PureTech Health plc American Depositary Shares - PRTC STOCK NEWS

PureTech Health (Nasdaq: PRTC, LSE: PRTC), a clinical-stage biotherapeutics company, has announced its management team's participation in two upcoming investor conferences. Bharatt Chowrira, CEO, and Eric Elenko, Co-founder and President, will present at the UBS Global Healthcare Conference on November 13, 2024, at 8:45 a.m. PST, and the Jefferies London Healthcare Conference on November 19, 2024, at 2:30 p.m. GMT. Webcasts of both presentations will be accessible through PureTech's investor relations website.

PureTech Health's Founded Entity, Seaport Therapeutics, has closed an oversubscribed $225 million Series B financing round, bringing its total capital raised to $325 million since its launch in April 2024. The round was led by General Atlantic, with participation from various top-tier investors and founding investors.

Seaport will use the proceeds to advance its clinical-stage pipeline of neuropsychiatric medicines and further develop its Glyph™ technology platform. The platform is designed to enhance oral bioavailability and reduce side effects of clinically active drugs. PureTech will hold a 36.7% equity ownership in Seaport on a diluted basis following the financing.

Seaport's pipeline includes SPT-300 for major depressive disorder, SPT-320 for generalized anxiety disorder, and SPT-348 for mood and other neuropsychiatric disorders. The company aims to deliver novel therapeutics for patients suffering from depression, anxiety, and other neuropsychiatric disorders.

PureTech Health presented research on idiopathic pulmonary fibrosis (IPF) and its clinical trial strategy for LYT-100 (deupirfenidone) at the CHEST 2024 Annual Meeting. The company shared insights from a 90-person IPF patient survey, highlighting the high disease burden and gaps in symptom management. Key findings include:

- 86% experience shortness of breath
- 78% report fatigue
- 77% suffer from cough
- Differences in care between ILD centers and community pulmonary practices

PureTech also presented its plan to use a Bayesian approach in evaluating the Phase 2b ELEVATE IPF trial of LYT-100. This method aims to enhance statistical power and reduce placebo group size. Topline results from the trial are expected by the end of 2024.

PureTech Health plc (Nasdaq: PRTC, LSE: PRTC) announced its participation in the CHEST 2024 Annual Meeting in Boston from October 6-9. The company will present three studies related to LYT-100 (deupirfenidone) for treating idiopathic pulmonary fibrosis (IPF). These presentations will inform clinical, commercial, and patient engagement strategies for LYT-100.

Key points:

• Topline data from the Phase 2b ELEVATE IPF trial of LYT-100 is expected by the end of 2024
• A streamlined development program is planned, potentially advancing to Phase 3 pending positive outcomes and regulatory feedback
• PureTech believes successful Phase 2b and Phase 3 trials could support registration in the U.S. and other regions

The presentations will cover patient experiences at ILD centers vs. community practices, the ongoing burden of IPF in the antifibrotic era, and a Bayesian approach for the ELEVATE IPF trial.

PureTech Health announced that KarXT, now marketed as Cobenfy, has received FDA approval for treating schizophrenia in adults. This milestone triggers $29 million in payments to PureTech and unlocks potential future payments and royalties. Cobenfy, invented by PureTech, is the first new drug mechanism approved in over 50 years for schizophrenia treatment.

The approval validates PureTech's unique R&D model, which has now produced three FDA-approved therapeutics. PureTech has generated approximately $1.1 billion from its involvement with Karuna Therapeutics, which was recently acquired by Bristol Myers Squibb. This success enables PureTech to self-fund the advancement of several programs, including LYT-100 for idiopathic pulmonary fibrosis, with topline data expected by year-end.

PureTech Health's Founded Entity, Vor Bio (Nasdaq: VOR), announced new clinical data from its ongoing Phase 1/2 VBP101 study of trem-cel followed by Mylotarg in relapsed/refractory AML patients. The data showed:

• Reliable engraftment with 100% primary neutrophil engraftment
• High CD33 editing efficiency (median 89%)
• Shielding of the blood system across multiple Mylotarg doses
• Broadened therapeutic index for Mylotarg
• Early evidence of patient benefit in relapse-free survival

Vor Bio plans to discuss a pivotal trial design with the FDA by year-end. The company also reported progress with VCAR33ALLO and introduced a new preclinical asset, VADC45, targeting CD45 for various blood disorders.

PureTech Health plc (Nasdaq: PRTC, LSE: PRTC) has announced the appointment of Michele Holcomb, PhD, to its board of directors as an independent non-executive director, effective September 23, 2024. Dr. Holcomb brings over 30 years of experience in global healthcare, having held notable positions at Cardinal Health, Teva Pharmaceuticals, and McKinsey & Company. Her expertise in leading transformational growth initiatives and driving organizational progress is expected to complement PureTech's board leadership as the company enters its next phase of growth.

Dr. Holcomb will join the Audit Committee, while Dr. Raju Kucherlapati, Chair of the PureTech Board, will step down from this committee. The appointment is seen as strategic for PureTech's focus on innovating and progressing major advances for patients, leveraging Dr. Holcomb's broad biopharma experience to deliver on the company's commitment to developing innovative medicines and building shareholder value.

PureTech Health plc (Nasdaq: PRTC, LSE: PRTC) has announced plans to release its half-yearly results for the six months ended June 30, 2024, on Wednesday, August 28, 2024. The company will host a presentation and conference call for analysts and shareholders at 9:00am EDT / 2:00pm BST on the same day. Interested parties can access a webcast of the presentation on PureTech's investor relations website. This announcement provides investors and analysts with a scheduled opportunity to review PureTech's financial performance and operational progress for the first half of 2024.

PureTech Health (Nasdaq: PRTC, LSE: PRTC) announced that its Founded Entity, Seaport Therapeutics, has appointed David Wheadon, M.D., to its Board of Directors. Dr. Wheadon brings over 30 years of experience in regulatory affairs, clinical strategy, and global health policy from major pharmaceutical companies.

Dr. Wheadon most recently served as Senior Vice President of Global Regulatory Affairs, Patient Safety and Quality Assurance at AstraZeneca. He has also held leadership positions at PhRMA, Juvenile Diabetes Research Foundation, Abbott, GlaxoSmithKline, and Eli Lilly. His expertise is expected to benefit Seaport as they advance their clinical-stage pipeline of therapeutics for depression, anxiety, and other neuropsychiatric disorders.