Immutep Announces Second Japanese Patent Grant for LAG-3 Antagonist Antibody LAG525
Immutep Limited (ASX: IMM; NASDAQ: IMMP) announced the grant of patent no. 7030750 by the Japanese Patent Office for antibody molecules targeting LAG-3, crucial for cancer treatment. This divisional patent follows a previous grant in 2019, with corresponding patents in territories like Australia, China, Europe, and the U.S. The patent, co-owned with Novartis AG, will expire on March 13, 2035. LAG525, a humanized form of IMP701, is being evaluated by Novartis in clinical trials for cancer, with Immutep set to receive milestone payments and royalties upon commercialization.
- Grant of Japanese patent no. 7030750 enhances Immutep's intellectual property portfolio.
- LAG525 is under clinical evaluation by Novartis, providing potential future revenue streams.
- Patent covers pharmaceutical compositions for cancer treatment, indicating strong market relevance.
- Dependency on Novartis for the development of LAG525 limits Immutep's control over drug commercialization.
- No immediate financial metrics provided, creating uncertainty about short-term revenue impact.
SYDNEY, AUSTRALIA, March 18, 2022 (GLOBE NEWSWIRE) -- Immutep Limited (ASX: IMM; NASDAQ: IMMP) ("Immutep” or “the Company”), is pleased to announce the grant of patent no. 7030750 entitled “Antibody molecules to LAG-3 and uses thereof” by the Japanese Patent Office.
This new Japanese patent was filed as a divisional application and follows the grant of the parent Japanese patent announced in 2019. Corresponding patents in this family have been granted in other territories including Australia, China, Europe and the United States, as announced in 2018 through 2021.
The claims of the patent are directed to pharmaceutical compositions for use in the treatment of cancer, where the composition comprises LAG525 in a specific dose and for use in a defined treatment regimen. The compositions may also be administered in combination with a second agent such as an anti-PD-1 antibody, an anti-PD-L1 antibody or a chemotherapeutic agent.
The patent is co-owned by Novartis AG and Immutep S.A.S., and will expire on 13 March 2035.
LAG525 (INN: leramilimab) is a humanised form of Immutep’s IMP701 antibody, the rights to which are fully out-licensed to Novartis.
About IMP701 and LAG525
IMP701 is a therapeutic antagonist antibody originally developed by Immutep S.A. (now Immutep S.A.S.) to target LAG-3. This antibody plays a role in controlling the signalling pathways in both effector T cells and regulatory T cells (Treg). The antibody works by activating effector T cells by blocking inhibitory signals that would otherwise switch them off, and also by inhibiting Treg function that normally prevents T cells from responding to antigen stimulation. The antibody therefore removes two brakes that prevent the immune system from killing cancer cells. In contrast, some other antagonist LAG-3 antibodies in development target only the effector T cell pathway and don’t address the Treg pathway.
LAG525, a humanised form of IMP701, is being evaluated by Novartis in Phase I and Phase II clinical trials for the treatment of cancer. Novartis has full responsibility for the continued development of the antibody program and Immutep is eligible to receive development-based milestone payments and royalties on sales following commercialisation of the antibody.
About Immutep
Immutep is a globally active biotechnology company that is a leader in the development of LAG-3 related immunotherapeutic products for the treatment of cancer and autoimmune disease. Immutep is dedicated to leveraging its technology and expertise to bring innovative treatment options to market for patients and to maximize value to shareholders. Immutep is listed on the Australian Securities Exchange (IMM), and on the NASDAQ (IMMP) in the United States.
Immutep’s current lead product candidate is eftilagimod alpha (“efti” or “IMP321”), a soluble LAG-3 fusion protein (LAG-3Ig), which is a first-in-class antigen presenting cell (APC) activator being explored in cancer and infectious disease. Immutep is also developing an agonist of LAG-3 (IMP761) for autoimmune disease. Additional LAG-3 products, including antibodies for immune response modulation, are being developed by Immutep’s large pharmaceutical partners.
Further information can be found on the Company’s website www.immutep.com or by contacting:
Australian Investors/Media:
Catherine Strong, Citadel-MAGNUS
+61 (0)406 759 268; cstrong@citadelmagnus.com
U.S. Media:
Tim McCarthy, LifeSci Advisors
+1 (212) 915.2564; tim@lifesciadvisors.com
FAQ
What is the significance of the patent granted to Immutep Limited on March 18, 2022?
What is LAG525 and how is it related to Immutep Limited?
How does Immutep Limited benefit from the Japanese patent no. 7030750?
What is the expiration date of the new patent granted to Immutep Limited?
Which territories have corresponding patents granted to Immutep Limited besides Japan?
