TransCode Therapeutics, Inc. - RNAZ STOCK NEWS

TransCode Therapeutics (RNAZ) has received a notice from Nasdaq granting its request to maintain its listing on The Nasdaq Stock Market, subject to specific compliance conditions. The decision follows TransCode's appearance before the Nasdaq Hearings Panel on October 1, 2024. The Panel issued a Public Reprimand Letter regarding compliance issues with listing standards, including bid price requirements, equity requirements, and shareholder approval of certain transactions.

TransCode Therapeutics (NASDAQ: RNAZ) announced that the Safety Review Committee (SRC) has unanimously approved opening the second cohort in its Phase 1 clinical trial of TTX-MC138, following a favorable safety review of Cohort 1 data. TTX-MC138, designed to inhibit microRNA-10b important in metastatic cancer progression, showed no significant safety or dose-limiting toxicities in the first cohort. All patients from Cohort 1 remain on study, and the second cohort will receive approximately double the initial dose. TransCode is notably the only company with an ongoing US clinical trial targeting microRNA in cancer, utilizing technology recognized by the 2024 Nobel Prize in Physiology and Medicine.

TransCode Therapeutics (NASDAQ: RNAZ) has completed initial dosing of the first cohort in its Phase 1a dose-escalation clinical trial for TTX-MC138, an antisense oligonucleotide designed to inhibit microRNA-10b, a driver of metastasis in multiple cancers. Key points:

• All patients in the cohort received their first dose and remain on study for continued treatment
• No significant safety or dose limiting toxicities reported
• TTX-MC138 uses TransCode's proprietary TTX delivery system
• TransCode is the only company with an ongoing US clinical trial targeting microRNA in cancer
• The trial's progress coincides with the 2024 Nobel Prize in Physiology and Medicine recognizing microRNA technology

The company views the rapid enrollment and absence of dose limiting toxicities as encouraging signs for the continued assessment of TTX-MC138's safety and tolerability.

TransCode Therapeutics (NASDAQ: RNAZ) has announced the dosing of the first two patients in its Phase 1 clinical trial for TTX-MC138, a first-in-class therapeutic candidate designed to treat metastatic cancers. The trial, a multicenter, open-label, dose-escalation and dose-expansion study, aims to evaluate the safety and tolerability of TTX-MC138 in patients with metastatic cancer. Several additional patients have been screened for enrollment.

TTX-MC138 is an antisense oligonucleotide conjugated to TransCode's proprietary TTX delivery system, designed to inhibit microRNA-10b, a known driver of metastasis in multiple cancers. This Phase 1 trial follows a successful Phase 0 clinical trial that showed evidence of delivery and pharmacodynamic activity of a radiolabeled version of TTX-MC138.

TransCode Therapeutics (NASDAQ: RNAZ) has published a study in Oncotarget demonstrating the efficacy of its lead therapeutic candidate, TTX-MC138, against metastatic cancer. The research, conducted in collaboration with Michigan State University, reveals that TTX-MC138 reduces tumor cell capacity for self-renewal by targeting miR-10b, a molecule expressed in stem-like breast cancer cells.

Key findings include:

• Stem-like breast cancer cells increase expression of miR-10b
• TTX-MC138 treatment reduces cancer cell stemness
• Cancer cell stemness is important for metastasis and tumor formation

This study provides insights into TTX-MC138's mechanisms, potentially aiding in predicting clinical responses, defining molecular biomarkers, and improving patient stratification for future clinical trials.

TransCode Therapeutics (NASDAQ: RNAZ) has been awarded a $2 million Direct to Phase II Small Business Innovation Research (SBIR) grant from the National Institutes of Health (NIH) to support the clinical evaluation of its lead therapeutic candidate, TTX-MC138. The grant, awarded by the National Cancer Institute (NCI), will be disbursed over two years.

TransCode has recently activated three clinical trial sites for a Phase I/II clinical trial of TTX-MC138 for treating advanced solid tumors. The trial aims to assess the safety of TTX-MC138 and may provide early evidence of its clinical activity in patients with metastatic disease. TTX-MC138 is described as a first-in-class therapeutic candidate with novel relevance to metastatic disease, potentially offering a viable treatment option for many metastatic cancer patients.

TransCode Therapeutics (NASDAQ: RNAZ) has initiated its Phase 1 clinical trial for TTX-MC138, its lead RNA therapeutic candidate for cancer treatment. Two clinical trial sites have been activated, with patient enrollment expected to begin this quarter. The trial, designed to evaluate the safety and preliminary anti-tumor activity of TTX-MC138, may include up to five sites in total.

The study comprises a dose-escalation phase followed by a dose-expansion phase. It aims to assess the safety, tolerability, and potential clinical activity of TTX-MC138 in patients with various metastatic solid cancers. This marks a significant milestone for TransCode in advancing RNA therapeutics in oncology.

TransCode Therapeutics (Nasdaq: RNAZ), a clinical-stage RNA oncology company, has closed its previously announced public offering. The company sold 10,000,000 shares of common stock at $0.30 per share, raising $3,000,000 in gross proceeds before deducting fees and expenses. TransCode plans to use the net proceeds for product development activities, including clinical trials for its lead therapeutic candidate TTX-MC138, related IND enabling studies, and general corporate purposes. ThinkEquity acted as the sole placement agent for the offering, which was made pursuant to an effective shelf registration statement filed with the SEC.

TransCode Therapeutics (Nasdaq: RNAZ), an RNA oncology company, has announced the pricing of a public offering of 10,000,000 shares of common stock at $0.30 per share. The offering is expected to raise $3,000,000 in gross proceeds and close on July 24, 2024. The company plans to use the net proceeds for product development activities, including clinical trials for its lead candidate TTX-MC138, and for working capital. ThinkEquity is acting as the sole placement agent for this offering, which is being conducted under a shelf registration statement filed with the SEC.