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Terns Pharmaceuticals, Inc. - TERN STOCK NEWS

Welcome to our dedicated page for Terns Pharmaceuticals news (Ticker: TERN), a resource for investors and traders seeking the latest updates and insights on Terns Pharmaceuticals stock.

Introduction

Terns Pharmaceuticals, Inc. (symbol: TERN) is a clinical‐stage biopharmaceutical company that harnesses molecularly‐targeted, oral small molecule drugs to address life‐threatening diseases. With a focus on liver diseases, oncological conditions, obesity, and hematologic disorders like chronic myeloid leukemia (CML), Terns integrates advanced medicinal chemistry with in‐depth disease biology to craft innovative therapeutic candidates. The company utilizes a capital‐efficient drug discovery framework and robust clinical development capabilities, particularly in China and the United States, to optimize the targeting of clinically validated objectives.

Core Business Areas and Pipeline

Terns’ pipeline is strategically organized into several clinical stage programs, each aimed at addressing significant unmet medical needs. The company is advancing candidates such as:

  • Allosteric BCR-ABL Inhibitor: Designed for CML, this oral small molecule offers a novel mechanism that selectively targets the myristoyl pocket on BCR-ABL, potentially overcoming limitations of traditional active-site tyrosine kinase inhibitors (TKIs). Its dosing convenience and safety profile are carefully engineered to address resistance and improve tolerability.
  • Small Molecule GLP-1 Receptor Agonist: Focused on the treatment of obesity, this candidate aims to deliver meaningful weight loss through once-daily dosing, with pharmacokinetic properties that optimize target coverage and patient tolerability.
  • THR-β Agonist: Under investigation for improving metabolic parameters and addressing liver-related disorders.
  • GIPR Modulators: Representing an extension of its metabolic portfolio, these modulators are being developed to complement other treatment strategies and address complex endocrine pathways.

Business Model and Operational Excellence

Terns Pharmaceuticals’ success is rooted in its efficient drug discovery and development model. By combining deep expertise in medicinal chemistry with strategic clinical operations, the company curates a pipeline that is both scientifically advanced and commercially viable. Its dual operational bases in San Mateo, California and Shanghai bolster its research capabilities, allowing for cost-effective clinical development and leveraging regulatory expertise across diverse markets.

Competitive Differentiation and Industry Position

In a competitive biopharmaceutical landscape, Terns distinguishes itself with several key attributes:

  • Innovative Mechanisms: The use of an allosteric inhibition approach for its BCR-ABL inhibitor provides a potential edge over conventional active-site TKIs. This mechanism may offer improved safety, tolerability, and dosing flexibility, addressing significant gaps in current clinical practice.
  • Optimized Drug Profiles: The company’s candidates are designed with pharmacokinetic and pharmacodynamic precision in mind, ensuring effective target engagement. For example, the GLP-1 receptor agonist exhibits sustained receptor activation without necessitating complex dosing regimes, potentially enhancing patient compliance.
  • Strategic Global Partnerships: With clinical programs conducted via integrated teams in both China and the United States, Terns leverages a unique global footprint that supports efficient trial execution and rapid clinical iteration, reinforcing its position in the niche of targeted, small molecule therapies.

Scientific Rigor and Research Approach

The company’s research is driven by a deep understanding of disease biology and robust structure-based drug discovery techniques. Utilizing advanced three-dimensional quantitative structure-activity relationship (QSAR) modeling and iterative medicinal chemistry, Terns meticulously optimizes compounds to improve metabolic stability and maximize therapeutic index. This rigorous scientific approach is evident across its multiple pipeline programs, underlining the company's commitment to innovation and reliability in therapeutic development.

Clinical and Operational Capabilities

At its core, Terns emphasizes a balanced approach to early clinical development. The company’s clinical studies are designed to assess safety, pharmacokinetics, and pharmacodynamics with a strong attention to detail. This methodology ensures that each candidate, whether addressing obesity through GLP-1 modulation or targeting CML with an allosteric inhibitor, is evaluated with the highest standards of clinical accuracy. The operational infrastructure supports swift trial enrollment and meticulous data collection, reinforcing Terns’ reputation for disciplined and effective clinical execution.

Market Significance and Investment Research Context

Terns Pharmaceuticals occupies a unique spot within the biopharmaceutical industry. Its innovative approach to small molecule drug development not only addresses significant clinical needs but also offers a model for capital efficiency in a sector often characterized by high operational costs. The company’s scientific methodology, geographic reach, and comprehensive pipeline provide investors and analysts with an insightful case study on how focused R&D and strategic execution can create substantial competitive differentiation in the treatment of complex diseases. The detailed documentation of clinical progress and methodological transparency further serve to enhance the trustworthiness and authoritativeness of its research endeavors.

Conclusion

In summary, Terns Pharmaceuticals exemplifies the integration of cutting-edge science with efficient clinical development. Its dedication to discovering and advancing molecularly-targeted therapies, particularly in the areas of liver diseases, oncology, obesity, and hematologic conditions, is underpinned by a robust research model and international operational expertise. For professionals seeking a detailed understanding of innovative drug development paradigms and clinical stage progression in the biopharmaceutical sector, Terns offers a compelling narrative grounded in scientific rigor and operational excellence.

Rhea-AI Summary

On October 18, 2021, Terns Pharmaceuticals announced three accepted abstracts for presentation at The Liver Meeting® Digital Experience 2021, focusing on their non-alcoholic steatohepatitis (NASH) programs. Key presentations include:

  • TERN-101: Favorable safety and efficacy from the Phase 2a LIFT Study.
  • TERN-501: Well-tolerated in first-in-human trials, showing dose-dependent cholesterol changes.

These findings underscore Terns' commitment to developing effective therapies for chronic liver diseases.

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Terns Pharmaceuticals, a clinical-stage biopharmaceutical company, announced its participation in the H.C. Wainwright 5th Annual NASH Investor Conference set for October 12, 2021, at 2:30 p.m. ET. The company is focused on developing therapies for non-alcoholic steatohepatitis (NASH) and chronic liver diseases, featuring a portfolio that includes three clinical-stage programs and a preclinical program. A live audio webcast of the presentation will be available on Terns’ investor relations page, with a replay archived for 30 days.

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Terns Pharmaceuticals has appointed Dr. Ann E. Taylor to its Board of Directors. With over 35 years in drug development, including her tenure as Chief Medical Officer at AstraZeneca, Dr. Taylor is expected to bring valuable expertise to Terns, particularly in developing treatments for non-alcoholic steatohepatitis (NASH) and chronic liver diseases. Terns is known for its innovative therapeutic approaches, including a diverse pipeline featuring small-molecule therapies aimed at addressing NASH.

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Terns Pharmaceuticals has completed patient enrollment for Part 1 of the AVIATION Trial, a Phase 1b study for TERN-201, a selective VAP-1 inhibitor targeting chronic liver inflammation and fibrosis in NASH patients. Preliminary top-line data is expected in 1Q 2022. The trial aims to assess the safety and tolerability of TERN-201 in comparison to a placebo over 12 weeks. TERN-201 has shown promise in preclinical studies, and the company received FDA Fast Track Designation for the treatment of NASH.

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Terns Pharmaceuticals, a clinical-stage biopharmaceutical company focused on therapies for non-alcoholic steatohepatitis (NASH), announced upcoming presentations at key investor conferences in September 2021. The conferences include the 2021 Virtual Wells Fargo Healthcare Conference on September 9, the H.C. Wainwright 23rd Annual Global Investment Conference on September 13, and the Oppenheimer Fall Healthcare Summit on September 20. Investors can access live webcasts on Terns' investor relations page, with replays available for 30 days.

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Terns Pharmaceuticals reported financial results for Q2 2021, achieving significant clinical milestones in its NASH pipeline. The company initiated the Phase 1b AVIATION Trial for TERN-201 and completed a multiple ascending dose portion of the TERN-501 trial. Cash reserves are strong at $185.1 million, projected to last until 2024. Top-line data from TERN-501 is expected in 4Q 2021 and from TERN-201 in 1H 2022. Despite a net loss of $10.7 million for the quarter, decreased R&D expenses show a positive trend for operating efficiency.

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Terns Pharmaceuticals, Inc. (Nasdaq: TERN), a clinical-stage biopharmaceutical company, has announced its participation in two key healthcare conferences. Management will join a liver disease panel at the 2021 Wedbush PacGrow Healthcare Conference on August 10 at 2:20 PM ET. Additionally, Terns will present at the Canaccord Genuity 41st Annual Growth Conference on August 11 at 1:00 PM ET. Both events will be available via live webcast on Terns' investor relations page, with replays accessible for 30 days post-presentation.

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Terns Pharmaceuticals initiated patient dosing for the AVIATION Trial, a Phase 1b study evaluating TERN-201, a selective VAP-1 inhibitor targeting chronic liver inflammation and fibrosis in NASH. This trial aims to assess the safety and efficacy of TERN-201 over a 12-week period, with preliminary data expected in 2022. TERN-201 demonstrated well-tolerated results in prior studies, showing significant potential in reducing liver inflammation. The drug's selective inhibition may complement other therapies in Terns’ portfolio.

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Terns Pharmaceuticals reported positive results from the Phase 2a LIFT clinical trial of TERN-101, an FXR agonist for NASH treatment. The trial demonstrated no discontinuations due to adverse events, including pruritus, and significant improvements in corrected T1 (cT1), a liver inflammation and fibrosis marker. After 12 weeks, significant changes in cT1 were observed in the 10 mg and 15 mg groups compared to placebo. Terns plans a combination trial of TERN-101 with TERN-501 in early 2022, following these promising outcomes.

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Terns Pharmaceuticals, Inc. (Nasdaq: TERN) announced a conference call to discuss new top-line data from the Phase 2a LIFT study evaluating TERN-101 in patients with non-alcoholic steatohepatitis (NASH). The call is scheduled for June 14, 2021, at 8:30 a.m. ET, with a live webcast available. Terns focuses on developing small-molecule therapies targeting NASH and chronic liver diseases, aiming to offer significant clinical benefits based on validated mechanisms of action. The details of the webcast and conference call are provided for interested stakeholders.

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FAQ

What is the current stock price of Terns Pharmaceuticals (TERN)?

The current stock price of Terns Pharmaceuticals (TERN) is $2.1 as of April 4, 2025.

What is the market cap of Terns Pharmaceuticals (TERN)?

The market cap of Terns Pharmaceuticals (TERN) is approximately 193.8M.

What is the primary focus of Terns Pharmaceuticals?

Terns Pharmaceuticals is focused on developing molecularly-targeted, oral small molecule drugs. Its research is primarily aimed at addressing serious diseases such as liver disorders, oncology conditions, obesity, and chronic myeloid leukemia.

How does Terns generate its revenue?

The company operates through a capital-efficient drug discovery and clinical development model. It advances a comprehensive portfolio of clinical stage candidates, aiming to address significant unmet medical needs without relying on large-scale commercialization revenue at early stages.

What distinguishes TERN-701 in its pipeline?

TERN-701 is an allosteric BCR-ABL inhibitor developed for the treatment of CML. It differentiates itself by targeting a unique binding pocket, potentially offering improved safety, tolerability, and simplified dosing compared to traditional active-site inhibitors.

How does the company approach its drug discovery process?

Terns integrates advanced structure-based drug design, quantitative structure-activity relationship models, and robust medicinal chemistry. This comprehensive approach helps optimize candidate compounds for better metabolic stability and effective target engagement.

In what therapeutic areas does Terns Pharmaceuticals operate?

The company operates primarily in the realms of liver diseases, oncology, obesity, and hematologic conditions, including chronic myeloid leukemia. This diversity in focus areas underlines its commitment to addressing significant, unmet clinical needs.

What role does global collaboration play in the company’s strategy?

Terns benefits from a dual operational base in the United States and China. This international presence enhances its clinical development capabilities, regulatory expertise, and overall operational efficiency in advancing its pipeline.

How is Terns addressing the challenges in the obesity treatment market?

Through its development of a small molecule GLP-1 receptor agonist, Terns aims to provide meaningful weight loss with a simplified dosing regimen. The candidate is designed to improve patient compliance while maintaining robust efficacy and tolerability.

What are the key strengths highlighted in Terns Pharmaceuticals’ clinical programs?

Key strengths include the novel mechanisms of action, optimized pharmacokinetic profiles, and a disciplined clinical execution model. These factors combine to support a compelling narrative of innovative, targeted therapy development focused on critical diseases.
Terns Pharmaceuticals, Inc.

Nasdaq:TERN

TERN Rankings

TERN Stock Data

193.80M
79.54M
0.26%
108.17%
7.29%
Biotechnology
Pharmaceutical Preparations
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United States
FOSTER CITY