accelerate antibody therapy development in collaboration with global biotech and pharma partners. This development solidifies Vancouver's position as an innovation hub and supports AbCellera's long-term goal of establishing Canada's first clinical-grade antibody manufacturing facility.
AbCellera (Nasdaq: ABCL) will release its first-quarter 2021 financial results on May 13, 2021, and host an earnings conference call at 2:00 p.m. PT (5:00 p.m. ET). A live webcast will be accessible via the Investor Relations website, with a replay available afterward.
AbCellera specializes in antibody discovery by analyzing immune systems, partnering with various drug developers to streamline drug development processes.
AbCellera (Nasdaq: ABCL) and Empirico Inc. announced a strategic collaboration focusing on multi-target drug discovery. The partnership utilizes advanced technologies and data analysis to identify therapeutic targets and antibodies. Empirico will select up to five targets using its Precision Insights Platform, while AbCellera will leverage its AI for antibody discovery. AbCellera will receive research payments and may earn royalties from developed products. The collaboration aims to address challenges in drug development by linking human genetics to therapy insights.
AbCellera (Nasdaq: ABCL) announced the publication of preclinical data in Science Translational Medicine demonstrating the high potency of bamlanivimab (LY-CoV555) against SARS-CoV-2. The findings indicate that bamlanivimab significantly reduces viral load post-exposure, highlighting its potential to decrease viral shedding and transmission. In clinical trials, bamlanivimab has shown to cut hospitalizations by 70% in high-risk COVID-19 patients. It has also been authorized in over 15 countries and supports ongoing efforts to develop next-generation antibodies.
AbCellera (Nasdaq: ABCL) has announced an expanded collaboration with Gilead Sciences that includes a multi-year, multi-target antibody discovery initiative and access to AbCellera's Trianni Mouse® technology. The agreement entails upfront payments, milestone payments, and royalties based on the commercialization of antibodies developed. AbCellera will produce panels of antibodies for up to eight new targets across various indications, enhancing drug development efficiency with advanced technology.
AbCellera (Nasdaq: ABCL) announced positive results from a Phase 3 trial of bamlanivimab and etesevimab, reducing COVID-19-related hospitalizations and deaths by 87% in high-risk patients. No deaths occurred in the treatment group, while 14 were reported in the placebo cohort. Milestones achieved include Emergency Use Authorization from the FDA and expanded access in the EU. The study involved 769 patients, showing a safety profile consistent with earlier trials. Bamlanivimab was the first COVID-19 therapeutic candidate to receive FDA EUA.
AbCellera (Nasdaq: ABCL) announced a positive scientific opinion from the EMA's CHMP for the use of bamlanivimab alone and in combination with etesevimab for treating COVID-19 in high-risk patients aged 12 and older. This recommendation allows EU member states to make informed decisions on therapy usage before market authorization. The CHMP opinion was backed by positive results from Eli Lilly's BLAZE-1 trial, showing a 70% reduction in hospitalization rates. Bamlanivimab has also received authorization in over 10 countries and generated $871 million in sales in 2020.
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