G1 Therapeutics Provides Second Quarter 2024 Financial Results and Operational Highlights
G1 Therapeutics (Nasdaq: GTHX) reported Q2 2024 financial results and operational highlights. Key points include:
1. Merger agreement with Pharmacosmos for $7.15 per share, expected to close in late Q3 2024.
2. COSELA net revenue of $15.8 million, a 12% increase from Q1.
3. Reaffirmed 2024 COSELA net revenue guidance of $60-70 million.
4. Q2 net loss of $5.5 million, compared to net income of $8.7 million in Q2 2023.
5. Cash runway extended to anticipated profitability in H2 2025.
6. License agreements for lerociclib with Pepper Bio and Deimos Biosciences.
7. Positive Phase 2 results for trilaciclib in combination with TROP2 ADC.
8. Discontinued mTNBC indication after Phase 3 PRESERVE 2 trial missed primary OS endpoint.
G1 Therapeutics (Nasdaq: GTHX) ha riportato i risultati finanziari e i punti salienti operativi per il secondo trimestre del 2024. I punti chiave includono:
1. Accordo di fusione con Pharmacosmos a $7.15 per azione, previsto per la chiusura entro la fine del terzo trimestre del 2024.
2. Ricavi netti di COSELA pari a $15.8 milioni, un aumento del 12% rispetto al primo trimestre.
3. Conferma della guidance sui ricavi netti di COSELA per il 2024, pari a $60-70 milioni.
4. Perdita netta nel secondo trimestre di $5.5 milioni, rispetto a un utile netto di $8.7 milioni nel secondo trimestre del 2023.
5. Estensione della liquidità fino a una profittabilità prevista nel secondo semestre del 2025.
6. Accordi di licenza per lerociclib con Pepper Bio e Deimos Biosciences.
7. Risultati positivi della Fase 2 per trilaciclib in combinazione con TROP2 ADC.
8. Interruzione dell'indicazione mTNBC dopo che il trial di Fase 3 PRESERVE 2 ha mancato il principale obiettivo di sopravvivenza globale.
G1 Therapeutics (Nasdaq: GTHX) presentó los resultados financieros y los aspectos operativos del segundo trimestre de 2024. Los puntos clave incluyen:
1. Acuerdo de fusión con Pharmacosmos a $7.15 por acción, que se espera cerrar a finales del tercer trimestre de 2024.
2. Ingresos netos de COSELA de $15.8 millones, un aumento del 12% en comparación con el primer trimestre.
3. Reafirmación de la proyección de ingresos netos de COSELA para 2024 de $60-70 millones.
4. Pérdida neta del segundo trimestre de $5.5 millones, en comparación con un ingreso neto de $8.7 millones en el segundo trimestre de 2023.
5. Ampliación de la liquidez hasta la rentabilidad anticipada en la segunda mitad de 2025.
6. Acuerdos de licencia para lerociclib con Pepper Bio y Deimos Biosciences.
7. Resultados positivos de la Fase 2 para trilaciclib en combinación con TROP2 ADC.
8. Descontinuación de la indicación mTNBC tras el fallo del ensayo de Fase 3 PRESERVE 2 en su objetivo primario de supervivencia.
G1 Therapeutics (Nasdaq: GTHX)는 2024년 2분기 재무 결과 및 운영 하이라이트를 발표했습니다. 주요 사항은 다음과 같습니다:
1. Pharmacosmos와의 합병 계약은 주당 $7.15로, 2024년 3분기 말에 마감될 것으로 예상됩니다.
2. COSELA의 순수익은 $15.8 백만으로, 1분기 대비 12% 증가했습니다.
3. 2024년 COSELA 순수익 전망을 $60-70 백만으로 재확인했습니다.
4. 2분기 순손실은 $5.5 백만으로, 2023년 2분기 순이익 $8.7 백만에 비해 감소했습니다.
5. 2025년 하반기 예상 수익성까지 현금 자금이 연장되었습니다.
6. Pepper Bio 및 Deimos Biosciences와 lerociclib에 대한 라이센스 계약.
7. TROP2 ADC와 병용한 trilaciclib의 긍정적인 2상 결과.
8. 3상 PRESERVE 2 시험에서 주요 생존 목표를 달성하지 못한 후 mTNBC 적응증이 중단되었습니다.
G1 Therapeutics (Nasdaq: GTHX) a publié les résultats financiers et les points forts opérationnels pour le deuxième trimestre de 2024. Les points clés incluent :
1. Accord de fusion avec Pharmacosmos à 7,15 $ par action, dont la clôture est attendue à la fin du troisième trimestre 2024.
2. Chiffre d'affaires net de COSELA de 15,8 millions $, soit une augmentation de 12 % par rapport au premier trimestre.
3. Confirmation de la prévision de chiffre d'affaires net de COSELA pour 2024 de 60 à 70 millions $.
4. Perte nette au deuxième trimestre de 5,5 millions $, contre un bénéfice net de 8,7 millions $ au deuxième trimestre 2023.
5. Durée de cash prolongée jusqu'à une rentabilité prévue au second semestre 2025.
6. Accords de licence pour lerociclib avec Pepper Bio et Deimos Biosciences.
7. Résultats positifs de la phase 2 pour trilaciclib en combinaison avec TROP2 ADC.
8. Arrêt de l'indication mTNBC après que l'essai de phase 3 PRESERVE 2 n'a pas atteint son objectif principal de survie.
G1 Therapeutics (Nasdaq: GTHX) hat die finanziellen Ergebnisse und operativen Highlights für das 2. Quartal 2024 bekannt gegeben. Die wichtigsten Punkte sind:
1. Fusionsvereinbarung mit Pharmacosmos zu 7,15 $ pro Aktie, die voraussichtlich Ende Q3 2024 abgeschlossen wird.
2. Nettoerlöse von COSELA in Höhe von 15,8 Millionen $, was einem Anstieg von 12 % gegenüber Q1 entspricht.
3. Bestätigung der Prognose für Nettoerlöse von COSELA für 2024 zwischen 60 und 70 Millionen $.
4. Nettoverlust im 2. Quartal von 5,5 Millionen $, verglichen mit einem Nettogewinn von 8,7 Millionen $ im 2. Quartal 2023.
5. Liquiditätsvorlauf bis zur erwarteten Rentabilität im 2. Halbjahr 2025 verlängert.
6. Lizenzvereinbarungen für lerociclib mit Pepper Bio und Deimos Biosciences.
7. Positive Phase-2-Ergebnisse für trilaciclib in Kombination mit TROP2 ADC.
8. Einstellung der mTNBC-Indikation, nachdem die Phase-3-Studie PRESERVE 2 das primäre Überlebensziel verfehlt hat.
- COSELA net revenue grew 12% quarter-over-quarter to $15.8 million
- Reaffirmed 2024 COSELA net revenue guidance of $60-70 million
- Vial volume grew 10% in Q2 compared to Q1 2024
- Expected 25-30% reduction in full-year operational expenses compared to 2023
- Cash runway extended to anticipated profitability in H2 2025
- License agreements for lerociclib with potential for up to $135 million in milestone payments
- Net loss of $5.5 million in Q2 2024 compared to net income of $8.7 million in Q2 2023
- Total revenues decreased to $16.5 million in Q2 2024 from $42.4 million in Q2 2023
- Phase 3 PRESERVE 2 trial in mTNBC did not achieve primary OS endpoint
- Discontinued all expenditures into the mTNBC indication and market
Insights
The Q2 2024 results for G1 Therapeutics show mixed signals. On the positive side, COSELA net revenue grew
The company's cost-cutting efforts are noteworthy, with operating expenses down to
The pending acquisition by Pharmacosmos at
The clinical updates for G1 Therapeutics' trilaciclib present a mixed picture. The positive efficacy results from the Phase 2 trial of trilaciclib in combination with sacituzumab govitecan (SG) are encouraging. The median overall survival of 15.9 months compared to the expected 12.1 months for SG alone is noteworthy, as is the
However, the final analysis of the Phase 3 PRESERVE 2 trial in metastatic triple-negative breast cancer (mTNBC) is disappointing. While trilaciclib showed myeloprotective effects, it failed to meet the primary overall survival endpoint. This led to the discontinuation of all expenditures in the mTNBC indication, which is a significant setback for the company's pipeline.
The myeloprotective effects of trilaciclib remain consistent across studies, which could still provide value in combination therapies. However, the mixed results highlight the challenges in developing new cancer treatments and the importance of diversifying clinical pipelines.
The pending acquisition of G1 Therapeutics by Pharmacosmos is a significant development for the company and its shareholders. The offer price of
The licensing agreements for lerociclib with Pepper Bio and Deimos Biosciences demonstrate G1's ability to monetize its pipeline assets. These deals could provide additional revenue streams and validate the potential of G1's drug candidates beyond COSELA.
However, the mixed clinical results and financial performance create uncertainty about G1's standalone prospects. The acquisition by Pharmacosmos may provide the resources and support needed to fully realize COSELA's potential and advance other pipeline candidates. For investors, this transaction offers a definitive exit point, albeit at a valuation that may not fully reflect the long-term potential of G1's assets.
- Entered into Definitive Merger Agreement to be Acquired by Pharmacosmos; Transaction Expected to Close in Late Third Quarter 2024 -
- Achieved
- Drove Double Digit Quarter-Over-Quarter Growth in COSELA Vial Volume and Net Revenue -
- Reaffirmed 2024 Net COSELA Revenue Guidance of Between
- Due to the Pending Transaction with Pharmacosmos, G1 will Not Host a Conference Call and Webcast to Discuss the Second Quarter Financial Results and Business Update -
RESEARCH TRIANGLE PARK, N.C., Aug. 08, 2024 (GLOBE NEWSWIRE) -- G1 Therapeutics, Inc. (Nasdaq: GTHX), a commercial-stage oncology company, today provided a corporate and financial update for the second quarter ended June 30, 2024.
"We are excited about what will be possible by the combined Pharmacosmos + G1 team as we meet the needs of more cancer patients. This transaction delivers a significant premium to our shareholders and better and broader access to COSELA for the cancer patients we seek to treat,” said Jack Bailey, Chief Executive Officer of G1 Therapeutics. “In the meantime, as we move toward closing, our focus remains on accelerating and expanding the growth of the COSELA business in extensive stage small cell lung cancer; the double-digit quarter-over-quarter growth we experienced in vial volume and net revenue represents continued progress in that regard. We also reaffirmed our 2024 net sales guidance of between
Second Quarter 2024 and Recent Highlights
Pending Transaction with Pharmacosmos
- G1 to be Acquired by Pharmacosmos: G1 announced a definitive merger agreement to be acquired by Pharmacosmos for
$7.15 per share. Specifically, on August 7, 2024, we and Pharmacosmos entered into an Agreement and Plan of Merger (the “Merger Agreement”), pursuant to which Pharmacosmos, through its U.S. subsidiary Pharmacosmos Therapeutics Inc., will cause a cash tender offer to be commenced to acquire all of the issued and outstanding shares of the Company’s common stock, at a price per share of$7.15 , net to the seller in cash, without interest and subject to any withholding of taxes required by applicable law. Following the consummation of the transaction, G1 will become a wholly owned subsidiary of Pharmacosmos. The transaction is expected to close late in the third quarter of 2024, subject to satisfaction or waiver of customary closing conditions. (See August 7, 2024 press release here)
Financial
- Net COSELA Revenue Grew
12% Over the Prior Quarter to$15.8 Million : Vial volume grew10% in the second quarter over the first quarter of 2024. - Year-Over-Year Reduction in Operating Expenses Expected in 2024: The Company now expects full year operational expense to be
25% to30% below that of 2023. - Current Cash Runway Extends to Profitability: G1 ended the second quarter of 2024 with cash, cash equivalents, and marketable securities of
$60.7 million . G1 believes it has sufficient cash runway to achieve anticipated company profitability in the second half of 2025.
Corporate
- Announced License Agreement for Lerociclib with Pepper Bio, Inc.: Pepper Bio will gain exclusive rights to develop, manufacture, and commercialize lerociclib for all indications except for certain radioprotectant uses in the US, Europe, Japan, and all other global markets, excluding the Asia-Pacific region. Under the terms of the agreement, G1 expects to receive upfront payments totaling mid-single digit millions within 12 months and is eligible to receive a maximum of
$135 million upon achievement of development and commercial milestones in up to three indications. Pepper Bio will pay G1 a low double-digit royalty on aggregate annual net sales of lerociclib. (see May 1, 2024 press release here) - Announced License Agreement for Lerociclib with Deimos Biosciences: Deimos Biosciences has the exclusive rights to develop, manufacture, and commercialize lerociclib for certain radioprotective uses in the US, Europe, Japan, and all other global markets, excluding the Asia-Pacific region, which G1 has already licensed to Genor Biopharma. Under the terms of the agreement, G1 is expected to receive shares of Deimos Biosciences’ common stock representing
10% of Deimos Biosciences’ outstanding equity capitalization on a fully diluted basis, in addition to a20% royalty on aggregate annual net sales of lerociclib. (See May 22, 2024 press release here)
Clinical
- Positive Efficacy Results from Phase 2 Trial of Trilaciclib in Combination with a TROP2 ADC Presented at the 2024 ASCO Annual Meeting: In the Intent-to-Treat (ITT) population, patients receiving trilaciclib prior to sacituzumab govitecan (SG) experienced a median overall survival (OS) of 15.9 months compared to the expected 12.1 months for SG alone based on historical data from the ASCENT trial. Twelve-month OS was
60% . Mature safety results show a clinically meaningful on-target effect of trilaciclib to reduce the rates of multiple treatment emergent adverse events associated with SG compared to the previously published SG single agent safety profile from the ASCENT trial, including measures of myelosuppression and diarrhea. (See May 28, 2024 press release here) - Final Analysis of the Phase 3 PRESERVE 2 Trial in 1L Metastatic Triple Negative Breast Cancer (mTNBC) Showed Continued Evidence of Myeloprotection But Did Not Achieve Primary OS Endpoint: Consistent with other trilaciclib studies, evidence of myeloprotection was observed, including a reduction in the occurrence of severe neutropenia, which occurred in
8% of patients who received trilaciclib compared to29% of patients in the control arm. The trial did not demonstrate a statistically significant treatment effect in the ITT population, with a Hazard Ratio of 0.91. The Company has discontinued all expenditures into the mTNBC indication and market. (See June 24, 2024 press release here)
Second Quarter 2024 Financial Results
As of June 30, 2024, cash, cash equivalents and marketable securities totaled
Total revenues for the second quarter of 2024 were
Operating expenses for the second quarter of 2024 were
Cost of goods sold expense for the second quarter of 2024 was
Research and development (R&D) expenses for the second quarter of 2024 were
Selling, general, and administrative (SG&A) expenses for the second quarter of 2024 were
The net loss for the second quarter of 2024 was
2024 Financial Guidance
G1 today reaffirmed its full year 2024 revenue guidance. G1's guidance is based on current expectations for continued sales growth of COSELA in the U.S. and achievement of its forecasts. The Company expects to generate between
Webcast and Conference Call
Due to the pending transaction with Pharmacosmos, G1 will no longer be hosting conference to review our second quarter 2024 results at 8:30 am ET today, as originally planned.
About COSELA® (trilaciclib) for Injection
COSELA (trilaciclib) was approved by the U.S. Food and Drug Administration on February 12, 2021.
Indication
COSELA® (trilaciclib) is indicated to decrease the incidence of chemotherapy-induced myelosuppression in adult patients when administered prior to a platinum/etoposide-containing regimen or topotecan-containing regimen for extensive-stage small cell lung cancer.
Important Safety Information
COSELA is contraindicated in patients with a history of serious hypersensitivity reactions to trilaciclib.
Warnings and precautions include injection-site reactions (including phlebitis and thrombophlebitis), acute drug hypersensitivity reactions, interstitial lung disease (pneumonitis), and embryo-fetal toxicity.
The most common adverse reactions (>
This information is not comprehensive. Please click here for full Prescribing Information. https://www.g1therapeutics.com/cosela/pi/
To report suspected adverse reactions, contact G1 Therapeutics at 1-800-790-G1TX or call FDA at 1-800-FDA-1088 or visit www.fda.gov/medwatch.
About G1 Therapeutics
G1 Therapeutics, Inc. is a commercial-stage oncology biopharmaceutical company whose mission is to develop and deliver next-generation therapies that improve the lives of those affected by cancer, including the Company’s first commercial product, COSELA® (trilaciclib). G1’s goal is to provide innovative therapeutic advances for people living with cancer. G1 is based in Research Triangle Park, N.C. For additional information, please visit www.g1therapeutics.com and follow us on X (formerly known as Twitter) @G1Therapeutics and LinkedIn.
G1 Therapeutics® and the G1 Therapeutics logo and COSELA® and the COSELA logo are trademarks of G1 Therapeutics, Inc.
Forward-Looking Statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, statements regarding the proposed acquisition of G1 by Pharmacosmos, the expected timetable for completing the transaction, and G1’s future financial or operating performance. The words “may,” “will,” “could,” “would,” “should,” “expect,” “plan,” “anticipate,” “intend,” “believe,” “estimate,” “predict,” “project,” “potential,” “continue,” “seek,” “target” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this document are based on management’s current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation: (i) risks associated with the timing of the closing of the proposed transaction, including the risks that a condition to closing would not be satisfied within the expected timeframe or at all or that the closing of the proposed transaction will not occur; (ii) uncertainties as to how many of G1’s stockholders will tender their shares in the offer; (iii) the possibility that a governmental entity may prohibit, delay or refuse to grant approval for the consummation of the transaction; (iv) the possibility that competing offers will be made; (v) the outcome of any legal proceedings that may be instituted against the parties and others related to the merger agreement; (vi) unanticipated difficulties or expenditures relating to the proposed transaction, the response of business partners and competitors to the announcement of the proposed transaction, and/or potential difficulties in employee retention as a result of the announcement and pendency of the proposed transaction; (vii) G1’s ability to successfully demonstrate the efficacy and safety of its drug or drug candidates, and the preclinical or clinical results for its product candidates, which may not support further development of such product candidates; (viii) comments, feedback and actions of regulatory agencies; (ix) G1’s dependence on the commercial success of COSELA (trilaciclib); (x) the inherent uncertainties associated with developing new products or technologies and operating as commercial stage company; (xi) chemotherapy shortages; and (xii) other risks identified in G1’s SEC filings, including G1’s Annual Report on Form 10-K for the year ended December 31, 2023, and subsequent filings with the SEC. G1 cautions you not to place undue reliance on any forward-looking statements, which speak only as of the date they are made. G1 disclaims any obligation to publicly update or revise any such statements to reflect any change in expectations or in events, conditions or circumstances on which any such statements may be based, or that may affect the likelihood that actual results will differ from those set forth in the forward-looking statements.
Additional Information and Where to Find It
The tender offer referred to in this document has not yet commenced. This document is for informational purposes only and is neither an offer to purchase nor a solicitation of an offer to sell shares, nor is it a substitute for the tender offer materials that Pharmacosmos and its acquisition subsidiary will file with the SEC upon commencement of the tender offer. At the time the tender offer is commenced, Pharmacosmos and its acquisition subsidiary will cause to be filed a tender offer statement on Schedule TO with the SEC, and G1 will file a solicitation/recommendation statement on Schedule 14D-9 with respect to the tender offer. THE TENDER OFFER STATEMENT (INCLUDING AN OFFER TO PURCHASE, A RELATED LETTER OF TRANSMITTAL AND OTHER OFFER DOCUMENTS) AND THE SOLICITATION/RECOMMENDATION STATEMENT WILL CONTAIN IMPORTANT INFORMATION THAT SHOULD BE READ CAREFULLY AND CONSIDERED BY G1’S STOCKHOLDERS BEFORE ANY DECISION IS MADE WITH RESPECT TO THE TENDER OFFER. Both the tender offer statement and the solicitation/recommendation statement will be mailed to G1’s stockholders free of charge. A free copy of the tender offer statement and the solicitation/recommendation statement will also be made available to all stockholders of G1 by accessing https://investor.g1therapeutics.com/ or by contacting Investor Relations at ir@g1therapeutics.com. In addition, the tender offer statement and the solicitation/recommendation statement (and all other documents filed with the SEC) will be available at no charge on the SEC’s website: www.sec.gov, upon filing with the SEC.
G1’S STOCKHOLDERS ARE ADVISED TO READ THE SCHEDULE TO AND THE SCHEDULE 14D-9, AS EACH MAY BE AMENDED OR SUPPLEMENTED FROM TIME TO TIME, AND ANY OTHER RELEVANT DOCUMENTS FILED WITH THE SEC WHEN THEY BECOME AVAILABLE BEFORE THEY MAKE ANY DECISION WITH RESPECT TO THE TENDER OFFER, BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION ABOUT THE PROPOSED TRANSACTION AND THE PARTIES THERETO.
G1 Therapeutics Contacts:
John W. Umstead V
Chief Financial Officer
919-747-8419
jumstead@g1therapeutics.com
Will Roberts
Communications Officer
Vice President, Investor Relations & Corporate Communications
919-907-1944
wroberts@g1therapeutics.com
| G1 Therapeutics, Inc. Balance Sheet Data (unaudited) (in thousands) | |||||||
| June 30, 2024 | December 31, 2023 | ||||||
| Cash and cash equivalents and Marketable securities | $ | 60,730 | $ | 82,156 | |||
| Working Capital | $ | 55,418 | $ | 85,232 | |||
| Total Assets | $ | 98,689 | $ | 121,540 | |||
| Accumulated deficit | $ | (795,673 | ) | $ | (779,985 | ) | |
| Total stockholders' equity | $ | 24,592 | $ | 35,386 | |||
| G1 Therapeutics, Inc. Condensed Statements of Operations (unaudited) (in thousands, except share and per share amounts) | |||||||||||||||
| Three Months Ended June 30, | Six Months Ended June 30, | ||||||||||||||
| 2024 | 2023 | 2024 | 2023 | ||||||||||||
| Revenues | |||||||||||||||
| Product sales, net | $ | 15,838 | $ | 11,091 | $ | 29,917 | $ | 21,583 | |||||||
| License revenue | 708 | 31,301 | 1,105 | 33,755 | |||||||||||
| Total revenues | 16,546 | 42,392 | 31,022 | 55,338 | |||||||||||
| Operating expenses | |||||||||||||||
| Cost of goods sold | 733 | 1,404 | 1,812 | 2,863 | |||||||||||
| Research and development | 5,738 | 12,040 | 13,056 | 27,520 | |||||||||||
| Selling, general and administrative | 13,610 | 17,432 | 28,737 | 39,185 | |||||||||||
| Total operating expenses | 20,081 | 30,876 | 43,605 | 69,568 | |||||||||||
| Income (loss) from operations | (3,535 | ) | 11,516 | (12,583 | ) | (14,230 | ) | ||||||||
| Other income (expense) | |||||||||||||||
| Interest income | 225 | 643 | 506 | 1,359 | |||||||||||
| Interest expense | (2,726 | ) | (2,710 | ) | (4,704 | ) | (5,799 | ) | |||||||
| Other income | 567 | 569 | 1,093 | 1,093 | |||||||||||
| Total other expense, net | (1,934 | ) | (1,498 | ) | (3,105 | ) | (3,347 | ) | |||||||
| Income (loss) before income taxes | (5,469 | ) | 10,018 | (15,688 | ) | (17,577 | ) | ||||||||
| Income tax expense | — | 1,308 | — | 1,308 | |||||||||||
| Net income (loss) | $ | (5,469 | ) | $ | 8,710 | $ | (15,688 | ) | $ | (18,885 | ) | ||||
| Earnings per share attributable to | |||||||||||||||
| Basic | $ | (0.10 | ) | $ | 0.17 | $ | (0.30 | ) | $ | (0.37 | ) | ||||
| Diluted | $ | (0.10 | ) | $ | 0.14 | $ | (0.30 | ) | $ | (0.37 | ) | ||||
| Weighted average common shares | |||||||||||||||
| Basic | 52,475,190 | 51,667,099 | 52,323,436 | 51,657,456 | |||||||||||
| Diluted | 52,475,190 | 61,040,507 | 52,323,436 | 51,657,456 | |||||||||||
FAQ
What was G1 Therapeutics' (GTHX) COSELA net revenue in Q2 2024?
What is the status of G1 Therapeutics' (GTHX) merger with Pharmacosmos?
What is G1 Therapeutics' (GTHX) financial guidance for COSELA revenue in 2024?
What were the results of G1 Therapeutics' (GTHX) Phase 3 PRESERVE 2 trial in mTNBC?
