Nuvation Bio to Present Matching-adjusted Indirect Comparison Data for Taletrectinib vs. Crizotinib During Mini Oral Presentation at the European Lung Cancer Congress 2025

Rhea-AI Summary

Nuvation Bio (NYSE: NUVB) has announced an upcoming presentation of new comparative data for taletrectinib versus crizotinib in treating ROS1-positive non-small cell lung cancer (NSCLC) at the European Lung Cancer Congress 2025 in Paris.

The research, featuring a matching-adjusted indirect comparison study, will be presented by Dr. Misako Nagasaka, Associate Professor at UCI School of Medicine's Division of Hematology and Oncology. The mini oral presentation, numbered LBA2, is scheduled for March 27, 2025, from 4:00 p.m. to 5:05 p.m. CET (11:00 a.m. to 12:05 p.m. ET).

The presentation materials will be subsequently available in the Publications section of Nuvation Bio's website.

NEW YORK--(BUSINESS WIRE)-- Nuvation Bio Inc. (NYSE: NUVB), a global biopharmaceutical company tackling some of the greatest unmet needs in oncology, today announced that new data from a matching-adjusted indirect comparison study evaluating taletrectinib versus crizotinib in ROS1-positive (ROS1+) non-small cell lung cancer (NSCLC) will be reported in a mini oral presentation at the European Lung Cancer Congress taking place March 26–29, 2025 in Paris, France.

Mini Oral Presentation Overview:

Title: Taletrectinib vs crizotinib in ROS1-positive non-small cell lung cancer: A matching-adjusted indirect comparison
Presenter: Misako Nagasaka, M.D., Ph.D., Associate Professor – Division of Hematology and Oncology, UCI School of Medicine
Date: Thursday, March 27, 2025
Session Time: 4:00 p.m. – 5:05 p.m. CET / 11:00 a.m. – 12:05 p.m. ET
Session: Mini Oral Session 1
Presentation Number: LBA2

The materials will be made available in the Publications section of Nuvation Bio’s website after the presentation.

About Taletrectinib

Taletrectinib is an oral, potent, central nervous system-active, selective, next-generation ROS1 inhibitor specifically designed for the treatment of patients with advanced ROS1+ NSCLC. Taletrectinib is being evaluated for the treatment of patients with advanced ROS1+ NSCLC in two Phase 2 single-arm pivotal studies: TRUST-I (NCT04395677) in China, and TRUST-II (NCT04919811), a global study.

Based on pooled results of the TRUST-I and TRUST-II clinical studies, the U.S. FDA has accepted and granted Priority Review to Nuvation Bio’s NDA for taletrectinib for advanced ROS1+ NSCLC (line agnostic, full approval) and assigned a PDUFA goal date of June 23, 2025. The U.S. FDA previously granted taletrectinib Breakthrough Therapy Designation for the treatment of patients with locally advanced or metastatic ROS1+ NSCLC who either have or have not previously been treated with ROS1 TKIs, and Orphan Drug Designation for the treatment of patients with ROS1+ NSCLC and other NSCLC indications. In January 2025, China’s NMPA approved taletrectinib for the treatment of adult patients with locally advanced or metastatic ROS1+ NSCLC.

About Nuvation Bio

Nuvation Bio is a global biopharmaceutical company tackling some of the greatest unmet needs in oncology by developing differentiated and novel product candidates. Nuvation Bio’s programs include taletrectinib (ROS1), safusidenib (mIDH1), NUV-1511 (DDC), and NUV-868 (BET). Nuvation Bio was founded in 2018 by biopharma industry veteran David Hung, M.D., who previously founded Medivation, Inc., which brought to patients one of the world’s leading prostate cancer medicines. Nuvation Bio has offices in New York, San Francisco, Boston, and Shanghai. For more information, please visit www.nuvationbio.com or follow the Company on LinkedIn and X (@nuvationbioinc).

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Nuvation Bio Investor Contact:

ir@nuvationbio.com



Nuvation Bio Media Contact:

media@nuvationbio.com

Source: Nuvation Bio Inc.

FAQ

When will Nuvation Bio (NUVB) present the taletrectinib comparison data at ELCC 2025?

Nuvation Bio will present the data on March 27, 2025, from 4:00-5:05 p.m. CET during Mini Oral Session 1.

What type of cancer treatment is NUVB's taletrectinib being compared to?

Taletrectinib is being compared to crizotinib in treating ROS1-positive non-small cell lung cancer (NSCLC).

Who will present NUVB's taletrectinib comparison study at ELCC 2025?

Dr. Misako Nagasaka, Associate Professor from UCI School of Medicine's Division of Hematology and Oncology, will present the study.

Where can investors find NUVB's taletrectinib presentation materials after the ELCC event?

The presentation materials will be available in the Publications section of Nuvation Bio's website after the presentation.