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ELAHERE® (mirvetuximab soravtansine-gynx) Shows Consistent Survival Benefit in Long-Term Analysis for Certain Ovarian Cancer Patients

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AbbVie (ABBV) announced final analysis results from the Phase 3 MIRASOL trial for ELAHERE® in treating folate receptor alpha-positive platinum-resistant ovarian cancer. After 30.5 months median follow-up, the drug showed:

  • 32% reduction in death risk compared to chemotherapy
  • Median progression-free survival of 5.59 months vs 3.98 months for chemotherapy
  • 41.9% objective response rate vs 15.9% for chemotherapy
  • Median overall survival of 16.85 months vs 13.34 months for chemotherapy

The study included 453 patients with high-grade serous epithelial PROC. Common side effects included blurred vision, keratopathy, and abdominal pain, with lower rates of serious adverse events compared to chemotherapy. ELAHERE received full FDA approval in March 2024 and European Commission approval in November 2024.

AbbVie (ABBV) ha annunciato i risultati dell'analisi finale del trial di Fase 3 MIRASOL per ELAHERE® nel trattamento del cancro ovarico resistente al platino e positivo per il recettore della folato alfa. Dopo un follow-up mediano di 30,5 mesi, il farmaco ha mostrato:

  • una riduzione del 32% del rischio di morte rispetto alla chemioterapia
  • una sopravvivenza libera da progressione mediana di 5,59 mesi contro 3,98 mesi per la chemioterapia
  • un tasso di risposta obiettiva del 41,9% contro il 15,9% per la chemioterapia
  • una sopravvivenza globale mediana di 16,85 mesi contro 13,34 mesi per la chemioterapia

Lo studio ha incluso 453 pazienti con carcinoma epiteliale seroso ad alto grado. Gli effetti collaterali comuni includevano visione offuscata, cheratopatia e dolore addominale, con tassi più bassi di eventi avversi gravi rispetto alla chemioterapia. ELAHERE ha ricevuto l'approvazione completa della FDA a marzo 2024 e l'approvazione della Commissione Europea a novembre 2024.

AbbVie (ABBV) anunció los resultados del análisis final del ensayo de Fase 3 MIRASOL para ELAHERE® en el tratamiento del cáncer de ovario resistente al platino y positivo para el receptor de folato alfa. Después de un seguimiento mediano de 30,5 meses, el fármaco mostró:

  • una reducción del 32% en el riesgo de muerte en comparación con la quimioterapia
  • una supervivencia libre de progresión mediana de 5,59 meses frente a 3,98 meses para la quimioterapia
  • una tasa de respuesta objetiva del 41,9% frente al 15,9% para la quimioterapia
  • una supervivencia global mediana de 16,85 meses frente a 13,34 meses para la quimioterapia

El estudio incluyó a 453 pacientes con carcinoma epitelial seroso de alto grado. Los efectos secundarios comunes incluyeron visión borrosa, queratopatía y dolor abdominal, con tasas más bajas de eventos adversos graves en comparación con la quimioterapia. ELAHERE recibió la aprobación completa de la FDA en marzo de 2024 y la aprobación de la Comisión Europea en noviembre de 2024.

AbbVie (ABBV)ELAHERE®의 플래티넘 내성 난소암 치료를 위한 3상 MIRASOL 시험의 최종 분석 결과를 발표했습니다. 30.5개월의 중간 추적 관찰 후, 이 약물은 다음과 같은 결과를 보였습니다:

  • 항암화학요법에 비해 사망 위험 32% 감소
  • 항암화학요법의 3.98개월에 비해 5.59개월의 중간 무진행 생존 기간
  • 항암화학요법의 15.9%에 비해 41.9%의 객관적 반응률
  • 항암화학요법의 13.34개월에 비해 16.85개월의 중간 전체 생존 기간

이 연구는 고등급 장액성 상피 PROC 환자 453명을 포함했습니다. 일반적인 부작용으로는 시야 흐림, 각막병증 및 복통이 있었으며, 항암화학요법에 비해 심각한 부작용의 비율이 낮았습니다. ELAHERE는 2024년 3월에 FDA의 전체 승인을 받았고, 2024년 11월에 유럽연합 집행위원회의 승인을 받았습니다.

AbbVie (ABBV) a annoncé les résultats de l'analyse finale de l'essai de Phase 3 MIRASOL pour ELAHERE® dans le traitement du cancer de l'ovaire résistant au platine et positif pour le récepteur alpha de folate. Après un suivi médian de 30,5 mois, le médicament a montré :

  • une réduction de 32 % du risque de décès par rapport à la chimiothérapie
  • une survie sans progression médiane de 5,59 mois contre 3,98 mois pour la chimiothérapie
  • un taux de réponse objectif de 41,9 % contre 15,9 % pour la chimiothérapie
  • une survie globale médiane de 16,85 mois contre 13,34 mois pour la chimiothérapie

Cette étude a inclus 453 patients atteints de carcinome épithélial séreux de haut grade. Les effets secondaires courants comprenaient une vision floue, une kératopathie et des douleurs abdominales, avec des taux d'événements indésirables graves plus faibles par rapport à la chimiothérapie. ELAHERE a reçu l'approbation complète de la FDA en mars 2024 et l'approbation de la Commission européenne en novembre 2024.

AbbVie (ABBV) hat die Ergebnisse der endgültigen Analyse der Phase-3-Studie MIRASOL für ELAHERE® zur Behandlung von platinresistentem, folat-rezeptor-alpha-positivem Ovarialkarzinom bekannt gegeben. Nach einer medianen Nachbeobachtungszeit von 30,5 Monaten zeigte das Medikament:

  • eine 32%ige Reduktion des Sterberisikos im Vergleich zur Chemotherapie
  • eine mediane progressionsfreie Überlebenszeit von 5,59 Monaten gegenüber 3,98 Monaten für die Chemotherapie
  • eine objektive Ansprechrate von 41,9% gegenüber 15,9% für die Chemotherapie
  • eine mediane Gesamtüberlebenszeit von 16,85 Monaten gegenüber 13,34 Monaten für die Chemotherapie

Die Studie umfasste 453 Patienten mit hochgradigem serösem Epithelkarzinom. Zu den häufigsten Nebenwirkungen gehörten verschwommenes Sehen, Keratopathie und Bauchschmerzen, mit niedrigeren Raten schwerwiegender unerwünschter Ereignisse im Vergleich zur Chemotherapie. ELAHERE erhielt im März 2024 die volle Zulassung der FDA und im November 2024 die Zulassung der Europäischen Kommission.

Positive
  • 32% reduction in death risk compared to chemotherapy
  • 37% reduction in tumor progression risk
  • Significantly higher objective response rate (41.9% vs 15.9%)
  • Lower rates of serious adverse events compared to chemotherapy
  • Recent FDA and EU regulatory approvals expand market access
Negative
  • median progression-free survival of 5.59 months
  • Multiple treatment-emergent adverse events affecting patient quality of life
  • Requires specific patient selection (FRα-positive tumors only)

Insights

This Phase 3 MIRASOL trial final analysis represents a significant clinical advancement in the treatment landscape for platinum-resistant ovarian cancer. With 32% reduction in death risk and improved median overall survival of 16.85 months versus 13.34 months for chemotherapy, these results demonstrate meaningful clinical benefit in a difficult-to-treat population.

The efficacy data is particularly compelling when examining progression-free survival (37% risk reduction) and objective response rate (41.9% versus 15.9% for chemotherapy). What's notably valuable for clinical practice is the consistent benefit shown across two separate follow-up analyses, confirming durability of response.

ELAHERE's targeted approach as an antibody-drug conjugate specifically for FRα-positive tumors exemplifies precision medicine's value in gynecologic oncology. The safety profile shows expected manageable adverse events primarily affecting vision, but with lower rates of serious adverse events than standard chemotherapy - a critical quality-of-life consideration for these patients.

For context, platinum-resistant ovarian cancer has historically had dismal outcomes with effective options. The investigator's characterization of ELAHERE as an "emerging standard of care" is well-supported by these results, which could ultimately reshape treatment algorithms. The potential expansion into earlier treatment settings mentioned in the article would represent another significant advancement if future studies demonstrate similar benefits.

ELAHERE's strong final Phase 3 data significantly strengthens AbbVie's oncology portfolio at a critical time. Following AbbVie's acquisition of ImmunoGen for $10.1 billion in 2023 to obtain this asset, these results validate that strategic investment and suggest potential for substantial return.

The timing is particularly advantageous as AbbVie navigates the loss of exclusivity for Humira, its blockbuster immunology drug. ELAHERE represents a key component of AbbVie's diversification strategy, establishing stronger footing in the high-margin oncology space where durable, targeted therapies command premium pricing.

With full FDA approval secured in March 2024 and European Commission approval in November 2024, ELAHERE now has the regulatory foundation for commercial success in major markets. The consistent survival benefit demonstrated in this final analysis will support physician adoption, payer discussions, and potential label expansions.

Ovarian cancer's market dynamics make this particularly valuable - approximately 20,000 women are diagnosed annually in the US alone, with most eventually developing platinum resistance. Without effective alternatives, ELAHERE addresses a critical treatment gap with compelling efficacy data.

The multiple presentations at the SGO Annual Meeting will further strengthen ELAHERE's clinical profile among key prescribers. With additional studies examining ELAHERE in earlier treatment settings, AbbVie has potential to expand the addressable patient population substantially, increasing the product's commercial ceiling and strengthening the company's oncology franchise.

  • Final data analysis from Phase 3 MIRASOL trial after 30.5-month median follow-up demonstrated 32% reduction in risk of death with ELAHERE compared to chemotherapy in folate receptor alpha (FRα)-positive platinum-resistant ovarian cancer (PROC)
  • Data presented in a late-breaking oral presentation at the Society of Gynecologic Oncology (SGO) Annual Meeting on Women's Cancer in Seattle

NORTH CHICAGO, Ill., March 15, 2025 /PRNewswire/ -- AbbVie (NYSE: ABBV) today announced the final analysis of the confirmatory Phase 3 MIRASOL trial evaluating the efficacy and safety of ELAHERE® (mirvetuximab soravtansine-gynx) in women with folate receptor alpha (FRα)-positive platinum-resistant ovarian cancer (PROC) compared to chemotherapy. At 30.5 months median follow-up, treatment with ELAHERE continued to show significant improvements in progression-free survival (PFS) and overall survival (OS) compared to investigator's choice (IC) chemotherapy.1 Ovarian cancer patients often present with late-stage disease and are historically first treated with platinum-based chemotherapy, which they may become resistant to and require another therapy, such as ELAHERE.2 

"Ovarian cancer can be devastating, and when cancer cells stop responding to chemotherapy patients may feel hopeless about their journey. The data presented today reinforce the importance of ELAHERE as a transformative therapy for patients with limited options," said Svetlana Kobina, MD, PhD, vice president, oncology medical affairs, AbbVie. "We remain steadfast in our commitment to bring forward innovative therapies that improve the lives of patients with difficult-to-treat cancers."

In the United States, ovarian cancer is the leading cause of death from gynecological cancers.3 Each year, approximately 20,000 women are diagnosed.4 Unfortunately, most patients develop platinum-resistant disease, which is difficult to treat.5 In this setting, single-agent chemotherapies are associated with minimal survival benefit while adding significant toxicity burden.6

The Phase 3 MIRASOL study included 453 patients with high-grade serous epithelial PROC whose tumors express high levels of FRα and had been treated with up to three prior therapies.1 Key findings from the 30.5-month median follow-up include:

  • ELAHERE treatment achieved superior efficacy versus IC chemotherapy, with a median PFS of 5.59 months versus 3.98 months, representing a 37% reduction in the risk of tumor progression or death (HR 0.63; [95% CI: 0.51, 0.79]) and a higher objective response rate of 41.9% versus 15.9%.
  • Superior and clinically meaningful overall survival for patients receiving ELAHERE (median 16.85 months) compared to IC chemotherapy (median 13.34 months), representing a 32% reduction in the risk of death (HR 0.68 [95% CI: 0.54, 0.84]).
  • Other endpoints included safety and duration of response (DOR), which were consistent with the primary data analysis at 13.1-months median follow-up.

The most common treatment-emergent adverse events (TEAEs) occurring in at least 20% of patients in the ELAHERE arm were blurred vision, keratopathy, abdominal pain, fatigue, diarrhea, dry eye, constipation, nausea and peripheral neuropathy. Compared with IC chemotherapy, treatment with ELAHERE was overall associated with lower rates of grade ≥3 TEAEs, serious AEs and discontinuations due to AEs.

"The final data showcase the significant improvement in overall survival benefit of treatment with ELAHERE compared to standard of care chemotherapy," said investigator and presenter, Toon Van Gorp, MD, PhD, Professor of Gynecologic Oncology, University of Leuven. "The significant improvements in survival, along with the well-characterized safety profile, reinforce ELAHERE as an emerging standard of care for difficult-to-treat ovarian cancer and warrants further study of this medicine in earlier treatment settings."

A separate analysis from the Phase 3 MIRASOL study evaluating the impact of [ELAHERE] treatment-emergent ocular events on patient-reported health-related quality of life (HRQoL), will be shared during an oral presentation March 17 at the SGO Annual Meeting scientific plenary session.

ELAHERE was granted full approval by the U.S. Food and Drug Administration in March 2024 and was approved by the European Commission in November 2024. Marketing Authorization Applications for ELAHERE are also under review in multiple other countries.

About the Phase 3 MIRASOL Trial
MIRASOL is a randomized Phase 3 trial of ELAHERE versus investigator's choice (IC) of single-agent chemotherapy (weekly paclitaxel, pegylated liposomal doxorubicin, or topotecan). Eligibility criteria include patients with PROC whose tumors express high levels of FRα, using the Ventana FOLR1 RxDx Assay, and who have been treated with up to three prior regimens. The primary endpoint of this trial is progression-free survival (PFS) by investigator assessment. Key secondary endpoints include objective response rate (ORR) and overall survival (OS). The trial enrolled 453 patients. Patients were stratified by number of prior lines of therapy (14% had one prior line of therapy, 39% had two prior lines of therapy, and 47% had three prior lines of therapy) and by IC chemotherapy, with paclitaxel as the most commonly chosen (41%), followed by PLD (36%) and topotecan (23%). Sixty-two percent of patients received prior bevacizumab; 55% received a prior PARP inhibitor.

More information can be found on www.clinicaltrials.gov (NCT04209855).

About ELAHERE
ELAHERE (mirvetuximab soravtansine-gynx) is a first-in-class antibody-drug conjugate (ADC) comprising a folate receptor alpha-binding antibody, cleavable linker, and the maytansinoid payload DM4, a potent tubulin inhibitor designed to kill the targeted cancer cells. Patients requiring access support may call 1-833-ELAHERE or visit www.elahere.com.

ELAHERE U.S. USE and IMPORTANT SAFETY INFORMATION7
What is ELAHERE?
ELAHERE is a prescription medicine used to treat adults with folate receptor-alpha positive ovarian cancer, fallopian tube cancer, or primary peritoneal cancer who:

  • have not responded to or are no longer responding to treatment with platinum-based chemotherapy and
  • have received 1 to 3 prior types of chemotherapy.

Your healthcare provider will perform a test to make sure that ELAHERE is right for you.
It is not known if ELAHERE is safe and effective in children.

IMPORTANT SAFETY INFORMATION
What is the most important information I should know about ELAHERE?
ELAHERE can cause serious side effects, including:
Eye problems. Eye problems are common with ELAHERE and can also be severe. Tell your healthcare provider right away if you develop any eye problems during treatment with ELAHERE, including blurred vision, dry eyes, sensitivity to light, eye pain, eye redness, or new or worsening vision changes.

  • Your healthcare provider will send you to see an eye care professional to check your eyes before you start treatment with ELAHERE, during treatment with ELAHERE, and as needed for any worsening signs and symptoms of eye problems.
  • Your healthcare provider will prescribe steroid eye drops and lubricating eye drops before you start and during your treatment with ELAHERE. You should use eye drops as directed by your healthcare provider.
  • Do not wear contact lenses throughout your treatment with ELAHERE unless you are told to use them by your healthcare provider.

What should I tell my healthcare provider before receiving ELAHERE?
Tell your healthcare provider about all of your medical conditions, including if you:

  • have vision or eye problems.
  • have numbness or tingling in your hands or feet.
  • have liver problems.
  • are pregnant or plan to become pregnant. ELAHERE can harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with ELAHERE.

Patients who are able to become pregnant:

    • Your healthcare provider should do a pregnancy test before you start treatment with ELAHERE.
    • You should use an effective birth control (contraception) during treatment and for 7 months after your last dose of ELAHERE.
  • are breastfeeding or plan to breastfeed. It is not known if ELAHERE passes into your breast milk. Do not breastfeed during treatment and for 1 month after your last dose of ELAHERE.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking certain other medicines during treatment with ELAHERE may cause side effects.

What are the possible side effects of ELAHERE?
ELAHERE can cause serious side effects, including:

  • Eye problems. Eye problems are common with ELAHERE and can also be severe. Tell your healthcare provider right away if you develop any eye problems during treatment with ELAHERE, including blurred vision, dry eyes, sensitivity to light, eye pain, eye redness, or new or worsening vision changes.
  • Lung problems (pneumonitis). ELAHERE can cause severe or life-threatening inflammation of the lungs that may lead to death. Tell your healthcare provider right away if you get new or worsening symptoms, including trouble breathing, shortness of breath, cough, or chest pain.
  • Peripheral neuropathy. Nerve problems called peripheral neuropathy are common during treatment with ELAHERE and can also be severe. Your healthcare provider will monitor you for signs and symptoms of nerve problems. Tell your healthcare provider if you get new or worsening numbness, tingling, burning sensation or pain in your hands or feet or muscle weakness.

The most common side effects and abnormal labs of ELAHERE include:

•      increased liver enzymes in the blood

•      feeling tired

•      blurred vision

•      nausea

•      diarrhea

•      stomach-area (abdominal) pain

•      changes in the cornea (part of the eye)

•      peripheral neuropathy

•      muscle, bone, or joint pain

•      decreased red or white blood cell counts

 

•     decreased platelets

•     decreased magnesium level in the blood

•     dry eye

•     constipation

•     vomiting

•     decreased albumin level in the blood

•     decreased appetite

Your healthcare provider may change your dose of ELAHERE, delay treatment, or completely stop treatment if you have certain side effects.

These are not all of the possible side effects of ELAHERE. Call your doctor for medical advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑1088.

Please see Full Prescribing Information, including Boxed WARNING and Medication Guide.

About AbbVie in Oncology
At AbbVie, we are committed to transforming standards of care for patients living with difficult-to-treat cancers. We are advancing a dynamic pipeline of investigational therapies across a range of cancer types in both blood cancers and solid tumors. We are focusing on creating targeted medicines that either impede the reproduction of cancer cells or enable their elimination. We achieve this through various, targeted treatment modalities and biology interventions, including small molecule therapeutics, antibody-drug conjugates (ADCs), Immuno-Oncology-based therapeutics, multi-specific antibody and in situ CAR-T platforms. Our dedicated and experienced team joins forces with innovative partners to accelerate the delivery of potential breakthrough medicines.

Today, our expansive oncology portfolio comprises approved and investigational treatments for a wide range of blood and solid tumors. We are evaluating more than 20 investigational medicines in multiple clinical trials across some of the world's most widespread and debilitating cancers. As we work to have a remarkable impact on people's lives, we are committed to exploring solutions to help patients obtain access to our cancer medicines. For more information, please visit http://www.abbvie.com/oncology.

About AbbVie
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology, neuroscience and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X (formerly Twitter), and YouTube. 

AbbVie Forward-Looking Statements 
Some statements in this news release are, or may be considered, forward-looking statements for purposes of the Private Securities Litigation Reform Act of 1995. The words "believe," "expect," "anticipate," "project" and similar expressions and uses of future or conditional verbs, generally identify forward-looking statements. AbbVie cautions that these forward-looking statements are subject to risks and uncertainties that may cause actual results to differ materially from those expressed or implied in the forward-looking statements. Such risks and uncertainties include, but are not limited to, challenges to intellectual property, competition from other products, difficulties inherent in the research and development process, adverse litigation or government action, and changes to laws and regulations applicable to our industry. Additional information about the economic, competitive, governmental, technological and other factors that may affect AbbVie's operations is set forth in Item 1A, "Risk Factors," of AbbVie's 2024 Annual Report on Form 10-K, which has been filed with the Securities and Exchange Commission, as updated by its subsequent Quarterly Reports on Form 10-Q. AbbVie undertakes no obligation, and specifically declines, to release publicly any revisions to forward-looking statements as a result of subsequent events or developments, except as required by law. 

Disclosure: Dr. Van Gorp has financial interests related to AbbVie.

References:

  1. Van Gorp T, et al. Final overall survival analysis among patients with FRα-positive platinum-resistant ovarian cancer (PROC) treated with mirvetuximab soravtansine (MIRV) vs. investigator's choice chemotherapy (ICC) in the Phase 3 MIRASOL (GOG 3045/ENGOT-ov55) study. Data presented at the 2025 Society of Gynecologic Oncology Annual Meeting on Women's Cancer.
  2. Hanker, LC, et al. The impact of second to sixth line therapy on survival of relapsed ovarian cancer after primary taxane/platinum-based therapy, Annals of Oncology, Volume 23, Issue 10, 2012.
  3. WHO International Agency for Research on Cancer. GLOBOCAN 2022. Cancer Today. Absolute numbers, Mortality, Females, age [0-74], in 2022. Continents. Available here.
  4. Whittemore AS. Characteristics relating to ovarian cancer risk: implications for prevention and detection. Gynecol Oncol. 1994 Dec;55(3 Pt 2):S15-9. doi: 10.1006/gyno.1994.1334. PMID: 7835800.
  5. Hanker, LC, et al. The impact of second to sixth line therapy on survival of relapsed ovarian cancer after primary taxane/platinum-based therapy, Annals of Oncology, Volume 23, Issue 10, 2012.
  6. Matulonis, UA, er al. Efficacy and safety of mirvetuximab soravtansine in patients with platinum-resistant ovarian cancer with high folate receptor alpha expression: Results from the SORAYA Study. J Clin Oncol. 2023 May 1;41(13):2436-2445. doi: 10.1200/JCO.22.01900. Epub 2023 Jan 30. PMID: 36716407; PMCID: PMC10150846.
  7. ELAHERE [package insert]. North Chicago, IL: AbbVie Inc: 2025.

U.S. Media:

Investors: 


Stephanie Tennessen

Liz Shea


+1 (224) 214-8638

+1 (847) 935-2211


stephanie.tennessen@abbvie.com

liz.shea@abbvie.com





Global Media:



Marianne Ostrogorski



+1 (224) 240-6336



marianne.ostrogorski@abbvie.com 



 

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SOURCE AbbVie

FAQ

What are the survival benefits of ELAHERE compared to chemotherapy in ovarian cancer treatment?

ELAHERE showed a 32% reduction in death risk, with median overall survival of 16.85 months versus 13.34 months for chemotherapy.

What is the progression-free survival rate for ABBV's ELAHERE in ovarian cancer patients?

ELAHERE achieved 5.59 months median progression-free survival compared to 3.98 months for chemotherapy, representing a 37% risk reduction.

What are the main side effects of ELAHERE in treating ovarian cancer?

Main side effects include blurred vision, keratopathy, abdominal pain, fatigue, diarrhea, dry eye, constipation, nausea and peripheral neuropathy.

When did ELAHERE receive FDA and European approval for ovarian cancer treatment?

ELAHERE received full FDA approval in March 2024 and European Commission approval in November 2024.

What is the objective response rate of ELAHERE in the MIRASOL trial for ABBV?

ELAHERE showed a 41.9% objective response rate compared to 15.9% for chemotherapy in the Phase 3 MIRASOL trial.
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