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Monopar Therapeutics Inc. - MNPR STOCK NEWS

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Monopar Therapeutics Inc. (Nasdaq: MNPR) is a clinical-stage biopharmaceutical company focused on developing proprietary therapeutics aimed at prolonging life and enhancing the quality of life for cancer patients. Founded in 2014 and headquartered in Wilmette, Illinois, the company has made significant strides in the oncology sector with a robust pipeline of innovative treatments.

Monopar's leading candidate, Validive®, is a clonidine mucobuccal tablet currently in Phase III clinical trials. It aims to treat severe oral mucositis in patients undergoing radiation therapy for oropharyngeal cancer. Another key product, camsirubicin, is a next-generation analog of doxorubicin designed to limit cardiotoxicity while retaining its anticancer efficacy. This compound is presently in a Phase 1b dose-escalation trial for soft tissue sarcoma.

Additionally, Monopar is developing MNPR-101, a humanized monoclonal antibody targeting the urokinase plasminogen activator receptor (uPAR) for the treatment of advanced solid tumors and severe COVID-19. The company's MNPR-101-Zr is currently enrolling patients in a Phase 1 dosimetry clinical trial to evaluate its safety and biodistribution in various advanced cancers.

Monopar has established strategic partnerships to bolster its research and development efforts. The collaboration with Grupo Español de Investigación en Sarcomas is pivotal for advancing camsirubicin, while the partnership with NorthStar Medical Radioisotopes focuses on developing radio-immuno-therapeutics, including the supply of actinium-225 (Ac-225) for MNPR-101.

Financially, Monopar reported significant progress in reducing net loss from $10.5 million in 2022 to $8.4 million in 2023. The company ended 2023 with $7.3 million in cash and additional funding of $3.2 million expected in Q1 2024. These resources are projected to sustain operations through June 2025, enabling Monopar to reach key clinical milestones.

For more information on Monopar Therapeutics and their groundbreaking work in oncology, visit www.monopartx.com.

Rhea-AI Summary

Monopar Therapeutics Inc. reported its first-quarter 2024 financial results and a strategic focus on its radiopharma pipeline. The company initiated the MNPR-101-Zr Phase 1 clinical trial and aims to launch the MNPR-101-RIT Phase 1 trial by Q4 2024 or Q1 2025. Monopar is winding down non-radiopharma programs to concentrate resources on radiopharma assets. The company is well-funded till at least June 30, 2025, with a net loss of $1.6 million for Q1 2024. R&D expenses decreased, while G&A expenses saw a slight drop.

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Monopar Therapeutics Inc. announced that its abstract on the preclinical data for its radiopharmaceutical program MNPR-101-Zr has been selected for a presentation at the Society of Nuclear Medicine and Molecular Imaging 2024 Annual Meeting in Toronto, Canada. The event, scheduled from June 8 to June 11, 2024, is a significant platform for showcasing innovative treatments for cancer patients.
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Monopar Therapeutics Inc. files a provisional patent application for MNPR-101 radiopharma optimization findings, aiming to enhance the clinical profile of the construct and strengthen intellectual property. The company focuses on developing innovative cancer treatments, with recent advancements in the MNPR-101-Zr construct and Phase 1 dosimetry clinical trial initiation.
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Monopar Therapeutics Inc. announces the activation of its Phase 1 dosimetry clinical trial for MNPR-101-Zr, a radiopharmaceutical imaging agent targeting uPAR in various cancers. The trial, led by Professor Rodney Hicks at MTIC, aims to evaluate safety and dosimetry in advanced cancer patients.
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Monopar Therapeutics Inc. (Nasdaq: MNPR) reported its fourth quarter and full-year 2023 financial results, along with recent developments. The company announced the initiation of a Phase 1 dosimetry clinical trial for its MNPR-101 Radiopharmaceutical Program targeting uPAR. Positive preclinical data support the potential of MNPR-101 to provide significant clinical benefits. Monopar also shared biodistribution data using therapeutic radioisotopes conjugated to MNPR-101, showing promising results in tumor elimination. The company is enrolling patients in the fifth dose level cohort for its Camsirubicin Phase 1b Dose-Escalation Trial. Financially, Monopar reported $7.3 million in cash and short-term investments as of December 31, 2023, with a net loss of $1.8 million for the fourth quarter of 2023. Research and Development expenses decreased, while General and Administrative expenses slightly increased.
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Monopar Therapeutics Inc. (MNPR) announces positive preclinical imaging data for its proprietary uPAR targeting agent MNPR-101, demonstrating highly preferential uptake in tumors. The data support the tumor-targeting ability of MNPR-101 and explain the elimination of tumors observed in previous studies. Monopar also received clearance to begin a Phase 1 dosimetry clinical trial for MNPR-101-Zr in advanced cancer patients, reinforcing its efforts in developing radiodiagnostic and radiotherapeutic treatments for uPAR-positive cancers.
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Monopar Therapeutics Inc. announced that Professor Rodney Hicks will lead the MNPR-101-Zr Phase 1 dosimetry clinical trial in advanced cancer patients using advanced PET/CT scanners. The trial aims to develop innovative treatments for pancreatic cancer and triple negative breast cancer.
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Monopar Therapeutics Inc. (MNPR) announces promising preclinical imaging and therapeutic efficacy data for its MNPR-101 radiopharmaceutical program targeting cancers expressing uPAR, including triple-negative breast, colorectal, and pancreatic cancers. The company's in-house team successfully increased tumor uptake while minimizing healthy tissue uptake, showcasing high specificity and durable tumor uptake. Preclinical data demonstrate compelling anti-tumor benefits with near complete tumor elimination in human tumor xenograft mouse models. Monopar received clearance to begin a Phase 1 dosimetry clinical trial for MNPR-101-Zr in advanced cancer patients.
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Monopar Therapeutics Inc. (MNPR) receives clearance for a Phase 1 dosimetry trial of MNPR-101-Zr, a radiopharmaceutical targeting uPAR-expressing tumors. The trial aims to assess tumor uptake, biodistribution, and safety using PET imaging. Positive preclinical results support the potential for MNPR-101 as a targeted radiopharmaceutical for various advanced cancer indications.
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MNPR - Monopar Therapeutics Inc. Announces Third Quarter 2023 Financial Results and Recent Developments including MNPR-101 Radiopharma Program entering First-in-Human Studies and Camsirubicin Phase 1b Trial Efficacy and Safety Data. MNPR-101 is a highly selective antibody against uPAR, showing promising results in preclinical studies. Camsirubicin Phase 1b Trial has treated patients with advanced soft tissue sarcoma, with positive results and no observed dose-limiting toxicity. MNPR-202, a camsirubicin analog, shows encouraging preclinical results. The third quarter ended with $8.5 million in cash and a net loss of $2.0 million.
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FAQ

What is the current stock price of Monopar Therapeutics (MNPR)?

The current stock price of Monopar Therapeutics (MNPR) is $19.71 as of November 21, 2024.

What is the market cap of Monopar Therapeutics (MNPR)?

The market cap of Monopar Therapeutics (MNPR) is approximately 103.0M.

What is Monopar Therapeutics Inc.?

Monopar Therapeutics Inc. is a clinical-stage biopharmaceutical company focused on developing innovative treatments for cancer patients.

What are the key products in Monopar's pipeline?

Monopar's pipeline includes Validive® for severe oral mucositis, camsirubicin for soft tissue sarcoma, MNPR-101 for advanced cancers and severe COVID-19, and MNPR-101-Zr for imaging advanced cancers.

What is the status of Validive®?

Validive® is in Phase III clinical trials aimed at treating severe oral mucositis in oropharyngeal cancer patients undergoing radiation therapy.

Who are Monopar's key partners?

Monopar has partnered with Grupo Español de Investigación en Sarcomas for camsirubicin development and NorthStar Medical Radioisotopes for radio-immuno-therapeutics.

What financial position does Monopar hold?

As of December 31, 2023, Monopar had $7.3 million in cash with an additional $3.2 million expected in Q1 2024. These funds are projected to sustain operations through June 2025.

What is MNPR-101?

MNPR-101 is a humanized monoclonal antibody targeting uPAR for treating advanced solid tumors and severe COVID-19, currently in a Phase 1 dosimetry clinical trial.

How has Monopar reduced its net loss?

Monopar's net loss decreased from $10.5 million in 2022 to $8.4 million in 2023, primarily due to reductions in R&D and clinical trial expenses.

What are the future plans for MNPR-101?

Monopar plans to expand the clinical trial for MNPR-101-Zr or initiate new studies testing its efficacy with a therapeutic radioisotope based on Phase 1 results.

What collaborations support Monopar's MNPR-101 development?

Monopar collaborates with NorthStar Medical Radioisotopes, which supplies Ac-225 and aids in the development of MNPR-101 for radiopharmaceutical applications.

Where can I find more information about Monopar?

For more information, visit Monopar's official website at www.monopartx.com.

Monopar Therapeutics Inc.

Nasdaq:MNPR

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103.02M
3.01M
42.94%
24.47%
1.42%
Biotechnology
Pharmaceutical Preparations
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United States of America
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