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Pharmacosmos Group and G1 Therapeutics Announce Successful Closing of Tender Offer

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Pharmacosmos A/S has successfully completed the tender offer to acquire G1 Therapeutics (Nasdaq: GTHX) for $7.15 per share in cash, valuing the company at approximately $405 million. The transaction aims to maximize the access and uptake of COSELA® (trilaciclib), the first and only proactive multilineage myeloprotection agent. As of the expiration date, 74.64% of outstanding G1 Therapeutics shares were validly tendered. Following the merger, G1 Therapeutics will become a wholly owned subsidiary of Pharmacosmos Therapeutics Inc. G1 Therapeutics shares will be delisted from NASDAQ and deregistered under the Securities Exchange Act of 1934.

Pharmacosmos A/S ha completato con successo l'offerta pubblica di acquisto per acquisire G1 Therapeutics (Nasdaq: GTHX) a $7.15 per azione in contante, valutando l'azienda a circa $405 milioni. L'operazione mira a massimizzare l'accesso e l'adozione di COSELA® (trilaciclib), il primo e unico agente di protezione mieloide proattivo multilinare. Alla data di scadenza, 74.64% delle azioni in circolazione di G1 Therapeutics sono state validamente offerte. A seguito della fusione, G1 Therapeutics diventerà una filiale interamente controllata da Pharmacosmos Therapeutics Inc. Le azioni di G1 Therapeutics saranno rimosse dalla listina NASDAQ e saranno deregistrate ai sensi del Securities Exchange Act del 1934.

Pharmacosmos A/S ha completado con éxito la oferta pública de adquisición para adquirir G1 Therapeutics (Nasdaq: GTHX) a $7.15 por acción en efectivo, valuando la empresa en aproximadamente $405 millones. La transacción tiene como objetivo maximizar el acceso y la adopción de COSELA® (trilaciclib), el primer y único agente de mieloprotección multilinaje proactivo. A partir de la fecha de expiración, 74.64% de las acciones en circulación de G1 Therapeutics fueron válidamente ofrecidas. Tras la fusión, G1 Therapeutics se convertirá en una subsidiaria de propiedad total de Pharmacosmos Therapeutics Inc. Las acciones de G1 Therapeutics serán eliminadas de NASDAQ y desregistradas bajo el Securities Exchange Act de 1934.

Pharmacosmos A/S는 G1 Therapeutics (Nasdaq: GTHX)를 주당 $7.15의 현금으로 인수하는 공개입찰을 성공적으로 완료하였으며, 이 회사의 가치는 약 $405 백만입니다. 이 거래는 COSELA® (trilaciclib), 최초이자 유일무이한 다계통 골수 보호제의 접근과 사용을 극대화하는 것을 목표로 하고 있습니다. 만료일 기준, 74.64%의 G1 Therapeutics의 발행 주식이 유효하게 제안되었습니다. 합병 후 G1 Therapeutics는 Pharmacosmos Therapeutics Inc.의 완전 자회사로 전환됩니다. G1 Therapeutics의 주식은 NASDAQ에서 상장 폐지되며, 1934년 증권거래법에 따라 등록이 취소됩니다.

Pharmacosmos A/S a réussi à finaliser l'offre publique d'achat pour acquérir G1 Therapeutics (Nasdaq: GTHX) pour $7.15 par action en espèces, portant la valorisation de l'entreprise à environ $405 millions. La transaction vise à maximiser l'accès et l'utilisation de COSELA® (trilaciclib), le premier et unique agent de myélo-protection multiligne proactif. À la date d'expiration, 74.64% des actions en circulation de G1 Therapeutics ont été valablement offertes. Suite à la fusion, G1 Therapeutics deviendra une filiale entièrement détenue de Pharmacosmos Therapeutics Inc. Les actions de G1 Therapeutics seront retirées de NASDAQ et radiées en vertu de la Securities Exchange Act de 1934.

Pharmacosmos A/S hat das öffentliche Übernahmeangebot zur Akquisition von G1 Therapeutics (Nasdaq: GTHX) erfolgreich abgeschlossen, wobei $7.15 pro Aktie in bar angeboten wurden, was das Unternehmen mit etwa $405 Millionen bewertet. Die Transaktion zielt darauf ab, den Zugang und die Nutzung von COSELA® (trilaciclib), dem ersten und einzigen proaktiven, mehrlinienigen Myeloprotektionsmittel, zu maximieren. Zum Ablaufdatum wurden 74.64% der ausstehenden Aktien von G1 Therapeutics gültig angeboten. Nach der Fusion wird G1 Therapeutics eine hundertprozentige Tochtergesellschaft von Pharmacosmos Therapeutics Inc. werden. Die Aktien von G1 Therapeutics werden von NASDAQ abgezogen und gemäß dem Securities Exchange Act von 1934 deregistriert.

Positive
  • Acquisition valued at approximately $405 million, providing a premium to G1 Therapeutics shareholders
  • Potential for increased access and uptake of COSELA® (trilaciclib) in the US and international markets
  • Expansion of Pharmacosmos' product portfolio with an innovative first-in-class product
Negative
  • G1 Therapeutics will lose its independence as a public company
  • Potential job losses or restructuring following the acquisition
  • Delisting from NASDAQ may reduce liquidity for remaining shareholders

Insights

The acquisition of G1 Therapeutics by Pharmacosmos for $405 million at $7.15 per share represents a significant premium of approximately 118% over G1's closing price before the announcement. This deal strengthens Pharmacosmos' oncology portfolio, particularly with COSELA®, a first-in-class myeloprotection agent. The transaction's successful completion, with 74.64% of shares tendered, indicates strong shareholder support. Financially, this move allows Pharmacosmos to diversify its revenue streams and potentially accelerate COSELA's market penetration. For G1 investors, the all-cash deal provides immediate liquidity and a substantial return. However, the delisting from NASDAQ removes future upside potential for G1 shareholders. The acquisition's success will hinge on Pharmacosmos' ability to expand COSELA's reach both in the US and internationally, particularly in the UK and EU markets.

The acquisition of G1 Therapeutics by Pharmacosmos is a significant development in the oncology field, particularly for small cell lung cancer (SCLC) treatment. COSELA® (trilaciclib) is a groundbreaking therapy as the first and only FDA-approved proactive multilineage myeloprotection agent. Its ability to decrease chemotherapy-induced myelosuppression addresses a critical need in SCLC treatment, potentially improving patient outcomes and quality of life. The merger could accelerate COSELA's adoption and accessibility, benefiting more SCLC patients. Pharmacosmos' global presence and resources may facilitate faster international approvals and market penetration. However, it's important to monitor how this transition affects ongoing research and development, particularly for potential new indications or combinations of COSELA. The oncology community will be watching closely to see if this acquisition leads to expanded clinical trials and new therapeutic applications for trilaciclib.

This acquisition marks a strategic move in the oncology market, particularly in the supportive care segment. The global myelosuppression treatment market is projected to grow significantly, driven by increasing cancer incidence and chemotherapy use. COSELA®, as a first-in-class therapy, has a unique market position with potential for substantial growth. Pharmacosmos' established presence in iron deficiency treatments complements this acquisition, potentially creating synergies in patient care pathways. The deal aligns with the trend of larger pharmaceutical companies acquiring innovative biotech firms to bolster their pipelines. However, challenges lie ahead in expanding COSELA's market share, especially in competitive international markets. Key factors to watch include reimbursement decisions, inclusion in treatment guidelines and real-world evidence supporting COSELA's clinical benefits. The success of this acquisition will depend on Pharmacosmos' ability to leverage its existing infrastructure and expertise to maximize COSELA's commercial potential while navigating the complex oncology market landscape.

- Transaction Will Maximize the Access and Uptake of COSELA® (trilaciclib), the First and Only Proactive Multilineage Myeloprotection Agent -

- G1 Stockholders to Receive U.S. $7.15 Per Share in Cash -

HOLBAEK, Denmark and RESEARCH TRIANGLE PARK, N.C., Sept. 18, 2024 (GLOBE NEWSWIRE) -- Pharmacosmos A/S, a leader in the development of innovative treatments for patients suffering from iron deficiency and iron deficiency anemia, and G1 Therapeutics, Inc. (Nasdaq: GTHX), a commercial-stage oncology company focused on delivering next-generation therapies that improve the lives of those affected by cancer, today announced that Pharmacosmos A/S has successfully completed the previously announced tender offer to acquire all outstanding shares of G1 Therapeutics for U.S. $7.15 per share net to the holder in cash, without interest and less any applicable withholding taxes (the “Offer Price”), for a total equity value of approximately $405 million.

“We are excited to announce the completion of Pharmacosmos’ acquisition of G1. This acquisition fits perfectly with our strategy and positions our company for the next phase of growth. We are particularly thrilled to expand our product portfolio with Cosela, an innovative first-in-class product that is making a real difference for patients with small cell lung cancer. Our focus will now be on bringing Cosela to more patients and customers in the US, where it is already approved, and to start the work to have it registered and made available internationally including in the UK and EU,” said Tobias S Christensen - CEO and President of Pharmacosmos A/S.

The tender offer commenced on August 20, 2024 and expired one minute after 11:59 p.m. Eastern Time on September 17, 2024 (the "Expiration Date"). As of the Expiration Date, a total of 39,486,447 shares of G1 Therapeutics common stock were validly tendered, and not validly withdrawn, representing approximately 74.64% of the outstanding shares of G1 Therapeutics common stock as of the Expiration Date. As of the Expiration Date, the number of shares validly tendered in accordance with the terms of the tender offer and not validly withdrawn satisfied the minimum tender condition, and all other conditions to the tender offer were satisfied. On September 18, 2024, Genesis Merger Sub, Inc., an indirect wholly owned subsidiary of Pharmacosmos A/S (“Purchaser”), irrevocably accepted for payment all shares validly tendered and not validly withdrawn and has paid the depositary for such shares.

Following the closing of the tender offer, on September 18, 2024 Purchaser merged with and into G1 Therapeutics, with G1 Therapeutics continuing as the surviving corporation and a wholly owned subsidiary of Pharmacosmos Therapeutics Inc., a U.S. subsidiary of Pharmacosmos A/S. In connection with the merger, all shares of G1 Therapeutics common stock (other than (i) shares of common stock held in the treasury of G1 Therapeutics, (ii) shares of common stock owned by Pharmacosmos A/S, Purchaser, G1 Therapeutics or any of their respective direct or indirect wholly owned subsidiaries, and (iii) shares of common stock held by stockholders who have properly demanded appraisal of such shares in accordance with Delaware law) that had not been validly tendered were converted into the right to receive an amount in cash equal to the Offer Price. As a result of the transaction, G1 Therapeutics shares ceased to be traded on NASDAQ as of the date of closing of the acquisition, and shares of G1 Therapeutics common stock will be delisted from NASDAQ and deregistered under the Securities Exchange Act of 1934, as amended.

“Since our founding in 2008, G1 has been committed to improving the lives of patients living with cancer; this effort culminated in the approval and launch of COSELA® (trilaciclib), the first and only therapy that proactively delivers multilineage myeloprotection to patients with extensive-stage small cell lung cancer being treated with chemotherapy,” said Jack Bailey, Chief Executive Officer at G1 Therapeutics. “The closing of this transaction is an exciting moment for everyone working in G1 and Pharmcosmos, and the patients we seek to treat, as the combined team moves forward with COSELA to meet the needs of even more cancer patients. Finally, I want to thank the members of the G1 team throughout these last 16 years that made this innovation possible.”

Advisors

For Pharmacosmos, MTS Health Partners, L.P. served as exclusive financial advisor, and Arnold & Porter Kaye Scholer LLP served as legal counsel. For G1 Therapeutics, Centerview Partners LLC served as exclusive financial advisor, and Ropes & Gray LLP and Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. served as legal counsel.

Indication

COSELA® (trilaciclib) is indicated to decrease the incidence of chemotherapy-induced myelosuppression in adult patients when administered prior to a platinum/etoposide-containing regimen or topotecan-containing regimen for extensive-stage small cell lung cancer.

Important Safety Information

COSELA is contraindicated in patients with a history of serious hypersensitivity reactions to trilaciclib.

Warnings and precautions include injection-site reactions (including phlebitis and thrombophlebitis), acute drug hypersensitivity reactions, interstitial lung disease (pneumonitis), and embryo-fetal toxicity.

The most common adverse reactions (>10%) were fatigue, hypocalcemia, hypokalemia, hypophosphatemia, aspartate aminotransferase increased, headache, and pneumonia.

This information is not comprehensive. Please click here for full Prescribing Information. https://www.g1therapeutics.com/cosela/pi/      

To report suspected adverse reactions, contact G1 Therapeutics at 1-800-790-G1TX or call FDA at 1-800-FDA-1088 or visit www.fda.gov/medwatch.

Pharmacosmos Group

Pharmacosmos A/S, headquartered in Holbaek, Denmark, and founded in 1965, is a highly specialised company focused on carbohydrate chemistry and a global leader in the development of innovative treatments for patients suffering from iron deficiency and iron deficiency anaemia. With companies in the UK, Ireland, Nordics, Germany, the USA, and China, as well as through partners, Pharmacosmos markets its products around the world. With a strong and ongoing commitment to R&D, Pharmacosmos is able to leverage a unique carbohydrate production platform along with deep expertise in the synthesis of iron-carbohydrate complexes. The Pharmacosmos Group has more than 500 employees.

About G1 Therapeutics

G1 Therapeutics, Inc. is a commercial-stage oncology biopharmaceutical company whose mission is to develop and deliver next-generation therapies that improve the lives of those affected by cancer, including the Company’s first commercial product, COSELA® (trilaciclib). G1’s goal is to provide innovative therapeutic advances for people living with cancer. G1 is based in Research Triangle Park, N.C. For additional information, please visit www.g1therapeutics.com and follow us on X (formerly known as Twitter) @G1Therapeutics and LinkedIn.

G1 Therapeutics® and the G1 Therapeutics logo and COSELA® and the COSELA logo are trademarks of G1 Therapeutics, Inc.

Pharmacosmos A/S Contact:

Christian Lundquist Madsen
VP Global Marketing & Communication
+45 5948 5959
clm@pharmacosmos.com

G1 Therapeutics Contacts:

Will Roberts
Communications Officer
Vice President, Investor Relations and Corporate Communications
(919) 907-1944
wroberts@g1therapeutics.com


FAQ

What is the acquisition price for G1 Therapeutics (GTHX)?

Pharmacosmos A/S is acquiring G1 Therapeutics (GTHX) for $7.15 per share in cash, valuing the company at approximately $405 million.

What percentage of G1 Therapeutics (GTHX) shares were tendered in the offer?

As of the expiration date, 74.64% of outstanding G1 Therapeutics (GTHX) shares were validly tendered in the offer.

What will happen to G1 Therapeutics (GTHX) stock after the acquisition?

G1 Therapeutics (GTHX) shares will be delisted from NASDAQ and deregistered under the Securities Exchange Act of 1934 following the acquisition.

What is the main product of G1 Therapeutics (GTHX) that Pharmacosmos is interested in?

Pharmacosmos is particularly interested in COSELA® (trilaciclib), G1 Therapeutics' first-in-class product for myeloprotection in small cell lung cancer patients.

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