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Revolution Medicines, Inc. (RVMD) is a clinical-stage precision oncology company dedicated to discovering and developing innovative targeted therapies that address the unmet needs of cancer patients. The company leverages its proprietary product engine to target frontier oncology pathways, with a strong focus on the RAS and mTOR signaling pathways, which are crucial for cancer growth and survival. Revolution Medicines’ approach draws inspiration from nature and evolution, harnessing insights from natural products to guide the discovery and development of small molecules that modulate key cancer targets.
The company’s research and development pipeline features several promising candidates, including RMC-4630, a SHP2 inhibitor, and a portfolio of RAS(ON) inhibitors such as RMC-6236, RMC-6291, and RMC-9805. These novel therapies aim to inhibit the active form of RAS proteins, which are common drivers in numerous cancer types. Revolution Medicines is also advancing the SOS1 and 4EBP1/mTORC1 programs, which hold significant potential in combination treatment strategies.
Recent achievements highlight the company’s progress in clinical development. Notably, the RMC-6236 Phase 1/1b trial demonstrated promising clinical activity and a favorable safety profile in patients with advanced solid tumors harboring KRAS mutations. The trial results showed an objective response rate of 38% in non-small cell lung cancer (NSCLC) and 20% in pancreatic ductal adenocarcinoma (PDAC), with disease control rates of 85% and 87%, respectively.
In October 2023, Revolution Medicines announced a pivotal milestone with the merger with EQRx, Inc., enhancing its financial position and enabling further investment in its clinical programs. The merger is expected to add approximately $1.1 billion in net cash proceeds, supporting the advancement of their RAS(ON) and RAS Companion Inhibitors. Dr. Sandra Horning, a renowned oncologist and former Genentech executive, joined the board of directors, bringing invaluable experience to the company.
Revolution Medicines continues to engage the scientific community and stakeholders through presentations at major conferences and investor webcasts. The company remains committed to advancing its robust pipeline of oncology therapies, aiming to revolutionize the treatment landscape for RAS-addicted cancers and improve outcomes for cancer patients worldwide.
Revolution Medicines (RVMD) has successfully closed its upsized public offering, raising $862.5 million in gross proceeds. The offering consisted of 16,576,088 shares of common stock at $46.00 per share and pre-funded warrants to purchase 2,173,917 shares at $45.9999 per share. The total includes 2,445,652 additional shares from the full exercise of the underwriters' option.
The offering was managed by J.P. Morgan, TD Cowen, Goldman Sachs & Co. , and Guggenheim Securities as joint book-running managers, with UBS Investment Bank acting as lead manager.
Revolution Medicines (RVMD) has announced the pricing of an upsized public offering totaling $750.0 million. The offering consists of 14,130,436 shares of common stock priced at $46.00 per share, and pre-funded warrants to purchase 2,173,917 shares at $45.9999 per warrant. The company has granted underwriters a 30-day option to purchase up to an additional 2,445,652 shares. The offering, expected to close on December 5, 2024, is being managed by J.P. Morgan, TD Cowen, Goldman Sachs & Co. , and Guggenheim Securities as joint book-running managers, with UBS Investment Bank acting as lead manager.
Revolution Medicines (Nasdaq: RVMD), a clinical-stage oncology company, has announced a public offering of common stock worth up to $600.0 million. The company plans to grant underwriters a 30-day option to purchase an additional $90.0 million of shares. J.P. Morgan, TD Cowen, Goldman Sachs & Co. and Guggenheim Securities will serve as joint book-running managers, with UBS Investment Bank as lead manager. The offering's completion depends on market conditions, with no guaranteed timeline or final terms.
Revolution Medicines announced clinical updates from its RAS(ON) inhibitor portfolio, highlighting progress in treating RAS-addicted cancers. The company reported compelling Phase 1/1b data for RMC-6236 in pancreatic cancer and non-small cell lung cancer. In pancreatic cancer patients, RMC-6236 showed a 36% objective response rate for KRAS G12X mutations. The drug demonstrated favorable safety profiles both as monotherapy and in combinations with pembrolizumab. Initial antitumor activity was observed in colorectal cancer patients using RMC-6236 and RMC-6291 combination therapy. The company plans to initiate Phase 3 trials, including RASolve 301 in Q1 2025.
Revolution Medicines (Nasdaq: RVMD) has announced a forthcoming investor webcast to provide clinical updates on their RAS(ON) inhibitor portfolio. The event, focused on their targeted therapies for RAS-addicted cancers, is scheduled for December 2, 2024, at 8:00 a.m. Eastern Time. The webcast will be accessible online, with a replay available on the company's website's Events & Presentations page for at least 14 days after the live event.
Revolution Medicines (RVMD) reported Q3 2024 financial results and clinical progress. The company announced a net loss of $156.3 million, up from $108.4 million in Q3 2023. R&D expenses increased to $151.8 million from $107.7 million year-over-year. The company maintains a strong cash position of $1.55 billion, expected to fund operations into 2027.
Key clinical highlights include the initiation of Phase 3 trial for RMC-6236 in pancreatic cancer patients and promising initial results for RMC-9805 in KRAS G12D mutation patients. The company reaffirmed its 2024 guidance projecting GAAP net loss between $560-600 million.
Revolution Medicines (Nasdaq: RVMD), a clinical-stage oncology company focused on RAS-addicted cancers, announces its participation in two major healthcare conferences. CEO Mark A. Goldsmith will present at Guggenheim's Inaugural Healthcare Innovation Conference on November 12, 2024, at 3:00 p.m. ET in Boston, and the UBS Global Healthcare Conference on November 13, 2024, at 5:00 p.m. ET in Rancho Palos Verdes. Both presentations will be available via webcast on the company's website, with replays accessible for at least 14 days after the events.
Revolution Medicines (Nasdaq: RVMD), a clinical-stage oncology company, will report its financial results for the third quarter of 2024 on November 6, 2024, after market close.
A webcast hosted by senior management will follow at 4:30 p.m. Eastern Time (1:30 p.m. Pacific Time) to discuss the results and provide a corporate update. The webcast will be available live and as an archived replay on the company's website for at least 14 days.
Revolution Medicines announced preliminary safety and antitumor data for RMC-9805, its RAS(ON) G12D-selective inhibitor, in patients with previously treated pancreatic ductal adenocarcinoma (PDAC). The Phase 1/1b study included 179 patients treated with varying doses. At 1200 mg daily dose, the drug showed a 30% objective response rate and 80% disease control rate. The treatment demonstrated an encouraging safety profile with primarily Grade 1 adverse events, including GI-related toxicities and rash. No Grade 4 or 5 treatment-related adverse events were observed, and no patients discontinued treatment due to adverse events.
Revolution Medicines announced encouraging data for RMC-6236, its RAS(ON) multi-selective inhibitor, in treating pancreatic ductal adenocarcinoma (PDAC). The Phase 1/1b study included 127 patients treated with doses ranging from 160mg to 300mg daily. Key results showed median progression-free survival of 8.5 months and overall survival of 14.5 months in second-line KRAS G12X mutation patients. The treatment demonstrated a 29% objective response rate in second-line patients and showed manageable safety profile with primarily Grade 1 or 2 adverse events. The most common side effects were rash and GI-related toxicities, with no treatment discontinuations due to adverse events.
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