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Rapport Therapeutics, Inc. (RAPP) is a clinical-stage biopharmaceutical company committed to the discovery and development of transformational small-molecule medicines for patients suffering from central nervous system (CNS) disorders. The company's unique approach is rooted in its foundational science, which has elucidated the complexities of neuronal receptor biology. This allows Rapport Therapeutics to map and target specific neuronal receptor complexes effectively.
Neuronal receptors are intricate assemblies comprising receptor principal subunits and receptor-associated proteins (RAPs). These RAPs play a significant role in regulating receptor expression and function. Rapport Therapeutics leverages this insight to advance its RAP technology platform, enabling the creation of precision small molecule product candidates. This strategy holds the promise of overcoming many of the limitations faced by conventional neurology drug discovery efforts.
The company's precision neuroscience pipeline includes its lead clinical program, RAP-219. This program is designed to achieve neuroanatomical specificity by selectively targeting a RAP expressed in discrete regions of the brain. RAP-219 is currently undergoing clinical trials focused on treating focal epilepsy, peripheral neuropathic pain, and bipolar disorder. Additionally, Rapport Therapeutics is engaged in other preclinical and late-stage discovery programs targeting CNS disorders such as chronic pain and hearing disorders.
Recently, Rapport Therapeutics successfully closed its initial public offering (IPO) with joint book-running managers Goldman Sachs & Co. LLC, Jefferies, TD Cowen, and Stifel. In addition to the IPO, the company sold 1,058,824 shares of common stock in a concurrent private placement to existing stockholders. The gross proceeds from these transactions, before deducting relevant expenses, amounted to approximately $174 million. These funds are expected to support the continued advancement of the company's clinical and preclinical programs.
Rapport Therapeutics (Nasdaq: RAPP) has appointed Dr. Jeffrey Sevigny as Chief Medical Officer (CMO), effective immediately. Dr. Sevigny brings over 15 years of leadership experience in translational and clinical drug development, particularly in neuroscience and rare diseases.
Previously serving as CMO at Prevail Therapeutics (an Eli Lilly subsidiary) and SVP of Neuroscience at Eli Lilly, Dr. Sevigny has demonstrated success in building clinical development organizations and achieving corporate milestones including IPO and acquisition processes. His career includes leadership positions at major pharmaceutical companies including Roche, Biogen, Novartis, and Merck.
In his new role, Dr. Sevigny will oversee Rapport's clinical strategy and advance its pipeline of precision medicines, particularly the RAP-219 program, which has shown promising Phase 1 data. His expertise in late-stage clinical trials and regulatory approvals will be important for the company's development of treatments for central nervous system (CNS) disorders.
Rapport Therapeutics (Nasdaq: RAPP), a clinical-stage biotech company focused on developing small molecule precision medicines for CNS disorders, has announced its participation in two major investor conferences in March 2025.
The company will participate in:
- The TD Cowen 45th Annual Health Care Conference in Boston, featuring a fireside chat on March 4, 2025, from 3:10-3:40pm EST
- The Stifel 2025 Virtual CNS Forum, with a fireside chat scheduled for March 19, 2025, from 10:30-10:55am EST
Investors and interested parties can access live and archived webcasts of both presentations through the Investors section of Rapport's website at investors.rapportrx.com.
Rapport Therapeutics (NASDAQ: RAPP) announced new Phase 1 data for RAP-219, its CNS disorder treatment candidate. The PET trial demonstrated that RAP-219 achieved and exceeded target receptor occupancy within five days while maintaining good tolerability. The MAD-2 trial showed favorable results with faster titration and higher exposures than the initial MAD trial.
Key findings from four Phase 1 trials involving 100 healthy volunteers showed RAP-219 was generally well-tolerated with no serious adverse events, no TEAEs greater than Grade 2, and only three treatment discontinuations (3%). The PET trial confirmed TARPγ8-containing AMPA receptors are enriched in the hippocampus and cerebral cortex, with minimal presence in the cerebellum and brain stem.
The company announced that Bradley Galer stepped down as chief medical officer, with a search for successor underway. A Phase 2a proof-of-concept trial for focal epilepsy is ongoing with topline results expected in mid-2025.
Rapport Therapeutics (NASDAQ: RAPP) has announced positive Phase 1 data for RAP-219, its CNS disorder treatment candidate. The PET trial demonstrated that RAP-219 achieved and exceeded target receptor occupancy within five days of dosing, supporting the dosing regimen in the ongoing Phase 2a focal epilepsy trial.
Key findings from trials involving 100 healthy volunteers showed RAP-219 was generally well-tolerated with no serious adverse events, and only 3% treatment discontinuations. The drug demonstrated favorable tolerability across various dosing regimens, with no sedation or motoric impairments observed.
The PET trial confirmed TARP8-containing AMPA receptors are enriched in the hippocampus and cerebral cortex, with minimal presence in the cerebellum and brain stem. The MAD-2 trial showed successful dose escalation and faster therapeutic level achievement. The company expects topline data from the ongoing Phase 2a trial in focal epilepsy by mid-2025.
Rapport Therapeutics (NASDAQ: RAPP) presented data showing a significant correlation between reductions in RNS-measured long episodes (LEs) and clinical seizures in focal epilepsy patients. The analysis revealed that a 30% reduction in LEs corresponds to a ≥50% reduction in clinical seizures, validating their biomarker approach for ongoing trials.
The company presented additional findings at the American Epilepsy Society Annual Meeting, including Phase 1 results showing RAP-219 was well-tolerated at target therapeutic exposures, food interaction studies indicating flexible dosing options, and preclinical data demonstrating dose-dependent antiseizure effects. Rapport's Phase 2a proof-of-concept trial for RAP-219 is ongoing with topline data expected in mid-2025.
Rapport Therapeutics (NASDAQ: RAPP) announced multiple presentations at the upcoming American Epilepsy Society Annual Meeting (December 6-10, 2024, Los Angeles). The company will present new data on the correlation between long episode frequency reduction and clinically meaningful reduction in patient-reported seizures, derived from an RNS® System study.
The presentations include data from their Phase 2a trial of RAP-219, their lead product candidate for drug-resistant focal epilepsy. Four poster presentations will cover antiseizure effects, pharmacokinetics, safety, and tolerability studies. A Scientific Exhibit Room session will showcase these posters along with additional information about RAP-219's development and trial design.
Rapport Therapeutics (NASDAQ: RAPP) reported Q3 2024 financial results and business updates. The company's lead program RAP-219 continues Phase 2a trials for focal epilepsy, with topline data expected mid-2025. The FDA placed a clinical hold on their Investigational New Drug Application for diabetic peripheral neuropathic pain. Four new biotech leaders joined the Board of Directors. Q3 financial results showed a net loss of $17.5 million, with R&D expenses of $15.5 million and G&A expenses of $6.1 million. The company ended Q3 with $320.7 million in cash and equivalents, expected to fund operations through 2026.
Rapport Therapeutics (Nasdaq: RAPP), a clinical-stage biotech company developing small molecule precision medicines for CNS disorders, has announced its participation in two major healthcare conferences in November 2024. The company will engage in fireside chats at the Stifel Healthcare Conference in New York City on November 18 at 1:15pm ET, and the Jefferies London Healthcare Conference on November 20 at 4:00pm GMT/11am ET. Live and archived webcasts will be available on the company's investor relations website.
Rapport Therapeutics (Nasdaq: RAPP), a clinical-stage biotech company focusing on CNS disorders, announced presentations at two upcoming epilepsy conferences. At the 15th Annual European Epilepsy Congress in Rome (Sept. 7-11, 2024), they will present on the novel design of a Phase 2a proof-of-concept trial for RAP-219 in drug-resistant focal epilepsy. At the 2024 Epilepsy Foundation Pipeline Conference in Atlanta (Sept. 25-26, 2024), they will discuss RAP-219's mechanism of action and the trial design.
Presentations include:
- EEC: 'Novel Design of a Focal Epilepsy Proof-of-Concept Study of RAP-219' (Sept. 08, 2024)
- Pipeline Conference: 'RAP-219 a novel, potent, and selective negative modulator of AMPAR TARPγ8' (Sept. 26, 2024)
Presentations will be available on Rapport's website after the conferences.
Rapport Therapeutics (Nasdaq: RAPP), a clinical-stage biotech company developing small molecule medicines for CNS disorders, has announced its participation in two upcoming investor conferences. The company will present at:
1. The Morgan Stanley 22nd Annual Global Healthcare Conference in New York City on September 5, 2024, at 4:50 pm ET.
2. TD Cowen's 4th Annual Novel Mechanisms in Neuropsychiatry Summit (Virtual) on September 26, 2024, at 11:40 am ET.
A live and archived webcast of the Morgan Stanley Conference fireside chat will be available on the company's investor relations website. This presentation offers investors an opportunity to gain insights into Rapport Therapeutics' progress in developing innovative treatments for central nervous system disorders.
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