Palisade Bio Inc - PALI STOCK NEWS

Palisade Bio (Nasdaq: PALI), a clinical-stage biopharmaceutical company focused on developing therapeutics for autoimmune, inflammatory, and fibrotic diseases, has participated in the Virtual Investor 'Top 5 for '25' On-Demand Conference. CEO JD Finley presented the company's top five investment highlights for 2025. The presentation is now available for viewing on the company's website and through the conference platform.

Palisade Bio (NASDAQ: PALI) presented positive preclinical data for PALI-2108, their oral colon-specific PDE4 inhibitor prodrug for ulcerative colitis treatment, at the 2025 Crohn's and Colitis Congress. The drug demonstrated effectiveness in reducing colitis symptoms in mice without CNS toxicity.

Key findings showed that PALI-2108 effectively converts to the active PDE4 inhibitor PALI-0008 in the colon following oral administration in mice, dogs, and humans. The drug outperformed standard treatments in preclinical studies, showing superior potency and target engagement compared to other PDE4 inhibitors.

The company is currently conducting a Phase 1a/b clinical study (NCT06663605) evaluating safety, tolerability, and pharmacokinetics in healthy volunteers and UC patients. Topline data is expected in the first half of 2025.

Palisade Bio (NASDAQ: PALI) announced the acceptance of its abstract for poster presentation at the 2025 Crohn's & Colitis Congress in San Francisco. The presentation, scheduled for February 7, 2025, will showcase research on PALI-2108, a colon-specific PDE4B inhibitor prodrug. The poster, titled 'PALI-2108, a Colon-Specific PDE4B Inhibitor Prodrug is Activated in the Colon and Reduces Ulcerative Colitis Symptoms in an Acute Colitis DSS Mouse Model,' will be presented during the Poster and Exhibition Hall Reception at Moscone West.

Palisade Bio (Nasdaq: PALI), a clinical-stage biopharmaceutical company specializing in autoimmune, inflammatory, and fibrotic diseases, has announced its upcoming participation in the LIVE! with Webull Corporate Connect: Healthcare Investment Webinar. JD Finley, the company's Chief Executive Officer, will present at the virtual event scheduled for Wednesday, January 29, 2025, at 2:20 PM ET.

The presentation will be part of the Virtual Biotech Investment Webinar segment of the conference, offering investors an opportunity to gain insights into Palisade Bio's developments and strategic direction in the healthcare sector.

Palisade Bio (NASDAQ: PALI) has successfully completed all five Single Ascending Dose (SAD) cohorts and advanced to Multiple Ascending Dose (MAD) cohorts in its Phase 1a/b study of PALI-2108 for Ulcerative Colitis treatment. The SAD study, testing doses from 15mg to 450mg, demonstrated favorable safety and tolerability with no serious adverse events or treatment-related laboratory abnormalities.

The preliminary pharmacokinetic analysis showed PALI-2108's delayed-release and extended-release characteristics, providing sustained, dose-dependent drug exposure with high local concentrations in the colon. Only mild treatment-emergent adverse events were observed at the highest dose of 450mg.

The ongoing MAD portion will assess repeat dosing and further evaluate safety and pharmacokinetics in both healthy volunteers and UC patients. The company remains on track to report topline data in the first half of 2025.

Palisade Bio (NASDAQ: PALI), a clinical-stage biopharmaceutical company focused on developing therapeutics for autoimmune, inflammatory, and fibrotic diseases, has announced an inducement grant under Nasdaq Listing Rule 5635(c)(4). The company has issued stock options to a new employee as part of its 2021 Inducement Plan.

The grant consists of options to purchase 2,600 shares of common stock, issued on January 3, 2025, with an exercise price matching the closing price on the grant date. The options will vest quarterly over a three-year period, subject to continued employment with the company.

Palisade Bio (NASDAQ: PALI) has appointed Dr. Brian G. Feagan to its Clinical Advisory Board. Dr. Feagan brings over 30 years of experience in gastroenterology and has served as Principal Investigator in more than 140 multi-center randomized controlled trials for Crohn's disease and ulcerative colitis. He currently serves as a Professor of Medicine at the Schulich School of Medicine & Dentistry and is the Senior Scientific Director of Alimentiv, Inc.

His expertise will support the development of PALI-2108, the company's treatment candidate for ulcerative colitis. Dr. Feagan highlighted PALI-2108's potential advantages, particularly its localized bioactivation approach, which could address tolerability issues associated with systemic distribution of similar therapeutics.

Palisade Bio (NASDAQ: PALI) has closed its previously announced underwritten public offering, raising approximately $5 million in gross proceeds. The offering consists of 158,000 Class A Units (common stock + warrants) at $1.525 per unit and 3,120,688 Class B Units (prefunded warrants + warrants) at $1.5249 per unit. The Common Warrants have a $1.40 exercise price with a five-year term.

Ladenburg Thalmann & Co. acted as sole bookrunner, with a 45-day option to purchase additional shares/warrants. The company has repriced approximately one million previously issued warrants to $1.40 per share. Net proceeds will fund Phase 1 clinical trial of PALI-2108, pre-clinical studies, research and development, and working capital.

Palisade Bio (NASDAQ: PALI) has announced the pricing of an underwritten public offering expected to generate approximately $5 million in gross proceeds. The offering consists of 158,000 Class A Units (common stock plus warrants) at $1.525 per unit and 3,120,688 Class B Units (prefunded warrants plus warrants) at $1.5249 per unit. The Common Warrants will have an exercise price of $1.40 per share with a five-year term.

Ladenburg Thalmann & Co. Inc. is serving as the sole bookrunning manager. The offering is expected to close around December 13, 2024. The company plans to use the proceeds to fund their Phase 1 clinical trial of PALI-2108, pre-clinical studies, research and development, and working capital.