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Rapport Therapeutics, Inc. (RAPP) is a clinical-stage biopharmaceutical company committed to the discovery and development of transformational small-molecule medicines for patients suffering from central nervous system (CNS) disorders. The company's unique approach is rooted in its foundational science, which has elucidated the complexities of neuronal receptor biology. This allows Rapport Therapeutics to map and target specific neuronal receptor complexes effectively.
Neuronal receptors are intricate assemblies comprising receptor principal subunits and receptor-associated proteins (RAPs). These RAPs play a significant role in regulating receptor expression and function. Rapport Therapeutics leverages this insight to advance its RAP technology platform, enabling the creation of precision small molecule product candidates. This strategy holds the promise of overcoming many of the limitations faced by conventional neurology drug discovery efforts.
The company's precision neuroscience pipeline includes its lead clinical program, RAP-219. This program is designed to achieve neuroanatomical specificity by selectively targeting a RAP expressed in discrete regions of the brain. RAP-219 is currently undergoing clinical trials focused on treating focal epilepsy, peripheral neuropathic pain, and bipolar disorder. Additionally, Rapport Therapeutics is engaged in other preclinical and late-stage discovery programs targeting CNS disorders such as chronic pain and hearing disorders.
Recently, Rapport Therapeutics successfully closed its initial public offering (IPO) with joint book-running managers Goldman Sachs & Co. LLC, Jefferies, TD Cowen, and Stifel. In addition to the IPO, the company sold 1,058,824 shares of common stock in a concurrent private placement to existing stockholders. The gross proceeds from these transactions, before deducting relevant expenses, amounted to approximately $174 million. These funds are expected to support the continued advancement of the company's clinical and preclinical programs.
Rapport Therapeutics (NASDAQ: RAPP) presented data showing a significant correlation between reductions in RNS-measured long episodes (LEs) and clinical seizures in focal epilepsy patients. The analysis revealed that a 30% reduction in LEs corresponds to a ≥50% reduction in clinical seizures, validating their biomarker approach for ongoing trials.
The company presented additional findings at the American Epilepsy Society Annual Meeting, including Phase 1 results showing RAP-219 was well-tolerated at target therapeutic exposures, food interaction studies indicating flexible dosing options, and preclinical data demonstrating dose-dependent antiseizure effects. Rapport's Phase 2a proof-of-concept trial for RAP-219 is ongoing with topline data expected in mid-2025.
Rapport Therapeutics (NASDAQ: RAPP) announced multiple presentations at the upcoming American Epilepsy Society Annual Meeting (December 6-10, 2024, Los Angeles). The company will present new data on the correlation between long episode frequency reduction and clinically meaningful reduction in patient-reported seizures, derived from an RNS® System study.
The presentations include data from their Phase 2a trial of RAP-219, their lead product candidate for drug-resistant focal epilepsy. Four poster presentations will cover antiseizure effects, pharmacokinetics, safety, and tolerability studies. A Scientific Exhibit Room session will showcase these posters along with additional information about RAP-219's development and trial design.
Rapport Therapeutics (NASDAQ: RAPP) reported Q3 2024 financial results and business updates. The company's lead program RAP-219 continues Phase 2a trials for focal epilepsy, with topline data expected mid-2025. The FDA placed a clinical hold on their Investigational New Drug Application for diabetic peripheral neuropathic pain. Four new biotech leaders joined the Board of Directors. Q3 financial results showed a net loss of $17.5 million, with R&D expenses of $15.5 million and G&A expenses of $6.1 million. The company ended Q3 with $320.7 million in cash and equivalents, expected to fund operations through 2026.
Rapport Therapeutics (Nasdaq: RAPP), a clinical-stage biotech company developing small molecule precision medicines for CNS disorders, has announced its participation in two major healthcare conferences in November 2024. The company will engage in fireside chats at the Stifel Healthcare Conference in New York City on November 18 at 1:15pm ET, and the Jefferies London Healthcare Conference on November 20 at 4:00pm GMT/11am ET. Live and archived webcasts will be available on the company's investor relations website.
Rapport Therapeutics (Nasdaq: RAPP), a clinical-stage biotech company focusing on CNS disorders, announced presentations at two upcoming epilepsy conferences. At the 15th Annual European Epilepsy Congress in Rome (Sept. 7-11, 2024), they will present on the novel design of a Phase 2a proof-of-concept trial for RAP-219 in drug-resistant focal epilepsy. At the 2024 Epilepsy Foundation Pipeline Conference in Atlanta (Sept. 25-26, 2024), they will discuss RAP-219's mechanism of action and the trial design.
Presentations include:
- EEC: 'Novel Design of a Focal Epilepsy Proof-of-Concept Study of RAP-219' (Sept. 08, 2024)
- Pipeline Conference: 'RAP-219 a novel, potent, and selective negative modulator of AMPAR TARPγ8' (Sept. 26, 2024)
Presentations will be available on Rapport's website after the conferences.
Rapport Therapeutics (Nasdaq: RAPP), a clinical-stage biotech company developing small molecule medicines for CNS disorders, has announced its participation in two upcoming investor conferences. The company will present at:
1. The Morgan Stanley 22nd Annual Global Healthcare Conference in New York City on September 5, 2024, at 4:50 pm ET.
2. TD Cowen's 4th Annual Novel Mechanisms in Neuropsychiatry Summit (Virtual) on September 26, 2024, at 11:40 am ET.
A live and archived webcast of the Morgan Stanley Conference fireside chat will be available on the company's investor relations website. This presentation offers investors an opportunity to gain insights into Rapport Therapeutics' progress in developing innovative treatments for central nervous system disorders.
Contineum Therapeutics (Nasdaq: CTNM) reported Q2 2024 financial results and recent business highlights. Key points include:
- Strong cash position of $219 million at Q2 end
- Appointed Troy Ignelzi and Sarah Boyce to Board of Directors
- Strengthened management team with John Healy and Kristina Haeckl
- Enrollment on track for PIPE-307 Phase 2 VISTA trial in RRMS
- Published preclinical and clinical results on PIPE-307 and PIPE-791
- Completed IPO with net proceeds of $107.9 million
Financial results:
- R&D expenses: $7.9 million (Q2 2024) vs $9.5 million (Q2 2023)
- G&A expenses: $3.0 million (Q2 2024) vs $1.6 million (Q2 2023)
Rapport Therapeutics (RAPP) reported Q2 2024 financials and provided a business update. Key highlights include:
1. Completed IPO, raising $174.4 million in gross proceeds
2. Phase 2a trial of RAP-219 in focal epilepsy on track for Q3 2024 initiation, with topline data expected mid-2025
3. Two additional proof-of-concept trials for RAP-219 planned: peripheral neuropathic pain (2H 2024) and bipolar disorder (2025)
4. Q2 2024 net loss: $18.1 million
5. Cash position: $336.1 million, expected to fund operations through end of 2026
6. Advancing preclinical programs, including RAP-199 and two nAChR discovery-stage programs
Rapport Therapeutics (Nasdaq: RAPP) will present preclinical data on RTX-1738, an analog to their lead product candidate RAP-219, at the IASP 2024 World Congress on Pain in Amsterdam. The poster presentation, scheduled for August 6, 2024, will showcase RTX-1738's analgesic activity across various acute and chronic pain models.
RTX-1738 is an AMPAR negative allosteric modulator designed to target TARPγ8, a receptor associated protein. This approach aims to achieve neuroanatomical specificity in treating central nervous system disorders. The company's lead candidate, RAP-219, is currently in a Phase 2a trial for drug-resistant focal epilepsy. Rapport plans to initiate additional Phase 2a trials for RAP-219 in peripheral neuropathic pain and bipolar disorder in late 2024 and 2025, respectively.
Rapport Therapeutics, a clinical-stage biotechnology firm specializing in central nervous system disorder treatments, closed its initial public offering (IPO) on June 12, 2024. The IPO involved 9,200,000 shares of common stock at $17.00 per share, totaling approximately $174 million, including the full exercise of the underwriters' option to purchase additional shares and a concurrent private placement. Trading began on June 7, 2024, under the ticker symbol 'RAPP'. Goldman Sachs, Jefferies, TD Cowen, and Stifel managed the offering. The concurrent private placement involved selling 1,058,824 shares to existing stockholders. The proceeds will be used to further Rapport's development of small molecule medicines.
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