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Monopar Therapeutics Inc. - MNPR STOCK NEWS

Welcome to our dedicated page for Monopar Therapeutics news (Ticker: MNPR), a resource for investors and traders seeking the latest updates and insights on Monopar Therapeutics stock.

Monopar Therapeutics Inc. (Nasdaq: MNPR) is a clinical-stage biopharmaceutical company focused on developing proprietary therapeutics aimed at prolonging life and enhancing the quality of life for cancer patients. Founded in 2014 and headquartered in Wilmette, Illinois, the company has made significant strides in the oncology sector with a robust pipeline of innovative treatments.

Monopar's leading candidate, Validive®, is a clonidine mucobuccal tablet currently in Phase III clinical trials. It aims to treat severe oral mucositis in patients undergoing radiation therapy for oropharyngeal cancer. Another key product, camsirubicin, is a next-generation analog of doxorubicin designed to limit cardiotoxicity while retaining its anticancer efficacy. This compound is presently in a Phase 1b dose-escalation trial for soft tissue sarcoma.

Additionally, Monopar is developing MNPR-101, a humanized monoclonal antibody targeting the urokinase plasminogen activator receptor (uPAR) for the treatment of advanced solid tumors and severe COVID-19. The company's MNPR-101-Zr is currently enrolling patients in a Phase 1 dosimetry clinical trial to evaluate its safety and biodistribution in various advanced cancers.

Monopar has established strategic partnerships to bolster its research and development efforts. The collaboration with Grupo Español de Investigación en Sarcomas is pivotal for advancing camsirubicin, while the partnership with NorthStar Medical Radioisotopes focuses on developing radio-immuno-therapeutics, including the supply of actinium-225 (Ac-225) for MNPR-101.

Financially, Monopar reported significant progress in reducing net loss from $10.5 million in 2022 to $8.4 million in 2023. The company ended 2023 with $7.3 million in cash and additional funding of $3.2 million expected in Q1 2024. These resources are projected to sustain operations through June 2025, enabling Monopar to reach key clinical milestones.

For more information on Monopar Therapeutics and their groundbreaking work in oncology, visit www.monopartx.com.

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Monopar Therapeutics Inc. (MNPR) announces promising preclinical imaging and therapeutic efficacy data for its MNPR-101 radiopharmaceutical program targeting cancers expressing uPAR, including triple-negative breast, colorectal, and pancreatic cancers. The company's in-house team successfully increased tumor uptake while minimizing healthy tissue uptake, showcasing high specificity and durable tumor uptake. Preclinical data demonstrate compelling anti-tumor benefits with near complete tumor elimination in human tumor xenograft mouse models. Monopar received clearance to begin a Phase 1 dosimetry clinical trial for MNPR-101-Zr in advanced cancer patients.
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Monopar Therapeutics Inc. (MNPR) receives clearance for a Phase 1 dosimetry trial of MNPR-101-Zr, a radiopharmaceutical targeting uPAR-expressing tumors. The trial aims to assess tumor uptake, biodistribution, and safety using PET imaging. Positive preclinical results support the potential for MNPR-101 as a targeted radiopharmaceutical for various advanced cancer indications.
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MNPR - Monopar Therapeutics Inc. Announces Third Quarter 2023 Financial Results and Recent Developments including MNPR-101 Radiopharma Program entering First-in-Human Studies and Camsirubicin Phase 1b Trial Efficacy and Safety Data. MNPR-101 is a highly selective antibody against uPAR, showing promising results in preclinical studies. Camsirubicin Phase 1b Trial has treated patients with advanced soft tissue sarcoma, with positive results and no observed dose-limiting toxicity. MNPR-202, a camsirubicin analog, shows encouraging preclinical results. The third quarter ended with $8.5 million in cash and a net loss of $2.0 million.
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Monopar Therapeutics Inc. will present data from its ongoing Phase 1b clinical trial of camsirubicin in patients with advanced soft tissue sarcoma at the 2023 Connective Tissue Oncology Society Annual Meeting. So far, 9 out of 14 patients have had stable disease after camsirubicin treatment, and 3 patients experienced a 20% tumor size reduction. No dose-limiting toxicity has been observed.
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Monopar Therapeutics to present at Roth MKM 2023 Healthcare Opportunities Conference
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Monopar Therapeutics to present at H.C. Wainwright Conference
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Monopar Therapeutics Inc. announces encouraging results from the Phase 1b trial of Camsirubicin, with tumor size reductions in patients. MNPR-101 radiopharma program is progressing towards first-in-human studies. Second quarter 2023 financial results show a net loss of $2.2 million.
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Monopar Therapeutics provides positive update on Phase 1b clinical trial of camsirubicin in patients with advanced soft tissue sarcoma (ASTS). Tumor size reductions of 18% and 20% observed in patients at 650 mg/m2 dose level. Dose-response hypothesis supported. No drug-related cardiotoxicity observed. Hair loss and oral mucositis rates lower compared to doxorubicin. Phase 2 trial planned with GEIS collaboration.
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Monopar Therapeutics Inc. has announced a collaboration with the Cancer Science Institute of Singapore to evaluate radiopharmaceutical versions of MNPR-101 in aggressive cancers. Dr. Anand Jeyasekharan will be the Principal Investigator on the collaboration. The collaboration aims to identify high uPAR expressing cancers and explore the use of radiolabeled MNPR-101 for clinical imaging and potential therapeutic options.
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FAQ

What is the current stock price of Monopar Therapeutics (MNPR)?

The current stock price of Monopar Therapeutics (MNPR) is $25.82 as of December 20, 2024.

What is the market cap of Monopar Therapeutics (MNPR)?

The market cap of Monopar Therapeutics (MNPR) is approximately 125.6M.

What is Monopar Therapeutics Inc.?

Monopar Therapeutics Inc. is a clinical-stage biopharmaceutical company focused on developing innovative treatments for cancer patients.

What are the key products in Monopar's pipeline?

Monopar's pipeline includes Validive® for severe oral mucositis, camsirubicin for soft tissue sarcoma, MNPR-101 for advanced cancers and severe COVID-19, and MNPR-101-Zr for imaging advanced cancers.

What is the status of Validive®?

Validive® is in Phase III clinical trials aimed at treating severe oral mucositis in oropharyngeal cancer patients undergoing radiation therapy.

Who are Monopar's key partners?

Monopar has partnered with Grupo Español de Investigación en Sarcomas for camsirubicin development and NorthStar Medical Radioisotopes for radio-immuno-therapeutics.

What financial position does Monopar hold?

As of December 31, 2023, Monopar had $7.3 million in cash with an additional $3.2 million expected in Q1 2024. These funds are projected to sustain operations through June 2025.

What is MNPR-101?

MNPR-101 is a humanized monoclonal antibody targeting uPAR for treating advanced solid tumors and severe COVID-19, currently in a Phase 1 dosimetry clinical trial.

How has Monopar reduced its net loss?

Monopar's net loss decreased from $10.5 million in 2022 to $8.4 million in 2023, primarily due to reductions in R&D and clinical trial expenses.

What are the future plans for MNPR-101?

Monopar plans to expand the clinical trial for MNPR-101-Zr or initiate new studies testing its efficacy with a therapeutic radioisotope based on Phase 1 results.

What collaborations support Monopar's MNPR-101 development?

Monopar collaborates with NorthStar Medical Radioisotopes, which supplies Ac-225 and aids in the development of MNPR-101 for radiopharmaceutical applications.

Where can I find more information about Monopar?

For more information, visit Monopar's official website at www.monopartx.com.

Monopar Therapeutics Inc.

Nasdaq:MNPR

MNPR Rankings

MNPR Stock Data

125.56M
3.01M
42.94%
24.47%
1.42%
Biotechnology
Pharmaceutical Preparations
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United States of America
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