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Gain Therapeutics, Inc. (NASDAQ: GANX) is a pioneering biotechnology company committed to the discovery and development of novel small molecule therapeutics. Specializing in addressing rare genetic diseases, Gain Therapeutics focuses on orphan diseases caused by inborn errors of metabolism. With a strong emphasis on lysosomal storage disorders, central nervous system disorders, metabolic disorders, and oncology, the company's innovative approach aims to provide solutions where there is a high unmet medical need.
At the forefront of Gain Therapeutics' pipeline is GT-02287, a promising clinical-stage product candidate targeting GBA1 Parkinson's disease. Currently in Phase 1 clinical trials, GT-02287 is designed to be a disease-modifying treatment. It functions as an allosteric protein modulator to restore the activity of the lysosomal enzyme glucocerebrosidase (GCase), tackling the underlying cause of disease rather than just alleviating symptoms.
The company's proprietary Magellan™ platform leverages AI-supported structural biology and advanced algorithms to discover novel allosteric binding sites on disease-implicated proteins. This innovative computational technology identifies potential small molecules that can bind to these sites, offering new avenues for therapeutic development. Magellan builds upon Gain’s original SEE-Tx® platform, enhancing it with AI and virtual screening capabilities to explore vast chemical spaces.
Recent achievements highlight Gain Therapeutics' impact on the biotech landscape. Data presented at the 20th WORLDSymposium™ showcased the progressive reversal of motor deficits in preclinical models, alongside a significant reduction of neurodegeneration biomarkers. This underscores the potential of GT-02287 as a best-in-class treatment for neurodegenerative diseases.
Gain Therapeutics collaborates with notable organizations including The Michael J. Fox Foundation for Parkinson’s Research and The Silverstein Foundation for Parkinson’s with GBA. These partnerships provide essential support and validation for the company's mission to transform therapeutic landscapes with innovative treatments.
For more information, visit GainTherapeutics.com and follow their updates on LinkedIn.
Gain Therapeutics, Inc. (Nasdaq: GANX) announced that its CEO, Matthias Alder, will present a corporate update at the Sidoti Small-Cap Virtual Investor Conference on January 18, 2023, at 2:30 PM ET. The presentation will showcase the company’s advancements in drug discovery through its computational platform, focusing on drug-protein interactions and targeting various diseases, including Parkinson’s disease. The event can be accessed via the company’s investor relations page, with a replay available for 90 days post-event.
Gain Therapeutics (NASDAQ: GANX) recently reported its third-quarter financial results, highlighting a net loss of $4.56 million and cash reserves of $25.7 million as of September 30, 2022. The company presented promising preclinical data for GT-02287, its lead candidate for Parkinson's disease, demonstrating potential disease-modifying effects, including improved motor skills in mice. Gain anticipates beginning its Phase 1 clinical trial in mid-2023, leveraging its strong financial foundation to advance its research programs.
Gain Therapeutics (NASDAQ: GANX) announced positive preclinical data for its investigational small molecule therapeutic, GT-02287, targeting Parkinson’s Disease. Presented at the Shaare Zedek Medical Center symposium, the study demonstrated significant increases in GCase levels and reductions in α-synuclein aggregates using patient-derived neurons. This suggests GT-02287 may correct GBA1 mutations, which affect 14% of Parkinson's patients. The findings support GT-02287's potential as a disease-modifying treatment, reinforcing Gain's approach using its proprietary computational drug discovery platform.
Gain Therapeutics, Inc. (NASDAQ: GANX) has appointed Matthias Alder as its new Chief Executive Officer, effective immediately, following the departure of Eric Richman, who will remain on the board and serve as a senior advisor. Alder, the former Chief Operating Officer, brings over 25 years of experience in the pharmaceutical sector. His leadership is anticipated to drive the company's growth strategy and advance key programs targeting Parkinson's and Gaucher diseases. The board size has increased to eight members with Alder's appointment.
Gain Therapeutics (Nasdaq: GANX) presented preclinical data on GT-02287 at the International Congress of Parkinson’s Disease and Movement Disorders 2022 Annual Meeting. Results demonstrated a significant dose-dependent improvement in lysosomal health and fine motor skills in Parkinson’s disease models. GT-02287 shows promise in neutralizing CBE-mediated neurodegeneration and enhancing neuronal survival. This research indicates the potential for GT-02287 as a first-in-class disease-modifying therapy, aiming to restore enzyme function in Parkinson’s patients.
Gain Therapeutics, Inc. (Nasdaq: GANX) is set to present preclinical data at two significant medical meetings in September 2022. The first presentation will occur at the MDS 2022 International Congress in Madrid on September 17, featuring a poster on GT-02287, a promising allosteric regulator for Parkinson's disease. The second presentation will be at the GBA-PD Symposium in Jerusalem on September 22, discussing innovative strategies for GBA-PD. Gain's approach employs its unique computational discovery platform, SEE-Tx®, to drive advancements in drug development.
Gain Therapeutics (Nasdaq: GANX) announced that COO Matthias Alder will present at the H.C. Wainwright 24th Annual Global Investment Conference from September 12-14, 2022, in New York. The presentation is scheduled for September 12 at 7:00 AM ET and will be available via a webcast. Gain Therapeutics focuses on transforming drug discovery with its proprietary SEE-Tx® platform, targeting allosteric binding sites to develop treatments for various diseases, including neurodegenerative and metabolic disorders.
Gain Therapeutics, Inc. (Nasdaq: GANX) announced its participation in the 2022 BTIG Biotechnology Conference on August 9 at 12 p.m. ET. The event will take place in New York City on August 8-9. The company will engage in a fireside chat and host investor meetings. Gain's unique computational platform, SEE-Tx®, identifies novel allosteric binding sites to revolutionize drug discovery, targeting diseases like Parkinson’s. Their work has garnered funding from notable organizations, including The Michael J. Fox Foundation.
Gain Therapeutics, Inc. (Nasdaq: GANX) is set to present at the Jefferies Healthcare Conference from June 8-10, 2022, in New York, NY. COO Matthias Alder will host a corporate presentation on June 10 at 8:00 AM ET, with a live webcast available on the company's website. Gain Therapeutics focuses on transforming drug discovery through its proprietary technology, SEE-Tx®, which identifies novel allosteric binding sites for various diseases. Their pipeline targets neurodegenerative diseases, lysosomal storage disorders, and oncology, with significant funding support for their Parkinson’s disease program.
Gain Therapeutics, Inc. (Nasdaq: GANX) will present at the H.C. Wainwright Global Investment Conference on May 24, 2022, at 1:30 PM ET. CEO Eric Richman is set to lead the corporate presentation and host one-on-one meetings during the event, which runs from May 23-25 in Miami, Florida. Gain is known for its innovative drug discovery platform that targets allosteric binding sites to create small molecule treatments for various diseases, including neurodegenerative disorders. A live webcast will be available on their website, and an archived version will follow.
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