Polyrizon Initiates Preclinical Studies for Intranasal Naloxone Targeting Opioid Overdose Based on Its Innovative T&T Platform
Polyrizon (Nasdaq: PLRZ) has initiated preclinical studies for intranasal Naloxone, targeting opioid overdose treatment using its proprietary Trap and Target™ (T&T) platform. The study will be conducted in collaboration with Professor Fabio Sonvico from the University of Parma, focusing on key parameters like drug loading capacity, release kinetics, nasal deposition, and stability.
The company aims to enhance intranasal Naloxone delivery by improving bioavailability and optimizing drug release profiles for rapid opioid reversal in emergency situations. This development addresses the ongoing global opioid crisis, particularly driven by fentanyl and synthetic opioids.
Market projections indicate significant growth potential:
- Global Naloxone market expected to reach $2.47 billion by 2032 (11% CAGR)
- Naloxone intranasal spray market projected to hit $1.4 billion by 2030
Polyrizon (Nasdaq: PLRZ) ha avviato studi preclinici per il Naloxone intranasale, mirati al trattamento delle overdose da oppioidi utilizzando la sua piattaforma proprietaria Trap and Target™ (T&T). Lo studio sarà condotto in collaborazione con il Professor Fabio Sonvico dell'Università di Parma, concentrandosi su parametri chiave come la capacità di caricamento del farmaco, la cinetica di rilascio, la deposizione nasale e la stabilità.
L'azienda mira a migliorare la somministrazione intranasale di Naloxone aumentando la biodisponibilità e ottimizzando i profili di rilascio del farmaco per un rapido recupero dagli oppioidi in situazioni di emergenza. Questo sviluppo affronta la continua crisi globale degli oppioidi, particolarmente alimentata dal fentanyl e dagli oppioidi sintetici.
Le proiezioni di mercato indicano un significativo potenziale di crescita:
- Il mercato globale del Naloxone è previsto raggiungere i 2,47 miliardi di dollari entro il 2032 (CAGR dell'11%)
- Il mercato degli spray intranasali di Naloxone è proiettato a colpire 1,4 miliardi di dollari entro il 2030
Polyrizon (Nasdaq: PLRZ) ha iniciado estudios preclínicos para el Naloxona intranasal, dirigido al tratamiento de sobredosis por opioides utilizando su plataforma patentada Trap and Target™ (T&T). El estudio se llevará a cabo en colaboración con el Profesor Fabio Sonvico de la Universidad de Parma, centrándose en parámetros clave como la capacidad de carga del fármaco, la cinética de liberación, la deposición nasal y la estabilidad.
La empresa tiene como objetivo mejorar la entrega de Naloxona intranasal aumentando la biodisponibilidad y optimizando los perfiles de liberación del fármaco para una rápida reversión de opioides en situaciones de emergencia. Este desarrollo aborda la continua crisis global de opioides, impulsada en particular por el fentanilo y los opioides sintéticos.
Las proyecciones del mercado indican un potencial de crecimiento significativo:
- Se espera que el mercado global de Naloxona alcance los 2.47 mil millones de dólares para 2032 (CAGR del 11%)
- Se proyecta que el mercado de aerosoles intranasales de Naloxona alcance los 1.4 mil millones de dólares para 2030
Polyrizon (Nasdaq: PLRZ)는 독점 Trap and Target™ (T&T) 플랫폼을 사용하여 오피오이드 과다복용 치료를 목표로 하는 비강 내 날록손에 대한 전임상 연구를 시작했습니다. 이 연구는 파르마 대학교의 파비오 손비코 교수와 협력하여 약물 적재 용량, 방출 동력학, 비강 침착 및 안정성과 같은 주요 매개변수에 중점을 두고 진행될 것입니다.
회사는 긴급 상황에서 오피오이드의 빠른 역전 효과를 위해 생체이용률을 높이고 약물 방출 프로파일을 최적화하여 비강 내 날록손 전달을 개선하는 것을 목표로 하고 있습니다. 이 개발은 특히 펜타닐과 합성 오피오이드에 의해 촉발된 지속적인 글로벌 오피오이드 위기에 대응합니다.
시장 전망은 상당한 성장 잠재력을 나타냅니다:
- 전 세계 날록손 시장은 2032년까지 24억 7천만 달러에 이를 것으로 예상됩니다 (연평균 성장률 11%)
- 비강 내 날록손 스프레이 시장은 2030년까지 14억 달러에 이를 것으로 예상됩니다
Polyrizon (Nasdaq: PLRZ) a lancé des études précliniques pour le Naloxone intranasal, visant à traiter les overdoses d'opioïdes en utilisant sa plateforme propriétaire Trap and Target™ (T&T). L'étude sera menée en collaboration avec le professeur Fabio Sonvico de l'Université de Parme, en se concentrant sur des paramètres clés tels que la capacité de chargement du médicament, la cinétique de libération, la déposition nasale et la stabilité.
L'entreprise vise à améliorer l'administration intranasale de Naloxone en augmentant la biodisponibilité et en optimisant les profils de libération du médicament pour une inversion rapide des opioïdes en cas d'urgence. Ce développement répond à la crise mondiale des opioïdes en cours, particulièrement alimentée par le fentanyl et les opioïdes synthétiques.
Les projections du marché indiquent un potentiel de croissance significatif:
- Le marché mondial du Naloxone devrait atteindre 2,47 milliards de dollars d'ici 2032 (CAGR de 11 %)
- Le marché des sprays intranasaux de Naloxone devrait atteindre 1,4 milliard de dollars d'ici 2030
Polyrizon (Nasdaq: PLRZ) hat präklinische Studien für intranasales Naloxon initiiert, die sich auf die Behandlung von Opioidüberdosierungen konzentrieren und dabei die proprietäre Trap and Target™ (T&T) Plattform nutzen. Die Studie wird in Zusammenarbeit mit Professor Fabio Sonvico von der Universität Parma durchgeführt und konzentriert sich auf wichtige Parameter wie die Arzneimittelbeladungskapazität, die Freisetzungskinetik, die nasale Ablagerung und die Stabilität.
Das Unternehmen zielt darauf ab, die intranasale Naloxon-Abgabe zu verbessern, indem die Bioverfügbarkeit erhöht und die Freisetzungsprofile des Arzneimittels für eine schnelle Umkehrung von Opioiden in Notfallsituationen optimiert werden. Diese Entwicklung adressiert die anhaltende globale Opioidkrise, die insbesondere durch Fentanyl und synthetische Opioide vorangetrieben wird.
Marktprognosen deuten auf ein erhebliches Wachstumspotenzial hin:
- Der globale Naloxon-Markt wird voraussichtlich bis 2032 2,47 Milliarden Dollar erreichen (11 % CAGR)
- Der Markt für intranasale Naloxon-Sprays wird voraussichtlich bis 2030 1,4 Milliarden Dollar erreichen
- Entering preclinical studies phase for intranasal Naloxone development
- Targeting large market opportunity: $2.47B global Naloxone market by 2032
- Partnership with leading expert in intranasal drug delivery
- Proprietary T&T platform could provide competitive advantages in drug delivery
- Early-stage development (preclinical phase) with no guaranteed success
- Company still in development stage with no commercial products
- Facing established competition in the Naloxone market
Insights
Polyrizon's initiation of preclinical studies for intranasal Naloxone represents a strategic early-stage research milestone for this micro-cap biotech company. The company is targeting the opioid overdose treatment market with its Trap and Target™ (T&T) platform technology, which could potentially enhance drug delivery effectiveness.
The planned preclinical studies will evaluate fundamental parameters such as drug loading capacity, release kinetics, nasal deposition and stability - essential foundational work that must precede any safety or efficacy testing. This represents the first step in a lengthy development process that typically includes multiple preclinical studies, IND filing, and phased clinical trials before potential regulatory approval.
The market opportunity is substantial, with the global Naloxone market projected to reach
For a company with a market capitalization of just
This announcement establishes a potential development trajectory but represents an extremely early stage in pharmaceutical development with significant technical, regulatory, and commercial hurdles ahead.
Polyrizon's entry into the intranasal Naloxone space positions them in a growing market segment with established clinical need. Their approach focuses on potentially addressing key limitations of current intranasal Naloxone formulations through their proprietary T&T platform technology.
The intranasal route offers substantial advantages over injectable Naloxone - including ease of administration by non-medical personnel, elimination of needlestick risks, and significantly improved accessibility in emergency situations. These benefits have driven substantial market growth for intranasal formulations.
However, this market already has FDA-approved competitors (like Narcan® and generic alternatives), creating a high bar for differentiation. For Polyrizon to capture meaningful market share, their technology would need to demonstrate clear advantages in either bioavailability, onset of action, cost, or convenience - outcomes that remain entirely theoretical at this preclinical stage.
The company's market capitalization of
While the underlying market trend is positive, with governments and healthcare systems expanding Naloxone access to combat rising overdose deaths, investors should view this announcement as establishing a potential development program rather than a near-term value driver. The timeline from preclinical studies to potential commercialization typically spans 5+ years, assuming successful progression through all development phases.
Raanana, Israel, March 10, 2025 (GLOBE NEWSWIRE) -- Polyrizon Ltd. (Nasdaq: PLRZ) (the "Company" or "Polyrizon"), a development stage biotech company specializing in the development of innovative intranasal hydrogels, announced today the initiation of preclinical studies for intranasal Naloxone, a life-saving opioid overdose treatment.
The study will be conducted in collaboration with Professor Fabio Sonvico, Associate Professor at the Department of Food and Drug of the University of Parma (Italy) a leading expert in the development of intranasal and pulmonary drug delivery solutions and a member of the Company’s Scientific Advisory Board.
These preclinical studies mark a step forward in evaluating Polyrizon’s Trap and Target™ (T&T) platform for the intranasal administration of Naloxone, an opioid antagonist designed to rapidly reverse opioid overdose. These studies will assess key parameters, such as drug loading capacity, release kinetics, nasal deposition and stability, laying the groundwork for further safety and efficacy testing in preclinical and clinical studies.
"The opioid crisis continues to be a global public health emergency and improving Naloxone administration is essential for saving lives," said Tomer Izraeli CEO of Polyrizon. "Our proprietary T&T platform is designed to optimize drug delivery, and we believe it holds the potential to enhance intranasal Naloxone by offering higher bioavailability for increased drug effectiveness and optimized drug release profiles that ensure rapid opioid reversal when every second counts. These advantages could make a critical difference in emergency overdose situations, providing a safer and more accessible solution for at-risk individuals and first responders."
The ongoing opioid epidemic, largely driven by fentanyl and other synthetic opioids, has led to a dramatic rise in overdose fatalities worldwide. Naloxone, an FDA-approved opioid antagonist, has been shown to reverse opioid toxicity when administered promptly after respiratory depression occurs. The global Naloxone market is projected to reach
Intranasal delivery of Naloxone presents several advantages, including ease of administration, eliminating the need for trained medical personnel, reduced risk of needlestick injuries and increased accessibility, allowing emergency responders, caregivers, and at-risk individuals to carry and use it effectively.
About Polyrizon
Polyrizon is a development stage biotech company specializing in the development of innovative medical device hydrogels delivered in the form of nasal sprays, which form a thin hydrogel-based shield containment barrier in the nasal cavity that can provide a barrier against viruses and allergens from contacting the nasal epithelial tissue. Polyrizon’s proprietary Capture and Contain TM, or C&C, hydrogel technology, comprised of a mixture of naturally occurring building blocks, is delivered in the form of nasal sprays, and potentially functions as a “biological mask” with a thin shield containment barrier in the nasal cavity. Polyrizon are further developing certain aspects of our C&C hydrogel technology such as the bioadhesion and prolonged retention at the nasal deposition site for intranasal delivery of drugs. Polyrizon refers to its additional technology, which is in an earlier stage of pre-clinical development, that is focused on nasal delivery of active pharmaceutical ingredients, or APIs, as Trap and Target ™, or T&T. For more information, please visit https://polyrizon-biotech.com.
Forward Looking Statements
This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995 and other securities laws. Words such as “expects,” “anticipates,” “intends,” “plans,” “believes,” “seeks,” “estimates” and similar expressions or variations of such words are intended to identify forward-looking statements. For example, the Company is using forward-looking statements when it discusses its belief that its Trap and Target™ (T&T) platform holds the potential to enhance intranasal Naloxone by offering higher bioavailability for increased drug effectiveness and optimized drug release profiles that ensure rapid opioid reversal. Forward-looking statements are not historical facts, and are based upon management’s current expectations, beliefs and projections, many of which, by their nature, are inherently uncertain. Such expectations, beliefs and projections are expressed in good faith. However, there can be no assurance that management’s expectations, beliefs and projections will be achieved, and actual results may differ materially from what is expressed in or indicated by the forward-looking statements. Forward-looking statements are subject to risks and uncertainties that could cause actual performance or results to differ materially from those expressed in the forward-looking statements. For a more detailed description of the risks and uncertainties affecting the Company, reference is made to the Company’s reports filed from time to time with the Securities and Exchange Commission (“SEC”), including, but not limited to, the risks detailed in the Company’s prospectus (Registration No. 333-266745), dated October 24, 2024 and filed with the SEC. Forward-looking statements speak only as of the date the statements are made. The Company assumes no obligation to update forward-looking statements to reflect actual results, subsequent events or circumstances, changes in assumptions or changes in other factors affecting forward-looking information except to the extent required by applicable securities laws. If the Company does update one or more forward-looking statements, no inference should be drawn that the Company will make additional updates with respect thereto or with respect to other forward-looking statements. References and links to websites have been provided as a convenience, and the information contained on such websites is not incorporated by reference into this press release. Polyrizon is not responsible for the contents of third-party websites.
Contacts:
Michal Efraty
Investor Relations
FAQ
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