Salarius Pharmaceuticals Merger Partner, Decoy Therapeutics, Appoints Renowned MIT Professor Robert S. Langer to its Scientific Advisory Board
Decoy Therapeutics announces that MIT Professor and Moderna co-founder Robert S. Langer will join their Scientific Advisory Board following the completion of their merger with Salarius Pharmaceuticals (NASDAQ: SLRX). The appointment comes after the January 13, 2025 merger agreement announcement between the companies.
Dr. Langer, a renowned scientist and entrepreneur, brings extensive experience in drug delivery systems and tissue engineering. His pioneering work has contributed to breakthrough medicines like Roche's Avastin and Moderna's Spikevax COVID vaccine. As an MIT Institute Professor with over 1,600 scientific papers and 400+ company patent licenses, Dr. Langer will support Decoy's development of novel peptide-conjugate therapeutics through their proprietary IMP3ACT™ platform.
Decoy Therapeutics annuncia che il Professor del MIT e co-fondatore di Moderna, Robert S. Langer, entrerà a far parte del loro Comitato Scientifico dopo il completamento della fusione con Salarius Pharmaceuticals (NASDAQ: SLRX). La nomina segue l'annuncio dell'accordo di fusione tra le due aziende del 13 gennaio 2025.
Il Dr. Langer, scienziato e imprenditore di fama mondiale, porta con sé una vasta esperienza nei sistemi di somministrazione di farmaci e nell'ingegneria tissutale. Il suo lavoro pionieristico ha contribuito a medicinali rivoluzionari come l'Avastin di Roche e il vaccino COVID Spikevax di Moderna. In qualità di Professore Istituto al MIT, con oltre 1.600 pubblicazioni scientifiche e più di 400 licenze di brevetti aziendali, il Dr. Langer sosterrà lo sviluppo da parte di Decoy di nuovi terapeutici peptidici coniugati attraverso la loro esclusiva piattaforma IMP3ACT™.
Decoy Therapeutics anuncia que el Profesor del MIT y cofundador de Moderna, Robert S. Langer, se unirá a su Junta Asesora Científica tras la finalización de su fusión con Salarius Pharmaceuticals (NASDAQ: SLRX). El nombramiento se produce después del anuncio del acuerdo de fusión entre ambas empresas el 13 de enero de 2025.
El Dr. Langer, científico y empresario reconocido, aporta una amplia experiencia en sistemas de administración de fármacos e ingeniería de tejidos. Su trabajo pionero ha contribuido a medicamentos innovadores como Avastin de Roche y la vacuna COVID Spikevax de Moderna. Como Profesor del Instituto MIT, con más de 1.600 artículos científicos y más de 400 licencias de patentes empresariales, el Dr. Langer apoyará el desarrollo de Decoy de nuevos terapéuticos conjugados con péptidos a través de su exclusiva plataforma IMP3ACT™.
Decoy Therapeutics는 MIT 교수이자 Moderna 공동 창립자 로버트 S. 랭거(Robert S. Langer)가 Salarius Pharmaceuticals (NASDAQ: SLRX)와의 합병 완료 후 과학 자문 위원회에 합류할 것이라고 발표했습니다. 이 임명은 2025년 1월 13일 두 회사 간 합병 계약 발표 이후 이루어졌습니다.
랭거 박사는 약물 전달 시스템과 조직 공학 분야에서 풍부한 경험을 가진 저명한 과학자이자 기업가입니다. 그의 선구적인 연구는 Roche의 Avastin과 Moderna의 Spikevax COVID 백신과 같은 혁신적인 의약품 개발에 기여했습니다. MIT 연구소 교수로서 1,600편 이상의 과학 논문과 400개 이상의 기업 특허 라이선스를 보유한 랭거 박사는 Decoy의 독점적인 IMP3ACT™ 플랫폼을 통한 새로운 펩타이드 결합 치료제 개발을 지원할 예정입니다.
Decoy Therapeutics annonce que le professeur du MIT et cofondateur de Moderna, Robert S. Langer, rejoindra leur conseil consultatif scientifique suite à la finalisation de leur fusion avec Salarius Pharmaceuticals (NASDAQ : SLRX). Cette nomination fait suite à l'annonce de l'accord de fusion entre les entreprises le 13 janvier 2025.
Le Dr Langer, scientifique et entrepreneur de renom, apporte une vaste expérience dans les systèmes d'administration de médicaments et l'ingénierie tissulaire. Ses travaux pionniers ont contribué à des médicaments révolutionnaires tels que l'Avastin de Roche et le vaccin COVID Spikevax de Moderna. En tant que professeur de l'Institut MIT, avec plus de 1 600 publications scientifiques et plus de 400 licences de brevets d'entreprise, le Dr Langer soutiendra le développement par Decoy de nouveaux thérapeutiques conjugués à des peptides via leur plateforme exclusive IMP3ACT™.
Decoy Therapeutics gibt bekannt, dass der MIT-Professor und Moderna-Mitbegründer Robert S. Langer nach Abschluss der Fusion mit Salarius Pharmaceuticals (NASDAQ: SLRX) dem Wissenschaftlichen Beirat beitreten wird. Die Ernennung erfolgt nach der Bekanntgabe der Fusionsvereinbarung zwischen den Unternehmen am 13. Januar 2025.
Dr. Langer, ein renommierter Wissenschaftler und Unternehmer, bringt umfangreiche Erfahrung in der Wirkstoffabgabe und Gewebezüchtung mit. Seine bahnbrechende Arbeit hat zu Medikamenten wie Roche's Avastin und dem COVID-Impfstoff Spikevax von Moderna beigetragen. Als MIT-Institute Professor mit über 1.600 wissenschaftlichen Veröffentlichungen und mehr als 400 Unternehmenspatentlizenzen wird Dr. Langer Decoy bei der Entwicklung neuartiger peptidkonjugierter Therapeutika über deren proprietäre IMP3ACT™ Plattform unterstützen.
- Addition of renowned biotech expert and Moderna co-founder to Scientific Advisory Board strengthens R&D capabilities
- Access to Dr. Langer's expertise in drug delivery systems and commercialization (400+ licensed patents)
- Strategic advancement of proprietary IMP3ACT platform development
- Company still in preclinical stage with no marketed products
- Merger completion remains pending and subject to closing conditions
Decoy’s development of novel peptide-conjugate therapeutics arising from its proprietary IMP3ACT™ platform to benefit from Dr. Langer’s extensive scientific knowledge and experience
CAMBRIDGE, Mass. and HOUSTON, April 16, 2025 (GLOBE NEWSWIRE) -- Decoy Therapeutics, Inc. (Decoy), a privately held preclinical biopharmaceutical company engineering the next generation of peptide conjugate therapeutics, announces that Massachusetts Institute of Technology (MIT) Professor and Moderna co-founder Robert S. Langer, ScD will join the company’s Scientific Advisory Board (SAB) upon the successful completion of Decoy’s merger with Salarius Pharmaceuticals, Inc. (NASDAQ: SLRX). As announced on January 13, 2025, Decoy and Salarius Pharmaceuticals signed a definitive agreement under which Decoy Therapeutics will merge with a wholly owned subsidiary of Salarius Pharmaceuticals, with the newly formed company to be named Decoy Therapeutics.
Dr. Langer is a world-renowned scientist, entrepreneur and biotechnology visionary. His groundbreaking work in drug delivery systems design and in tissue engineering have earned him numerous awards, including the prestigious National Medal of Science and the Charles Stark Draper Prize. Drug development technologies that Dr. Langer pioneered have laid the foundations for transformative medicines including Roche’s cancer drug bevacizumab (Avastin®) and Moderna's Spikevax® mRNA Covid vaccine.
"It’s an honor to have Dr. Langer join our SAB,” commented Michael M. Lipp, PhD, Chief Technology Officer of Decoy. “Having worked in Dr. Langer’s lab and at start-up companies that were founded on innovations arising from his lab, I’ve seen first-hand the impact he brings in discovering transformational therapies and advancing their development. We are confident that Dr. Langer’s tremendous experience and know-how will provide invaluable support as we use our proprietary IMP3ACT platform to advance a portfolio of proprietary peptide-conjugate products.”
“Decoy is utilizing an innovative, next-generation peptide-conjugate platform to discover and develop much-needed and differentiated antiviral and cancer therapies,” said Dr. Langer. “I am excited to collaborate with the Decoy team and to lend my expertise to expedite the development of these potentially high-impact therapeutics.”
“We are thrilled Dr. Langer has agreed to join our SAB thus expanding our thought leadership,” added Shahin Gharakhanian, MD, acting Chief Medical Officer and SAB Chair of Decoy. “We look forward to synergizing his guidance with our current SAB members and incorporating his drug design perspectives, particularly calling upon his expertise in developing dosage forms and routes of administration for Decoy’s peptide-conjugate drugs.”
Dr. Langer is one of nine Institute Professors at MIT, the institution’s highest faculty honor, and is a faculty member of the Harvard-MIT program in Health Sciences and Technology. His pioneering work has benefited millions of people worldwide and includes isolating the first angiogenesis inhibitors (with Dr. Judah Folkman) leading to new treatments for cancer and blindness. He also created the first nanoparticles and microparticles for delivering large molecules including nucleic acids, and helped establish the field of tissue engineering, which enabled artificial skin for burn victims and organ-on-a-chip technology.
Dr. Langer has authored more than 1,600 scientific papers with more than 444,000 citations, making him the most-cited biological engineer in history. His patents have been licensed or sublicensed to over 400 companies and he has co-founded more than 40 ventures. Dr. Langer chaired the FDA’s Science Board from 1999–2002. He has received more than 220 awards and is one of only three living individuals to receive both the U.S. National Medal of Science and the National Medal of Technology and Innovation. His accolades include the Draper Prize, the Queen Elizabeth Prize for Engineering, the Albany Medical Center Prize, the Breakthrough Prize in Life Sciences, the Kyoto Prize, the Wolf Prize in Chemistry, the Millennium Technology Prize and the Kavli Prize in Nanoscience. He holds 44 honorary doctorates from institutions including Harvard University, Yale University, Columbia University and the University of Oxford, and has been elected to the National Academies of Medicine, Engineering and Sciences, as well as the National Academy of Inventors.
About Decoy’s Peptide Conjugate Technology
Decoy’s drug design engine uses the power of computational tools and fast peptide synthesis technology pioneered in the laboratory of Brad Pentelute, Ph.D., Professor of Chemistry at MIT and Decoy co-founder, to rapidly engineer and synthesize novel antivirals that directly target highly conserved viral machinery. Its proprietary IMP3ACT peptide conjugate drug design and manufacturing platform leverages machine learning and artificial intelligence (AI) tools. IMP3ACT allows for the rapid computational design and manufacturing of innovative peptide-conjugate therapeutics including rapid response to novel viral pathogens including H5N1 avian flu. Peptide conjugates are a new class of drug, perhaps best known for the popular diabetes and weight loss medications, that takes advantage of the strong activity and selectivity of peptides, and improves their targeting and durability by adding a lipid molecule. Decoy Therapeutics is expanding the use of this new drug class to indications including infectious diseases and cancer.
The IMP3ACT platform leverages peptide chemistry to design a-helical peptides using computational and machine learning tools. These peptides are transformed into multimeric conjugates by chemically linking a defined number of copies to lipids or other suitable membrane anchor moieties, enhancing their drug-like properties and dosing flexibility with extended pharmacokinetics. Decoy’s technology has produced peptide conjugates effective in vitro against multiple human coronaviruses, including all SARS-CoV-2 major variants of concern to date, and against RSV A, RSV B and hPIV3, and in vivo against the SARS-CoV-2 delta variant. By integrating machine learning algorithms in peptide design and synthesis, Decoy’s platform accelerates the creation of lead molecules for preclinical evaluations, simultaneously optimizing peptide conjugates for enhanced affinity, binding specificity, resistance to proteases, pharmacokinetic properties and manufacturability at early commercial scale.
About Decoy Therapeutics, Inc.
Decoy Therapeutics is a preclinical-stage biotechnology company that is leveraging machine learning and artificial intelligence tools alongside high-speed synthesis techniques to rapidly design, engineer and manufacture peptide-conjugate drug candidates that target serious unmet medical needs. The company’s initial pipeline is focused on respiratory viruses and GI cancers. Decoy has attracted financing from institutional investors as well as significant non-dilutive capital from the Massachusetts Life Sciences Seed Fund, the Google AI startup program and the NVIDIA Inception program among other sources. The company has also received QuickFire Challenge award funding provided by the Biomedical Advanced Research and Development Authority (BARDA) through BLUE KNIGHT™, a collaboration between Johnson & Johnson Innovation – JLABS and BARDA within the Administration for Strategic Preparedness and Response. For more information, please visit www.DecoyTx.com.
About Salarius Pharmaceuticals, Inc.
Salarius Pharmaceuticals is a clinical-stage biopharmaceutical company with two drug candidates for patients with cancer in need of new treatment options. Salarius’ product portfolio includes seclidemstat, the company’s lead candidate, which is being studied in an investigator-initiated Phase 1/2 clinical study in hematologic cancers underway at MD Anderson Cancer Center as a potential treatment for MDS and CMML in patients with limited treatment options. SP-3164, the company’s IND-stage second asset, is an oral small molecule protein degrader. Salarius previously received financial support for seclidemstat for the treatment of Ewing sarcoma from the National Pediatric Cancer Foundation and was a recipient of a Product Development Award from the Cancer Prevention and Research Institute of Texas (CPRIT). For more information, please visit www.salariuspharma.com.
About the Proposed Transaction
Definitive agreements were executed with unanimous approvals by the Boards of Directors of Salarius and Decoy. The closing consideration will consist primarily of nonvoting preferred stock of Salarius, and it is expected that following closing and a post-closing stockholder vote to approve the conversion of the preferred shares into common stock, Decoy investors would own approximately
Non-Solicitation
This communication shall not constitute an offer to sell or the solicitation of an offer to sell or the solicitation of an offer to buy any securities, nor shall there be any sale of securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction. No public offer of securities in connection with the merger shall be made except by means of a prospectus meeting the requirements of Section 10 of the Securities Act of 1933, as amended.
Forward-Looking Statements
This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995 regarding Salarius, Decoy, the proposed merger and other matters, including without limitation, statements relating to plans and expectations relating to the business, scientific advisory board, products, including expected achievement of milestones for its lead asset and future prospects of Decoy and the combined company. These statements may discuss goals, intentions and expectations as to future plans, trends, events, results of operations or financial condition, or otherwise, based on current beliefs of the management of Salarius, as well as assumptions made by, and information currently available to, management. Forward-looking statements generally include statements that are predictive in nature and depend upon or refer to future events or conditions, and include words such as “may,” “will,” “should,” “would,” “expect,” “anticipate,” “plan,” “likely,” “believe,” “estimate,” “project,” “intend,” and other similar expressions. Statements that are not historical facts are forward-looking statements. Forward-looking statements are based on current beliefs and assumptions that are subject to risks and uncertainties and are not guarantees of future performance. Actual results could differ materially from those contained in any forward-looking statement as a result of various factors, including, without limitation: the risk that the conditions to the closing are not satisfied, including uncertainties as to the timing of the consummation of the proposed merger; the ability of each of Salarius and Decoy to consummate the merger; risks related to Salarius’ ability to estimate and manage its operating expenses and its expenses associated with the proposed merger pending the closing; risks that the combined company will not achieve the synergies expected from the proposed merger; risks that Salarius and the combined company will not obtain sufficient financing to execute on their business plans and risks related to Decoy’s products and development plans, including unanticipated issues with any IND application process and the potential of the IMP3ACT™ platform. Readers are urged to carefully review and consider the various disclosures made by Salarius in its reports filed with the SEC, including its Annual Report on Form 10-K for the fiscal year ended December 31, 2024, as revised or supplemented by its Quarterly Reports on Form 10-Q and other documents filed with the SEC. If one or more of these risks or uncertainties materialize, or if the underlying assumptions prove incorrect, Salarius’ actual results may vary materially from those expected or projected.
CONTACTS:
Decoy Therapeutics, Inc.
Rick Pierce, CEO
Pierce@decoytx.com
617-447-8299
Business Development:
Peter Marschel, CBO
Peter@Decoytx.com
617-943-6305
Salarius Pharmaceuticals, Inc.
Alliance Advisors IR
Jody Cain
jcain@allianceadvisors.com
310-691-7100
FAQ
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