Orchestra BioMed Announces Data Demonstrating Favorable Impact of AVIM Therapy on Diastolic Dysfunction, a Key Driver of Heart Failure Progression, will be Presented as Late-Breaking Science at the THT 2025 Conference
Orchestra BioMed (NASDAQ: OBIO) announced late-breaking data showing favorable effects of atrioventricular interval modulation (AVIM) therapy on diastolic dysfunction in hypertensive patients. The retrospective analysis of the MODERATO II study revealed that AVIM therapy significantly improved echocardiographic markers of diastolic dysfunction, a key factor in heart failure development.
Key findings from the study of 36 patients with sufficient Echo data (61% with diastolic dysfunction) showed that AVIM therapy reduced ambulatory systolic blood pressure by 8.3±9.7 mmHg in treated patients versus 2.2±9.8 mmHg in the control group. Office systolic blood pressure decreased by 12.1±12.8 mmHg in treated patients compared to an increase of 2.9±26.4 mmHg in controls.
The therapy also demonstrated significant improvements in key measures of diastolic function, including increased e' (from 5.9±2.0 to 8.8±3.4cm/sec) and E/A ratio (from 0.86±0.39 to 1.60±0.84), indicating improved left ventricular relaxation and filling.
Orchestra BioMed (NASDAQ: OBIO) ha annunciato dati recenti che mostrano effetti favorevoli della modulazione dell'intervallo atrioventricolare (AVIM) sulla disfunzione diastolica nei pazienti ipertesi. L'analisi retrospettiva dello studio MODERATO II ha rivelato che la terapia AVIM ha migliorato significativamente i marcatori ecocardiografici della disfunzione diastolica, un fattore chiave nello sviluppo dell'insufficienza cardiaca.
I risultati chiave dello studio su 36 pazienti con dati ecografici sufficienti (61% con disfunzione diastolica) hanno mostrato che la terapia AVIM ha ridotto la pressione arteriosa sistolica ambulatoriale di 8.3±9.7 mmHg nei pazienti trattati rispetto a 2.2±9.8 mmHg nel gruppo di controllo. La pressione arteriosa sistolica in ufficio è diminuita di 12.1±12.8 mmHg nei pazienti trattati rispetto a un aumento di 2.9±26.4 mmHg nei controlli.
La terapia ha inoltre dimostrato miglioramenti significativi in misure chiave della funzione diastolica, inclusi l'aumento di e' (da 5.9±2.0 a 8.8±3.4 cm/sec) e il rapporto E/A (da 0.86±0.39 a 1.60±0.84), indicando un miglioramento del rilassamento e del riempimento ventricolare sinistro.
Orchestra BioMed (NASDAQ: OBIO) anunció datos de última hora que muestran efectos favorables de la modulación del intervalo auriculoventricular (AVIM) en la disfunción diastólica en pacientes hipertensos. El análisis retrospectivo del estudio MODERATO II reveló que la terapia AVIM mejoró significativamente los marcadores ecocardiográficos de la disfunción diastólica, un factor clave en el desarrollo de la insuficiencia cardíaca.
Los hallazgos clave del estudio de 36 pacientes con datos de ecocardiografía suficientes (61% con disfunción diastólica) mostraron que la terapia AVIM redujo la presión arterial sistólica ambulatoria en 8.3±9.7 mmHg en los pacientes tratados frente a 2.2±9.8 mmHg en el grupo de control. La presión arterial sistólica en consultorio disminuyó en 12.1±12.8 mmHg en los pacientes tratados en comparación con un aumento de 2.9±26.4 mmHg en los controles.
La terapia también demostró mejoras significativas en medidas clave de la función diastólica, incluyendo el aumento de e' (de 5.9±2.0 a 8.8±3.4 cm/seg) y la relación E/A (de 0.86±0.39 a 1.60±0.84), lo que indica una mejor relajación y llenado del ventrículo izquierdo.
Orchestra BioMed (NASDAQ: OBIO)는 고혈압 환자에서 심실 이완 기능 장애에 대한 심방심실 간격 조절(AVIM) 치료의 유리한 효과를 보여주는 최신 데이터를 발표했습니다. MODERATO II 연구의 후향적 분석에 따르면, AVIM 치료는 심부전 발병의 주요 요소인 이완 기능 장애의 심초음파 마커를 유의미하게 개선했습니다.
충분한 심초음파 데이터가 있는 36명의 환자를 대상으로 한 연구의 주요 결과(61%가 이완 기능 장애)를 보면, AVIM 치료는 치료받은 환자에서 8.3±9.7 mmHg의 외래 수축기 혈압을 감소시킨 반면, 대조군에서는 2.2±9.8 mmHg에 불과했습니다. 진료소에서의 수축기 혈압은 치료받은 환자에서 12.1±12.8 mmHg 감소한 반면, 대조군에서는 2.9±26.4 mmHg 증가했습니다.
이 치료는 또한 e'(5.9±2.0에서 8.8±3.4 cm/sec로) 및 E/A 비율(0.86±0.39에서 1.60±0.84로)의 주요 지표에서 유의미한 개선을 보여주어 좌심실 이완 및 충전이 개선되었음을 나타냅니다.
Orchestra BioMed (NASDAQ: OBIO) a annoncé des données de dernière minute montrant des effets favorables de la modulation de l'intervalle atrioventriculaire (AVIM) sur la dysfonction diastolique chez les patients hypertendus. L'analyse rétrospective de l'étude MODERATO II a révélé que la thérapie AVIM améliorait significativement les marqueurs échocardiographiques de la dysfonction diastolique, un facteur clé dans le développement de l'insuffisance cardiaque.
Les résultats clés de l'étude portant sur 36 patients avec des données d'échographie suffisantes (61 % avec une dysfonction diastolique) ont montré que la thérapie AVIM réduisait la pression artérielle systolique ambulatoire de 8.3±9.7 mmHg chez les patients traités contre 2.2±9.8 mmHg dans le groupe témoin. La pression artérielle systolique en cabinet a diminué de 12.1±12.8 mmHg chez les patients traités par rapport à une augmentation de 2.9±26.4 mmHg chez les contrôles.
La thérapie a également démontré des améliorations significatives dans les mesures clés de la fonction diastolique, y compris une augmentation de e' (de 5.9±2.0 à 8.8±3.4 cm/sec) et du rapport E/A (de 0.86±0.39 à 1.60±0.84), indiquant une amélioration du relâchement et du remplissage ventriculaire gauche.
Orchestra BioMed (NASDAQ: OBIO) hat aktuelle Daten veröffentlicht, die positive Auswirkungen der Modulation des atrioventrikulären Intervalls (AVIM) auf die diastolische Dysfunktion bei hypertensiven Patienten zeigen. Die retrospektive Analyse der MODERATO II-Studie ergab, dass die AVIM-Therapie die echokardiographischen Marker der diastolischen Dysfunktion signifikant verbesserte, ein Schlüsselfaktor für die Entwicklung von Herzinsuffizienz.
Wichtige Ergebnisse der Studie an 36 Patienten mit ausreichenden Echodaten (61% mit diastolischer Dysfunktion) zeigten, dass die AVIM-Therapie den ambulanten systolischen Blutdruck bei behandelten Patienten um 8.3±9.7 mmHg im Vergleich zu 2.2±9.8 mmHg in der Kontrollgruppe senkte. Der systolische Blutdruck in der Arztpraxis sank bei behandelten Patienten um 12.1±12.8 mmHg im Vergleich zu einem Anstieg von 2.9±26.4 mmHg bei den Kontrollen.
Die Therapie zeigte auch signifikante Verbesserungen in den wichtigsten Maßen der diastolischen Funktion, einschließlich einer Erhöhung von e' (von 5.9±2.0 auf 8.8±3.4 cm/sec) und des E/A-Verhältnisses (von 0.86±0.39 auf 1.60±0.84), was auf eine verbesserte Entspannung und Füllung des linken Ventrikels hinweist.
- Significant reduction in ambulatory systolic blood pressure by 8.3±9.7 mmHg in treated patients
- Office systolic blood pressure decreased by 12.1±12.8 mmHg in treated patients
- Improved markers of diastolic function with significant increases in e' and E/A ratio
- Potential new treatment paradigm for hypertension in pacemaker-indicated patients
- study size with only 36 patients having sufficient Echo data
Insights
The late-breaking data from Orchestra BioMed's MODERATO II study represents a significant advancement in cardiovascular medicine. The study demonstrates dual benefits of AVIM therapy: blood pressure reduction and improved diastolic function. This is particularly noteworthy as current treatments typically address only one of these aspects.
The improvements in diastolic function markers are clinically meaningful:
- The e' velocity increase from 5.9 to 8.8 cm/sec indicates substantially improved heart muscle relaxation
- The E/A ratio improvement from 0.86 to 1.60 suggests better left ventricular filling efficiency
- The 8.3 mmHg reduction in ambulatory blood pressure is considered clinically significant for cardiovascular risk reduction
The market implications are substantial. With diastolic dysfunction affecting approximately 50% of heart failure patients, AVIM therapy could address an underserved market segment. The therapy's ability to improve both blood pressure and diastolic function positions it uniquely in the treatment landscape, potentially reducing the progression to heart failure in high-risk patients.
The ongoing BACKBEAT global pivotal study will be important for market adoption. If it confirms these findings, AVIM therapy could become a standard treatment option for pacemaker patients with hypertension, representing a significant revenue opportunity for Orchestra BioMed through its risk-reward sharing partnerships.
- Late-breaking oral presentation features echocardiographic data analysis showing favorable impact of AVIM therapy on MODERATO II study patients with diastolic dysfunction, a key component in the development of heart failure
- Hypertension is the leading cause of diastolic dysfunction; both conditions are common in older patients and contribute to the development of heart failure
NEW HOPE, Pa., Feb. 12, 2025 (GLOBE NEWSWIRE) -- Orchestra BioMed Holdings, Inc. (Nasdaq: OBIO) (“Orchestra BioMed” or the “Company”), a biomedical company accelerating high-impact technologies to patients through risk-reward sharing partnerships, today announced a late-breaking oral presentation of data on the benefits of atrioventricular interval modulation (“AVIM”) therapy on patients with diastolic dysfunction at the Technology and Heart Failure Therapeutics (“THT”) 2025 Conference in Boston, Massachusetts. The retrospective analysis of data from the MODERATO II study demonstrated that AVIM therapy significantly improved echocardiographic (“Echo”) markers of diastolic dysfunction, an important component in the development of heart failure, in hypertensive patients.
The presentation titled "Effects of Atrioventricular Interval Modulation (AVIM) Therapy in Subjects with Hypertension and Diastolic Dysfunction" is being delivered in a late-breaking clinical science session at THT by Marat Fudim, M.D., M.H.S. Advanced Heart Failure Cardiologist, Duke Health on Wednesday, February 12, 2025, at 10:43am ET.
Dr. Fudim commented, “For many patients with long-standing hypertension, the heart can undergo structural and functional changes that result in diastolic dysfunction, the progression of which is directly linked to the development of heart failure. By reducing systolic blood pressure and favorably impacting intra-cardiac pressures and volumes, AVIM therapy directly affects diastolic filling and myocardial relaxation. This analysis of MODERATO II data provides exciting insights that suggest that, beyond lowering systolic blood pressure, AVIM therapy improves diastolic function and leads to favorable ventricular remodeling. Given the strong link between uncontrolled hypertension, diastolic dysfunction, and heart failure, these findings highlight the opportunity to intervene earlier and leverage AVIM therapy for the prevention of heart failure.”
Key Findings:
A retrospective, treatment-blinded analysis of MODERATO II assessed the impact of 6 months of AVIM therapy on systolic blood pressure (“SBP”) and Echo markers of diastolic dysfunction (“DD”) using core lab Echos with independent blinded adjudication. Patients were classified as with DD (“DD+”) or without DD (“DD-”) using the American Society of Echocardiography Guidelines. From the MODERATO II study cohort (n=47), 36 patients had technically sufficient Echo data, and
Using key measures of diastolic function, AVIM therapy:
- Significantly reduced office and ambulatory SBP in patients with DD through 6 months
- Ambulatory SBP (“aSBP”) was reduced in AVIM-treated DD+ patients (N=12) by 8.3±9.7 mmHg (p<0.01 vs baseline) compared to 2.2±9.8 mmHg in the control DD+ group (N=10)
- Office SBP (“oSBP”) was reduced in AVIM-treated DD+ patients by 12.1±12.8 mmHg (p<0.01 vs baseline) compared to an increase of 2.9±26.4 mmHg in the control DD+ group (N=10)
- SBP reduction was similar in patients with and without DD
- Significantly improved key measures of diastolic dysfunction
- In patients with DD, AVIM therapy demonstrated favorable Echo changes consistent with improved myocardial relaxation and diastolic compliance. Specifically, in comparison to DD+ control patients, AVIM-treated DD+ patients experienced a significant increase in e’ (from 5.9±2.0 to 8.8±3.4cm/sec; P<0.01) consistent with an improvement in left ventricular relaxation and a significant increase in E/A (from 0.86±0.39 to 1.60±0.84; P<0.01) consistent with improved passive filling of the left ventricle despite reduced filling time (the designed effect of AVIM therapy) with no significant changes in left atrial size.
“The late-breaking data shared at THT present a broader view of the potential benefits of AVIM therapy for patients with uncontrolled hypertension and increased cardiovascular risk. These findings provide further evidence that AVIM therapy, in addition to significantly reducing systolic blood pressure, may also favorably influence ventricular function in important ways for patients with diastolic dysfunction and at risk for heart failure,” said Avi Fischer, M.D., Senior Vice President of Medical Affairs and Innovation at Orchestra BioMed. “This could provide a new paradigm for the treatment of hypertension and its many associated risks in pacemaker-indicated patients and other higher risk populations, offering the opportunity to potentially intervene earlier in disease progression. We are eager to continue exploring the clinical effects of AVIM therapy through the ongoing BACKBEAT global pivotal study in which we fully expect to see many hypertensive patients like these that are not adequately controlled with antihypertensive medication and also have diastolic dysfunction and increased risk for heart failure. We believe this robust, double-blind, randomized study will define AVIM therapy’s potential role in the management of uncontrolled high blood pressure and its broader cardiovascular effects.”
About Orchestra BioMed
Orchestra BioMed (Nasdaq: OBIO) is a biomedical innovation company accelerating high-impact technologies to patients through risk-reward sharing partnerships with leading medical device companies. Orchestra BioMed’s partnership-enabled business model focuses on forging strategic collaborations with leading medical device companies to drive successful global commercialization of products it develops. Orchestra BioMed’s lead product candidate is atrioventricular interval modulation (AVIM) therapy for the treatment of hypertension, a significant risk factor for death worldwide. Orchestra BioMed is also developing the Virtue® Sirolimus AngioInfusion™ Balloon (SAB) for the treatment of atherosclerotic artery disease, the leading cause of mortality worldwide. Orchestra BioMed has a strategic collaboration with Medtronic, one of the largest medical device companies in the world, for development and commercialization of AVIM therapy for the treatment of hypertension in pacemaker-indicated patients, and a strategic partnership with Terumo, a global leader in medical technology, for development and commercialization of Virtue SAB for the treatment of artery disease. For further information about Orchestra BioMed, please visit www.orchestrabiomed.com, and follow us on LinkedIn.
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About AVIM Therapy
AVIM therapy is an investigational therapy compatible with standard dual-chamber pacemakers designed to substantially and persistently lower blood pressure. It has been evaluated in pilot studies in patients with hypertension who are also indicated for a pacemaker. MODERATO II, a double-blind, randomized pilot study, showed that patients treated with AVIM therapy experienced net reductions of 8.1 mmHg in 24-hour ambulatory systolic blood pressure (aSBP) and 12.3 mmHg in office systolic blood pressure (oSBP) at six months when compared to control patients. The BACKBEAT (BradycArdia paCemaKer with atrioventricular interval modulation for Blood prEssure treAtmenT) global pivotal study will further evaluate the safety and efficacy of AVIM therapy in lowering blood pressure in a similar target population of patients who have been indicated for, and recently implanted with, a dual-chamber cardiac pacemaker.
Forward-Looking Statements
Certain statements included in this press release that are not historical facts are forward-looking statements for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995. Forward-looking statements generally are accompanied by words such as “believe,” “may,” “will,” “estimate,” “continue,” “anticipate,” “intend,” “expect,” “should,” “would,” “plan,” “predict,” “potential,” “seem,” “seek,” “future,” “outlook” and similar expressions that predict or indicate future events or trends or that are not statements of historical matters. These forward-looking statements include, but are not limited to, statements relating to the potential efficacy, safety and commercial value of the Company’s commercial product candidates, including the ability of AVIM therapy to favorably influence ventricular function, implementation of the Company’s ongoing BACKBEAT global pivotal study, the ability of the Company’s partnerships to accelerate clinical development, and the Company’s late-stage development programs and strategic partnerships. These statements are based on various assumptions, whether or not identified in this press release, and on the current expectations of the Company’s management and are not predictions of actual performance. These forward-looking statements are provided for illustrative purposes only and are not intended to serve as and must not be relied on as a guarantee, an assurance, a prediction, or a definitive statement of fact or probability. Actual events and circumstances are difficult or impossible to predict and may differ from assumptions. Many actual events and circumstances are beyond the control of the Company. These forward-looking statements are subject to a number of risks and uncertainties, including changes in domestic and foreign business, market, financial, political, and legal conditions; risks related to regulatory approval of the Company’s product candidates and ongoing regulation of the Company’s product candidates, if approved; the timing of, and the Company’s ability to achieve, expected regulatory and business milestones; the impact of competitive products and product candidates; and the risk factors discussed under the heading “Item 1A. Risk Factors” in the Company’s annual report on Form 10-K for the year ended December 31, 2023, which was filed with the U.S. Securities and Exchange Commission on March 27, 2024, as updated by any risk factors disclosed under the heading “Item 1A. Risk Factors” in the Company’s subsequently filed quarterly reports on Form 10-Q.
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Investor Contact
Silas Newcomb
Orchestra BioMed
(908) 723-4489
Snewcomb@orchestrabiomed.com
Media Contact
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FAQ
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