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10x Genomics Reports Fourth Quarter and Full Year 2024 Financial Results and Provides Outlook for 2025

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10x Genomics (TXG) reported Q4 and full year 2024 financial results, showing revenue declines and continued operating losses. Q4 revenue decreased 10% to $165.0 million, while full-year revenue fell 1% to $610.8 million. The company's gross margin improved to 67% in Q4 and 68% for the full year.

Operating expenses decreased 6% to $160.8 million in Q4, with an operating loss of $49.8 million. For the full year, operating loss improved to $194.6 million from $265.3 million in 2023. The company ended 2024 with $393.4 million in cash and marketable securities.

Looking ahead, 10x Genomics provided 2025 revenue guidance of $610-630 million, projecting 0-3% growth. The company expects double-digit growth in both Chromium reactions and spatial revenue at the midpoint of guidance.

10x Genomics (TXG) ha riportato i risultati finanziari del quarto trimestre e dell'intero anno 2024, evidenziando un calo dei ricavi e perdite operative continue. I ricavi del Q4 sono diminuiti del 10% a 165,0 milioni di dollari, mentre i ricavi dell'intero anno sono scesi dell'1% a 610,8 milioni di dollari. Il margine lordo dell'azienda è migliorato al 67% nel Q4 e al 68% per l'intero anno.

Le spese operative sono diminuite del 6% a 160,8 milioni di dollari nel Q4, con una perdita operativa di 49,8 milioni di dollari. Per l'intero anno, la perdita operativa è migliorata a 194,6 milioni di dollari rispetto ai 265,3 milioni di dollari del 2023. L'azienda ha chiuso il 2024 con 393,4 milioni di dollari in contante e titoli negoziabili.

Guardando al futuro, 10x Genomics ha fornito una previsione di ricavi per il 2025 di 610-630 milioni di dollari, prevedendo una crescita dal 0 al 3%. L'azienda si aspetta una crescita a doppia cifra sia nelle reazioni di Chromium che nei ricavi spaziali al centro della previsione.

10x Genomics (TXG) informó sobre los resultados financieros del cuarto trimestre y del año completo 2024, mostrando caídas en los ingresos y pérdidas operativas continuas. Los ingresos del Q4 disminuyeron un 10% a 165,0 millones de dólares, mientras que los ingresos anuales cayeron un 1% a 610,8 millones de dólares. El margen bruto de la compañía mejoró al 67% en el Q4 y al 68% para el año completo.

Los gastos operativos disminuyeron un 6% a 160,8 millones de dólares en el Q4, con una pérdida operativa de 49,8 millones de dólares. Para el año completo, la pérdida operativa mejoró a 194,6 millones de dólares desde 265,3 millones de dólares en 2023. La compañía terminó 2024 con 393,4 millones de dólares en efectivo y valores negociables.

De cara al futuro, 10x Genomics proporcionó una guía de ingresos para 2025 de 610-630 millones de dólares, proyectando un crecimiento del 0 al 3%. La empresa espera un crecimiento de dos dígitos tanto en reacciones de Chromium como en ingresos espaciales en el punto medio de la guía.

10x Genomics (TXG)는 2024년 4분기 및 전체 연도 재무 결과를 발표하며 수익 감소와 지속적인 운영 손실을 보여주었습니다. 4분기 수익은 1억 6,500만 달러로 10% 감소했으며, 연간 수익은 6억 1,080만 달러로 1% 감소했습니다. 회사의 총 마진은 4분기 67%, 전체 연도 68%로 개선되었습니다.

운영 비용은 4분기 동안 1억 6,080만 달러로 6% 감소했으며, 운영 손실은 4,980만 달러에 달했습니다. 전체 연도 운영 손실은 2023년 2억 6,530만 달러에서 1억 9,460만 달러로 개선되었습니다. 회사는 2024년을 3억 9,340만 달러의 현금 및 유가 증권으로 마감했습니다.

앞으로 10x Genomics는 2025년 수익 가이던스를 6억 1,000~6억 3,000만 달러로 제공하며 0~3% 성장을 예상하고 있습니다. 회사는 가이던스 중간값에서 Chromium 반응 및 공간 수익 모두에서 두 자릿수 성장을 예상하고 있습니다.

10x Genomics (TXG) a publié les résultats financiers du quatrième trimestre et de l'année 2024, montrant une baisse des revenus et des pertes d'exploitation continues. Les revenus du Q4 ont diminué de 10% pour atteindre 165,0 millions de dollars, tandis que les revenus annuels ont chuté de 1% pour atteindre 610,8 millions de dollars. La marge brute de l'entreprise s'est améliorée à 67% au Q4 et à 68% pour l'année entière.

Les dépenses d'exploitation ont diminué de 6% pour atteindre 160,8 millions de dollars au Q4, avec une perte d'exploitation de 49,8 millions de dollars. Pour l'année entière, la perte d'exploitation s'est améliorée à 194,6 millions de dollars contre 265,3 millions de dollars en 2023. L'entreprise a terminé l'année 2024 avec 393,4 millions de dollars en liquidités et en titres négociables.

En regardant vers l'avenir, 10x Genomics a fourni une prévision de revenus pour 2025 de 610-630 millions de dollars, projetant une croissance de 0 à 3%. L'entreprise s'attend à une croissance à deux chiffres tant pour les réactions Chromium que pour les revenus spatiaux au point médian de la prévision.

10x Genomics (TXG) hat die finanziellen Ergebnisse für das vierte Quartal und das gesamte Jahr 2024 veröffentlicht, die einen Rückgang der Einnahmen und fortlaufende Betriebskostenverluste zeigen. Die Einnahmen im Q4 sanken um 10% auf 165,0 Millionen Dollar, während die Gesamteinnahmen um 1% auf 610,8 Millionen Dollar fielen. Die Bruttomarge des Unternehmens verbesserte sich im Q4 auf 67% und im gesamten Jahr auf 68%.

Die Betriebsausgaben sanken im Q4 um 6% auf 160,8 Millionen Dollar, mit einem Betriebsverlust von 49,8 Millionen Dollar. Für das gesamte Jahr verbesserte sich der Betriebsverlust auf 194,6 Millionen Dollar von 265,3 Millionen Dollar im Jahr 2023. Das Unternehmen schloss das Jahr 2024 mit 393,4 Millionen Dollar in bar und handelbaren Wertpapieren ab.

Für die Zukunft gab 10x Genomics eine Umsatzprognose für 2025 von 610-630 Millionen Dollar heraus und prognostizierte ein Wachstum von 0-3%. Das Unternehmen erwartet ein zweistelliges Wachstum sowohl bei den Chromium-Reaktionen als auch bei den räumlichen Einnahmen in der Mitte der Prognose.

Positive
  • Gross margin improved to 68% for full year 2024 from 66% in 2023
  • Operating loss decreased to $194.6M in 2024 from $265.3M in 2023
  • Cash position increased by $4.7M year-over-year to $393.4M
  • Operating expenses reduced by 10% year-over-year
Negative
  • Q4 2024 revenue declined 10% year-over-year to $165.0M
  • Full year 2024 revenue decreased 1% to $610.8M
  • Net loss of $182.6M for full year 2024
  • Weak 2025 guidance projecting only 0-3% revenue growth

Insights

The Q4 and FY2024 results from 10x Genomics present a complex picture of a company navigating challenging market conditions. The 10% Q4 revenue decline to $165.0 million and 1% full-year decrease to $610.8 million reflect significant headwinds in the academic research sector. However, beneath these top-line numbers lie several important developments:

The improvement in gross margins to 67% in Q4 (up from 63%) and 68% for the full year demonstrates successful product mix optimization and operational efficiency. The $160.8 million in operating expenses represents a 6% reduction, indicating disciplined cost management, though litigation expenses remain a concern.

The launch of the Billion Cells Project, in collaboration with the Chan Zuckerberg Initiative and Ultima Genomics, represents a strategic pivot toward AI-driven biology. This initiative could potentially create a moat in AI-based biological research tools, though monetization pathways remain unclear.

The 2025 guidance of $610-630 million appears conservative but includes an important nuance: the projection of double-digit growth in both Chromium reactions and spatial revenue suggests a strategic reallocation toward higher-margin product lines. This could indicate a shift from volume to value-based growth strategy.

The $393.4 million cash position provides approximately two years of runway at current burn rates, offering adequate buffer to weather market uncertainties and invest in strategic initiatives. However, the persistent operating losses ($194.6 million for 2024) underscore the need for accelerated pathway to profitability.

PLEASANTON, Calif., Feb. 12, 2025 /PRNewswire/ -- 10x Genomics, Inc. (Nasdaq: TXG), a leader in single cell and spatial biology, today reported financial results for the fourth quarter and full year ended December 31, 2024 and provided outlook for 2025.

Recent Updates

  • Revenue was $165.0 million for the fourth quarter and $610.8 million for the full year of 2024, representing 10% and 1% decreases over the corresponding periods of 2023.
  • In collaboration with the Chan Zuckerberg Initiative (CZI) and Ultima Genomics, launched the Billion Cells Project, an effort to generate an unprecedented one billion cell dataset to fuel rapid progress in AI model development in biology.
  • Cash and cash equivalents and marketable securities were $393.4 million as of December 31, 2024, an increase of $4.7 million over prior year.

"In 2024, we launched major new products across all three of our platforms and we made changes to our commercial organization and go-to-market strategy," said Serge Saxonov, Co-founder and CEO of 10x Genomics. "As we kick off 2025, our goal is to take advantage of these changes and deliver consistent execution. Despite the current uncertainty within U.S. academic research, we continue to have strong conviction in the large opportunity ahead."

Fourth Quarter 2024 Financial Results

Revenue was $165.0 million for the three months ended December 31, 2024, a 10% decrease from $184.0 million for the corresponding period. 

Gross margin was 67% for the fourth quarter of 2024, as compared to 63% for the corresponding prior year period. The increase in gross margin was primarily due to change in product mix.

Operating expenses were $160.8 million for the fourth quarter of 2024, a 6% decrease from $171.0 million for the corresponding prior year period. The decrease was primarily driven by a $19.6 million in-process research and development expense related to an agreement to acquire certain intangible and other assets in the prior year period, partially offset by an increase in outside litigation expenses.

Operating loss was $49.8 million for the fourth quarter of 2024, as compared to an operating loss of $55.2 million for the corresponding prior year period. Operating loss includes $32.5 million of stock-based compensation for the fourth quarter of 2024, as compared to $38.9 million for the fourth quarter of 2023.

Net loss was $49.0 million for the fourth quarter of 2024, as compared to a net loss of $49.0 million for the corresponding prior year period.

Full Year 2024 Financial Results

Revenue was $610.8 million for the year ended December 31, 2024, a 1% decrease from $618.7 million for 2023.

Gross margin was 68% for full year 2024, as compared to 66% for 2023. The increase in gross margin was primarily due to change in product mix.

Operating expenses were $609.0 million for full year 2024, as compared to $674.6 million for 2023, an decrease of 10%. The decrease was primarily driven by a $61.0 million in-process research and development expense related to an agreement to acquire certain intangible and other assets in the prior year period and lower personnel expenses, including stock-based compensation expense, partially offset by higher outside legal expenses.

Operating loss was $194.6 million for full year 2024, as compared to an operating loss of $265.3 million for 2023. This includes $140.7 million of stock-based compensation for full year 2024, as compared to $167.0 million for full year 2023.

Net loss was $182.6 million for full year 2024, as compared to a net loss of $255.1 million for 2023.

Cash and cash equivalents and marketable securities were $393.4 million as of December 31, 2024.

2025 Financial Guidance 

10x Genomics expects full year 2025 revenue to be in the range of $610 million to $630 million, representing 0% to 3% growth over full year 2024. At the midpoint, this guidance implies double-digit growth for both Chromium reactions and overall spatial revenue.

Webcast and Conference Call Information

10x Genomics will host a conference call to discuss the fourth quarter and full year 2024 financial results, business developments and outlook after market close on Thursday, February 12, 2025 at 1:30 PM Pacific Time / 4:30 PM Eastern Time. A webcast of the conference call can be accessed at http://investors.10xgenomics.com. The webcast will be archived and available for replay for at least 45 days after the event.

About 10x Genomics

10x Genomics is a life science technology company building products to accelerate the mastery of biology and advance human health. Our integrated solutions include instruments, consumables and software for single cell and spatial biology, which help academic and translational researchers and biopharmaceutical companies understand biological systems at a resolution and scale that matches the complexity of biology. Our products are behind breakthroughs in oncology, immunology, neuroscience and more, fueling powerful discoveries that are transforming the world's understanding of health and disease. To learn more, visit 10xgenomics.com or connect with us on LinkedIn, X (Twitter), Facebook, Bluesky or YouTube.

Forward Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 as contained in Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, which are subject to the "safe harbor" created by those sections. All statements included in this press release, other than statements of historical facts, may be forward-looking statements. Forward-looking statements generally can be identified by the use of forward-looking terminology such as "may," "might," "will," "should," "expect," "plan," "anticipate," "could," "intend," "target," "project," "contemplate," "believe," "see," "estimate," "predict," "potential," "would," "likely," "seek" or "continue" or the negatives of these terms or variations of them or similar terminology, but the absence of these words does not mean that a statement is not forward-looking. These forward-looking statements include statements regarding 10x Genomics, Inc.'s collaboration with CZI and Ultima Genomics, positioning, product launches, commercial organization restructuring, go-to-market strategy, goals, uncertainty within academic research, commercial opportunity and our financial performance and results of operations, including our expectations regarding revenue and guidance. These statements are based on management's current expectations, forecasts, beliefs, assumptions and information currently available to management. Actual outcomes and results could differ materially from these statements due to a number of factors and such statements should not be relied upon as representing 10x Genomics, Inc.'s views as of any date subsequent to the date of this press release. 10x Genomics, Inc. disclaims any obligation to update any forward-looking statements provided to reflect any change in our expectations or any change in events, conditions or circumstances on which any such statement is based, except as required by law. The material risks and uncertainties that could affect 10x Genomics, Inc.'s financial and operating results and cause actual results to differ materially from those indicated by the forward-looking statements made in this press release include those discussed under the captions "Risk Factors" and "Management's Discussion and Analysis of Financial Condition and Results of Operations" in the company's most recently-filed 10-K and elsewhere in the documents 10x Genomics, Inc. files with the Securities and Exchange Commission from time to time.

Disclosure Information

10x Genomics uses filings with the Securities and Exchange Commission, our website (www.10xgenomics.com), press releases, public conference calls, public webcasts and our social media accounts as means of disclosing material non-public information and for complying with our disclosure obligations under Regulation FD.

Contacts
Investors: investors@10xgenomics.com
Media: media@10xgenomics.com 

10x Genomics, Inc.

Consolidated Statement of Operations

(Unaudited)

(In thousands, except share and per share data)



Three Months Ended
December 31,


Year Ended
December 31,


2024


2023


2024


2023

Revenue (1)

$         165,021


$         183,979


$         610,785


$         618,727

Cost of revenue (2)

54,066


68,197


196,303


209,414

Gross profit

110,955


115,782


414,482


409,313

Operating expenses:








Research and development (2)

66,968


65,267


264,698


270,332

In-process research and development


19,578



60,980

Selling, general and administrative (2)

93,826


86,125


344,343


343,330

Total operating expenses

160,794


170,970


609,041


674,642

Loss from operations

(49,839)


(55,188)


(194,559)


(265,329)

Other income (expense):








Interest income

4,026


4,637


18,448


16,906

Interest expense


(8)


(4)


(33)

Other income (expense), net

(2,567)


3,961


(1,585)


(307)

Total other income

1,459


8,590


16,859


16,566

Loss before provision for income taxes

(48,380)


(46,598)


(177,700)


(248,763)

Provision for income taxes

648


2,354


4,927


6,336

Net loss

$          (49,028)


$          (48,952)


$       (182,627)


$       (255,099)









Net loss per share, basic and diluted

$              (0.40)


$              (0.41)


$              (1.52)


$              (2.18)

Weighted-average shares used to compute net loss per share, basic and diluted

121,596,351


118,565,724


120,451,550


117,165,036



(1)

The following table represents revenue by source for the periods indicated (in thousands). Spatial products includes the Company's Visium and Xenium products:

 



Three Months Ended
December 31,


Year Ended
December 31,



2024


2023


2024


2023

Instruments









Chromium


$           10,929


$           11,150


$           35,212


$           47,866

Spatial


13,425


27,248


57,503


75,605

Total instruments revenue


24,354


38,398


92,715


123,471

Consumables









Chromium


97,737


118,144


372,308


420,316

Spatial


35,795


22,170


121,124


59,237

Total consumables revenue


133,532


140,314


493,432


479,553

Services


7,135


5,267


24,638


15,703

Total revenue


$         165,021


$         183,979


$         610,785


$         618,727

 

The following table presents revenue by geography based on the location of the customer for the periods indicated (in thousands):




Three Months Ended
December 31,


Year Ended
December 31,



2024


2023


2024


2023

Americas









United States


$           84,285


$           99,322


$         334,318


$         360,091

Americas (excluding United States)


2,936


4,520


13,447


13,101

Total Americas


87,221


103,842


347,765


373,192

Europe, Middle East and Africa


49,828


50,589


159,762


142,276

Asia-Pacific









China


14,609


11,748


57,300


50,965

Asia-Pacific (excluding China)


13,363


17,800


45,958


52,294

Total Asia-Pacific


27,972


29,548


103,258


103,259

Total Revenue


$         165,021


$         183,979


$         610,785


$         618,727

 

(2)

Includes stock-based compensation expense as follows:




Three Months Ended
December 31,


Year Ended
December 31,

(in thousands)

2024


2023


2024


2023

Cost of revenue

$           2,221


$           1,928


$           8,348


$           7,068

Research and development

15,587


17,608


66,315


72,804

Selling, general and administrative

14,731


19,382


66,086


87,078

Total stock-based compensation expense

$         32,539


$         38,918


$       140,749


$       166,950

 

10x Genomics, Inc.

Consolidated Balance Sheets

(In thousands, except share and per share data)



December 31,


2024


2023

Assets




Current assets:




Cash and cash equivalents

$         344,067


$         359,284

Marketable securities

49,335


29,411

Accounts receivable, net

87,862


114,832

Inventory

83,107


73,706

Prepaid expenses and other current assets

20,016


18,789

Total current assets

584,387


596,022

Property and equipment, net

252,648


279,571

Operating lease right-of-use assets

57,290


65,361

Goodwill

4,511


4,511

Intangible assets, net

15,671


16,616

Other noncurrent assets

4,129


3,062

Total assets

$         918,636


$         965,143

Liabilities and stockholders' equity




Current liabilities:




Accounts payable

$           12,909


$           15,738

Accrued compensation and related benefits

33,615


30,105

Accrued expenses and other current liabilities

41,165


56,648

Deferred revenue

20,658


13,150

Operating lease liabilities

9,286


11,521

Total current liabilities

117,633


127,162

Operating lease liabilities, noncurrent

73,327


83,849

Deferred revenue, noncurrent

12,513


8,814

Other noncurrent liabilities

5,029


4,275

Total liabilities

208,502


224,100

Commitments and contingencies




Stockholders' equity:




Preferred stock, $0.00001 par value; 100,000,000 shares authorized, no shares issued or
outstanding as of December 31, 2024 and December 31, 2023


Common stock, $0.00001 par value; 1,100,000,000 shares authorized and 122,291,837
and 119,095,362 shares issued and outstanding as of December 31, 2024 and 2023

2


2

Additional paid-in capital

2,177,672


2,025,890

Accumulated deficit

(1,467,047)


(1,284,420)

Accumulated other comprehensive loss

(493)


(429)

Total stockholders' equity

710,134


741,043

Total liabilities and stockholders' equity

$         918,636


$         965,143

 

Cumulative instruments sold



As of December 31,


2024


2023


2022

Chromium


5,808


5,180


4,411

Visium CytAssist


810


531


211

Xenium


421


255


8

Cumulative instruments sold


7,039


5,966


4,630


Total consumables reactions sold



Year ended December 31,


2024


2023


2022

Chromium


310,900


312,500


290,900

Visium


35,400


29,300


28,300

Xenium


10,800


5,200


100

Total consumable reactions


357,100


347,000


319,300

 

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SOURCE 10x Genomics, Inc.

FAQ

What was 10x Genomics (TXG) revenue for Q4 2024?

10x Genomics reported Q4 2024 revenue of $165.0 million, representing a 10% decrease from $184.0 million in Q4 2023.

What is TXG's revenue guidance for 2025?

10x Genomics expects full year 2025 revenue to be between $610 million and $630 million, representing 0% to 3% growth over full year 2024.

How much cash does 10x Genomics (TXG) have as of December 2024?

10x Genomics had $393.4 million in cash, cash equivalents, and marketable securities as of December 31, 2024.

What was TXG's operating loss for full year 2024?

10x Genomics reported an operating loss of $194.6 million for full year 2024, compared to an operating loss of $265.3 million in 2023.

What was 10x Genomics' (TXG) gross margin in 2024?

10x Genomics achieved a gross margin of 68% for full year 2024, compared to 66% in 2023.

10X Genomics, Inc.

NASDAQ:TXG

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