Gain Therapeutics, Inc. - GANX STOCK NEWS

Gain Therapeutics (Nasdaq: GANX) showcased promising data for its lead compound GT-02329 targeting Gaucher disease at the 1st IWGDD Symposium. The compound boosts GCase levels and activity, effectively reducing toxic substrate accumulation in both human and mouse models. Specifically, the data highlighted increased GCase activity and decreases in glucosylceramide (GlcCer) and glucosylsphingosine (GlcSph). The company aims to further investigate GT-02329's potential as a therapy to alleviate neurological effects associated with Gaucher disease.

Gain Therapeutics, Inc. (Nasdaq: GANX) has announced promising pre-clinical results for its lead compound, GT-02287, targeting Parkinson’s Disease. Presented at the XXVII World Congress on Parkinson’s Disease, the compound successfully penetrates the brain, reduces alpha-synuclein levels, and improves dopamine production in neuronal models. Data showcases its ability to bind with the GCase protein, enhancing lysosomal function. The findings suggest potential disease-modifying effects, positioning GT-02287 as a candidate for clinical advancement this year.

Gain Therapeutics (Nasdaq: GANX) announced that CEO Eric Richman will participate in a fireside chat at the B. Riley Securities 2022 Virtual Neuro & Ophthalmology Conference on April 28, 2022, from 2:00 to 2:30 p.m. ET. Investors are invited to join via webcast. Gain Therapeutics specializes in drug discovery using its proprietary computational platform, SEE-Tx®, targeting allosteric regulators for various diseases. The company’s lead program focuses on Parkinson’s disease, supported by funding from notable organizations.

Gain Therapeutics (Nasdaq: GANX) presented promising pre-clinical data for its lead candidate GT-02287 at the 2022 Synuclein Meeting in Belgium. The compound enhances GCase levels, promotes lysosomal health, and depletes alpha-synuclein, indicating potential benefits for Parkinson's Disease patients. Key findings include increased GCase activity and neuron survival in relevant models. CEO Eric Richman emphasized the candidate's disease-modifying potential, while the data supports a therapeutic strategy targeting GCase for neurodegenerative diseases.

Gain Therapeutics (Nasdaq: GANX) announced promising pre-clinical data for its Gaucher Disease program, presented at the 2022 Glycolipid and Sphingolipid Biology GRC. The study highlighted that lead compounds significantly increase the levels and activity of the beta-glucocerebrosidase (GCase) protein, enhancing its co-localization with lysosomes and reducing toxic substrate accumulation in neurons. These orally bioavailable compounds may offer a potential treatment for patients with neuronopathic Gaucher disease, addressing a significant unmet medical need.

Gain Therapeutics, Inc. (Nasdaq: GANX) announced significant progress in its lead program for GBA1 Parkinson’s Disease, highlighted by compelling preclinical data and a strong cash position of $36.88 million as of December 31, 2021. The company plans to initiate a first-in-human clinical trial by the end of 2022, following their collaboration with Zentalis Pharmaceuticals to identify novel oncology molecules. Despite increased operating expenses leading to a net loss of $13.89 million, the increase in revenue to $165,000 indicates growing traction in their development efforts.

Gain Therapeutics (Nasdaq: GANX) presented new pre-clinical data at the International Conference on Alzheimer’s and Parkinson’s Diseases demonstrating the potential of their STAR small molecules in treating neurodegenerative diseases. The data shows that enhancing glucocerebrosidase (GCase) activity improves key pathological features linked to Parkinson’s and Alzheimer’s. Results from both Parkinson’s and Alzheimer’s models indicated reductions in neurotoxicity, inflammation, and toxic proteins, suggesting a promising therapeutic avenue for CNS diseases caused by protein misfolding.

Gain Therapeutics (NASDAQ: GANX) announced its participation in key investor and scientific conferences, emphasizing its commitment to neurodegenerative disease research. CEO Eric Richman will present at the Oppenheimer 32nd Annual Healthcare Conference on March 17, 2022, with a webcast available for investors. Additionally, Gain will showcase scientific data at the AD/PD™ 2022 Conference, running from March 15-20, 2022, and sponsor the Krabbe Translational Research Network Meeting from March 15-18, 2022. The company focuses on innovative treatments using its SEE-Tx™ platform.

Gain Therapeutics (NASDAQ: GANX) has unveiled promising pre-clinical data on its Gaucher Disease program at the 18th Annual WORLDSymposium. The study demonstrated that its STARs compounds significantly increase GCase protein levels, diminish inflammatory cytokines, and enhance lysosomal functions in GD-iPSC-derived dopaminergic neurons. These findings validate the company’s drug discovery platform, SEE-Tx®, and indicate potential for a first-in-class therapy. Gain aims to commence IND-enabling studies in Q4 2022, addressing unmet needs in neuronopathic Gaucher Disease treatment.