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Senti Biosciences has completed its business combination with Dynamics Special Purpose Corp., bringing in approximately $156.5 million in gross proceeds. The newly combined company will trade on the Nasdaq under the ticker symbol SNTI. The funding allows Senti Bio to advance its preclinical oncology candidates, SENTI-202 and SENTI-301, with IND filings expected in 2023. With substantial financial backing, Senti Bio aims to develop next-generation cell and gene therapies using gene circuit technology.
Senti Biosciences has appointed Dr. Kanya Rajangam as its new Chief Medical and Development Officer, effective July 2022. Dr. Rajangam brings extensive experience in developing cancer therapies, including CAR-NK cell therapies.
Senti Bio focuses on innovative cell and gene therapies utilizing gene circuits for oncology. The company aims to transition to a clinical-stage biotech, with plans to file IND applications for its lead candidates, SENTI-202 and SENTI-301, targeting acute myeloid leukemia and hepatocellular carcinoma, respectively, in 2023.
Senti Biosciences announced a $5.175 million funding round led by Leaps by Bayer, enhancing its capital for a planned business combination with Dynamics Special Purpose Corp (DYNS). This investment, through an unsecured convertible note, will convert into DYNS Class A common stock at $10 per share upon closure of the merger. The registration statement for this merger was declared effective by the SEC, with a stockholder meeting scheduled for June 7, 2022, to approve the merger. Senti Bio aims to advance its gene circuit-engineered therapies for oncology, with IND applications expected in 2023.
Senti Bio presented three significant advancements at the ASGCT annual meeting, focusing on enhancing allogeneic CAR-NK cell therapies for acute myeloid leukemia (SENTI-202) and hepatocellular carcinoma (SENTI-301). The SENTI-202 candidate incorporates Logic Gating to optimize the targeting of AML cells while protecting healthy cells, showing promising in vivo data. SENTI-301 employs Multi-Arming and Regulator Dial technologies to boost cytotoxicity in HCC treatments. These innovations aim to improve cancer-killing efficacy and reduce systemic toxicity, with IND filings expected in 2023.
