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Terns Pharmaceuticals, Inc. - TERN STOCK NEWS

Welcome to our dedicated page for Terns Pharmaceuticals news (Ticker: TERN), a resource for investors and traders seeking the latest updates and insights on Terns Pharmaceuticals stock.

Introduction

Terns Pharmaceuticals, Inc. (symbol: TERN) is a clinical‐stage biopharmaceutical company that harnesses molecularly‐targeted, oral small molecule drugs to address life‐threatening diseases. With a focus on liver diseases, oncological conditions, obesity, and hematologic disorders like chronic myeloid leukemia (CML), Terns integrates advanced medicinal chemistry with in‐depth disease biology to craft innovative therapeutic candidates. The company utilizes a capital‐efficient drug discovery framework and robust clinical development capabilities, particularly in China and the United States, to optimize the targeting of clinically validated objectives.

Core Business Areas and Pipeline

Terns’ pipeline is strategically organized into several clinical stage programs, each aimed at addressing significant unmet medical needs. The company is advancing candidates such as:

  • Allosteric BCR-ABL Inhibitor: Designed for CML, this oral small molecule offers a novel mechanism that selectively targets the myristoyl pocket on BCR-ABL, potentially overcoming limitations of traditional active-site tyrosine kinase inhibitors (TKIs). Its dosing convenience and safety profile are carefully engineered to address resistance and improve tolerability.
  • Small Molecule GLP-1 Receptor Agonist: Focused on the treatment of obesity, this candidate aims to deliver meaningful weight loss through once-daily dosing, with pharmacokinetic properties that optimize target coverage and patient tolerability.
  • THR-β Agonist: Under investigation for improving metabolic parameters and addressing liver-related disorders.
  • GIPR Modulators: Representing an extension of its metabolic portfolio, these modulators are being developed to complement other treatment strategies and address complex endocrine pathways.

Business Model and Operational Excellence

Terns Pharmaceuticals’ success is rooted in its efficient drug discovery and development model. By combining deep expertise in medicinal chemistry with strategic clinical operations, the company curates a pipeline that is both scientifically advanced and commercially viable. Its dual operational bases in San Mateo, California and Shanghai bolster its research capabilities, allowing for cost-effective clinical development and leveraging regulatory expertise across diverse markets.

Competitive Differentiation and Industry Position

In a competitive biopharmaceutical landscape, Terns distinguishes itself with several key attributes:

  • Innovative Mechanisms: The use of an allosteric inhibition approach for its BCR-ABL inhibitor provides a potential edge over conventional active-site TKIs. This mechanism may offer improved safety, tolerability, and dosing flexibility, addressing significant gaps in current clinical practice.
  • Optimized Drug Profiles: The company’s candidates are designed with pharmacokinetic and pharmacodynamic precision in mind, ensuring effective target engagement. For example, the GLP-1 receptor agonist exhibits sustained receptor activation without necessitating complex dosing regimes, potentially enhancing patient compliance.
  • Strategic Global Partnerships: With clinical programs conducted via integrated teams in both China and the United States, Terns leverages a unique global footprint that supports efficient trial execution and rapid clinical iteration, reinforcing its position in the niche of targeted, small molecule therapies.

Scientific Rigor and Research Approach

The company’s research is driven by a deep understanding of disease biology and robust structure-based drug discovery techniques. Utilizing advanced three-dimensional quantitative structure-activity relationship (QSAR) modeling and iterative medicinal chemistry, Terns meticulously optimizes compounds to improve metabolic stability and maximize therapeutic index. This rigorous scientific approach is evident across its multiple pipeline programs, underlining the company's commitment to innovation and reliability in therapeutic development.

Clinical and Operational Capabilities

At its core, Terns emphasizes a balanced approach to early clinical development. The company’s clinical studies are designed to assess safety, pharmacokinetics, and pharmacodynamics with a strong attention to detail. This methodology ensures that each candidate, whether addressing obesity through GLP-1 modulation or targeting CML with an allosteric inhibitor, is evaluated with the highest standards of clinical accuracy. The operational infrastructure supports swift trial enrollment and meticulous data collection, reinforcing Terns’ reputation for disciplined and effective clinical execution.

Market Significance and Investment Research Context

Terns Pharmaceuticals occupies a unique spot within the biopharmaceutical industry. Its innovative approach to small molecule drug development not only addresses significant clinical needs but also offers a model for capital efficiency in a sector often characterized by high operational costs. The company’s scientific methodology, geographic reach, and comprehensive pipeline provide investors and analysts with an insightful case study on how focused R&D and strategic execution can create substantial competitive differentiation in the treatment of complex diseases. The detailed documentation of clinical progress and methodological transparency further serve to enhance the trustworthiness and authoritativeness of its research endeavors.

Conclusion

In summary, Terns Pharmaceuticals exemplifies the integration of cutting-edge science with efficient clinical development. Its dedication to discovering and advancing molecularly-targeted therapies, particularly in the areas of liver diseases, oncology, obesity, and hematologic conditions, is underpinned by a robust research model and international operational expertise. For professionals seeking a detailed understanding of innovative drug development paradigms and clinical stage progression in the biopharmaceutical sector, Terns offers a compelling narrative grounded in scientific rigor and operational excellence.

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Terns Pharmaceuticals (TERN), a clinical-stage biopharmaceutical company focused on developing small-molecule treatments for oncology and obesity, has announced equity inducement grants to two new employees. The grants, approved under the 2022 Employment Inducement Award Plan and Nasdaq Listing Rule 5635(c)(4), consist of options to purchase 611,000 shares of Terns common stock.

The stock options come with a 10-year term and an exercise price of $2.56 per share, matching Terns' closing stock price on April 1, 2025. These options will vest over a four-year period, contingent on continued employment through the vesting dates.

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Terns Pharmaceuticals (TERN) has reported its Q4 and full year 2024 financial results, highlighting significant clinical progress in its pipeline. The company ended 2024 with $358.2 million in cash and equivalents, providing runway into 2028.

Key developments include:

  • Phase 1 CARDINAL trial of TERN-701 for chronic myeloid leukemia (CML) completed dose escalation, with dose expansion expected in Q2 2025
  • First patient enrolled in Phase 2 FALCON trial of TERN-601 for obesity, with 12-week data expected in Q4 2025
  • TERN-601 demonstrated weight loss up to 5.5% over 28 days in Phase 1 trials

Financial results show R&D expenses of $70.1 million for 2024 (up from $63.5 million in 2023), G&A expenses of $31.8 million (down from $39.1 million in 2023), and a net loss of $88.9 million (improved from $90.2 million in 2023).

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Terns Pharmaceuticals (Nasdaq: TERN) has granted an equity inducement award to its new Chief Financial Officer, Andrew Gengos, as announced on February 26, 2025. The award, approved under the 2022 Employment Inducement Award Plan and in accordance with Nasdaq Listing Rule 5635(c)(4), consists of an option to purchase 750,000 shares of Terns common stock.

The stock option features a 10-year term with an exercise price of $3.73 per share, matching Terns' closing stock price on February 24, 2025. The option will vest over a four-year period, contingent upon Mr. Gengos maintaining his employment with the company.

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Terns Pharmaceuticals (TERN) has provided program updates across its development pipeline and announced participation at the TD Cowen 45th Annual Healthcare Conference. The company reported strong progress with its TERN-701 CARDINAL study for chronic myeloid leukemia (CML), with dose expansion expected to begin in Q2 2025 and additional data in Q4 2025. New data shows TERN-701 has an improved drug-drug interaction profile compared to asciminib.

For its obesity program, Terns introduced the Phase 2 FALCON study design for TERN-601, an oral GLP-1 receptor agonist, scheduled to begin in early Q2 2025 with 12-week data expected in 2H 2025. The company aims to achieve competitive weight loss with best-in-class tolerability without complicated dose titrations.

Terns continues evaluating opportunities for TERN-501 in metabolic diseases and is advancing its TERN-800 series of GIPR modulators for obesity. With $372.8 million in cash as of September 30, 2024, the company expects runway into 2028.

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Terns Pharmaceuticals (Nasdaq: TERN) has appointed Andrew Gengos as Chief Financial Officer, effective immediately. Gengos brings 25 years of leadership experience in biotech and life sciences to the clinical-stage biopharmaceutical company.

Gengos most recently served as CFO of Athira Pharma and previously as Chief Business Officer at Cyteir Therapeutics, where he led the company's IPO finance team. His experience includes CEO roles at ImmunoCellular Therapeutics and Neuraltus Pharmaceuticals, and eight years as VP of Strategy and Corporate Development at Amgen.

The appointment comes as Terns, which focuses on developing small-molecule product candidates for oncology and obesity, anticipates clinical readouts later this year. Gengos holds an MBA from UCLA Anderson School of Management and a BS in Chemical Engineering from MIT.

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Terns Pharmaceuticals (Nasdaq: TERN) has appointed Robert Azelby to its Board of Directors, while Carl Gordon steps down after seven years of service. Azelby brings 25 years of biotechnology expertise, particularly in strategic, operational, and commercial leadership.

Azelby's extensive experience includes serving as CEO of Eliem Therapeutics (2020-2023) and Alder BioPharmaceuticals (2018-2019), as well as executive positions at Juno Therapeutics and Amgen. His appointment comes as Terns prepares TERN-701 for late-stage studies in chronic myeloid leukemia.

Currently, Azelby serves on the boards of ADC Therapeutics, Autolus Therapeutics, and Cardinal Health. He holds a B.A. in Economics and Religious Studies from the University of Virginia and an M.B.A. from Harvard Business School.

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Terns Pharmaceuticals (Nasdaq: TERN), a clinical-stage biopharmaceutical company focused on developing small-molecule treatments for serious diseases including oncology and obesity, has announced its participation in the upcoming Oppenheimer 35th Annual Healthcare Life Sciences Conference.

The company's senior management will deliver a presentation on Wednesday, February 12, 2025, at 4:00 p.m. ET. Investors and interested parties can access a live webcast of the presentation through the investor relations page at http://ir.ternspharma.com. The presentation recording will remain available on the company's website for a minimum of 30 days following the event.

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Terns Pharmaceuticals (Nasdaq: TERN) announced the grant of equity inducement awards to a new employee under its 2022 Employment Inducement Award Plan. The company granted stock options to purchase 250,000 shares at an exercise price of $4.46 per share, which was the closing price on January 31, 2025. The options have a 10-year term and vest over four years, contingent on continued employment. The grant was approved by the Compensation Committee in compliance with Nasdaq Listing Rule 5635(c)(4) and serves as a material inducement for the employee's acceptance of employment.

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Terns Pharmaceuticals (Nasdaq: TERN), a clinical-stage biopharmaceutical company focused on developing small-molecule product candidates for serious diseases including oncology and obesity, has announced its upcoming participation at the 43rd Annual J.P. Morgan Healthcare Conference.

The company's management will deliver their presentation on January 15th, 2025, at 4:30 p.m. PT. Investors and interested parties can access a live webcast of the presentation through the investor relations page at http://ir.ternspharma.com. The presentation recording will remain available on the company's website for a minimum of 30 days following the event.

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Terns Pharmaceuticals (Nasdaq: TERN) announced the granting of equity inducement awards to a new employee under its 2022 Employment Inducement Award Plan. The grant, approved by the Company's Compensation Committee in compliance with Nasdaq Listing Rule 5635(c)(4), includes options to purchase 9,000 shares of Terns common stock.

The options come with a 10-year term and an exercise price of $5.54 per share, matching Terns' closing stock price on December 31, 2024. The options will vest over a four-year period, contingent on the employee's continued service with the company.

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FAQ

What is the current stock price of Terns Pharmaceuticals (TERN)?

The current stock price of Terns Pharmaceuticals (TERN) is $2.1 as of April 4, 2025.

What is the market cap of Terns Pharmaceuticals (TERN)?

The market cap of Terns Pharmaceuticals (TERN) is approximately 193.8M.

What is the primary focus of Terns Pharmaceuticals?

Terns Pharmaceuticals is focused on developing molecularly-targeted, oral small molecule drugs. Its research is primarily aimed at addressing serious diseases such as liver disorders, oncology conditions, obesity, and chronic myeloid leukemia.

How does Terns generate its revenue?

The company operates through a capital-efficient drug discovery and clinical development model. It advances a comprehensive portfolio of clinical stage candidates, aiming to address significant unmet medical needs without relying on large-scale commercialization revenue at early stages.

What distinguishes TERN-701 in its pipeline?

TERN-701 is an allosteric BCR-ABL inhibitor developed for the treatment of CML. It differentiates itself by targeting a unique binding pocket, potentially offering improved safety, tolerability, and simplified dosing compared to traditional active-site inhibitors.

How does the company approach its drug discovery process?

Terns integrates advanced structure-based drug design, quantitative structure-activity relationship models, and robust medicinal chemistry. This comprehensive approach helps optimize candidate compounds for better metabolic stability and effective target engagement.

In what therapeutic areas does Terns Pharmaceuticals operate?

The company operates primarily in the realms of liver diseases, oncology, obesity, and hematologic conditions, including chronic myeloid leukemia. This diversity in focus areas underlines its commitment to addressing significant, unmet clinical needs.

What role does global collaboration play in the company’s strategy?

Terns benefits from a dual operational base in the United States and China. This international presence enhances its clinical development capabilities, regulatory expertise, and overall operational efficiency in advancing its pipeline.

How is Terns addressing the challenges in the obesity treatment market?

Through its development of a small molecule GLP-1 receptor agonist, Terns aims to provide meaningful weight loss with a simplified dosing regimen. The candidate is designed to improve patient compliance while maintaining robust efficacy and tolerability.

What are the key strengths highlighted in Terns Pharmaceuticals’ clinical programs?

Key strengths include the novel mechanisms of action, optimized pharmacokinetic profiles, and a disciplined clinical execution model. These factors combine to support a compelling narrative of innovative, targeted therapy development focused on critical diseases.
Terns Pharmaceuticals, Inc.

Nasdaq:TERN

TERN Rankings

TERN Stock Data

193.80M
79.54M
0.26%
108.17%
7.29%
Biotechnology
Pharmaceutical Preparations
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United States
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