Novocure Announces 19 Presentations at American Association for Cancer Research (AACR) Annual Meeting 2022 Suggesting Broad Applicability of Tumor Treating Fields
Novocure (NASDAQ: NVCR) announced 19 presentations on Tumor Treating Fields (TTFields) at the AACR Annual Meeting 2022 in New Orleans, from April 8-13, 2022. The research spans 10 tumor types, showcasing the potential for TTFields in various solid tumors. Highlights include studies on TTFields' efficacy with PARP inhibitors and its effect on the blood-brain barrier. CEO Dr. Uri Weinberg emphasized the significance of this ongoing research, indicating a broad applicability of TTFields in cancer treatments. The global development program spans multiple clinical trials across various cancer types.
- 19 presentations on TTFields demonstrating broad applicability across 10 tumor types.
- Research suggests enhanced efficacy of TTFields in combination with existing therapies.
- No systemic toxicity reported from TTFields treatment; only mild skin irritation noted.
- None.
Presentation highlights include research on: transcriptomics (gene expression) analysis for identification of pathways that are activated in response to TTFields, concurrent treatment of ovarian cell lines with TTFields and PARP inhibitors, transient and reversible enhanced blood brain barrier permeability by TTFields in a human 3D in vitro model and efficacy of TTFields concomitant with radiation therapy in murine solid tumor models.
“We believe ongoing research on Tumor Treating Fields suggests the potential for TTFields applicability across a variety of tumor types,” said Dr.
Presentations from Novocure-sponsored and partner programs include:
(Abstract #: CT234) PANOVA-3: A phase 3 study of Tumor Treating Fields (TTFields) with gemcitabine and nab-paclitaxel (GnP) for front-line treatment of locally advanced pancreatic adenocarcinoma.
(Abstract #: 4138) Prediction of progression-free survival in patients with primary glioblastoma: MRI T2 relaxivity and deep learning. A. Rulseh (Clinical Research Excluding Trials)
(Abstract #: 3447) Tumor Treating Fields (TTFields) treatment planning for a patient with astrocytoma in the spinal cord.
(Abstract #: 3450) Impact of model inaccuracy on dose estimation in TTFields therapy.
(Abstract #: 1801) Application of Tumor Treating Fields (TTFields) to cancer cells enhances their membrane permeability. A. Haber (Experimental and Molecular Therapeutics)
(Abstract #: 2659) Inhibition of PI3K sensitized cancer cells to Tumor Treating Fields (TTFields).
(Abstract #: 3465) Efficacy of concomitant application of Tumor Treating Fields (TTFields), temozolomide and lomustine in glioblastoma cancer cells in vitro. E. Dor-On (Clinical Research Excluding Trials)
(Abstract #: 1866) Transcriptomics analysis for identification of pathways involved in the response to Tumor Treating Fields (TTFields).
(Abstract #: 2601) Concomitant treatment of ovarian cell lines with Tumor Treating Fields (TTFields) and PARP inhibitors. E. Dor-On (Experimental and Molecular Therapeutics)
(Abstract #: 1305) Tumor Treating Fields (TTFields) promote a pro-inflammatory phenotype in macrophages.
(Abstract #: 1833) Tumor Treating Fields induce DNA damage and apoptosis in medulloblastoma.
(Abstract #: 3252) Tumor Treating Fields suppression of ciliogenesis enhances temozolomide toxicity.
(Abstract #: 387) Blood brain barrier (BBB) disruption by Tumor Treating Fields (TTFields) in a human 3D in vitro model.
(Abstract #: 380) Tumor Treating Fields enhance cellular drug uptake in mesothelioma cell lines.
(Abstract #: 2037) Spatial omic changes of malignant pleural mesothelioma following treatment using Tumor Treating Fields.
(Abstract #: 3156) Tumor Treating Fields reduce cellular survival of human mesenchymal stromal cells via apoptosis and senescence induction. A. Rühle (Tumor Biology)
(Abstract #: 299) Self-assembling nanoparticles: A novel approach for targeted cancer treatment using Tumor Treating Fields.
(Abstract #: 2315) Synergic antitumoral activity of TTFields stimulation and Chloride Intracellular
(Abstract #: 3316) Tumor Treating Fields in combination with radiation cause significant delay in tumor growth in in-vivo mice model.
About Tumor Treating Fields
Tumor Treating Fields, or TTFields, are electric fields that disrupt cancer cell division. Fundamental scientific research extends across more than two decades and, in all preclinical research to date, TTFields have demonstrated a consistent anti-mitotic effect. TTFields therapy is intended principally for use together with other standard-of-care cancer treatments. There is a growing body of evidence that supports TTFields’ broad applicability with certain other cancer therapies, including radiation therapy, certain chemotherapies and certain immunotherapies. In clinical research and commercial experience to date, TTFields therapy has exhibited no systemic toxicity, with mild to moderate skin irritation being the most common side effect. The TTFields global development program includes a network of preclinical collaborators and a broad range of clinical trials across all phases, including four phase 3 pivotal trials in a variety of tumor types. To date, more than 22,000 patients have been treated with TTFields therapy.
About Novocure
Novocure is a global oncology company working to extend survival in some of the most aggressive forms of cancer through the development and commercialization of its innovative therapy, Tumor Treating Fields. Novocure’s commercialized products are approved in certain countries for the treatment of adult patients with glioblastoma and in the
Headquartered in Jersey, and with a growing global footprint, Novocure has regional operating centers in Root,
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