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AbbVie Reports Full-Year and Fourth-Quarter 2024 Financial Results

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AbbVie (ABBV) reported full-year 2024 financial results with net revenues of $56.334 billion, up 3.7% on a reported basis. The company's diluted EPS was $2.39 (GAAP), down 12.1%, while adjusted EPS was $10.12, down 8.9%.

Key portfolio performance includes: Immunology revenues of $26.682 billion (+2.1%), with Skyrizi reaching $11.718 billion and Rinvoq $5.971 billion; Oncology revenues of $6.555 billion (+10.8%); Neuroscience portfolio at $8.999 billion (+16.6%); and Aesthetics portfolio at $5.176 billion (-2.2%).

Looking ahead, AbbVie provided 2025 adjusted EPS guidance of $12.12-$12.32 and raised its 2027 combined sales outlook for Skyrizi and Rinvoq to over $31 billion. The company expects high single-digit compound annual revenue growth through 2029.

AbbVie (ABBV) ha riportato i risultati finanziari per l'intero anno 2024 con ricavi netti di $56.334 miliardi, in aumento del 3,7% su base riportata. L'EPS diluito dell'azienda era di $2,39 (GAAP), in calo del 12,1%, mentre l'EPS rettificato era di $10,12, in calo dell'8,9%.

Le prestazioni chiave del portafoglio includono: ricavi dell'Immunologia pari a $26,682 miliardi (+2,1%), con Skyrizi che raggiunge $11,718 miliardi e Rinvoq $5,971 miliardi; ricavi dell'Oncologia di $6,555 miliardi (+10,8%); portafoglio delle Neuroscienze a $8,999 miliardi (+16,6%); e portafoglio Aesthetics a $5,176 miliardi (-2,2%).

Guardando al futuro, AbbVie ha fornito una guida EPS rettificata per il 2025 di $12,12-$12,32 e ha innalzato le sue previsioni di vendite combinate per Skyrizi e Rinvoq a oltre $31 miliardi per il 2027. L'azienda prevede una crescita annuale composta dei ricavi a due cifre alta fino al 2029.

AbbVie (ABBV) reportó los resultados financieros de todo el año 2024 con ingresos netos de $56.334 millones, un aumento del 3.7% en una base reportada. El EPS diluido de la empresa fue de $2.39 (GAAP), una disminución del 12.1%, mientras que el EPS ajustado fue de $10.12, una baja del 8.9%.

El rendimiento clave de la cartera incluye: ingresos de Inmunología de $26.682 millones (+2.1%), con Skyrizi alcanzando $11.718 millones y Rinvoq $5.971 millones; ingresos de Oncología de $6.555 millones (+10.8%); cartera de Neurociencia en $8.999 millones (+16.6%); y cartera de Estética en $5.176 millones (-2.2%).

Mirando hacia adelante, AbbVie proporcionó una guía de EPS ajustado para 2025 de $12.12-$12.32 y elevó su perspectiva de ventas combinadas para Skyrizi y Rinvoq a más de $31 mil millones para 2027. La empresa espera un crecimiento anual de ingresos de dígitos altos hasta 2029.

AbbVie (ABBV)는 2024년 전체 연도 재무 결과를 발표했으며, 순매출은 563억 3천400만 달러로, 보고 기준으로 3.7% 증가했습니다. 회사의 희석 EPS는 2.39달러(GAAP)로 12.1% 감소했으며, 조정 EPS는 10.12달러로 8.9% 감소했습니다.

주요 포트폴리오 성과는 다음과 같습니다: 면역학 수익 266억 8천200만 달러(+2.1%)로, 스카이리지(Skyrizi)가 117억 1천800만 달러에, 린voq(Rinvoq)가 59억 7천100만 달러에 달했습니다; 종양학 수익 65억 5천500만 달러(+10.8%); 신경과학 포트폴리오가 89억 9천900만 달러(+16.6%); 미용 포트폴리오가 51억 7천600만 달러(-2.2%)입니다.

앞으로 AbbVie는 2025년 조정 EPS 가이던스를 12.12-12.32달러로 제공했으며, 2027년 스카이리지(Skyrizi)와 린voq(Rinvoq)의 총 판매 전망을 310억 달러 이상으로 상향 조정했습니다. 회사는 2029년까지 높은 싱글 디지털 복합 연간 수익 성장을 예상하고 있습니다.

AbbVie (ABBV) a publié ses résultats financiers pour l'année complète 2024, avec des revenus nets de 56,334 milliards de dollars, en hausse de 3,7 % sur une base reportée. Le BPA dilué de la société était de 2,39 $ (GAAP), en baisse de 12,1 %, tandis que le BPA ajusté était de 10,12 $, en baisse de 8,9 %.

Les performances clés du portefeuille comprennent : les revenus de l'Immunologie de 26,682 milliards de dollars (+2,1 %), Skyrizi atteignant 11,718 milliards de dollars et Rinvoq 5,971 milliards de dollars ; les revenus de l'Oncologie de 6,555 milliards de dollars (+10,8 %) ; le portefeuille des Neurosciences à 8,999 milliards de dollars (+16,6 %) ; et le portefeuille des Esthétiques à 5,176 milliards de dollars (-2,2 %).

En regardant vers l'avenir, AbbVie a fourni une prévision de BPA ajusté pour 2025 de 12,12 à 12,32 $ et a augmenté sa perspective de ventes combinées pour Skyrizi et Rinvoq à plus de 31 milliards de dollars d'ici 2027. La société prévoit une croissance des revenus annuels à un chiffre élevé d'ici 2029.

AbbVie (ABBV) hat die Finanzzahlen für das Gesamtjahr 2024 veröffentlicht und meldet Nettoumsätze von 56,334 Milliarden Dollar, was einem Anstieg von 3,7 % auf Berichtsbasis entspricht. Der verwässerte EPS des Unternehmens betrug 2,39 $ (GAAP), ein Rückgang von 12,1 %, während der bereinigte EPS bei 10,12 $ lag, was einem Rückgang von 8,9 % entspricht.

Die wichtigsten Portfolioleistungen umfassen: Immunologie Umsätze von 26,682 Milliarden Dollar (+2,1 %), wobei Skyrizi 11,718 Milliarden Dollar und Rinvoq 5,971 Milliarden Dollar erreichten; Onkologie Umsätze von 6,555 Milliarden Dollar (+10,8 %); Neuroscience Portfolio bei 8,999 Milliarden Dollar (+16,6 %); und Ästhetik Portfolio bei 5,176 Milliarden Dollar (-2,2 %).

Für die Zukunft gab AbbVie eine bereinigte EPS-Prognose von 12,12 bis 12,32 Dollar für 2025 ab und erhöhte die kombinierte Umsatzprognose für Skyrizi und Rinvoq für 2027 auf über 31 Milliarden Dollar. Das Unternehmen rechnet bis 2029 mit einem Wachstum des Jahresumsatzes im hohen einstelligen Bereich.

Positive
  • Net revenues increased 3.7% to $56.334 billion in 2024
  • Skyrizi revenue reached $11.718 billion
  • Neuroscience portfolio grew 16.6% to $8.999 billion
  • Oncology portfolio increased 10.8% to $6.555 billion
  • Raised 2027 sales outlook for Skyrizi and Rinvoq to over $31 billion
  • Projects high single-digit revenue growth through 2029
Negative
  • GAAP diluted EPS decreased 12.1% to $2.39
  • Adjusted diluted EPS declined 8.9% to $10.12
  • Aesthetics portfolio revenue decreased 2.2% to $5.176 billion
  • $3.5 billion after-tax intangible asset impairment charge for emraclidine
  • Phase 2 EMPOWER trials for emraclidine failed to meet primary endpoint

Insights

AbbVie's FY2024 results reveal a compelling growth story amid the challenging Humira patent cliff transition. The 3.7% revenue growth to $56.334B demonstrates successful portfolio diversification, with particularly strong performance in key growth drivers:

  • Immunology franchise transformation is exceeding expectations: Skyrizi ($11.718B) and Rinvoq ($5.971B) are effectively offsetting Humira's decline, with their combined 2027 revenue target raised by $4B to $31B
  • Neuroscience portfolio showed remarkable 16.6% growth, with Vraylar and Botox Therapeutic emerging as billion-dollar franchises
  • Strategic acquisitions (Nimble, Aliada) and collaborations strengthen the R&D pipeline, particularly in oncology and neuroscience

The operational performance is particularly noteworthy, with Q4 adjusted operating margin at 34.7% despite increased R&D investments. While the $3.5B emraclidine impairment charge impacts short-term GAAP metrics, the core business fundamentals remain robust. The 2025 adjusted EPS guidance of $12.12-$12.32 and projected high single-digit revenue growth through 2029 reflect management's confidence in sustained long-term growth, supported by a diversified portfolio and strategic pipeline investments.

AbbVie's market performance reveals sophisticated portfolio management and strong competitive positioning across therapeutic areas. The immunology franchise transformation is particularly noteworthy:

  • Skyrizi's 57.7% growth indicates exceptional market penetration in psoriasis and other indications, likely capturing significant market share from competitors
  • Rinvoq's 46.2% growth demonstrates successful expansion across multiple immune-mediated conditions
  • The neuroscience portfolio's 19.8% growth reflects strong market adoption, particularly in migraine (Ubrelvy/Qulipta) and therapeutic toxin markets

The aesthetics portfolio's temporary softness (-2.2%) likely reflects current market dynamics rather than competitive losses, with the projected high single-digit growth from 2025 suggesting anticipated market recovery. The strategic focus on novel modalities through recent acquisitions (Nimble, Aliada) and collaborations positions AbbVie favorably in emerging therapeutic areas, particularly in oncology where Elahere's EU approval strengthens the company's presence in precision medicine markets.

  • Reports Full-Year Diluted EPS of $2.39 on a GAAP Basis, a Decrease of 12.1 Percent; Adjusted Diluted EPS of $10.12, a Decrease of 8.9 Percent; These Results Include an Unfavorable Impact of $1.52 Per Share Related to 2024 Acquired IPR&D and Milestones Expense
     
  • Delivers Full-Year Net Revenues of $56.334 Billion, an Increase of 3.7 Percent on a Reported Basis and 4.6 Percent on an Operational Basis 
     
  • Full-Year Global Net Revenues from the Immunology Portfolio Were $26.682 Billion, an Increase of 2.1 Percent on a Reported Basis, or 2.9 Percent on an Operational Basis; Global Humira Net Revenues Were $8.993 Billion; Global Skyrizi Net Revenues Were $11.718 Billion; Global Rinvoq Net Revenues Were $5.971 Billion 
     
  • Full-Year Global Net Revenues from the Oncology Portfolio Were $6.555 Billion, an Increase of 10.8 Percent on a Reported Basis, or 12.0 Percent on an Operational Basis; Global Imbruvica Net Revenues Were $3.347 Billion; Global Venclexta Net Revenues Were $2.583 Billion
     
  • Full-Year Global Net Revenues from the Neuroscience Portfolio Were $8.999 Billion, an Increase of 16.6 Percent on a Reported Basis, or 16.9 Percent on an Operational Basis; Global Botox Therapeutic Net Revenues Were $3.283 Billion; Global Vraylar Net Revenues Were $3.267 Billion; Combined Global Ubrelvy and Qulipta Net Revenues were $1.664 Billion
     
  • Full-Year Global Net Revenues from the Aesthetics Portfolio Were $5.176 Billion, a Decrease of 2.2 Percent on a Reported Basis, or 0.6 Percent on an Operational Basis; Global Botox Cosmetic Net Revenues Were $2.720 Billion; Global Juvederm Net Revenues Were $1.177 Billion
     
  • Reports Fourth-Quarter Diluted Loss Per Share of $0.02 on a GAAP Basis, Inclusive of the Recent Partial Intangible Asset Impairment Charge Related to Emraclidine; Adjusted Diluted EPS of $2.16; These Results Include an Unfavorable Impact of $0.88 Per Share Related to Fourth-Quarter 2024 Acquired IPR&D and Milestones Expense 
     
  • Delivers Fourth-Quarter Net Revenues of $15.102 Billion, an Increase of 5.6 Percent on a Reported Basis and 6.1 Percent on an Operational Basis
     
  • Provides 2025 Adjusted Diluted EPS Guidance Range of $12.12 to $12.32; Excludes Any Unfavorable Impact Related to Acquired IPR&D and Milestones Expense
     
  • Reaffirms Expectations for High Single-Digit Compound Annual Revenue Growth Rate through 2029; Raises 2027 Combined Sales Outlook for Skyrizi and Rinvoq to More Than $31 Billion; Updates Outlook for Aesthetics to Deliver High Single-Digit Compound Annual Revenue Growth Rate from 2025 through 2029

NORTH CHICAGO, Ill., Jan. 31, 2025 /PRNewswire/ -- AbbVie (NYSE:ABBV) announced financial results for the fourth quarter and full year ended December 31, 2024.

"2024 was a year of significant progress for AbbVie. Our growth platform delivered outstanding results, we advanced our pipeline with key regulatory approvals and promising data, and we strengthened our business through strategic transactions," said Robert A. Michael, chief executive officer, AbbVie. "We are entering 2025 with significant momentum and expect net revenues to exceed their previous peak in just the second full year following the U.S. Humira loss of exclusivity."

Fourth-Quarter Results

  • Worldwide net revenues were $15.102 billion, an increase of 5.6 percent on a reported basis, or 6.1 percent on an operational basis.
     
  • Global net revenues from the immunology portfolio were $7.294 billion, an increase of 4.9 percent on a reported basis, or 5.3 percent on an operational basis.
    • Global Humira net revenues of $1.682 billion decreased 49.1 percent on a reported basis, or 48.7 percent on an operational basis. U.S. Humira net revenues were $1.246 billion, a decrease of 54.5 percent. Internationally, Humira net revenues were $436 million, a decrease of 22.7 percent on a reported basis, or 20.5 percent on an operational basis.
    • Global Skyrizi net revenues were $3.778 billion, an increase of 57.7 percent on a reported basis, or 57.9 percent on an operational basis.
    • Global Rinvoq net revenues were $1.834 billion, an increase of 46.2 percent on a reported basis, or 47.1 percent on an operational basis.
       
  • Global net revenues from the oncology portfolio were $1.691 billion, an increase of 12.0 percent on a reported basis, or 12.9 percent on an operational basis.
    • Global Imbruvica net revenues were $848 million, a decrease of 6.2 percent, with U.S. net revenues of $625 million and international profit sharing of $223 million.
    • Global Venclexta net revenues were $655 million, an increase of 11.0 percent on a reported basis, or 13.0 percent on an operational basis.
    • Global Elahere net revenues were $148 million.
       
  • Global net revenues from the neuroscience portfolio were $2.509 billion, an increase of 19.8 percent on a reported basis, or 19.9 percent on an operational basis.
    • Global Botox Therapeutic net revenues were $873 million, an increase of 12.5 percent on a reported basis, or 13.0 percent on an operational basis.
    • Global Vraylar net revenues were $924 million, an increase of 17.1 percent.
    • Global Ubrelvy net revenues were $303 million, an increase of 29.6 percent.
    • Global Qulipta net revenues were $201 million, an increase of 76.4 percent on a reported basis, or 76.2 percent on an operational basis.
       
  • Global net revenues from the aesthetics portfolio were $1.298 billion, a decrease of 5.2 percent on a reported basis, or 4.4 percent on an operational basis.
    • Global Botox Cosmetic net revenues were $687 million, a decrease of 4.2 percent on a reported basis, or 3.4 percent on an operational basis.
    • Global Juvederm net revenues were $279 million, a decrease of 16.3 percent on a reported basis, or 15.1 percent on an operational basis.
       
  • On a GAAP basis, the gross margin ratio in the fourth quarter was 70.9 percent. The adjusted gross margin ratio was 83.8 percent.
     
  • On a GAAP basis, selling, general and administrative (SG&A) expense was 25.5 percent of net revenues. The adjusted SG&A expense was 23.6 percent of net revenues.
     
  • On a GAAP basis, research and development (R&D) expense was 44.9 percent of net revenues. The adjusted R&D expense was 15.1 percent of net revenues.
     
  • Acquired IPR&D and milestones expense was 10.4 percent of net revenues.
     
  • On a GAAP basis, the operating margin in the fourth quarter was negative 9.9 percent. The adjusted operating margin was 34.7 percent.
     
  • Net interest expense was $610 million.
     
  • On a GAAP basis, the tax rate in the quarter was 99.0 percent. The adjusted tax rate was 20.2 percent.
     
  • Diluted loss per share in the fourth quarter was $0.02 on a GAAP basis, inclusive of the recent partial intangible asset impairment charge related to emraclidine. Adjusted diluted EPS, excluding specified items, was $2.16. These results include an unfavorable impact of $0.88 per share related to acquired IPR&D and milestones expense.

Note: "Operational" comparisons are presented at constant currency rates that reflect comparative local currency net revenues at the prior year's foreign exchange rates. 

Recent Events

  • AbbVie announced the European Commission (EC) granted marketing authorization for Elahere (mirvetuximab soravtansine) for the treatment of adult patients with folate receptor-alpha (FRα) positive, platinum-resistant high grade serous epithelial ovarian, fallopian tube or primary peritoneal cancer who have received one to three prior systemic treatment regimens. Elahere is the first novel therapy approved in the European Union (EU) specifically for patients with FRα positive, platinum-resistant ovarian cancer.
     
  • At the American Society of Hematology (ASH) Annual Meeting, AbbVie announced updated clinical trial results that showed Epkinly (epcoritamab) combination therapy demonstrated high response rates in adult patients with relapsed or refractory (r/r) follicular lymphoma (FL). The company also announced new results from two ongoing clinical trials which showed Epkinly induced durable complete responses as monotherapy and combination treatment in patients with diffuse large B-cell lymphoma (DLBCL). Epkinly is being co-developed by AbbVie and Genmab.
     
  • AbbVie and EvolveImmune Therapeutics, an immuno-oncology company developing next-generation biotherapeutics to overcome the therapeutic challenges of cancer cell resistance to current immunotherapies, announced a collaboration and option-to-license agreement to develop multispecific biologics for multiple targets in oncology. The discovery partnership will leverage AbbVie's oncology expertise and EvolveImmune's T-cell engager platform to develop novel antibody-based therapies for solid and hematologic malignancies.
     
  • AbbVie and Simcere Zaiming announced a partnership to develop a novel trispecific antibody candidate in multiple myeloma (MM). This option-to-license agreement will develop SIM0500, an investigational new drug candidate that is currently in Phase 1 clinical trials in patients with r/r MM.
     
  • AbbVie and Neomorph announced a collaboration and license agreement that will leverage AbbVie's drug development expertise and Neomorph's leading molecular glue discovery platform to develop novel molecular glue degraders for multiple targets across oncology and immunology.
     
  • AbbVie announced that it completed its acquisition of Nimble Therapeutics, strengthening AbbVie's pipeline and R&D capabilities. The transaction includes Nimble's lead asset, an investigational oral peptide IL23R inhibitor in preclinical development for the treatment of psoriasis (PsO) as well as Nimble's peptide synthesis, screening, and optimization platform used to help drive rapid discovery and optimization of peptide candidates for a range of targets.
     
  • AbbVie announced positive topline results from its pivotal Phase 3 TEMPO-2 trial evaluating tavapadon as a flexible-dose monotherapy in early Parkinson's disease (PD). In the study, tavapadon met the primary endpoint, demonstrating a statistically significant improvement from baseline in the Movement Disorder Society - Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Parts II and III combined score at week 26. Tavapadon also met the key secondary endpoint, demonstrating statistically significant improvement from baseline in the MDS-UPDRS Part II score. Tavapadon has demonstrated positive results across all three Phase 3 TEMPO trials and AbbVie remains on track to submit a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) later this year.
     
  • AbbVie announced that its two Phase 2 EMPOWER trials investigating emraclidine as a once-daily, oral monotherapy treatment for adults with schizophrenia who are experiencing an acute exacerbation of psychotic symptoms, did not meet their primary endpoint of showing a statistically significant reduction (improvement) in the change from baseline in the Positive and Negative Syndrome Scale (PANSS) total score compared to the placebo group at week 6. Following the results of these trials, AbbVie began an evaluation of the emraclidine intangible asset for impairment which resulted in a significant decrease in the estimated future cash flows for the product. Based on the revised cash flows, the company recorded a non-cash after-tax intangible asset impairment charge of $3.5 billion. AbbVie continues to evaluate information with respect to the Cerevel-related clinical development programs and will monitor the remaining intangible assets of $3.6 billion.
  • AbbVie announced that it completed its acquisition of Aliada Therapeutics. The transaction strengthens AbbVie's neuroscience pipeline and R&D capabilities with the addition of a potential best-in-class disease-modifying therapy for Alzheimer's disease (AD), ALIA-1758, and novel blood-brain barrier (BBB)-crossing technology.

Full-Year 2025 Outlook

AbbVie is issuing its adjusted diluted EPS guidance for the full-year 2025 of $12.12 to $12.32. The company's 2025 adjusted diluted EPS guidance excludes any impact from acquired IPR&D and milestones that may be incurred during 2025, as both cannot be reliably forecasted.

Long-Term Outlook

AbbVie is reaffirming its expectations for a high single-digit compound annual revenue growth rate through 2029. This guidance assumes 2024 as the base year in the compound annual growth rate calculation.

AbbVie is raising its long-term outlook for Skyrizi and Rinvoq revenues. The company now expects combined Skyrizi and Rinvoq 2027 revenues of more than $31 billion, an increase of approximately $4 billion compared to previous guidance for combined revenues of more than $27 billion in 2027. This guidance assumes Skyrizi revenues of more than $20 billion and Rinvoq revenues of more than $11 billion in 2027.

AbbVie is also updating its outlook for aesthetics revenues. The company now expects a high single-digit compound annual revenue growth rate for aesthetics through 2029. This guidance assumes 2025 as the base year in the compound annual growth rate calculation.

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience and eye care - and products and services across our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X (formerly Twitter), Facebook, Instagram, YouTube or LinkedIn.

Conference Call

AbbVie will host an investor conference call today at 8:00 a.m. Central Time to discuss our fourth-quarter performance. The call will be webcast through AbbVie's Investor Relations website at investors.abbvie.com. An archived edition of the call will be available after 11:00 a.m. Central Time.

Non-GAAP Financial Results

Financial results for 2024 and 2023 are presented on both a reported and a non-GAAP basis. Reported results were prepared in accordance with GAAP and include all revenue and expenses recognized during the period. Non-GAAP results adjust for certain non-cash items and for factors that are unusual or unpredictable, and exclude those costs, expenses, and other specified items presented in the reconciliation tables later in this release. AbbVie's management believes non-GAAP financial measures provide useful information to investors regarding AbbVie's results of operations and assist management, analysts, and investors in evaluating the performance of the business. Non-GAAP financial measures should be considered in addition to, and not as a substitute for, measures of financial performance prepared in accordance with GAAP.

Forward-Looking Statements

Some statements in this news release are, or may be considered, forward-looking statements for purposes of the Private Securities Litigation Reform Act of 1995. The words "believe," "expect," "anticipate," "project" and similar expressions and uses of future or conditional verbs, generally identify forward-looking statements. AbbVie cautions that these forward-looking statements are subject to risks and uncertainties that may cause actual results to differ materially from those expressed or implied in the forward-looking statements. Such risks and uncertainties include, but are not limited to, challenges to intellectual property, competition from other products, difficulties inherent in the research and development process, adverse litigation or government action, and changes to laws and regulations applicable to our industry. Additional information about the economic, competitive, governmental, technological and other factors that may affect AbbVie's operations is set forth in Item 1A, "Risk Factors," of AbbVie's 2023 Annual Report on Form 10-K, which has been filed with the Securities and Exchange Commission, as updated by its Quarterly Reports on Form 10-Q and in other documents that AbbVie subsequently files with the Securities and Exchange Commission that update, supplement or supersede such information. AbbVie undertakes no obligation, and specifically declines, to release publicly any revisions to forward-looking statements as a result of subsequent events or developments, except as required by law.

Media:

Investors:

Gabby Tarbert

Liz Shea

(224) 244-0111

(847) 935-2211




Todd Bosse


(847) 936-1182




Jeffrey Byrne


(847) 938-2923

 

AbbVie Inc.

Key Product Revenues

Quarter Ended December 31, 2024

(Unaudited)








% Change vs. 4Q23


Net Revenues (in millions)


Reported


Operationala


U.S.


Int'l.


Total


U.S.


Int'l.


Total


Int'l.


Total

NET REVENUES

$  11,734


$  3,368


$  15,102


5.6 %


5.6 %


5.6 %


7.8 %


6.1 %

















Immunology

5,905


1,389


7,294


2.2


17.8


4.9


20.2


5.3

Humira

1,246


436


1,682


(54.5)


(22.7)


(49.1)


(20.5)


(48.7)

Skyrizi

3,312


466


3,778


57.3


61.1


57.7


62.4


57.9

Rinvoq

1,347


487


1,834


45.0


49.5


46.2


53.1


47.1

















Oncology

1,102


589


1,691


13.4


9.4


12.0


11.8


12.9

Imbruvicab

625


223


848


(8.6)


1.2


(6.2)


1.2


(6.2)

Venclexta

313


342


655


13.0


9.3


11.0


13.2


13.0

Elahere

146


2


148


n/m


n/m


n/m


n/m


n/m

Epkinlyc

18


22


40


48.9


>100.0


>100.0


>100.0


>100.0

















Aesthetics

839


459


1,298


(5.0)


(5.6)


(5.2)


(3.2)


(4.4)

Botox Cosmetic

429


258


687


(5.2)


(2.5)


(4.2)


(0.3)


(3.4)

Juvederm Collection

120


159


279


(22.5)


(10.9)


(16.3)


(8.7)


(15.1)

Other Aesthetics

290


42


332


5.2


(2.3)


4.2


1.5


4.7

















Neuroscience

2,210


299


2,509


18.8


28.4


19.8


29.3


19.9

Botox Therapeutic

730


143


873


12.4


13.2


12.5


16.3


13.0

Vraylar

922


2


924


17.1


25.8


17.1


26.4


17.1

Duodopa

24


84


108


2.8


(8.1)


(5.8)


(9.7)


(7.0)

Ubrelvy

296


7


303


28.9


65.3


29.6


66.2


29.6

Qulipta

186


15


201


65.7


>100.0


76.4


>100.0


76.2

Other Neuroscience

52


48


100


(11.7)


>100.0


50.9


>100.0


50.4

















Eye Care

358


288


646


12.8


7.3


10.2


9.8


11.4

Ozurdex

36


84


120


(3.2)


3.0


1.1


3.5


1.4

Lumigan/Ganfort

58


61


119


83.9


0.9


29.4


2.2


30.2

Alphagan/Combigan

41


37


78


33.6


6.8


19.2


10.2


21.0

Restasis

102


12


114


(13.7)


14.9


(11.3)


19.7


(10.9)

Other Eye Care

121


94


215


20.9


15.4


18.4


20.3


20.6

















Other Key Products

748


164


912


(3.8)


(14.1)


(5.8)


(13.9)


(5.8)

Mavyret

137


154


291


7.8


(15.4)


(5.8)


(15.1)


(5.6)

Creon

388



388


3.3


n/m


3.3


n/m


3.3

Linzess/Constella       

223


10


233


(18.7)


11.0


(17.8)


10.3


(17.8)



a

"Operational" comparisons are presented at constant currency rates that reflect comparative local currency net revenues at the prior year's foreign exchange rates.

b

Reflects profit sharing for Imbruvica international revenues.

c

Epkinly U.S. revenues reflect profit sharing. International revenues reflect product revenues as well as profit sharing from certain international territories.

n/m = not meaningful

 

AbbVie Inc.

Key Product Revenues

Twelve Months Ended December 31, 2024

(Unaudited)









% Change vs. 12M23


Net Revenues (in millions)


Reported


Operationala


U.S.


Int'l.


Total


U.S.


Int'l.


Total


Int'l.


Total

NET REVENUES

$  43,029


$  13,305


$  56,334


2.7 %


7.0 %


3.7 %


11.1 %


4.6 %

















Immunology

21,487


5,195


26,682


(1.2)


18.1


2.1


23.1


2.9

Humira

7,142


1,851


8,993


(41.3)


(17.5)


(37.6)


(13.2)


(36.9)

Skyrizi

10,086


1,632


11,718


49.3


61.6


50.9


65.4


51.4

Rinvoq

4,259


1,712


5,971


50.8


49.6


50.4


57.0


52.5

















Oncology

4,219


2,336


6,555


11.7


9.3


10.8


12.5


12.0

Imbruvicab

2,448


899


3,347


(8.1)


(3.5)


(6.9)


(3.5)


(6.9)

Venclexta

1,234


1,349


2,583


13.5


12.3


12.9


18.0


15.9

Elaherec

477


2


479


n/m


n/m


n/m


n/m


n/m

Epkinlyd

60


86


146


>100.0


>100.0


>100.0


>100.0


>100.0

















Aesthetics

3,269


1,907


5,176


0.6


(6.7)


(2.2)


(2.5)


(0.6)

Botox Cosmetic

1,682


1,038


2,720


0.7


2.7


1.4


6.7


2.9

Juvederm Collection

469


708


1,177


(9.6)


(17.6)


(14.6)


(13.4)


(12.0)

Other Aesthetics

1,118


161


1,279


5.5


(7.1)


3.7


(1.0)


4.6

















Neuroscience

7,907


1,092


8,999


16.5


17.7


16.6


20.1


16.9

Botox Therapeutic

2,718


565


3,283


9.8


9.8


9.8


14.0


10.5

Vraylar

3,260


7


3,267


18.4


57.8


18.4


58.6


18.4

Duodopa

96


351


447


(1.8)


(5.3)


(4.6)


(5.4)


(4.7)

Ubrelvy

981


25


1,006


22.1


>100.0


23.4


>100.0


23.4

Qulipta

628


30


658


55.3


>100.0


61.3


>100.0


61.3

Other Neuroscience

224


114


338


(11.6)


>100.0


22.4


>100.0


22.7

















Eye Care

1,064


1,178


2,242


(15.3)


1.5


(7.2)


5.2


(5.4)

Ozurdex

138


356


494


(4.1)


8.3


4.5


10.7


6.2

Lumigan/Ganfort

187


242


429


7.5


(6.4)


(0.9)


(3.9)


0.6

Alphagan/Combigan

95


153


248


(21.8)


1.5


(8.8)


7.6


(5.4)

Restasis

172


52


224


(55.2)


(3.0)


(48.7)


2.1


(48.1)

Other Eye Care

472


375


847


8.9


1.5


5.5


6.1


7.6

















Other Key Products

2,894


754


3,648


(3.5)


(6.5)


(4.2)


(3.9)


(3.7)

Mavyret

595


716


1,311


(9.7)


(7.2)


(8.3)


(4.5)


(6.9)

Creon

1,383



1,383


9.1


n/m


9.1


n/m


9.1

Linzess/Constella

916


38


954


(14.6)


7.5


(13.9)


7.2


(13.9)



a

"Operational" comparisons are presented at constant currency rates that reflect comparative local currency net revenues at the prior year's foreign exchange rates.

b

Reflects profit sharing for Imbruvica international revenues.

c

Reflects partial year Elahere revenue based on the February 12, 2024 close date of the ImmunoGen acquisition.

d

Epkinly U.S. revenues reflect profit sharing. International revenues reflect product revenues as well as profit sharing from certain international territories.

n/m = not meaningful

 

AbbVie Inc.

Consolidated Statements of Earnings

(Unaudited)


(in millions, except per share data)

Fourth Quarter

Ended December 31


Twelve Months

Ended December 31


2024


2023


2024


2023

Net revenues

$       15,102


$       14,301


$       56,334


$       54,318

Cost of products sold

4,396


5,704


16,904


20,415

Selling, general and administrative

3,855


3,193


14,752


12,872

Research and development

6,774


1,927


12,791


7,675

Acquired IPR&D and milestones

1,574


282


2,757


778

Other operating income, net

(7)



(7)


(179)

Total operating costs and expenses

16,592


11,106


47,197


41,561









Operating earnings (loss)

(1,490)


3,195


9,137


12,757









Interest expense, net

610


378


2,160


1,684

Net foreign exchange loss

19


49


21


146

Other expense, net

150


1,556


3,240


4,677

Earnings (loss) before income tax expense

(2,269)


1,212


3,716


6,250

Income tax expense (benefit)

(2,246)


388


(570)


1,377

Net earnings (loss)

(23)


824


4,286


4,873

Net earnings (loss) attributable to noncontrolling interest

(1)


2


8


10

Net earnings (loss) attributable to AbbVie Inc.

$              (22)


$             822


$          4,278


$          4,863









Diluted earnings (loss) per share attributable to AbbVie Inc.          

$           (0.02)


$            0.46


$            2.39


$            2.72









Adjusted diluted earnings per sharea

$            2.16


$            2.79


$          10.12


$          11.11









Weighted-average diluted shares outstanding

1,769


1,772


1,773


1,773









Adjusted weighted-average diluted shares outstandinga

1,773


1,772


1,773


1,773



a

Refer to the Reconciliation of GAAP Reported to Non-GAAP Adjusted Information for further details. Weighted-average diluted shares outstanding includes the effect of dilutive securities. Due to the GAAP net loss in the fourth quarter ended December 31, 2024, certain shares issuable under stock-based compensation plans that were dilutive on a non-GAAP basis were excluded from the computation of GAAP diluted EPS because the effects would have been antidilutive.

 

AbbVie Inc.

Reconciliation of GAAP Reported to Non-GAAP Adjusted Information

(Unaudited)


1.     Specified items impacted results as follows:


Quarter Ended December 31, 2024

(in millions, except per share data)

Earnings (Loss)


Diluted


Pre-tax


After-taxa


EPS

As reported (GAAP)

$            (2,269)


$                 (22)


$              (0.02)

Adjusted for specified items:






Intangible asset amortization

1,896


1,607


0.90

Intangible asset impairment

4,476


3,512


1.98

Change in fair value of contingent consideration                                          

279


271


0.15

Litigation matters

173


136


0.08

Income tax items


(1,869)


(1.05)

Other

258


209


0.12

As adjusted (non-GAAP)

$              4,813


$              3,844


$                2.16


 a Represents net earnings (loss) attributable to AbbVie Inc.


Intangible asset impairment reflects a partial after-tax impairment charge of $3.5 billion related to the emraclidine intangible asset
acquired as part of the Cerevel Therapeutics acquisition. Income tax items primarily reflect an income tax benefit related to the
settlement of income tax examinations, partially offset by changes in income tax reserves.


Reported GAAP earnings and adjusted non-GAAP earnings for the three months ended December 31, 2024 included acquired
IPR&D and milestones expense of $1.6 billion on a pre-tax and after-tax basis, representing an unfavorable impact of $0.88 to
both diluted EPS and adjusted diluted EPS.


2.     The impact of the specified items by line item was as follows:



Quarter Ended December 31, 2024

(in millions)

Cost of
products
sold


SG&A


R&D


Other
operating
income,
net


Other
expense,
net

As reported (GAAP)

$    4,396


$    3,855


$    6,774


$           (7)


$        150

Adjusted for specified items:










Intangible asset amortization

(1,896)





Intangible asset impairment



(4,476)



Change in fair value of contingent consideration                        





(279)

Litigation matters


(173)




Other

(47)


(121)


(25)


7


(72)

As adjusted (non-GAAP)

$    2,453


$    3,561


$    2,273


$           —


$      (201)


3.     The adjusted tax rate for the fourth quarter of 2024 was 20.2 percent, as detailed below:



Quarter Ended December 31, 2024

(dollars in millions)

Pre-tax
earnings (loss)


Income taxes


Tax rate

As reported (GAAP)

$           (2,269)


$           (2,246)


99.0 %

Specified items

7,082


3,216


45.4 %

As adjusted (non-GAAP)                                                                                   

$            4,813


$               970


20.2 %

 

AbbVie Inc.

Reconciliation of GAAP Reported to Non-GAAP Adjusted Information

(Unaudited)


1.     Specified items impacted results as follows:



Quarter Ended December 31, 2023

(in millions, except per share data)

Earnings


Diluted


Pre-tax


After-taxa


EPS

As reported (GAAP)

$              1,212


$                 822


$                0.46

Adjusted for specified items:






Intangible asset amortization

1,889


1,584


0.89

Intangible asset impairment

1,405


1,166


0.66

Acquisition and integration costs

123


107


0.06

Change in fair value of contingent consideration                                     

1,696


1,655


0.93

Litigation matters

(491)


(386)


(0.22)

Other

156


11


0.01

As adjusted (non-GAAP)

$              5,990


$              4,959


$                2.79


 a Represents net earnings attributable to AbbVie Inc.


Intangible asset impairment primarily reflects a partial impairment charge related to the CoolSculpting intangible asset triggered by
a strategic decision to reduce ongoing sales and marketing investment for the product. Litigation matters primarily includes income
related to a favorable settlement of a litigation matter.


Reported GAAP earnings and adjusted non-GAAP earnings for the three months ended December 31, 2023 included acquired
IPR&D and milestones expense of $282 million on a pre-tax and $264 million on an after-tax basis, representing an unfavorable
impact of $0.15 to both diluted EPS and adjusted diluted EPS.


2.     The impact of the specified items by line item was as follows:



Quarter Ended December 31, 2023

(in millions)

Cost of
products
sold


SG&A


R&D


Interest
expense,
net


Other
expense,
net

As reported (GAAP)

$     5,704


$     3,193


$     1,927


$        378


$     1,556

Adjusted for specified items:










Intangible asset amortization

(1,889)





Intangible asset impairment

(1,405)





Acquisition and integration costs

(24)


(78)


(6)


(15)


Change in fair value of contingent consideration





(1,696)

Litigation matters


491




Other

(89)


(66)


1



(2)

As adjusted (non-GAAP)

$     2,297


$     3,540


$     1,922


$        363


$      (142)


3.     The adjusted tax rate for the fourth quarter of 2023 was 17.2 percent, as detailed below:



Quarter Ended December 31, 2023

(dollars in millions)

Pre-tax
earnings


Income taxes


Tax rate

As reported (GAAP)

$             1,212


$                388


32.1 %

Specified items

4,778


641


13.4 %

As adjusted (non-GAAP)                                                                              

$             5,990


$             1,029


17.2 %

 

AbbVie Inc.

Reconciliation of GAAP Reported to Non-GAAP Adjusted Information

(Unaudited)


1.     Specified items impacted results as follows:



Twelve Months Ended December 31, 2024

(in millions, except per share data)

Earnings


Diluted


Pre-tax


After-taxa


EPS

As reported (GAAP)

$              3,716


$              4,278


$                2.39

Adjusted for specified items:






Intangible asset amortization

7,622


6,461


3.63

Intangible asset impairment

4,476


3,512


1.98

Acquisition and integration costs

1,061


978


0.55

Change in fair value of contingent consideration                                        

3,771


3,673


2.07

Litigation matters

910


721


0.41

Income tax items


(1,819)


(1.02)

Other

256


197


0.11

As adjusted (non-GAAP)

$           21,812


$           18,001


$              10.12


 a Represents net earnings attributable to AbbVie Inc.


Intangible asset impairment reflects a partial after-tax impairment charge of $3.5 billion related to the emraclidine intangible asset 
acquired as part of the Cerevel Therapeutics acquisition. Acquisition and integration costs primarily reflect costs related to the
ImmunoGen and Cerevel Therapeutics acquisitions. Income tax items primarily reflect an income tax benefit related to the
settlement of income tax examinations, partially offset by changes in income tax reserves. Litigation matters primarily include
charges related to actual and potential settlements of litigation.


Reported GAAP earnings and adjusted non-GAAP earnings for the twelve months ended December 31, 2024 included acquired
IPR&D and milestones expense of $2.8 billion on a pre-tax and $2.7 billion on an after-tax basis, representing an unfavorable
impact of $1.52 to both diluted EPS and adjusted diluted EPS.


2.     The impact of the specified items by line item was as follows:



Twelve Months Ended December 31, 2024

(in millions)

Cost of
products
sold


SG&A


R&D


Other
operating
income,
net


Interest
expense,
net


Other
expense,
net

As reported (GAAP)

$  16,904


$  14,752


$  12,791


$           (7)


$    2,160


$    3,240

Adjusted for specified items:












Intangible asset amortization

(7,622)






Intangible asset impairment



(4,476)




Acquisition and integration costs

(225)


(554)


(258)



(24)


Change in fair value of contingent consideration






(3,771)

Litigation matters


(910)





Other

(110)


(54)


(1)


7



(98)

As adjusted (non-GAAP)

$    8,947


$  13,234


$    8,056


$           —


$    2,136


$      (629)


3.     The adjusted tax rate for the full-year 2024 was 17.4 percent, as detailed below:



Twelve Months Ended December 31, 2024

(dollars in millions)

Pre-tax
earnings


Income taxes


Tax rate

As reported (GAAP)

$             3,716


$               (570)


(15.3) %

Specified items

18,096


4,373


24.2 %

As adjusted (non-GAAP)                                                                               

$           21,812


$             3,803


17.4 %

 

AbbVie Inc.

Reconciliation of GAAP Reported to Non-GAAP Adjusted Information

(Unaudited)


1.     Specified items impacted results as follows:



Twelve Months Ended December 31, 2023

(in millions, except per share data)

Earnings


Diluted


Pre-tax


After-taxa


EPS

As reported (GAAP)

$              6,250


$              4,863


$                2.72

Adjusted for specified items:






Intangible asset amortization

7,946


6,685


3.76

Intangible asset impairment

4,229


3,455


1.96

Acquisition and integration costs

161


122


0.07

Change in fair value of contingent consideration                                    

5,128


5,003


2.81

Litigation matters

(485)


(381)


(0.22)

Other

225


22


0.01

As adjusted (non-GAAP)

$           23,454


$           19,769


$              11.11


 a Represents net earnings attributable to AbbVie Inc.


Intangible asset impairment primarily reflects partial impairment charges related to the U.S. Imbruvica and CoolSculpting intangible
assets. The Imbruvica impairment charge of $2.1 billion was triggered by selection of Imbruvica for price negotiation as part of the
IRA of 2022 and the CoolSculpting impairment charge of $1.0 billion was triggered by a strategic decision to reduce ongoing sales
and marketing investment for the product. Acquisition and integration costs primarily include costs related to the Allergan acquisition,
including a one-time gain of $169 million related to the termination of a development liability associated with a previously divested
product. Litigation matters primarily includes income related to a favorable settlement of a litigation matter.


Reported GAAP earnings and adjusted non-GAAP earnings for the twelve months ended December 31, 2023 included acquired
IPR&D and milestones expense of $778 million on a pre-tax and $741 million on an after-tax basis, representing an unfavorable
impact of $0.42 to both diluted EPS and adjusted diluted EPS.


2.     The impact of the specified items by line item was as follows:



Twelve Months Ended December 31, 2023

(in millions)

Cost of
products
sold


SG&A


R&D


Other
operating
income,
net


Interest
expense,
net


Other
expense,
net

As reported (GAAP)

$  20,415


$  12,872


$    7,675


$      (179)


$    1,684


$    4,677

Adjusted for specified items:












Intangible asset amortization

(7,946)






Intangible asset impairment

(3,599)



(630)





Acquisition and integration costs

(90)


(212)


(13)


169


(15)


Change in fair value of contingent consideration






(5,128)

Litigation matters


485





Other

(134)


(73)


(3)


10



(25)

As adjusted (non-GAAP)

$    8,646


$  13,072


$    7,029


$           —


$    1,669


$      (476)


3.     The adjusted tax rate for the full-year 2023 was 15.7 percent, as detailed below:



Twelve Months Ended December 31, 2023

(dollars in millions)

Pre-tax
earnings


Income taxes


Tax rate

As reported (GAAP)

$             6,250


$             1,377


22.0 %

Specified items

17,204


2,298


13.4 %

As adjusted (non-GAAP)                                                                                

$           23,454


$             3,675


15.7 %

 

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SOURCE AbbVie

FAQ

What was AbbVie's (ABBV) revenue growth in 2024?

AbbVie reported full-year 2024 net revenues of $56.334 billion, representing a 3.7% increase on a reported basis and 4.6% on an operational basis.

How much did ABBV's Skyrizi and Rinvoq generate in revenue for 2024?

In 2024, Skyrizi generated $11.718 billion in global net revenues, while Rinvoq generated $5.971 billion.

What is AbbVie's (ABBV) earnings guidance for 2025?

AbbVie provided adjusted diluted EPS guidance for 2025 of $12.12 to $12.32, excluding any impact from acquired IPR&D and milestones.

What is ABBV's revenue projection for Skyrizi and Rinvoq by 2027?

AbbVie raised its 2027 outlook for combined Skyrizi and Rinvoq revenues to more than $31 billion, with Skyrizi expected to exceed $20 billion and Rinvoq over $11 billion.

How did ABBV's Humira sales perform in Q4 2024?

Global Humira net revenues were $1.682 billion in Q4 2024, decreasing 49.1% on a reported basis, with U.S. revenues down 54.5% to $1.246 billion.

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