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Terns Pharmaceuticals, Inc. (Nasdaq: TERN) is a clinical-stage biopharmaceutical company with a mission to innovate and develop small-molecule, molecularly-targeted, oral therapies for the treatment of serious diseases, including liver diseases and cancers. Based in San Mateo, California and Shanghai, Terns leverages its expertise in disease biology and medicinal chemistry to advance its growing pipeline of drugs aimed at addressing significant unmet medical needs globally.
The company is renowned for its cost-efficient drug discovery model and robust clinical development capabilities, especially within China. Terns Pharmaceuticals is focused on developing a portfolio of small-molecule candidates tailored for non-alcoholic steatohepatitis (NASH), oncology, and obesity.
One of the company's flagship programs is the TERN-501, an investigational orally administered thyroid hormone receptor-β (THR-β) agonist aimed at treating NASH. The Phase 2a DUET clinical trial revealed promising results, showing significant impacts on liver fat content and fibro-inflammation markers within a short period. This positions TERN-501 as a potential leading therapy for NASH.
Additionally, Terns is developing TERN-701, an allosteric BCR-ABL inhibitor for chronic myeloid leukemia (CML), and TERN-601, a small-molecule GLP-1 receptor agonist for obesity. Both candidates have shown encouraging preclinical and early clinical data, promising significant advancements in their respective fields.
Financially, as of the latest quarter, Terns Pharmaceuticals reported cash, cash equivalents, and marketable securities amounting to $266.6 million, supporting the planned operating expenses into 2026. Recent clinical trials and corporate updates highlight the company's ongoing dedication to addressing global health challenges through innovative drug development.
For more information, please visit their website at www.ternspharma.com.
Terns Pharmaceuticals (Nasdaq: TERN) has announced key leadership changes. Elona Kogan, Esq., has been appointed as the new Chief Legal Officer, bringing over 20 years of experience in the life sciences sector. Meanwhile, Mark Vignola, Ph.D., the current Chief Financial Officer, will be transitioning out by January 2025 or upon the appointment of a successor. Bryan Yoon, Esq., Chief Operating Officer, will remain until September 3, 2024, to assist with the transition.
These changes come as Terns, a clinical-stage biopharmaceutical company, continues to advance its pipeline of small-molecule product candidates for serious diseases, including oncology and obesity. CEO Amy Burroughs expressed confidence in the company's future, highlighting the experienced leadership team and upcoming data readouts from their pipeline.
Terns Pharmaceuticals announced new preclinical data supporting their compound TERN-501 in combination with a GLP-1 receptor agonist for treating obesity. The data was presented at the ADA’s 84th Annual Scientific Sessions. TERN-501, a highly selective THR-β receptor agonist, was shown to enhance weight loss efficacy when used with a GLP-1 receptor agonist, specifically semaglutide, in obese mice. This combination resulted in increased fat mass loss and preserved lean mass, potentially overcoming metabolic adaptation that limits the effectiveness of GLP-1 therapies alone. The results suggest TERN-501 could be a promising adjunct to GLP-1 therapies for obesity and other metabolic disorders. Additionally, Terns will participate in the Piper Sandler Virtual Obesity Day on June 26, 2024.
Terns Pharmaceuticals, a clinical-stage biopharmaceutical firm, announced equity inducement awards for two new employees under its 2022 Employment Inducement Award Plan.
These awards follow Nasdaq Listing Rule 5635(c)(4) and were approved as a material inducement to the employees' acceptance of their positions.
Scott Harris, the new Chief Development Officer, received an option to purchase 475,000 shares of Terns common stock at an exercise price of $6.32 per share, while another non-executive employee was granted an option to purchase 36,000 shares at an exercise price of $6.01 per share.
Both options have a 10-year term and vest over four years.
Terns Pharmaceuticals, a clinical-stage biopharmaceutical company listed on Nasdaq under the ticker TERN, announced its participation in two major investor conferences in June 2024. Senior management will present at the Jefferies Global Healthcare Conference on June 5 at 5:00 p.m. ET in New York City, and at the Goldman Sachs 45th Annual Global Healthcare Conference on June 11 at 3:20 p.m. ET in Miami. Both events will feature fireside chats, with live webcasts available on the Terns Pharmaceuticals investor relations webpage. Replays of these webcasts will be archived for at least 30 days.
Terns Pharmaceuticals, a clinical-stage biopharmaceutical company focusing on oncology and obesity, will participate in a virtual fireside chat at UBS Obesity Therapeutics Day on May 23, 2024. The event, which will include members of Terns' senior management, will be webcast live at 1:00 p.m. ET and archived for 30 days on their investor relations page.
Terns Pharmaceuticals, Inc. reported its first quarter 2024 financial results and corporate updates, highlighting the progress on its two lead programs, TERN-701 for CML and TERN-601 for obesity. The company has a cash position of $241 million expected to last into 2026. Recent developments include positive findings from the Phase 1 study of TERN-701 and the progress of TERN-601's first-in-human trial. The company also announced key appointments in its leadership team. Financially, Terns reported a net loss of $22.4 million for Q1 2024, with R&D expenses of $18.6 million and G&A expenses of $6.9 million.
Terns Pharmaceuticals, Inc. announced the appointment of Scott Harris as chief development officer and the departure of Erin Quirk, M.D., president, head of research and development. Dr. Quirk will be leaving the company to pursue other opportunities. Mr. Harris will oversee various operations, and key executives will now report directly to the CEO. The company expressed gratitude to Dr. Quirk for her contributions and confidence in the leadership team's ability to advance their pipeline. Mr. Harris brings over 25 years of experience in drug development and is optimistic about Terns' future.
Terns Pharmaceuticals, a clinical-stage biopharmaceutical company, will participate in The Citizens JMP Life Sciences Conference 2024. Senior management will join a fireside chat to discuss the company's small-molecule product candidates for serious diseases like oncology and obesity. The event will be live webcasted on May 14, 2024, at 1:30 p.m. ET, with a replay available for 30 days.
Terns Pharmaceuticals, Inc. announced the granting of an equity inducement award to Melita Sun Jung, the new Chief Business Officer, under the terms of the Inducement Plan. The award includes an option to purchase 475,000 shares of Terns common stock at an exercise price of $5.08 per share, with a 10-year term and vesting over four years.
Terns Pharmaceuticals, a biopharmaceutical company, announces positive data from a Phase 1 study of TERN-701, a potential BCR-ABL inhibitor for CML treatment, showing no food effect on dosing. The ongoing study in healthy volunteers displayed promising results, supporting once-daily dosing with or without food. The company aims to differentiate TERN-701 from the current standard, asciminib, by offering more convenient dosing options. Phase 1 CARDINAL trial is ongoing, with interim data expected in late 2024.
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