Measuring Nucleosomes Using Nu.Q® NETs is a Promising Biomarker for Septic Shock
- Volition's Nu.Q® NETs test is a promising biomarker for evaluating disease severity in septic shock patients.
- The study found a significant positive correlation between nucleosome levels and disease severity indicators.
- Elevated nucleosome levels were independently associated with both five and 28-day mortality in septic shock patients.
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The 150-patient study published in Annals of Intensive Care was led by Professor Guillaume Monneret, Head of Clinical Immunology Laboratory at Hospices Civils de
Professor Monneret and his team used Volition's automated nucleosome quantification assay, Nu.Q® NETs, to measure nucleosome levels in patients with septic shock and to determine whether there is an association with mortality.
Nu.Q® NETs is a simple, low cost and routine blood test which can detect clinically elevated levels of NETs by identifying the unique biomarker H3.1. Composed of decondensed chromatin, NETs play an important role in the immune system, trapping and killing bacteria, fungi and viruses. However, excessive production can lead to tissue damage and, in severe cases, sepsis, organ failure, and death.
Professor Guillaume Monneret, Head of Clinical Immunology Laboratory at Hospices Civils de
"This was the first study to investigate both nucleosomes and immunological parameters in septic shock. We saw a significant elevation of nucleosomes in septic shock patients. We also found a significant positive correlation between nucleosome levels and a range of disease severity indicators including SOFA, SAPS II, IL–6 concentrations, and neutrophil count. Additionally, significantly elevated nucleosome levels were independently associated with both five and 28-day mortality, even after adjusting for typical confounding factors such as age, severity scores, and IL-6.
"In summary, we were able to show an association of increased circulating H3.1 nucleosomes with severity and mortality in septic shock patients."
Remi Rabeuf, Lifecycle Leader at Volition, said: "This is the first published data from our global centers of excellence program and we are delighted that Professor Monneret's findings show that Nu.Q® NETs is a promising biomarker for the evaluation of disease severity and could support sepsis prognosis."
There are an estimated 11 million sepsis-related deaths worldwide each year, accounting for
Volition is developing simple, easy-to-use, cost-effective blood tests to help diagnose and monitor a range of life-altering diseases including cancer in both humans and animals. For more information about Volition's Nu.Q® technology go to: www.volition.com
Notes:
- Haem Rahimi M; Bidar F; Lukaszewicz AC; Garnier L; Payen-Gay L; Venet F; Monneret G, Association of pronounced Elevation of NET formation and Nucleosome Biomarkers with Mortality in Patients with Septic Shock, Annals of Intensive Care (2023) 13:102
- World Health Organisation October 2023
About Volition
Volition is a multi-national epigenetics company powered by Nu.Q®, its proprietary nucleosome quantification platform. Through its subsidiaries, Volition is developing simple, easy to use, cost effective blood tests to help diagnose and monitor a range of life-altering diseases including some cancers and diseases associated with NETosis such as sepsis and COVID-19. Early diagnosis and monitoring have the potential to not only prolong the life of patients but also improve their quality of life. The tests are based on the science of Nucleosomics™, which is the practice of identifying and measuring nucleosomes in the bloodstream or other bodily fluid - an indication that disease is present.
Volition's research and development activities are centered in
For more information about Volition's Nu.Q® technology go to: www.volition.com
The contents found at the Volition and World Health Organisation website addresses are not incorporated by reference into this document and should not be considered part of this document. The website addresses are included in this document as inactive textual references only.
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