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AbbVie Inc. (NYSE: ABBV), headquartered in North Chicago, Illinois, is a leading pharmaceutical company ranked 6th on the list of largest biomedical companies by revenue. Known for their commitment to delivering innovative medicines, AbbVie focuses on several key therapeutic areas including immunology, oncology, neuroscience, and eye care. Their portfolio also includes products and services in aesthetics through Allergan Aesthetics, a company they acquired in 2020.
AbbVie’s flagship product, Humira (adalimumab), generated $21 billion in revenue in 2022, accounting for 37% of the company's total revenues. Humira is approved for the treatment of various autoimmune diseases such as rheumatoid arthritis, Crohn's disease, plaque psoriasis, and ulcerative colitis. Beyond Humira, AbbVie has developed other notable immunology drugs, including Skyrizi and Rinvoq, which have shown strong market performance.
In the oncology sector, AbbVie markets Imbruvica and Venclexta, which are critical in treating hematological malignancies. The acquisition of Allergan also brought in new products in aesthetics, including Botox, which is not only a cosmetic treatment but also used therapeutically for various conditions.
AbbVie's research and development efforts are robust, with numerous clinical trials ongoing across its therapeutic areas. Recent achievements include positive topline results from the LEVEL UP study, which demonstrated the efficacy of Rinvoq in treating atopic dermatitis. Financially, AbbVie continues to perform well, reporting first-quarter 2024 revenues of $12.310 billion, a 0.7% increase from the previous year.
Strategic partnerships are also a cornerstone of AbbVie’s growth strategy. Recent collaborations include an agreement with Gilgamesh Pharmaceuticals to develop neuroplastogens for psychiatric disorders and a partnership with Landos Biopharma to enhance their immunology portfolio.
AbbVie remains focused on its mission to address serious health issues and improve patient outcomes globally, leveraging its comprehensive pipeline and innovative solutions in biomedical research.
AbbVie (NYSE: ABBV) will participate in the Wolfe Research Healthcare Conference on November 17, 2021, at 8:30 a.m. Central time. Key executives including Dr. Michael Severino, Robert A. Michael, and Jeffrey R. Stewart will present at the event. A live audio webcast will be available on AbbVie's Investor Relations website, with an archived version accessible later the same day. AbbVie's mission focuses on delivering innovative medicines in various therapeutic areas, including immunology, oncology, and more.
AbbVie (NYSE: ABBV) reported promising results from post-hoc analyses of the Phase 3 SELECT-PsA 1 and SELECT-PsA 2 trials, demonstrating that upadacitinib (RINVOQ®) provided greater clinical responses for active psoriatic arthritis (PsA) patients with axial involvement compared to both placebo and HUMIRA® at 24 weeks. Specifically, 69.8% of patients on upadacitinib achieved clinically important improvement. Safety profiles were consistent with previous studies, with no new risks identified. Upadacitinib is currently under FDA review for PsA treatment.
NORTH CHICAGO, Ill., Nov. 8, 2021 – Allergan, part of AbbVie (NYSE: ABBV), will present new analyses of VUITYTM (pilocarpine HCl) and DURYSTA® (bimatoprost) at the AAO 2021 Annual Meeting (Nov. 12-15). VUITY is the first FDA-approved eye drop for presbyopia, aiding nearly 128 million U.S. adults. DURYSTA aims to reduce intraocular pressure in glaucoma patients. Key presentations include pooled safety and efficacy data and real-world studies of glaucoma treatment. This reflects AbbVie's commitment to advancing eye care.
AbbVie presented integrated data from two Phase 3 trials, KEEPsAKE 1 and KEEPsAKE 2, showing that treatment with risankizumab (SKYRIZI) significantly improved signs and symptoms of psoriatic arthritis (PsA) after 24 weeks compared to placebo. Patients receiving risankizumab achieved an ACR20 response rate of 55.5% versus 31.3% for placebo. No new safety signals were reported, with serious treatment-emergent adverse events at 3.0% for risankizumab and 4.4% for placebo. Regulatory reviews for approval in the U.S. and EU are ongoing.
Genmab A/S (GMAB) announced several abstract presentations at the 63rd Annual ASH Meeting, showcasing the efficacy of epcoritamab (DuoBody®-CD3xCD20) for treating B-cell non-Hodgkin lymphoma and chronic lymphocytic leukemia. Over 20 abstracts from Genmab and its partners, including AbbVie (ABBV) and Janssen, will be shared, highlighting clinical trial results. A virtual R&D Update and ASH Data Review is scheduled for December 14, focusing on these advancements in oncology.
AbbVie (NYSE: ABBV) is set to present nearly 30 abstracts at the upcoming American Society of Hematology (ASH) Annual Meeting, scheduled for December 11-14 in Atlanta, Georgia. Key studies include the Phase 2 CAPTIVATE and Phase 3 GLOW trials, which assess treatments for chronic lymphocytic leukemia (CLL) using ibrutinib and venetoclax. Additional research will cover various hematologic cancers, focusing on venetoclax's efficacy in CLL and multiple myeloma. The findings aim to advance care standards for patients with significant unmet medical needs.
AbbVie (NYSE: ABBV) will present new data on RINVOQ®, SKYRIZI®, and HUMIRA® at the ACR Convergence 2021, held virtually from November 3-9. This includes 38 abstracts focusing on rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. Notable presentations highlight long-term safety and efficacy data for RINVOQ in rheumatoid arthritis, along with efficacy data for risankizumab in psoriatic arthritis. However, use of RINVOQ and risankizumab in psoriatic arthritis is not yet FDA-approved.
Allergan, a subsidiary of AbbVie (NYSE: ABBV), announced FDA approval for VUITY (pilocarpine HCl ophthalmic solution) 1.25% to treat presbyopia, affecting 128 million Americans. This marks VUITY as the first FDA-approved eye drop for this condition, providing rapid relief within 15 minutes and lasting up to 6 hours. The approval is based on two phase 3 studies (GEMINI 1 and GEMINI 2) showing significant improvement in near vision without distance vision loss. The most common side effects are headache and eye redness.
AbbVie announced results from two Phase 3 trials of cariprazine (VRAYLAR) as an adjunctive treatment for major depressive disorder (MDD). In Study 3111-301-001, patients on 1.5 mg/day of cariprazine showed significant improvement in their MADRS scores compared to placebo (p=0.0050). However, 3.0 mg/day did not reach significance. Study 3111-302-001 did not meet its primary endpoint. Positive findings from a prior Phase 2/3 study prompted AbbVie to plan an sNDA with the FDA for expanded cariprazine use. Safety data aligned with established profiles, with common side effects including akathisia and nausea.